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  1. Article ; Online: Asymptomatic bacteriuria: Impact of an antimicrobial stewardship bundle to reduce unnecessary antibiotics in patients without urinary catheters.

    Rico, Matthew / Sulaiman, Rand / MacLeod, Rachel

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2021  Volume 78, Issue Supplement_3, Page(s) S83–S87

    Abstract: Purpose: The purpose of this study was to evaluate the effect of an antimicrobial stewardship bundle on the management of asymptomatic bacteriuria (ASB).: Methods: In this quasi-experimental study, patients were selected by retrospective, consecutive ...

    Abstract Purpose: The purpose of this study was to evaluate the effect of an antimicrobial stewardship bundle on the management of asymptomatic bacteriuria (ASB).
    Methods: In this quasi-experimental study, patients were selected by retrospective, consecutive sampling of patients with a positive urine culture report in 3 separate groups: preintervention, postdiagnostic intervention, and posteducation. Patients met the prespecified criteria for non-catheter-associated ASB. The diagnostic intervention involved a new urinalysis/urine culture ordering process in place of urinalysis with reflex to urine culture. Additionally, an educational intervention involved pharmacist-led sessions to educate providers with patient cases and guideline-based recommendations. The primary outcome of this study was the difference in the rate of inappropriate management of ASB, defined as the use of antimicrobial agents intended to treat ASB. Secondary outcomes included length of antimicrobial therapy, length of stay, and change in urine culture orders per 1,000 patient-days.
    Results: A total of 120 patients were included. There was a significant reduction in the inappropriate management of ASB between the preintervention and postdiagnostic intervention groups (P = 0.0349). This was not seen when comparing the postdiagnostic intervention and posteducation groups (P = 0.93). Additionally, there was a significant difference in urinalysis/urine culture ordering between the preintervention and postdiagnostic intervention groups (370 vs 224 urinalysis orders per 1,000 days present, P < 0.0001; 131 vs 54 urine culture orders per 1,000 days present, P < 0.0001).
    Conclusion: An antimicrobial stewardship bundle involving a diagnostic stewardship intervention and pharmacist-led education reduced treatment of ASB in patients without urinary catheters.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Bacteriuria/diagnosis ; Bacteriuria/drug therapy ; Humans ; Retrospective Studies ; Urinary Catheters ; Urinary Tract Infections/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-05-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxab220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Antimicrobial and Biofilm-Preventing Activity of l-Borneol Possessing 2(5H)-Furanone Derivative F131 against S. aureus—C. albicans Mixed Cultures

    Sulaiman, Rand / Trizna, Elena / Kolesnikova, Alena / Khabibrakhmanova, Alsu / Kurbangalieva, Almira / Bogachev, Mikhail / Kayumov, Airat

    Pathogens (Basel, Switzerland)

    2022  Volume 12, Issue 1

    Abstract: ... Candida ... ...

    Abstract Candida albicans
    Language English
    Publishing date 2022-12-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12010026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19 paraclinical diagnostic tools: Updates and future trends.

    Alsuliman, Tamim / Sulaiman, Rand / Ismail, Sawsan / Srour, Micha / Alrstom, Ali

    Current research in translational medicine

    2020  Volume 68, Issue 3, Page(s) 83–91

    Abstract: Motivation: COVID-19 is one of the most widely affecting pandemics. As for many respiratory viruses-caused diseases, diagnosis of COVID-19 relies on two main compartments: clinical and paraclinical diagnostic criteria. Rapid and accurate diagnosis is ... ...

    Abstract Motivation: COVID-19 is one of the most widely affecting pandemics. As for many respiratory viruses-caused diseases, diagnosis of COVID-19 relies on two main compartments: clinical and paraclinical diagnostic criteria. Rapid and accurate diagnosis is vital in such a pandemic. On one side, rapidity may enhance management effectiveness, while on the other, coupling efficiency and less costly procedures may permit more effective community-scale management.
    Methodology and main structure: In this review, we shed light on the most used and the most validated diagnostic tools. Furthermore, we intend to include few under-development techniques that may be potentially useful in this context. The practical intent of our work is to provide clinicians with a realistic summarized review of the essential elements in the applied paraclinical diagnosis of COVID-19.
    MeSH term(s) Betacoronavirus/isolation & purification ; Betacoronavirus/physiology ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/classification ; Clinical Laboratory Techniques/methods ; Clinical Laboratory Techniques/trends ; Coronavirus Infections/classification ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Emergency Medical Services/methods ; Emergency Medical Technicians/organization & administration ; Emergency Medical Technicians/trends ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Sensitivity and Specificity ; Time Factors
    Keywords covid19
    Language English
    Publishing date 2020-06-20
    Publishing country France
    Document type Journal Article ; Review
    ISSN 2452-3186
    ISSN (online) 2452-3186
    DOI 10.1016/j.retram.2020.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: COVID-19 paraclinical diagnostic tools: Updates and future trends

