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  1. Article ; Online: Genomes of extinct hominins and human reproductive evolution

    Pallav Sengupta / Sulagna Dutta / Bhupender S. Chhikara

    EXCLI Journal : Experimental and Clinical Sciences, Vol 22, Pp 392-

    2023  Volume 394

    Keywords hominins ; reproductive evolution ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Mapping the age of laboratory rabbit strains to human

    Pallav Sengupta / Sulagna Dutta

    International Journal of Preventive Medicine, Vol 11, Iss 1, Pp 194-

    2020  Volume 194

    Abstract: Rabbit strains find immense application in biomedical research with every strain having their discrete advantage in specific research endeavor. Acceptability of rabbit strains as laboratory animals owes to their breeding ease, availability, cost- ... ...

    Abstract Rabbit strains find immense application in biomedical research with every strain having their discrete advantage in specific research endeavor. Acceptability of rabbit strains as laboratory animals owes to their breeding ease, availability, cost-effectiveness, ethical conveniences, larger size, compared to rats and mice, and responsiveness. With respect to different life phases, the article displays that one human year is equivalent to: (1) in developmental phase, 56.77 days for New Zealand White (NZW) and New Zealand Red (NZR) rabbits, 71.01 days for Dutch belted and Polish rabbits, and 85.28 days for Californian rabbits; (2) in the prepubertal phase, 13.04 days for NZW and Dutch belted, 15.65 days for NZR and Californian, and 10.43 days for Polish rabbits; (3) in the adult phase, 18.25 days for NZW and Californian rabbits, 22.75 days for NZR, and 12 days for Dutch Belted and Polish rabbits; (4) during reproductive senescence, 42.94 days for NZW, NZR and Californian rabbits, 28.62 days for Dutch belted, and 25.05 days for Polish rabbits; (5) in the post-senescence phase, 50.34 days for NZW, 25.17 days for NZR, Dutch Belted and Californian and 31.46 days for Polish rabbits. The laboratory rabbit strains differ in various physiological, developmental and genetic make-ups, which also reflect upon the correlation of their age at different life stages with that of a human. The present article aids selection of laboratory rabbit strain of accurate age as per experimental need, by precisely relating the same with age of human considering different life stages.
    Keywords aging ; animal models ; physiology ; rabbits ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Influence of ejaculatory abstinence period on semen quality of 5165 normozoospermic and oligozoospermic Nigerian men

    Roland E. Akhigbe / Moses A. Hamed / Sulagna Dutta / Pallav Sengupta

    Health Science Reports, Vol 5, Iss 5, Pp n/a-n/a (2022)

    A retrospective study

    2022  

    Abstract: Abstract Background and Aims Several studies have shown that the length of ejaculatory abstinence alters sperm quality. However, the available data are conflicting and none seems to exist in a Nigerian population. The present study aims to compare the ... ...

    Abstract Abstract Background and Aims Several studies have shown that the length of ejaculatory abstinence alters sperm quality. However, the available data are conflicting and none seems to exist in a Nigerian population. The present study aims to compare the semen quality in normozoospermic and oligozoospermic semen samples of a homogenous Nigerian population, following varying ejaculatory abstinence days (EAD); less than 2, 2–3, and 3–7 days. Methods The present retrospective study included 5165 semen samples collected over 5 years, from April 2015 to April 2020. Results In normozoospermic samples, sperm count and total sperm count were significantly higher in prolonged EAD. In oligozoospermic patients, semen volume significantly increased with prolonged EAD, while sperm count, total sperm count, and progressive motility were significantly reduced with prolonged EAD. In addition, EAD and sperm volume positively correlated in oligozoospermic patients. Conclusion Our findings indicate that EAD affects sperm quality in both normozoospermic and oligozoospermic men with varying impacts. Prolonged EAD increased sperm count and total sperm count in normozoospermic patients, while EAD increased semen volume but reduced sperm count, total sperm count, and progressive motility in oligozoospermic patients.
    Keywords ejaculatory abstinence ; male fertility ; Nigeria ; sperm count ; sperm motility ; sperm quality ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Hormones in male reproduction and fertility

    Pallav Sengupta / Sulagna Dutta

    Asian Pacific Journal of Reproduction, Vol 8, Iss 5, Pp 187-

    2019  Volume 188

    Keywords Medicine ; R
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction

    Sulagna Dutta / Pallav Sengupta / Petr Slama / Shubhadeep Roychoudhury

    International Journal of Molecular Sciences, Vol 22, Iss 10043, p

    2021  Volume 10043

    Abstract: Inflammation is among the core causatives of male infertility. Despite male infertility being a serious global issue, “bits and pieces” of its complex etiopathology still remain missing. During inflammation, levels of proinflammatory mediators in the ... ...

