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  1. Article ; Online: The Rare Occurrence of Reoperation After Cervical Laminoplasty: A 14-Year Retrospective Review of Reoperative Rates at a Single Institution.

    Barkley, Ariana S / Eaton, Jessica / Carroll, Kate / Sullivan, Liam T / Zhang, Fangyi / Ravanpay, Ali

    Clinical spine surgery

    2021  Volume 34, Issue 6, Page(s) E342–E348

    Abstract: Study design: Retrospective cohort study.: Objective: To determine the rate of recurrent or adjacent-level stenosis requiring reoperation after single-door cervical laminoplasty for spondylotic myelopathy at our institution.: Summary of background ... ...

    Abstract Study design: Retrospective cohort study.
    Objective: To determine the rate of recurrent or adjacent-level stenosis requiring reoperation after single-door cervical laminoplasty for spondylotic myelopathy at our institution.
    Summary of background data: Adjacent-level stenosis requiring reoperation is a commonly evaluated condition for anterior or posterior arthrodesis, however, there are few studies that evaluate adjacent-level stenosis in the case of cervical laminoplasty.
    Methods: Retrospective review of adults undergoing cervical laminoplasty for spondylotic myelopathy between January 2005 and May 2018 at our institution. Demographics, symptom duration, stenotic levels, preoperative and postoperative Medical Research Council motor, American Spinal Injury Association, modified Japanese Orthopaedic Association scores, and Nurick grade were obtained. Postoperative data included presence of C5 palsy, infection rate, alleviation or persistence of symptoms, and rate of recurrent or adjacent-level stenosis.
    Results: A total of 102 patients underwent cervical laminoplasty; mean age was 56.7 years (±12.96). Most were men (n=76, 74.5%), with myelopathy (n=64, 63.4%), C4 (n=94, 93.1%), and C5 (n=92, 91.1%) cervical stenosis; mean symptom duration was 55 days (7 d to 2.8 y). Average follow-up was 6.4 months (±3.4). After surgery, there was statistically significant improvement in Nurick grade (3.1±2.2 vs. 2.7±2.4, P=0.002) and modified Japanese Orthopaedic Association score (11.4±3.7 vs. 13.9±3.6, P<0.001); American Spinal Injury Association scores also improved (P<0.001). Rate of postoperative C5 palsy was 7.8% (n=8); postoperative infection rate was 1.96% (n=2). Reoperation rate was 4.9% (n=5); reoperation for recurrent or adjacent-level stenosis was 1.96% (n=2).
    Conclusions: Recurrent or adjacent-level stenosis requiring reoperation after cervical laminoplasty is rare. Longitudinal studies are needed to verify correlation between motion preservation and incidence of adjacent or recurrent stenosis.
    Level of evidence: Level III-treatment benefits: nonrandomized controlled cohort/follow-up study.
    MeSH term(s) Adult ; Cervical Vertebrae/surgery ; Follow-Up Studies ; Humans ; Laminectomy ; Laminoplasty/adverse effects ; Male ; Middle Aged ; Reoperation ; Retrospective Studies ; Spinal Cord Diseases/surgery ; Treatment Outcome
    Language English
    Publishing date 2021-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2849646-2
    ISSN 2380-0194 ; 2380-0186
    ISSN (online) 2380-0194
    ISSN 2380-0186
    DOI 10.1097/BSD.0000000000001142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Distinct features of brain perivascular fibroblasts and mural cells revealed by

    Bonney, Stephanie K / Sullivan, Liam T / Cherry, Timothy J / Daneman, Richard / Shih, Andy Y

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2021  Volume 42, Issue 6, Page(s) 966–978

    Abstract: Perivascular fibroblasts (PVFs) are recognized for their pro-fibrotic role in many central nervous system disorders. Like mural cells, PVFs surround blood vessels and express Pdgfrβ. However, these shared attributes hinder the ability to distinguish PVFs ...

    Abstract Perivascular fibroblasts (PVFs) are recognized for their pro-fibrotic role in many central nervous system disorders. Like mural cells, PVFs surround blood vessels and express Pdgfrβ. However, these shared attributes hinder the ability to distinguish PVFs from mural cells. We used
    MeSH term(s) Animals ; Brain/blood supply ; Capillaries/diagnostic imaging ; Fibroblasts/metabolism ; Mice ; Mice, Transgenic ; Pericytes/metabolism
    Language English
    Publishing date 2021-12-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X211068528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Acute Postoperative Seizures and Engel Class Outcome at 1 Year Postselective Laser Amygdalohippocampal Ablation for Mesial Temporal Lobe Epilepsy.

