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Article ; Online: A pilot study: effect of irisin on trabecular bone in a streptozotocin-induced animal model of type 1 diabetic osteopathy utilizing a micro-CT.

Mohsin, Sahar / Brock, Fiona / Kaimala, Suneesh / Greenwood, Charlene / Sulaiman, Mohsin / Rogers, Keith / Adeghate, Ernest

PeerJ

2023 Volume 11, Page(s) e16278

Abstract: Background: Osteoporosis is a significant co-morbidity of type 1 diabetes mellitus (DM1) leading to increased fracture risk. Exercise-induced hormone 'irisin' in low dosage has been shown to have a beneficial effect on bone metabolism by increasing ... ...

Abstract	Background: Osteoporosis is a significant co-morbidity of type 1 diabetes mellitus (DM1) leading to increased fracture risk. Exercise-induced hormone 'irisin' in low dosage has been shown to have a beneficial effect on bone metabolism by increasing osteoblast differentiation and reducing osteoclast maturation, and inhibiting apoptosis and inflammation. We investigated the role of irisin in treating diabetic osteopathy by observing its effect on trabecular bone. Methods: DM1 was induced by intraperitoneal injection of streptozotocin 60 mg/kg body weight. Irisin in low dosage (5 µg twice a week for 6 weeks I/P) was injected into half of the control and 4-week diabetic male Wistar rats. Animals were sacrificed six months after induction of diabetes. The trabecular bone in the femoral head and neck was analyzed using a micro-CT technique. Bone turnover markers were measured using ELISA, Western blot, and RT-PCR techniques. Results: It was found that DM1 deteriorates the trabecular bone microstructure by increasing trabecular separation (Tb-Sp) and decreasing trabecular thickness (Tb-Th), bone volume fraction (BV/TV), and bone mineral density (BMD). Irisin treatment positively affects bone quality by increasing trabecular number Conclusions: This is the first pilot study to our knowledge that shows that a low dose of irisin marginally improves the trabecular bone in DM1 and is an effective peptide in reducing sclerostin levels.
MeSH term(s)	Rats ; Animals ; Male ; X-Ray Microtomography ; Fibronectins ; Pilot Projects ; Streptozocin ; Osteocalcin ; Diabetes Mellitus, Type 1/drug therapy ; Cancellous Bone/diagnostic imaging ; Rats, Wistar ; Models, Animal
Chemical Substances	Fibronectins ; Streptozocin (5W494URQ81) ; Osteocalcin (104982-03-8)
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.16278
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sulfated polysaccharide ascophyllan from Padina tetrastromatica enhances healing of burn wounds by ameliorating inflammatory responses and oxidative damage.

Sulaiman, Mohsin / Alyileili, Salem Rashed / Raghavankutty, Mahadevan / Kurup, G Muraleedhara

Molecular biology reports

2020 Volume 47, Issue 11, Page(s) 8701–8710

Abstract: Sulfated polysaccharide ascophyllan from marine brown algae has been identified to have burn wound healing properties. Thus, we examined the effects of ascophyllan fraction (AF3) on the inflammatory response and oxidative damage in burn wounds. Full- ... ...