    Alsuliman, Tamim / Sulaiman, Rand / Ismail, Sawsan / Srour, Micha / Alrstom, Ali

    Curr Res Transl Med

    Abstract: MOTIVATION: COVID-19 is one of the most widely affecting pandemics. As for many respiratory viruses-caused diseases, diagnosis of COVID-19 relies on two main compartments: clinical and paraclinical diagnostic criteria. Rapid and accurate diagnosis is ... ...

    Abstract MOTIVATION: COVID-19 is one of the most widely affecting pandemics. As for many respiratory viruses-caused diseases, diagnosis of COVID-19 relies on two main compartments: clinical and paraclinical diagnostic criteria. Rapid and accurate diagnosis is vital in such a pandemic. On one side, rapidity may enhance management effectiveness, while on the other, coupling efficiency and less costly procedures may permit more effective community-scale management. METHODOLOGY AND MAIN STRUCTURE: In this review, we shed light on the most used and the most validated diagnostic tools. Furthermore, we intend to include few under-development techniques that may be potentially useful in this context. The practical intent of our work is to provide clinicians with a realistic summarized review of the essential elements in the applied paraclinical diagnosis of COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #610063
    Database COVID19

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  5. Article ; Online: COVID-19 paraclinical diagnostic tools

    Alsuliman, Tamim / Sulaiman, Rand / Ismail, Sawsan / Srour, Micha / Alrstom, Ali

    ISSN: 2452-3186 ; Current Research in Translational Medicine ; https://hal.sorbonne-universite.fr/hal-02938974 ; Current Research in Translational Medicine, Elsevier-Masson SAS, 2020, 68 (3), pp.83-91. ⟨10.1016/j.retram.2020.06.001⟩

    Updates and future trends

    2020  

    Abstract: International audience ... Motivation: COVID-19 is one of the most widely affecting pandemics. As for many respiratory viruses-caused diseases, diagnosis of COVID-19 relies on two main compartments: clinical and paraclinical diagnostic criteria. Rapid and ... ...

    Abstract International audience

    Motivation: COVID-19 is one of the most widely affecting pandemics. As for many respiratory viruses-caused diseases, diagnosis of COVID-19 relies on two main compartments: clinical and paraclinical diagnostic criteria. Rapid and accurate diagnosis is vital in such a pandemic. On one side, rapidity may enhance management effectiveness, while on the other, coupling efficiency and less costly procedures may permit more effective community-scale management.Methodology and main structure: In this review, we shed light on the most used and the most validated diagnostic tools. Furthermore, we intend to include few under-development techniques that may be potentially useful in this context. The practical intent of our work is to provide clinicians with a realistic summarized review of the essential elements in the applied paraclinical diagnosis of COVID-19.
    Keywords COVID-19 ; CT ; Diagnosis ; Paraclinical ; rRT-PCR ; [SDV]Life Sciences [q-bio] ; covid19
    Subject code 610
    Language English
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: COVID-19 paraclinical diagnostic tools

    Alsuliman, Tamim / Sulaiman, Rand / Ismail, Sawsan / Srour, Micha / Alrstom, Ali

    Current Research in Translational Medicine

    Updates and future trends

    2020  Volume 68, Issue 3, Page(s) 83–91

    Keywords General Biochemistry, Genetics and Molecular Biology ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2452-3186
    DOI 10.1016/j.retram.2020.06.001
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Dalbavancin and Oritavancin: An Innovative Approach to the Treatment of Gram-Positive Infections.

    Roberts, Karrine D / Sulaiman, Rand M / Rybak, Michael J

    Pharmacotherapy

    2015  Volume 35, Issue 10, Page(s) 935–948

    Abstract: Health care-associated infections, especially those caused by multidrug-resistant gram-positive organisms, such as methicillin-resistant Staphylococcus aureus (MRSA), are a growing public health threat. In 2014, the U.S. Food and Drug Administration ... ...

