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  1. AU="Sulejczak, Dorota"
  2. AU="Carvalho, Ana C"
  3. AU="Guo, Mengmeng" AU="Guo, Mengmeng"
  4. AU="Boehler, Michael"
  5. AU="Mirfakhraei, Mahdi"
  6. AU="de Jongste, Johan C"
  7. AU="Holmgren, A Jay"
  8. AU="Mićanović, S"
  9. AU="Chiu, Joanne S"
  10. AU=D'Amora Paulo
  11. AU="Jansen, Hans"
  12. AU=Beukes Eldre W
  13. AU="Francis, Sarah"
  14. AU="Camara, Amadou K.S."
  15. AU="Chaudhari, Sachin R."
  16. AU="Ovchinnikova, Tatiana V"
  17. AU="Aït Ali, F"
  18. AU="Jeong, Jae Cheon"
  19. AU="Luca Baldassari"
  20. AU="Wakfie-Corieh, C G"
  21. AU="Desouza, Cyrus V"
  22. AU="Esaka, Naoki"
  23. AU="Haruka Wada"
  24. AU="Klouda, Timothy"
  25. AU="Olsson-Brown, Anna C."
  26. AU="Schmauß, Max"
  27. AU="Raza, Syed Tasleem"
  28. AU="Humphreys, H"
  29. AU="Robert A Casero Jr"
  30. AU="Marinec, Paul S"
  31. AU="Rajebhosale, Prithviraj"

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  1. Artikel: Air Pollution: A Silent Key Driver of Dementia.

    Serafin, Pawel / Zaremba, Malgorzata / Sulejczak, Dorota / Kleczkowska, Patrycja

    Biomedicines

    2023  Band 11, Heft 5

    Abstract: In 2017, the Lancet Commission on Dementia Prevention, Intervention, and Care included air pollution in its list of potential risk factors for dementia; in 2018, the Lancet Commission on Pollution concluded that the evidence for a causal relationship ... ...

    Abstract In 2017, the Lancet Commission on Dementia Prevention, Intervention, and Care included air pollution in its list of potential risk factors for dementia; in 2018, the Lancet Commission on Pollution concluded that the evidence for a causal relationship between fine particulate matter (PM) and dementia is encouraging. However, few interventions exist to delay or prevent the onset of dementia. Air quality data are becoming increasingly available, and the science underlying the associated health effects is also evolving rapidly. Recent interest in this area has led to the publication of population-based cohort studies, but these studies have used different approaches to identify cases of dementia. The purpose of this article is to review recent evidence describing the association between exposure to air pollution and dementia with special emphasis on fine particulate matter of 2.5 microns or less. We also summarize here the proposed detailed mechanisms by which air pollutants reach the brain and activate the innate immune response. In addition, the article also provides a short overview of existing limitations in the treatment of dementia.
    Sprache Englisch
    Erscheinungsdatum 2023-05-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11051477
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Stemness properties of SSEA-4+ subpopulation isolated from heterogenous Wharton's jelly mesenchymal stem/stromal cells.

    Smolinska, Agnieszka / Chodkowska, Magdalena / Kominek, Agata / Janiec, Jakub / Piwocka, Katarzyna / Sulejczak, Dorota / Sarnowska, Anna

    Frontiers in cell and developmental biology

    2024  Band 12, Seite(n) 1227034

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2024-02-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2024.1227034
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  3. Artikel ; Online: "Neuropatologia Polska". The journal and its topics in the first decade of existence (1963-1972).

    Paluchowski, Piotr / Gulczyński, Jacek / Michalski, Mateusz / Wierzba-Bobrowicz, Teresa / Sulejczak, Dorota / Iżycka-Świeszewska, Ewa

    Folia neuropathologica

    2024  Band 61, Heft 4, Seite(n) 337–348

    Abstract: In this article authors would like to present the history of the "Neuropatologia Polska" journal (since 1994: "Folia Neuropathologica") in its first decade of existence. It outlines the circumstances surrounding the creation of the journal and shows how ... ...

