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  1. Book ; Online ; Conference proceedings: Supercomputing Frontiers

    Panda, Dhabaleswar K. / Sullivan, Michael

    7th Asian Conference, SCFA 2022, Singapore, March 1–3, 2022, Proceedings

    (Lecture Notes in Computer Science ; 13214)

    2022  

    Author's details edited by Dhabaleswar K. Panda, Michael Sullivan
    Series title Lecture Notes in Computer Science ; 13214
    Keywords Computer engineering ; Computer networks  ; Software engineering ; Operating systems (Computers) ; Microprocessors ; Computer architecture
    Subject code 621.39 ; 004.6
    Language English
    Size 1 Online-Ressource (VIII, 141 p. 53 illus., 47 illus. in color)
    Edition 1st ed. 2022
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; Conference proceedings
    HBZ-ID HT021412114
    ISBN 978-3-031-10419-0 ; 9783031104183 ; 9783031104206 ; 3-031-10419-6 ; 3031104188 ; 303110420X
    DOI 10.1007/978-3-031-10419-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; Conference proceedings: Supercomputing Frontiers

    Panda, Dhabaleswar K. / Sullivan, Michael

    7th Asian Conference, SCFA 2022, Singapore, March 1-3, 2022, Proceedings

    (Lecture Notes in Computer Science)

    2022  

    Series title Lecture Notes in Computer Science
    Keywords Computer networking & communications ; Software Engineering ; Operating systems ; Computer architecture & logic design ; Network hardware ; cloud computing ; computer networks ; computer programming ; computer systems ; CUDA ; distributed computer systems ; gpu ; gpus ; hpc ; microprocessor chips ; mpi ; parallel algorithms ; parallel architectures ; parallel processing systems ; parallel programming ; programming languages ; signal processing ; telecommunication systems ; algorithms ; high performance computing
    Language 0|e
    Size 1 electronic resource (141 pages)
    Publisher Springer Nature
    Publishing place Cham
    Document type Book ; Online ; Conference proceedings
    Note English ; Open Access
    HBZ-ID HT021619781
    ISBN 9783031104190 ; 3031104196
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Near-real time determination of BAHD acyl-coenzyme A transferase reaction rates and kinetic parameters using Ellman's reagent.

    Sullivan, Michael L

    Methods in enzymology

    2022  Volume 683, Page(s) 19–39

    Abstract: BAHD acyl-coenzyme A (CoA) acyltransferases play key roles in a large number of biosynthetic reactions involved in plant specialized metabolism. One approach to measure reaction rates for these enzymes is to quantify the amide or ester reaction products ... ...

    Abstract BAHD acyl-coenzyme A (CoA) acyltransferases play key roles in a large number of biosynthetic reactions involved in plant specialized metabolism. One approach to measure reaction rates for these enzymes is to quantify the amide or ester reaction products following chromatographic separation of reaction components, an approach that can be labor intensive and time consuming, and complicated by a lack of pure standards. We previously developed and validated an alternative approach using 5,5'-dithio-bis-(2-nitrobenzoic acid) (DTNB, Ellman's reagent) to spectrophotometrically monitor reaction progress by the release of free CoA in the reaction. This approach allows near-real time measurement of reaction rates, permitting reaction conditions (buffer, reactant, and enzyme concentrations, etc.) to be changed "on the fly." The ease and rapidity of data collection allows a high density of data points to be collected for determination of kinetic parameters. Here we provide a detailed procedure for using DTNB to measure BAHD acyl-CoA acyltransferase reaction rates, and as an example, use it to determine kinetic parameters for red clover hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyltransferase, a BAHD acyl-CoA hydroxycinnamoyltransferase not previously characterized with respect to kinetic parameters. This approach may be more generally applicable to transferases using CoA donors.
    MeSH term(s) Dithionitrobenzoic Acid/chemistry ; Coenzyme A-Transferases ; Acyltransferases/metabolism
    Chemical Substances Dithionitrobenzoic Acid (9BZQ3U62JX) ; acyl-CoA transferase (EC 2.8.3.-) ; shikimate ; Coenzyme A-Transferases (EC 2.8.3.-) ; Acyltransferases (EC 2.3.-)
    Language English
    Publishing date 2022-11-29
    Publishing country United States
    Document type Journal Article
    ISSN 1557-7988
    ISSN (online) 1557-7988
    DOI 10.1016/bs.mie.2022.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Preparation of hydroxycinnamoyl-coenzyme A thioesters using recombinant 4-coumarate:coenzyme A ligase (4CL) for characterization of BAHD hydroxycinnamoyltransferase enzyme activities.

    Sullivan, Michael L

    Methods in enzymology

    2022  Volume 683, Page(s) 3–18

    Abstract: Analyses of the enzymatic activities of hydroxycinnamoyl-coenzyme A (CoA) hydroxycinnamoyltransferases of the BAHD family require hydroxycinnamoyl-CoA thioesters as assay reagents. Here we describe a simple, cost-effective method for preparing p- ... ...