Abstract	Sulfated polysaccharide ascophyllan from marine brown algae has been identified to have burn wound healing properties. Thus, we examined the effects of ascophyllan fraction (AF3) on the inflammatory response and oxidative damage in burn wounds. Full-thickness burn wounds in rats were then treated twice per day with topical AF3 ointment (5%), while control groups were treated with 10% povidone-iodine (positive control) and petroleum jelly-based ointment (negative control). The activity of cyclooxygenase-2 and myeloperoxidase and levels of C-reactive protein, nitric oxide, and proinflammatory cytokines (tumor necrosis factor-α, interleukin-6, and interleukin-1β) were observed to have significantly decreased in peripheral blood mononuclear cells, serum, and wound tissue of the group treated with AF3 ointment on day 8 after wounding. The expression of inducible nitric oxide synthase, endothelial nitric oxide synthase, and vascular endothelial growth factor at the mRNA level was determined to be upregulated in the wound tissue of the AF3 ointment-treated group. After treatment with AF3 ointment, the antioxidant enzyme activity and level of reduced glutathione were upregulated, whereas the content of thiobarbituric acid reactive substances decreased. Treatment of burn wounds using 5% AF3 ointment decreases oxidative damage associated with inflammation deceptively via inhibition of inflammatory enzymes, regulation of proinflammatory cytokines, upregulation of angiogenesis, and activity of antioxidant enzymes.
MeSH term(s)	Animals ; Antioxidants/administration & dosage ; Antioxidants/pharmacology ; Burns/drug therapy ; Cytokines/metabolism ; Male ; Ointments/administration & dosage ; Ointments/pharmacology ; Oxidative Stress/drug effects ; Phaeophyceae/chemistry ; Polysaccharides/administration & dosage ; Polysaccharides/pharmacology ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Wound Healing/drug effects
Chemical Substances	Antioxidants ; Cytokines ; Ointments ; Polysaccharides ; Reactive Oxygen Species ; ascophyllin
Language	English
Publishing date	2020-11-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-020-05914-5
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Article: Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration.

Hassan, Mozan / Sulaiman, Mohsin / Yuvaraju, Priya Dharshini / Galiwango, Emmanuel / Rehman, Ihtesham Ur / Al-Marzouqi, Ali H / Khaleel, Abbas / Mohsin, Sahar

Journal of functional biomaterials

2022 Volume 13, Issue 1

Abstract: Synthetic bone graft substitutes have attracted increasing attention in tissue engineering. This study aimed to fabricate a novel, bioactive, porous scaffold that can be used as a bone substitute. Strontium and zinc doped nano-hydroxyapatite (Sr/Zn n-HAp) ...

Abstract	Synthetic bone graft substitutes have attracted increasing attention in tissue engineering. This study aimed to fabricate a novel, bioactive, porous scaffold that can be used as a bone substitute. Strontium and zinc doped nano-hydroxyapatite (Sr/Zn n-HAp) were synthesized by a water-based sol-gel technique. Sr/Zn n-HAp and poly (lactide-co-glycolide) (PLGA) were used to fabricate composite scaffolds by supercritical carbon dioxide technique. FTIR, XRD, TEM, SEM, and TGA were used to characterize Sr/Zn n-HAp and the composite scaffolds. The synthesized scaffolds were adequately porous with an average pore size range between 189 to 406 µm. The scaffolds demonstrated bioactive behavior by forming crystals when immersed in the simulated body fluid. The scaffolds after immersing in Tris/HCl buffer increased the pH value of the medium, establishing their favorable biodegradable behavior. ICP-MS study for the scaffolds detected the presence of Sr, Ca, and Zn ions in the SBF within the first week, which would augment osseointegration if implanted in the body. nHAp and their composites (PLGA-nHAp) showed ultimate compressive strength ranging between 0.4-19.8 MPa. A 2.5% Sr/Zn substituted nHAp-PLGA composite showed a compressive behavior resembling that of cancellous bone indicating it as a good candidate for cancellous bone substitute.
Language	English
Publishing date	2022-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2648525-4
ISSN	2079-4983
ISSN	2079-4983
DOI	10.3390/jfb13010013
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Article: Sulfated polysaccharide ascophyllan from Padina tetrastromatica enhances healing of burn wounds by ameliorating inflammatory responses and oxidative damage

Sulaiman, Mohsin / Alyileili, Salem Rashed / Raghavankutty, Mahadevan / Kurup, G. Muraleedhara