    Abstract In this article authors would like to present the history of the "Neuropatologia Polska" journal (since 1994: "Folia Neuropathologica") in its first decade of existence. It outlines the circumstances surrounding the creation of the journal and shows how it evolved in the first years. The vast material analysed from the consecutive issues of the journal in the years from 1963 to 1972 was subjected to statistical and content analysis. From its first year, the journal has included works of a very high substantive level and a wide range of topics. The authors presented the results of contemporary research in many areas. The "Neuropatologia Polska" journal (later "Folia Neuropathologica") set paths for the development of neuropathology in clinical and experimental aspects. What is very important, it created a platform for international cooperation in many fields, included researchers and scientists from Western countries and foreign academic centres in difficult times. This article was created on the 60th anniversary of creation of "Neuropatologia Polska".
    Sprache Englisch
    Erscheinungsdatum 2024-01-29
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ZDB-ID 1310363-5
    ISSN 1509-572X ; 0028-3894 ; 1641-4640
    ISSN (online) 1509-572X
    ISSN 0028-3894 ; 1641-4640
    DOI 10.5114/fn.2023.134307
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  4. Artikel ; Online: MicroRNAs as Prognostic Biomarkers and Therapeutic Targets in Chondrosarcoma.

    Skipar, Palina / Dey, Mritunjoy / Piątkowski, Jakub / Sulejczak, Dorota / Rutkowski, Piotr / Czarnecka, Anna M

    International journal of molecular sciences

    2024  Band 25, Heft 6

    Abstract: Chondrosarcoma, the second most common primary malignant bone tumor, originates from cartilaginous tissue and accounts for almost 20% of all primary bone tumors. The management of chondrosarcoma remains challenging due to its diverse clinical course and ... ...

    Abstract Chondrosarcoma, the second most common primary malignant bone tumor, originates from cartilaginous tissue and accounts for almost 20% of all primary bone tumors. The management of chondrosarcoma remains challenging due to its diverse clinical course and prognosis, which can range from benign to highly aggressive with a huge risk of metastasis. Emerging research has demonstrated the importance of microRNA (miRNA) dysregulation in the pathogenesis of chondrosarcoma. MiRNAs are small, noncoding RNA molecules that play an essential role in gene expression regulation by targeting specific messenger RNAs (mRNAs) for degradation or translational repression. This article provides an extensive review of current miRNA research in chondrosarcoma, focusing on diagnostic strategies, cell cycle regulation, drug resistance, biomarkers of progression, and stem cell phenotype. We will examine recent studies identifying differentially expressed miRNAs in chondrosarcoma compared to normal cartilage tissue, exploring their potential as diagnostic and prognostic biomarkers. Furthermore, we will discuss the role of miRNAs in regulating cell cycle progression and their potential as therapeutic targets to overcome drug resistance. We will also investigate the prospective utility of miRNAs as biomarkers of progression and their role in modulating the stem cell phenotype of chondrosarcoma cells. This article offers a comprehensive analysis of current miRNA research in chondrosarcoma, focusing on its potential as diagnostic and prognostic biomarkers, therapeutic targets, and regulators of disease progression. By integrating the latest discoveries in this field, we aim to contribute to the development of novel approaches to the prevention, diagnosis, and treatment of chondrosarcoma, ultimately enhancing patient outcomes.
    Mesh-Begriff(e) Humans ; MicroRNAs/metabolism ; Prognosis ; Gene Expression Regulation, Neoplastic ; Chondrosarcoma/diagnosis ; Chondrosarcoma/drug therapy ; Chondrosarcoma/genetics ; Bone Neoplasms/diagnosis ; Bone Neoplasms/drug therapy ; Bone Neoplasms/genetics ; Neoplasms, Second Primary/genetics ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism
    Chemische Substanzen MicroRNAs ; Biomarkers, Tumor
    Sprache Englisch
    Erscheinungsdatum 2024-03-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063176
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  5. Artikel ; Online: Proinflammatory microglial response is a common mechanism of Aroclor 1254- and Tetrabromobisphenol-A-induced neurotoxicity in immature chronically exposed rats.

    Dąbrowska-Bouta, Beata / Sulkowski, Grzegorz / Frontczak-Baniewicz, Małgorzata / Sulejczak, Dorota / Strużyńska, Lidia

    Folia neuropathologica

    2024  Band 62, Heft 1, Seite(n) 1–12

    Abstract: Polychlorinated biphenyls (PCBs) and brominated flame retardants (BFRs) are dominant environmental and food contaminants. Tetrabromobisphenol A (TBBPA) is the most widely used BFR in the world to improve the fire safety of laminates in electrical and ... ...