    Barkley, Ariana S / Sullivan, Liam T / Gibson, Alec W / Zalewski, Kody / Mac Donald, Christine L / Barber, Jason K / Hakimian, Shahin / Ko, Andrew L / Ojemann, Jeffrey G / Hauptman, Jason S

    Neurosurgery

    2022  Volume 91, Issue 2, Page(s) 347–354

    Abstract: Background: MRI-guided laser interstitial thermal therapy (MRgLITT) for mesial temporal lobe epilepsy is a safe, minimally invasive alternative to traditional surgical approaches. Prognostic factors associated with efficacy are debated; preoperative ... ...

    Abstract Background: MRI-guided laser interstitial thermal therapy (MRgLITT) for mesial temporal lobe epilepsy is a safe, minimally invasive alternative to traditional surgical approaches. Prognostic factors associated with efficacy are debated; preoperative epilepsy duration and semiology seem to be important variables.
    Objective: To determine whether acute postoperative seizure (APOS) after MRgLITT for mesial temporal lobe epilepsy is associated with seizure freedom/Engel class outcome at 1 year.
    Methods: A single-institution retrospective study including adults undergoing first time MRgLITT for mesial temporal lobe epilepsy (2010-2019) with ≥1-year follow-up. Preoperative data included sex, epilepsy duration, number of antiepileptics attempted, weekly seizure frequency, seizure semiology, and radiographically verified anatomic lesion at seizure focus. Postoperative data included clinical detection of APOS within 7 days postoperatively, and immediate amygdala, hippocampal, entorhinal, and parahippocampal residual volumes determined using quantitative imaging postprocessing. Primary outcome was seizure freedom/Engel classification 1 year postoperatively.
    Results: Of 116 patients, 53% (n = 61) were female, with an average epilepsy duration of 21 (±14) years, average 6 failed antiepileptics (±3), and weekly seizure frequency of 5. APOS was associated with worse Engel class ( P = .010), conferring 6.3 times greater odds of having no improvement vs achieving seizure freedom at 1 year. Residual amygdala, hippocampal, entorhinal, and parahippocampal volumes were not statistically significant prognostic factors.
    Conclusion: APOS was associated with a lower chance of seizure freedom at 1 year post-MRgLITT for mesial temporal lobe epilepsy. Amygdala, hippocampal, entorhinal, and parahippocampal residual volumes after ablation were not significant prognostic factors.
    MeSH term(s) Adult ; Anticonvulsants ; Drug Resistant Epilepsy/surgery ; Epilepsy, Temporal Lobe/diagnostic imaging ; Epilepsy, Temporal Lobe/surgery ; Female ; Humans ; Laser Therapy/methods ; Lasers ; Magnetic Resonance Imaging/methods ; Male ; Retrospective Studies ; Seizures/etiology ; Seizures/surgery ; Treatment Outcome
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/neu.0000000000002023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Life History and Rearing of Anastatus orientalis (Hymenoptera: Eupelmidae), an Egg Parasitoid of the Spotted Lanternfly (Hemiptera: Fulgoridae).

    Broadley, Hannah J / Gould, Juli R / Sullivan, Liam T / Wang, Xiao-Yi / Hoelmer, Kim A / Hickin, Mauri L / Elkinton, Joseph S

    Environmental entomology

    2020  Volume 50, Issue 1, Page(s) 28–35

    Abstract: To support efforts to manage and contain spotted lanternfly (SLF), Lycorma delicatula White (Hemiptera: Fulgoridae), research is being conducted to develop classical biological control methods. To date, two potential biocontrol agents from China have ... ...