Molecular biology reports. 2020 Nov., v. 47, no. 11

2020

Abstract	Sulfated polysaccharide ascophyllan from marine brown algae has been identified to have burn wound healing properties. Thus, we examined the effects of ascophyllan fraction (AF3) on the inflammatory response and oxidative damage in burn wounds. Full-thickness burn wounds in rats were then treated twice per day with topical AF3 ointment (5%), while control groups were treated with 10% povidone-iodine (positive control) and petroleum jelly-based ointment (negative control). The activity of cyclooxygenase-2 and myeloperoxidase and levels of C-reactive protein, nitric oxide, and proinflammatory cytokines (tumor necrosis factor-α, interleukin-6, and interleukin-1β) were observed to have significantly decreased in peripheral blood mononuclear cells, serum, and wound tissue of the group treated with AF3 ointment on day 8 after wounding. The expression of inducible nitric oxide synthase, endothelial nitric oxide synthase, and vascular endothelial growth factor at the mRNA level was determined to be upregulated in the wound tissue of the AF3 ointment-treated group. After treatment with AF3 ointment, the antioxidant enzyme activity and level of reduced glutathione were upregulated, whereas the content of thiobarbituric acid reactive substances decreased. Treatment of burn wounds using 5% AF3 ointment decreases oxidative damage associated with inflammation deceptively via inhibition of inflammatory enzymes, regulation of proinflammatory cytokines, upregulation of angiogenesis, and activity of antioxidant enzymes.
Keywords	C-reactive protein ; Padina ; angiogenesis ; antioxidant enzymes ; blood serum ; endothelial nitric oxide synthase ; enzyme activity ; gene expression ; glutathione ; inducible nitric oxide synthase ; inflammation ; interleukin-6 ; molecular biology ; myeloperoxidase ; necrosis ; neoplasms ; nitric oxide ; ointments ; petroleum ; polysaccharides ; prostaglandin synthase ; vascular endothelial growth factors
Language	English
Dates of publication	2020-11
Size	p. 8701-8710.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-020-05914-5
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of Trichoderma reesei Degraded Date Pits Supplementation on Growth Performance, Immunoglobulin Levels, and Intestinal Barrier Functions of Broiler Chickens.

Alyileili, Salem Rashed / El-Tarabily, Khaled / Ibrahim, Wissam Hachem / Sulaiman, Mohsin / Hussein, Ahmed Soliman

Recent patents on food, nutrition & agriculture

2019 Volume 11, Issue 2, Page(s) 168–181

Abstract: Background: Date palm (Phoenix dactylifera L.) is a dominant fruit crop in most Arabian countries. Date pits, as a major byproduct which remained after consumption of date flesh, proved to be a valuable source of energy.: Objectives: The impact of ... ...

Abstract	Background: Date palm (Phoenix dactylifera L.) is a dominant fruit crop in most Arabian countries. Date pits, as a major byproduct which remained after consumption of date flesh, proved to be a valuable source of energy. Objectives: The impact of degraded date pits (DDP) on growth performance, intestinal bacterial population, and expression profiles of intestinal genes in broilers was determined. Recent patents have been established on DDP from the European patent office (EP2586318B1), Hong Kong patent registry office (HK1184642) and by the United States patent and trademark office (US8968729B2 and US10265368B2). Methods: Solid-state degradation system (SSD) was used for the preparation of DDP using Trichoderma reesei. One-day-old Brazilian broiler chicks "Cobb 500" were randomly divided into six treatments with six replicates, which consisted of a normal diet containing only corn-soy (control), diet containing corn-soy + (20%, 50g/100Kg oxytetracycline), diet containing corn-soy + 10% (DDP), diet containing corn-soy + 0.2% mannan oligosaccharides (MOS), diet containing corn-soy + 0.1% mannose, and diet containing corn-soy + 0.2% mannose. Results: There were no significant differences in body weight, feed intake, and feed conversion ratio (FCR) in broilers among the treatments. The bacterial count was significantly decreased in 10% DDP diet-fed broilers, 0.2% MOS and antibiotic diet-fed broilers. Immunoglobulin levels in serum and intestinal contents and expression pattern of genes in jejunum were upregulated in 10% DDP and 0.2% MOS diet-fed broilers. Conclusion: DDP can be used as an energy source for replacing part of corn, mannan oligosaccharide and also recommended as a potential alternative to antimicrobials in broilers diet.
MeSH term(s)	Animal Feed ; Animals ; Body Weight ; Chickens/growth & development ; Chickens/immunology ; Chickens/metabolism ; Chickens/microbiology ; Diet ; Dietary Supplements ; Energy Intake ; Hypocreales ; Immunoglobulins/metabolism ; Intestines/drug effects ; Intestines/physiology ; Jejunum/metabolism ; Meat ; Patents as Topic ; Phoeniceae/microbiology ; Random Allocation ; Seeds
Chemical Substances	Immunoglobulins
Language	English
Publishing date	2019-07-18
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2486959-4
ISSN	1876-1429 ; 2212-7984
ISSN (online)	1876-1429
ISSN	2212-7984
DOI	10.2174/2212798410666190716163009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Z 7831: Show issues