    Abstract Analyses of the enzymatic activities of hydroxycinnamoyl-coenzyme A (CoA) hydroxycinnamoyltransferases of the BAHD family require hydroxycinnamoyl-CoA thioesters as assay reagents. Here we describe a simple, cost-effective method for preparing p-coumaroyl-, caffeoyl- and feruloyl-CoA thioesters using the Arabidopsis thaliana 4-coumarate:CoA ligase 1 (4CL1) expressed in Escherichia coli. Preparation of the 4CL enzyme, in vitro synthesis of the thioesters, and thioester purification utilizing a C-18 solid phase extraction column are detailed. The hydroxycinnamoyl-CoA thioesters produced are suitable for downstream qualitative and quantitative analyses.
    MeSH term(s) Coenzyme A Ligases/genetics
    Chemical Substances Coenzyme A Ligases (EC 6.2.1.-)
    Language English
    Publishing date 2022-11-23
    Publishing country United States
    Document type Journal Article
    ISSN 1557-7988
    ISSN (online) 1557-7988
    DOI 10.1016/bs.mie.2022.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Temporal Relations Between Pain Catastrophizing and Adverse Health and Mental Health Outcomes After Whiplash Injury.

    Paré, Catherine / Yamada, Keiko / Sullivan, Michael J L

    The Clinical journal of pain

    2024  Volume 40, Issue 1, Page(s) 10–17

    Abstract: Objectives: Pain catastrophizing has been shown to be a prognostic indicator for pain severity and the co-occurrence of mental health conditions such as depression and post-traumatic stress disorder after whiplash injury. However, the pattern of ... ...

    Abstract Objectives: Pain catastrophizing has been shown to be a prognostic indicator for pain severity and the co-occurrence of mental health conditions such as depression and post-traumatic stress disorder after whiplash injury. However, the pattern of available findings is limited in its implications for the possible "antecedent" or "causal" role of pain catastrophizing. The purpose of the present study was to examine the temporal relations between pain catastrophizing, pain severity, depressive symptoms, and post-traumatic stress symptoms (PTSS) in individuals receiving treatment for whiplash injury.
    Materials and methods: The sample consisted of 388 individuals enrolled in a multidisciplinary program for whiplash injury. Participants completed self-report measures of pain catastrophizing, pain severity, depressive symptoms, and PTSS at the time of admission, mid-treatment (4 week), and treatment completion (7 week). A cross-lagged panel analysis was used to examine the temporal relations between pain catastrophizing, pain severity, depressive symptoms, and PTSS across all 3 timepoints.
    Results: Model fit was acceptable after the inclusion of modification indices. Pain catastrophizing at the time of admission predicted all other variables at 4 weeks. Pain catastrophizing at 4 weeks also predicted all other variables at 7 weeks. In addition, some bidirectional relations were present, particularly for variables assessed at week 4 and week 7.
    Discussion: Findings support the view that pain catastrophizing might play a transdiagnostic role in the onset and maintenance of health and mental health conditions. The findings call for greater emphasis on the development of treatment techniques that target pain catastrophizing in intervention programs for whiplash injury.
    MeSH term(s) Humans ; Whiplash Injuries/complications ; Whiplash Injuries/psychology ; Pain Measurement/methods ; Pain/psychology ; Catastrophization/psychology ; Outcome Assessment, Health Care
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632582-8
    ISSN 1536-5409 ; 0749-8047
    ISSN (online) 1536-5409
    ISSN 0749-8047
    DOI 10.1097/AJP.0000000000001168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2078: Show issues Location:
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  6. Article ; Online: Tools for protein structure prediction and for molecular docking applied to enzyme active site analysis: A case study using a BAHD hydroxycinnamoyltransferase.

    Fanelli, Amanda / Sullivan, Michael L

    Methods in enzymology

    2022  Volume 683, Page(s) 41–79

    Abstract: Elucidating the structure of an enzyme and how substrates bind to the active site is an important step for understanding its reaction mechanism and function. Nevertheless, the methods available to obtain three-dimensional structures of proteins, such as ... ...