    Abstract Inflammation is among the core causatives of male infertility. Despite male infertility being a serious global issue, “bits and pieces” of its complex etiopathology still remain missing. During inflammation, levels of proinflammatory mediators in the male reproductive tract are greater than usual. According to epidemiological research, in numerous cases of male infertility, patients suffer from acute or chronic inflammation of the genitourinary tract which typically occurs without symptoms. Inflammatory responses in the male genital system are inextricably linked to oxidative stress (OS). OS is detrimental to male fertility parameters as it causes oxidative damage to reproductive cells and intracellular components. Multifarious male infertility causative factors pave the way for impairing male reproductive functions via the common mechanisms of OS and inflammation, both of which are interlinked pathophysiological processes, and the occurrence of any one of them induces the other. Both processes may be simultaneously found in the pathogenesis of male infertility. Thus, the present article aims to explain the role of inflammation and OS in male infertility in detail, as well as to show the mechanistic pathways that link causative factors of male reproductive tract inflammation, OS induction, and oxidant-sensitive cellular cascades leading to male infertility.
    Keywords cytokines ; inflammation ; male infertility ; oxidative stress ; reactive oxygen species ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 590
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Endocrinopathies and Male Infertility

    Pallav Sengupta / Sulagna Dutta / Ivan Rolland Karkada / Suresh V. Chinni

    Life, Vol 12, Iss 10, p

    2022  Volume 10

    Abstract: Male infertility is approaching a concerning prevalence worldwide, and inflicts various impacts on the affected couple. The hormonal assessment is a vital component of male fertility evaluation as endocrine disorders are markedly reversible causatives of ...

    Abstract Male infertility is approaching a concerning prevalence worldwide, and inflicts various impacts on the affected couple. The hormonal assessment is a vital component of male fertility evaluation as endocrine disorders are markedly reversible causatives of male infertility. Precise hormonal regulations are prerequisites to maintain normal male fertility parameters. The core male reproductive event, spermatogenesis, entails adequate testosterone concentration, which is produced via steroidogenesis in the Leydig cells. Physiological levels of both the gonadotropins are needed to achieve normal testicular functions. The hypothalamus-derived gonadotropin-releasing hormone (GnRH) is considered the supreme inducer of the gonadotropins and thereby the subsequent endocrine reproductive events. This hypothalamic–pituitary–gonadal (HPG) axis may be modulated by the thyroidal or adrenal axis and numerous other reproductive and nonreproductive hormones. Disruption of this fine hormonal balance and their crosstalk leads to a spectrum of endocrinopathies, inducing subfertility or infertility in men. This review article will discuss the most essential endocrinopathies associated with male factor infertility to aid precise understanding of the endocrine disruptions-mediated male infertility to encourage further research to reveal the detailed etiology of male infertility and perhaps to develop more customized therapies for endocrinopathy-induced male infertility.
    Keywords endocrinopathies ; male infertility ; hypothyroidism ; hyperprolactinemia ; Science ; Q
    Subject code 590
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Functions of follicular and marginal zone B cells in pregnancy

    Sulagna Dutta / Pallav Sengupta

    Asian Pacific Journal of Reproduction, Vol 7, Iss 4, Pp 191-

    2018  Volume 192

    Keywords Medicine ; R
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Coenzyme Q10 Improves Sperm Parameters, Oxidative Stress Markers and Sperm DNA Fragmentation in Infertile Patients with Idiopathic Oligoasthenozoospermia

    Ahmed T. Alahmar / Aldo E. Calogero / Pallav Sengupta / Sulagna Dutta

    The World Journal of Men's Health, Vol 39, Iss 2, Pp 346-

    2021  Volume 351

    Abstract: Purpose: Oxidative stress and sperm DNA fragmentation (SDF) are potential contributing factors for idiopathic male infertility. Coenzyme Q10 (CoQ10) have been reported to be effective in the treatment of idiopathic male infertility, in general, owing to ... ...