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Article: Intestinal Development and Histomorphometry of Broiler Chickens Fed

Alyileili, Salem R / El-Tarabily, Khaled A / Belal, Ibrahim E H / Ibrahim, Wissam H / Sulaiman, Mohsin / Hussein, Ahmed S

Frontiers in veterinary science

2020 Volume 7, Page(s) 349

Abstract: A study was conducted to investigate the impact of degraded date pits (DDP) on the development and morphology of the intestine in broilers. ...

Abstract	A study was conducted to investigate the impact of degraded date pits (DDP) on the development and morphology of the intestine in broilers.
Language	English
Publishing date	2020-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2020.00349
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Article: Effect of

Alyileili, Salem R / El-Tarabily, Khaled A / Belal, Ibrahim E H / Ibrahim, Wissam H / Sulaiman, Mohsin / Hussein, Ahmed S

Frontiers in veterinary science

2020 Volume 7, Page(s) 338

Abstract: The long-term use of antimicrobials as growth promoters in poultry feed leads to antimicrobial resistance in pathogens. Thus, alternatives to antibiotics are essential for reasons associated with both safety and cost-effectiveness. Underutilized plant ... ...

Abstract	The long-term use of antimicrobials as growth promoters in poultry feed leads to antimicrobial resistance in pathogens. Thus, alternatives to antibiotics are essential for reasons associated with both safety and cost-effectiveness. Underutilized plant sources need to be developed to replace antibiotics in broiler feed. Several feed resources have been introduced so far, but they have yet to be applied widely. Date pits are a major by-product of the date industry (6-8%) and have the potential antioxidant to replace antibiotics. In this study, fresh date pits were degraded using the mold
Keywords	covid19
Language	English
Publishing date	2020-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2020.00338
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effect of dietary inclusion of sugar syrup on production performance, egg quality and blood biochemical parameters in laying hens

Hussein, Ahmed S / Ayoub, Mostafa A / Elhwetiy, Ahmed Y / Ghurair, Jamal A / Sulaiman, Mohsin / Habib, Hosam M

Chinese Association of Animal Science and Veterinary Medicine Animal nutrition. 2018 Mar., v. 4, no. 1

2018

Abstract: The effects of dietary inclusion of sugar syrup on quality of egg, cholesterol level, production performance, serum total protein and blood biochemical parameters were evaluated in laying hens. A total of 300 commercial Lohmann LSL hens (30 weeks of age) ...

Abstract	The effects of dietary inclusion of sugar syrup on quality of egg, cholesterol level, production performance, serum total protein and blood biochemical parameters were evaluated in laying hens. A total of 300 commercial Lohmann LSL hens (30 weeks of age) were randomly distributed into 3 dietary treatments which consisted of a normal corn diet containing corn–soy and 2 diets containing 5% and 10% sugar syrup. Each treatment was replicated 5 times (n = 20). Egg production, feed intake, body weight and egg weight of laying hens fed different diets were recorded. The experiment lasted for 20 weeks. The Haugh unit scores of hens fed diets with sugar syrup were significantly increased (P < 0.05) compared with the control treatment. The sugar syrup had no significant effect on liver enzymes, total protein, blood glucose and creatinine in all treatments. The eggs laid by hens fed sugar syrup diets had lower cholesterol level (P < 0.05) compared with those laid by hens fed the control diet. Electrophoresis analysis showed that comparable electrophoretic patterns were noticed between serum proteins of treatment groups. From the results, it can be concluded that sugar syrup diets and corn diets have similar effects on feed intake, body weight, production of eggs and blood biochemical parameters in layer hens, which suggests sugar syrup can be used as an energy source for replacing part of corn in poultry layer diets.
Keywords	blood glucose ; blood proteins ; body weight ; cholesterol ; corn ; creatinine ; diet ; egg production ; egg weight ; eggs ; electrophoresis ; energy ; enzymes ; feed intake ; hen feeding ; laying hens ; liver ; protein content ; sugars ; syrups
Language	English
Dates of publication	2018-03
Size	p. 59-64.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2834745-6
ISSN	2405-6545
ISSN	2405-6545
DOI	10.1016/j.aninu.2017.11.001
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Article ; Online: Graded levels of sugar syrup in broiler rations and its effect on growth performance and blood biochemical parameters.