    Abstract Health care-associated infections, especially those caused by multidrug-resistant gram-positive organisms, such as methicillin-resistant Staphylococcus aureus (MRSA), are a growing public health threat. In 2014, the U.S. Food and Drug Administration approved two new lipoglycopeptides, oritavancin and dalbavancin, for the treatment of acute bacterial skin and skin structure infections. The rationale for the development of these antimicrobials was partly to aid in the battle against vancomycin resistance in both Staphylococcus and Enterococcus. Considered a subclass of the glycopeptide antibiotics, the new lipoglycopeptides have similar mechanisms of action of binding to the carboxyl terminal d-alanyl-d-alanine residue of the growing peptide chains but differ from their parent glycopeptides by the addition of lipophilic tails. This addition allows for these agents to have prolonged half-lives, giving them unique dosing profiles. In addition, by concentrating at the site of action, they have increased potency against MRSA compared with vancomycin, the current mainstay of therapy. In this review, we focus on comparing and contrasting these two new agents with regard to their pharmacology, mechanisms of action, spectrum of activity, safety profiles, dosage and administration, and drug and laboratory interactions, and we review the clinical trials evaluating their use.
    MeSH term(s) Animals ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cross Infection/drug therapy ; Cross Infection/microbiology ; Drug Interactions ; Glycopeptides/administration & dosage ; Glycopeptides/adverse effects ; Glycopeptides/pharmacology ; Glycopeptides/therapeutic use ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/microbiology ; Half-Life ; Humans ; Methicillin-Resistant Staphylococcus aureus ; Microbial Sensitivity Tests ; Randomized Controlled Trials as Topic ; Skin Diseases, Bacterial/drug therapy ; Skin Diseases, Bacterial/microbiology ; Teicoplanin/administration & dosage ; Teicoplanin/adverse effects ; Teicoplanin/analogs & derivatives ; Teicoplanin/pharmacology ; Teicoplanin/therapeutic use ; United States ; Vancomycin Resistance
    Chemical Substances Anti-Bacterial Agents ; Glycopeptides ; Teicoplanin (61036-62-2) ; dalbavancin (808UI9MS5K) ; oritavancin (PUG62FRZ2E)
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 603158-4
    ISSN 1875-9114 ; 0277-0008
    ISSN (online) 1875-9114
    ISSN 0277-0008
    DOI 10.1002/phar.1641
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  8. Article ; Online: Evaluation of a Rapid Fungal Detection Panel for Identification of Candidemia at an Academic Medical Center.

    Bomkamp, John P / Sulaiman, Rand / Hartwell, Jennifer L / Desai, Armisha / Winn, Vera C / Wrin, Justin / Kussin, Michelle L / Hiles, Jon J

    Journal of clinical microbiology

    2020  Volume 58, Issue 3

    Abstract: This study was conducted to assess the utility of the T2Candida panel across an academic health center and identify potential areas for diagnostic optimization. A retrospective chart review was conducted on patients with a T2Candida panel and mycolytic/ ... ...

    Abstract This study was conducted to assess the utility of the T2Candida panel across an academic health center and identify potential areas for diagnostic optimization. A retrospective chart review was conducted on patients with a T2Candida panel and mycolytic/fungal (myco/f lytic) blood culture collected simultaneously during hospitalizations from February 2017 to March 2018. The primary outcome of this study was to determine the sensitivity, specificity, and positive and negative predictive values of the panel compared to myco/f lytic blood culture. Secondary outcomes included
    MeSH term(s) Academic Medical Centers ; Candida ; Candidemia/diagnosis ; Candidemia/drug therapy ; Humans ; Micafungin ; Retrospective Studies
    Chemical Substances Micafungin (R10H71BSWG)
    Language English
    Publishing date 2020-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.01408-19
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  9. Article: Increasing the Efficacy of Treatment of

    Mahmoud, Ruba Y / Trizna, Elena Y / Sulaiman, Rand K / Pavelyev, Roman S / Gilfanov, Ilmir R / Lisovskaya, Svetlana A / Ostolopovskaya, Olga V / Frolova, Larisa L / Kutchin, Alexander V / Guseva, Galina B / Antina, Elena V / Berezin, Mikhail B / Nikitina, Liliya E / Kayumov, Airat R

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 12

    Abstract: Infectious diseases caused by various nosocomial microorganisms affect worldwide both immunocompromised and relatively healthy persons. Bacteria and fungi have different tools to evade antimicrobials, such as hydrolysis damaging the drug, efflux systems, ...

    Abstract Infectious diseases caused by various nosocomial microorganisms affect worldwide both immunocompromised and relatively healthy persons. Bacteria and fungi have different tools to evade antimicrobials, such as hydrolysis damaging the drug, efflux systems, and the formation of biofilm that significantly complicates the treatment of the infection. Here, we show that myrtenol potentiates the antimicrobial and biofilm-preventing activity of conventional drugs against
    Language English
    Publishing date 2022-12-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11121743
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