    Abstract Polychlorinated biphenyls (PCBs) and brominated flame retardants (BFRs) are dominant environmental and food contaminants. Tetrabromobisphenol A (TBBPA) is the most widely used BFR in the world to improve the fire safety of laminates in electrical and electronic equipment. Aroclor 1254, one of the PCBs, is widely distributed in the environment due to its extensive use in industrial applications around the world. Both groups of substances are potent toxicants. There is also increasing evidence that they have neurotoxic effects. In this study we tested the pro-inflammatory effects of Aroclor 1254 and TBBPA based on markers of microglial reactivity and levels of pro-inflammatory factors in the brain of immature rats. Aroclor 1254 or TBBPA were administered to the rats by oral gavage for two weeks at a dose of 10 mg/kg b.w. Both light and electron microscopy studies revealed features indicative of microglia activation in brains of exposed rats. Morphological changes were associated with overexpression of pro-inflammatory enzymes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Analysis of cytokine/chemokine array revealed significant secretion of inflammatory mediators following exposure to both TBBPA and Aroclor 1254, which was stronger in the cerebellum than in the forebrain of exposed immature rats. The results indicate a pro-inflammatory profile of microglia activation as one of the neurotoxic mechanisms of both examined toxicants.
    Mesh-Begriff(e) Animals ; Microglia/drug effects ; Microglia/metabolism ; Microglia/pathology ; Polybrominated Biphenyls/toxicity ; Rats ; Chlorodiphenyl (54% Chlorine)/toxicity ; Neurotoxicity Syndromes/pathology ; Neurotoxicity Syndromes/etiology ; Brain/drug effects ; Brain/pathology ; Brain/metabolism ; Male ; Flame Retardants/toxicity ; Rats, Wistar
    Chemische Substanzen tetrabromobisphenol A (FQI02RFC3A) ; Polybrominated Biphenyls ; Chlorodiphenyl (54% Chlorine) (11097-69-1) ; Flame Retardants
    Sprache Englisch
    Erscheinungsdatum 2024-04-05
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ZDB-ID 1310363-5
    ISSN 1509-572X ; 0028-3894 ; 1641-4640
    ISSN (online) 1509-572X
    ISSN 0028-3894 ; 1641-4640
    DOI 10.5114/fn.2023.133796
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  6. Artikel: Potential of Lactoferrin in the Treatment of Lung Diseases.

    Kaczyńska, Katarzyna / Jampolska, Monika / Wojciechowski, Piotr / Sulejczak, Dorota / Andrzejewski, Kryspin / Zając, Dominika

    Pharmaceuticals (Basel, Switzerland)

    2023  Band 16, Heft 2

    Abstract: Lactoferrin (LF) is a multifunctional iron-binding glycoprotein that exhibits a variety of properties, such as immunomodulatory, anti-inflammatory, antimicrobial, and anticancer, that can be used to treat numerous diseases. Lung diseases continue to be ... ...

    Abstract Lactoferrin (LF) is a multifunctional iron-binding glycoprotein that exhibits a variety of properties, such as immunomodulatory, anti-inflammatory, antimicrobial, and anticancer, that can be used to treat numerous diseases. Lung diseases continue to be the leading cause of death and disability worldwide. Many of the therapies currently used to treat these diseases have limited efficacy or are associated with side effects. Therefore, there is a constant pursuit for new drugs and therapies, and LF is frequently considered a therapeutic agent and/or adjunct to drug-based therapies for the treatment of lung diseases. This article focuses on a review of the existing and most up-to-date literature on the contribution of the beneficial effects of LF on the treatment of lung diseases, including asthma, viral infections, cystic fibrosis, or lung cancer, among others. Although in vitro and in vivo studies indicate significant potency of LF in the treatment of the listed diseases, only in the case of respiratory tract infections do human studies seem to confirm them by demonstrating the effectiveness of LF in reducing episodes of illness and shortening the recovery period. For lung cancer, COVID-19 and sepsis, the reports are conflicting, and for other diseases, there is a paucity of human studies conclusively confirming the beneficial effects of LF.
    Sprache Englisch
    Erscheinungsdatum 2023-01-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16020192
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  7. Artikel: Military Blood Service in Poland.

    Kryczka, Tomasz / Jedynak, Anna / Olszewski, Adam / Sierpinska, Lidia / Kuzniarska, Paula / Sulejczak, Dorota

    Journal of blood medicine

    2023  Band 14, Seite(n) 309–316

    Abstract: Introduction: On 24 February 2022, the Russia-Ukraine military conflict unfolded just across the eastern border of the European Union. It made everyone realize how important it is to secure blood supplies to health-care units in the event of an armed ... ...