    Abstract To support efforts to manage and contain spotted lanternfly (SLF), Lycorma delicatula White (Hemiptera: Fulgoridae), research is being conducted to develop classical biological control methods. To date, two potential biocontrol agents from China have been identified: an egg parasitoid, Anastatus orientalis, and a nymphal parasitoid, Dryinus sinicus Olmi (Hymenoptera: Dryinidae). The research detailed here focuses on investigating the biology and rearing of A. orientalis to assess its potential efficacy in a biocontrol program and optimize its rearing. Female wasps lived significantly longer than male wasps (68 and 23 d, respectively) and females produced an average of 94 total progeny that successfully emerged as adults, with most progeny produced between weeks one and four of the females' lives. The sex ratio of the progeny, with no re-mating, was initially highly female-biased but became progressively more male-biased, likely due to sperm depletion. There was no evidence of additional mortality to SLF eggs from wasp host feeding, but the data were highly variable and the sample size was small. There was high parasitoid emergence when oviposition conditions mimicked mid-September Beijing temperature and photoperiod; however, there was little emergence under 25°C and long-day conditions because most progeny entered a diapause. Storage of parasitized eggs in 5°C chill lowered parasitoid emergence rates. Lastly, there was no evidence that storing field-collected SLF egg masses in 5°C for 10 mo prior to parasitization affected parasitism rates. These findings inform our rearing protocol for A. orientalis and facilitate our testing of this species as a potential biological control agent for SLF.
    MeSH term(s) Animals ; China ; Female ; Hemiptera ; Hymenoptera ; Male ; Nymph ; Ovum ; Wasps
    Language English
    Publishing date 2020-11-25
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120799-4
    ISSN 1938-2936 ; 0046-2268 ; 0046-225X
    ISSN (online) 1938-2936
    ISSN 0046-2268 ; 0046-225X
    DOI 10.1093/ee/nvaa124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Stereotactic Brain Biopsy Hemorrhage Risk Factors and Implications for Postoperative Care at a Single Institution: An Argument For Postoperative Imaging.

    Barkley, Ariana S / Sullivan, Liam T / Gibson, Alec W / Camacho, David / Barber, Jason K / Ko, Andrew L / Silbergeld, Daniel L / Ravanpay, Ali C

    World neurosurgery

    2020  Volume 144, Page(s) e807–e812

    Abstract: Objective: To determine preoperative factors contributing to postoperative hemorrhage after stereotactic brain biopsy (STB), clinical implications of postoperative hemorrhage, and the role of postoperative imaging in clinical management.: Methods: ... ...

    Abstract Objective: To determine preoperative factors contributing to postoperative hemorrhage after stereotactic brain biopsy (STB), clinical implications of postoperative hemorrhage, and the role of postoperative imaging in clinical management.
    Methods: Retrospective review of STB (2005-2018) across 2 institutions including patients aged >18 years undergoing first STB. Patients with prior craniotomy, open biopsy, or prior STB were excluded. Preoperative variables included age, sex, neurosurgeon seniority, STB method. Postoperative variables included pathology, postoperative hemorrhage on computed tomography, immediate and 30-day postoperative seizure, infection, postoperative hospital stay duration, and 30-day return to operating room (OR). Analysis used the Fisher exact tests for categorical variables.
    Results: Overall, 410 patients were included. Average age was 56.5 (±16.5) years; 60% (n = 248) were men. The majority of biopsies were performed by senior neurosurgeons (66%, n = 270); frontal lobe (42%, n = 182) and glioblastoma (45%, n = 186) were the most common location and pathology. Postoperative hemorrhage occurred in 28% (114) of patients with 20% <0.05 cm
    Conclusions: Postbiopsy hemorrhage was associated with higher risk of immediate and delayed postoperative deficit and seizure. Postoperative computed tomography should be used to determine whether STB patients can be discharged same day or admitted for observation; clinical evaluation should determine return to OR for evacuation.
    MeSH term(s) Biopsy/adverse effects ; Brain Neoplasms/diagnosis ; Brain Neoplasms/epidemiology ; Brain Neoplasms/surgery ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/epidemiology ; Cerebral Hemorrhage/prevention & control ; Female ; Humans ; Male ; Middle Aged ; Neurosurgical Procedures/adverse effects ; Postoperative Hemorrhage/diagnostic imaging ; Postoperative Hemorrhage/epidemiology ; Postoperative Hemorrhage/prevention & control ; Retrospective Studies ; Risk Factors ; Stereotaxic Techniques/adverse effects
    Language English
    Publishing date 2020-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.09.084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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