    Abstract Purpose: Oxidative stress and sperm DNA fragmentation (SDF) are potential contributing factors for idiopathic male infertility. Coenzyme Q10 (CoQ10) have been reported to be effective in the treatment of idiopathic male infertility, in general, owing to its antioxidant properties. Thus, the present study intends to investigate the effects of CoQ10 therapy on semen parameters, oxidative stress markers and SDF in infertile men, specifically with idiopathic oligoasthenozoospermia (OA). Materials and Methods: In this case-control study, sixty-five infertile patients with idiopathic OA and forty fertile men (control) were included. All participants underwent semen analysis based on the World Health Organization guidelines (5th edition, 2010). Patients received CoQ10 at the dose of 200 mg/d orally for three months. Seminal plasma CoQ10, total antioxidant capacity (TAC), total reactive oxygen species (ROS), glutathione peroxidase (GPx), and SDF levels were measured in controls (baseline) and infertile patients pre- and post-CoQ10 treatment. Results: CoQ10 treatment for three months significantly improved sperm concentration (p<0.05), progressive motility (p<0.05), total motility (p<0.01), seminal fluid CoQ10 concentration (p<0.001), TAC (p<0.001), and GPx (p<0.001) levels in infertile men with OA. Further, ROS level (p<0.05) and SDF percentage (p<0.001) were reduced in OA patients as compared to the baseline. CoQ10 levels also correlated positively with sperm concentration (r=0.48, p=0.01) and total motility (r=0.59, p=0.003) while a negative correlation was recorded between SDF and sperm motility (r=-0.54, p=0.006). Conclusions: CoQ10 supplementation for three months could improve semen parameters, oxidative stress markers and reduce SDF in infertile men with idiopathic OA.
    Keywords coenzyme q10 ; dna fragmentation ; male infertility ; oxidative stress ; sperm ; Medicine ; R ; Diseases of the genitourinary system. Urology ; RC870-923
    Subject code 630
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Korean Society for Sexual Medicine and Andrology
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Reproductive toxicity of combined effects of endocrine disruptors on human reproduction

    Sulagna Dutta / Pallav Sengupta / Sovan Bagchi / Bhupender S. Chhikara / Aleš Pavlík / Petr Sláma / Shubhadeep Roychoudhury

    Frontiers in Cell and Developmental Biology, Vol

    2023  Volume 11

    Abstract: Confluence of environmental, genetic, and lifestyle variables is responsible for deterioration of human fecundity. Endocrine disruptors or endocrine disrupting chemicals (EDCs) may be found in a variety of foods, water, air, beverages, and tobacco smoke. ...

    Abstract Confluence of environmental, genetic, and lifestyle variables is responsible for deterioration of human fecundity. Endocrine disruptors or endocrine disrupting chemicals (EDCs) may be found in a variety of foods, water, air, beverages, and tobacco smoke. It has been demonstrated in experimental investigations that a wide range of endocrine disrupting chemicals have negative effects on human reproductive function. However, evidence on the reproductive consequences of human exposure to endocrine disrupting chemicals is sparse and/or conflicting in the scientific literature. The combined toxicological assessment is a practical method for assessing the hazards of cocktails of chemicals, co-existing in the environment. The current review provides a comprehensive overview of studies emphasizing the combined toxicity of endocrine disrupting chemicals on human reproduction. Endocrine disrupting chemicals interact with each other to disrupt the different endocrine axes, resulting in severe gonadal dysfunctions. Transgenerational epigenetic effects have also been induced in germ cells, mostly through DNA methylation and epimutations. Similarly, after acute or chronic exposure to endocrine disrupting chemicals combinations, increased oxidative stress (OS), elevated antioxidant enzymatic activity, disrupted reproductive cycle, and reduced steroidogenesis are often reported consequences. The article also discusses the concentration addition (CA) and independent action (IA) prediction models, which reveal the importance of various synergistic actions of endocrine disrupting chemicals mixtures. More crucially, this evidence-based study addresses the research limitations and information gaps, as well as particularly presents the future research views on combined endocrine disrupting chemicals toxicity on human reproduction.
    Keywords endocrine disrupting chemicals ; metals ; human fertility ; infertility ; oxidative stress ; reductive stress ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Role of melatonin in male reproduction

    Koushik Bhattacharya / Pallav Sengupta / Sulagna Dutta

    Asian Pacific Journal of Reproduction, Vol 8, Iss 5, Pp 211-

    2019  Volume 219

    Abstract: Melatonin, conventionally accepted as a pineal gland secretion, is a neuromodulator whose physiological concentrations are regulated by circadian rhythms. Alteration in melatonin levels owing to circadian influences is a major regulator of reproductive ... ...

    Abstract Melatonin, conventionally accepted as a pineal gland secretion, is a neuromodulator whose physiological concentrations are regulated by circadian rhythms. Alteration in melatonin levels owing to circadian influences is a major regulator of reproductive functions in animal species that are seasonal breeders. Attributing to its antioxidant properties and capability to cross physiological barriers, such as the blood-brain barrier, the blood-testis barrier as well as having almost no toxicity, melatonin finds high relevance in amelioration of male fertility parameters. Melatonin may affect male reproductive functions by influencing the release of hypothalamic gonadotropin-releasing hormone and pituitary luteinizing hormone, which are among the key hormones in regulation of male reproduction. It may directly act on testicular cells to influence testicular functions. The property of melatonin most essential for testicular functions is its ability to scavenge free radicals, thereby preventing testicular oxidative damage. This article summarizes the updated data on the versatility of melatonin as an endogenous rhythm setter, as an antioxidant molecule and its possible physiological impacts in male reproductive functions.
    Keywords Male infertility ; Melatonin ; Oxidative stress ; Reactive oxygen species ; Semen quality ; Medicine ; R
    Subject code 590
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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