    Abstract Elucidating the structure of an enzyme and how substrates bind to the active site is an important step for understanding its reaction mechanism and function. Nevertheless, the methods available to obtain three-dimensional structures of proteins, such as x-ray crystallography and NMR, can be expensive and time-consuming. Considering this, an alternative is using structural bioinformatic tools to predict the tertiary structure of a protein from its primary sequence, followed by molecular docking of one or more substrates into the enzyme structure model. In the past few years, significant advances have been made in these computational tools, which can give useful information about the active site and enzyme-substrate interactions before the structure can be resolved using physical methods. Here, using common bean (Phaseolus vulgaris) hydroxycinnamoyl-coenzyme A:tetrahydroxyhexanedioic acid hydroxycinnamoyltransferase (HHHT) as an example, we describe methods and workflows for protein structure prediction and molecular docking that can be performed on a personal computer using only open-source tools.
    MeSH term(s) Molecular Docking Simulation ; Catalytic Domain ; Models, Molecular ; Proteins ; Acyltransferases/chemistry ; Crystallography, X-Ray
    Chemical Substances Proteins ; Acyltransferases (EC 2.3.-)
    Language English
    Publishing date 2022-11-30
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1557-7988
    ISSN (online) 1557-7988
    DOI 10.1016/bs.mie.2022.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Daprodustat in renal anaemia: changing the response to cellular hypoxia, but is it a game changer?

    Sullivan, Michael K / Mark, Patrick B

    Cardiovascular research

    2022  Volume 118, Issue 8, Page(s) e54–e56

    MeSH term(s) Anemia/diagnosis ; Anemia/drug therapy ; Barbiturates ; Cell Hypoxia/physiology ; Glycine/analogs & derivatives ; Humans ; Hypoxia/drug therapy ; Renal Insufficiency, Chronic
    Chemical Substances Barbiturates ; GSK1278863 ; Glycine (TE7660XO1C)
    Language English
    Publishing date 2022-06-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvac067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
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  8. Article ; Online: Perceptions of Injustice and Problematic Pain Outcomes.

    Sullivan, Michael J L

    Pain medicine (Malden, Mass.)

    2020  Volume 21, Issue 7, Page(s) 1315–1336

    MeSH term(s) Catastrophization ; Humans ; Musculoskeletal Pain
    Language English
    Publishing date 2020-04-01
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1093/pm/pnaa149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6119: Show issues Location:
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  9. Article ; Online: Early Peanut Immunotherapy in Children (EPIC) trial: protocol for a pragmatic randomised controlled trial of peanut oral immunotherapy in children under 5 years of age.

    O'Sullivan, Michael David / Bear, Natasha / Metcalfe, Jessica

    BMJ paediatrics open

    2023  Volume 7, Issue 1

    Abstract: Introduction: Food allergy is a major public health challenge in Australia. Despite widespread uptake of infant feeding and allergy prevention guidelines the incidence of peanut allergy in infants has not fallen, and prevalence of peanut allergy in ... ...

    Abstract Introduction: Food allergy is a major public health challenge in Australia. Despite widespread uptake of infant feeding and allergy prevention guidelines the incidence of peanut allergy in infants has not fallen, and prevalence of peanut allergy in school-aged children continues to rise. Therefore, effective and accessible treatments for peanut allergy are required. There is high-quality evidence for efficacy of oral immunotherapy in children aged 4-17 years old; however, few randomised trials have investigated peanut oral immunotherapy (OIT) in young children. Furthermore, the use of food products for OIT with doses prepared and administered by parents without requiring pharmacy compounding has the potential to reduce costs associated with the OIT product.
    Methods and analysis: Early Peanut Immunotherapy in Children is an open-label randomised controlled trial of peanut OIT compared with standard care (avoidance) to induce desensitisation in children aged 1-4 years old with peanut allergy. n=50 participants will be randomised 1:1 to intervention (daily peanut OIT for 12 months) or control (peanut avoidance). The primary outcome is the proportion of children in each group with a peanut eliciting dose >600 mg peanut protein as assessed by open peanut challenge after 12 months, analysed by intention to treat. Secondary outcomes include safety as assessed by frequency and severity of treatment-related adverse events, quality of life measured using age-appropriate food allergy-specific questionnaires and immunological changes during OIT.
    Ethics: The trial is approved by the Child and Adolescent Health Service Human Research Ethics Committee and prospectively registered with the Australia and New Zealand Clinical Trials Registry.
    Dissemination: Trial outcomes will be published in a peer-review journal and presented and local and national scientific meetings.
    Trial registration number: ACTRN12621001001886.
    MeSH term(s) Child, Preschool ; Humans ; Infant ; Administration, Oral ; Arachis ; Desensitization, Immunologic/adverse effects ; Desensitization, Immunologic/methods ; Peanut Hypersensitivity/prevention & control ; Quality of Life ; Pragmatic Clinical Trials as Topic
    Language English
    Publishing date 2023-11-14
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-9772
    ISSN (online) 2399-9772
    DOI 10.1136/bmjpo-2023-002294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sex and gender differences in the management of chronic kidney disease and hypertension.

    Mayne, Kaitlin J / Sullivan, Michael K / Lees, Jennifer S

    Journal of human hypertension

    2023  Volume 37, Issue 8, Page(s) 649–653

    MeSH term(s) Male ; Female ; Humans ; Sex Factors ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/epidemiology ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy
    Language English
    Publishing date 2023-06-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-023-00843-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 2380: Show issues Location:
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