    Abstract Introduction: On 24 February 2022, the Russia-Ukraine military conflict unfolded just across the eastern border of the European Union. It made everyone realize how important it is to secure blood supplies to health-care units in the event of an armed conflict. This paper presents the principles of functioning of the Military Blood Donation Service and the Military Center for Blood Donation and Hemotherapy in Poland.
    Methods: The study used data collected in the "Military Blood Bank" information processing system and data from annual reports (2010-2021) sent to the Minister of Health of the Republic of Poland. The reports concerned, among others: demographic data on donors, reasons of permanent disqualifications, numbers of complete and incomplete donations, etc.
    Results: Since 2005, the number of donors registered in military blood donation centers ranged between 15 and 35 thousand/year. The most dramatic declines in donors were observed in 2010 and 2020. Successful donations accounted for more than 98% of all donations/year (except 2015), and their number varied between 20 and 32 thousand/year. Among the blood donors, men always predominated and the dominant age group (except for 2010) was 25-44 years. The reasons for permanent disqualification have varied over time: their proportions decreased for viral hepatitis and cardiovascular disease, and increased for respiratory and endocrine/metabolic diseases. Due to the COVID-19 pandemic in 2020/2021, these proportions have sometimes been reversed.
    Discussion: The Military Blood Donation Service has been functioning in Poland for several decades. It is specialized in supplying blood and blood products to the Armed Forces. Unfortunately, it was not possible to refer to the functioning of similar institutions in other countries. Therefore, when evaluating the functioning of Polish military blood donation, we had to rely on numerical values (eg, number of donors/year, donor profile, etc.), which prove a very good organization of blood donation centers. However, it should be noted that, as in other countries, a more active promotion of blood donation in the media is advisable in order to encourage as many young people as possible to donate blood.
    Sprache Englisch
    Erscheinungsdatum 2023-04-17
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2587464-0
    ISSN 1179-2736
    ISSN 1179-2736
    DOI 10.2147/JBM.S390673
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  8. Artikel ; Online: Effect of Hematopoietic Stem Cell Transplantation and Post-Transplantation Cyclophosphamide on the Microglia Phenotype in Rats with Experimental Allergic Encephalomyelitis.

    Kasarełło, Kaja / Seta, Martyna / Sulejczak, Dorota / Snarski, Emilian / Cudnoch-Jędrzejewska, Agnieszka

    Archivum immunologiae et therapiae experimentalis

    2023  Band 71, Heft 1, Seite(n) 10

    Abstract: Microglia are the resident immune cells of the central nervous system, playing a role in the inflammatory process development and resolution, presenting two main phenotypes, pro-inflammatory M1, and anti-inflammatory M2. Therapies affecting the microglia ...

    Abstract Microglia are the resident immune cells of the central nervous system, playing a role in the inflammatory process development and resolution, presenting two main phenotypes, pro-inflammatory M1, and anti-inflammatory M2. Therapies affecting the microglia phenotype may be beneficial in treating inflammatory neurodegenerative diseases. In our experiments, we used the animal multiple sclerosis model, experimental allergic encephalomyelitis (EAE). Rats were treated during the pre- or symptomatic phase of the disease with cyclophosphamide, followed by hematopoietic stem cell transplantation, and with/without post-transplantation cyclophosphamide. Our study aimed to analyze the microglia phenotype in animals subjected to this treatment. The number of M1 cells in the spinal cord, and inducible nitric oxide synthase (iNOS) levels in the brain were similar in all experimental groups. The differences were observed in M2 cells number and arginase 1 (Arg1) levels, which were decreased in EAE animals, and increased after treatment in the symptomatic phase of EAE, and in the pre-symptomatic phase, but only with post-transplantation cyclophosphamide. Analysis of gene expression in the brain showed decreased iNOS expression in EAE animals treated in the symptomatic phase of EAE and no differences in Arg1 expression. Results indicate that treatment applied to experimental animals influences the microglia phenotype, promoting differentiation towards M2 cells.
    Mesh-Begriff(e) Rats ; Animals ; Mice ; Encephalomyelitis, Autoimmune, Experimental/therapy ; Microglia/metabolism ; Phenotype ; Cyclophosphamide/therapeutic use ; Hematopoietic Stem Cell Transplantation ; Mice, Inbred C57BL
    Chemische Substanzen Cyclophosphamide (8N3DW7272P)
    Sprache Englisch
    Erscheinungsdatum 2023-03-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 282209-x
    ISSN 1661-4917 ; 0004-069X
    ISSN (online) 1661-4917
    ISSN 0004-069X
    DOI 10.1007/s00005-023-00675-y
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  9. Artikel ; Online: Advantages and disadvantages of disulfiram coadministered with popular addictive substances.