Hussein, Ahmed S / Al Ghurair, Jamal / John, P George Kunju / Habib, Hosam M / Sulaiman, Mohsin

Animal nutrition (Zhongguo xu mu shou yi xue hui)

2016 Volume 2, Issue 3, Page(s) 180–185

Abstract: Dietary energy for chickens normally includes cereal grains and fat. This innovative study investigated the effect of replacing part of the corn and fat in broiler chicken rations with graded levels of sugar syrup on growth performance and biochemical ... ...

Abstract	Dietary energy for chickens normally includes cereal grains and fat. This innovative study investigated the effect of replacing part of the corn and fat in broiler chicken rations with graded levels of sugar syrup on growth performance and biochemical parameters. Experimental treatments consisted of feeding a corn-soy basal diet alone, or with graded levels of sugar syrup in increments of 5%, 10% and 15%. All starter diets were isonitrogenous and isocaloric. Body weight gain and efficiency of feed utilization of chicks fed the control diet alone were not significantly (
Language	English
Publishing date	2016-07-21
Publishing country	China
Document type	Journal Article
ISSN	2405-6383
ISSN (online)	2405-6383
DOI	10.1016/j.aninu.2016.07.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Graded levels of sugar syrup in broiler rations and its effect on growth performance and blood biochemical parameters

Hussein, Ahmed S / Al Ghurair, Jamal / John, P. George Kunju / Habib, Hosam M / Sulaiman, Mohsin

Chinese Association of Animal Science and Veterinary Medicine Animal nutrition. 2016 Sept., v. 2, no. 3

2016

Abstract	Dietary energy for chickens normally includes cereal grains and fat. This innovative study investigated the effect of replacing part of the corn and fat in broiler chicken rations with graded levels of sugar syrup on growth performance and biochemical parameters. Experimental treatments consisted of feeding a corn-soy basal diet alone, or with graded levels of sugar syrup in increments of 5%, 10% and 15%. All starter diets were isonitrogenous and isocaloric. Body weight gain and efficiency of feed utilization of chicks fed the control diet alone were not significantly (P < 0.05) different from chicks fed diets supplemented with either 5% or 15% sugar syrup. Supplementation of sugar syrup to broiler diets had no significant effect on blood glucose, creatinine, total protein, or liver enzymes. Adding 5% sugar syrup to broiler rations significantly decreased blood cholesterol and triglycerides in chickens fed the sugar syrup diet compared with birds fed the control diet. In conclusion, the results shows sugar syrup can be used in poultry ration to replace part of the corn as a source of energy. These results allowed the authors to recommend the safe usage of sugar syrup in broiler rations.
Keywords	blood ; blood glucose ; body weight changes ; broiler chickens ; chicks ; cholesterol ; corn ; creatinine ; dietary supplements ; energy ; enzymes ; feed conversion ; growth performance ; liver ; protein content ; small cereal grains ; starter diets ; sugars ; syrups ; triacylglycerols
Language	English
Dates of publication	2016-09
Size	p. 180-185.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2834745-6
ISSN	2405-6545
ISSN	2405-6545
DOI	10.1016/j.aninu.2016.07.002
Database	NAL-Catalogue (AGRICOLA)

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