    Kleczkowska, Patrycja / Sulejczak, Dorota / Zaremba, Malgorzata

    European journal of pharmacology

    2021  Band 904, Seite(n) 174143

    Abstract: Disulfiram (DSF) is a well-known anti-alcohol agent that inhibits aldehyde dehydrogenase and results in extreme 'hangover' symptoms when consumed with alcohol. This drug, however, has been suggested as useful in other forms of drug addiction due to its ... ...

    Abstract Disulfiram (DSF) is a well-known anti-alcohol agent that inhibits aldehyde dehydrogenase and results in extreme 'hangover' symptoms when consumed with alcohol. This drug, however, has been suggested as useful in other forms of drug addiction due to its beneficial potential in both drug abuse reduction and withdrawal. However, among other drugs used in alcohol dependence, it carries the greatest risk of pharmacological interactions. Concomitant use of DSF and central nervous system stimulants usually leads to harmful, undesirable effects. To date, there is still limited data regarding the detailed safety profile of DSF as a concomitant drug. In this review article, we outline the current state of knowledge about DSF, its broad pharmacological action, as well as therapeutic effects, with a particular emphasis on the molecular understanding of its potential pharmacodynamic interactions with common addictive substances (e.g., alcohol, cocaine, cannabinoids, opioids) supported by relevant examples.
    Mesh-Begriff(e) Acetaldehyde Dehydrogenase Inhibitors/pharmacology ; Acetaldehyde Dehydrogenase Inhibitors/therapeutic use ; Alcohol Drinking/prevention & control ; Alcoholism/drug therapy ; Animals ; Disulfiram/adverse effects ; Disulfiram/pharmacology ; Disulfiram/therapeutic use ; Drug Interactions ; Humans ; Substance-Related Disorders/drug therapy
    Chemische Substanzen Acetaldehyde Dehydrogenase Inhibitors ; Disulfiram (TR3MLJ1UAI)
    Sprache Englisch
    Erscheinungsdatum 2021-05-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2021.174143
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  10. Artikel ; Online: Heat Shock Protein 90 Chaperones E1A Early Protein of Adenovirus 5 and Is Essential for Replication of the Virus.

    Dalidowska, Iga / Gazi, Olga / Sulejczak, Dorota / Przybylski, Maciej / Bieganowski, Pawel

    International journal of molecular sciences

    2021  Band 22, Heft 4

    Abstract: Adenovirus infections tend to be mild, but they may pose a serious threat for young and immunocompromised individuals. The treatment is complicated because there are no approved safe and specific drugs for adenovirus infections. Here, we present evidence ...

    Abstract Adenovirus infections tend to be mild, but they may pose a serious threat for young and immunocompromised individuals. The treatment is complicated because there are no approved safe and specific drugs for adenovirus infections. Here, we present evidence that 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG), an inhibitor of Hsp90 chaperone, decreases the rate of human adenovirus 5 (HAdV-5) replication in cell cultures by 95%. 17-AAG inhibited the transcription of early and late genes of HAdV-5, replication of viral DNA, and expression of viral proteins. 6 h after infection, Hsp90 inhibition results in a 6.3-fold reduction of the newly synthesized E1A protein level without a decrease in the E1A mRNA level. However, the Hsp90 inhibition does not increase the decay rate of the E1A protein that was constitutively expressed in the cell before exposure to the inhibitor. The co-immunoprecipitation proved that E1A protein interacted with Hsp90. Altogether, the presented results show, for the first time. that Hsp90 chaperones newly synthesized, but not mature, E1A protein. Because E1A serves as a transcriptional co-activator of adenovirus early genes, the anti-adenoviral activity of the Hsp90 inhibitor might be explained by the decreased E1A level.
    Mesh-Begriff(e) A549 Cells ; Adenoviridae/drug effects ; Adenoviridae/genetics ; Adenoviridae/physiology ; Adenovirus E1A Proteins/metabolism ; Benzoquinones/pharmacology ; DNA Replication/drug effects ; HEK293 Cells ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Lactams, Macrocyclic/pharmacology ; Protein Binding/drug effects ; Proteolysis/drug effects ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Virus/metabolism ; Transcription, Genetic/drug effects ; Virus Replication/genetics ; Virus Replication/physiology
    Chemische Substanzen Adenovirus E1A Proteins ; Benzoquinones ; HSP90 Heat-Shock Proteins ; Lactams, Macrocyclic ; RNA, Messenger ; Receptors, Virus ; tanespimycin (4GY0AVT3L4)
    Sprache Englisch
    Erscheinungsdatum 2021-02-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22042020
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