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  1. Article ; Online: Psychiatric Genetics Before "Genetics".

    Sullivan, Patrick F

    The American journal of psychiatry

    2021  Volume 178, Issue 6, Page(s) 475–476

    MeSH term(s) Genomics ; Humans ; Psychiatry
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2021.21020136
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  2. Article ; Online: The state of the science in psychiatric genomics.

    Sullivan, Patrick F / Kendler, Kenneth S

    Psychological medicine

    2021  Volume 51, Issue 13, Page(s) 2145–2147

    MeSH term(s) Cooperative Behavior ; Data Interpretation, Statistical ; Genomics/trends ; Humans ; Psychiatry/trends
    Language English
    Publishing date 2021-01-12
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291720004900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Schizophrenia and the dynamic genome.

    Sullivan, Patrick F

    Genome medicine

    2017  Volume 9, Issue 1, Page(s) 22

    MeSH term(s) DNA Copy Number Variations ; Genome, Human ; Humans ; Schizophrenia/genetics
    Language English
    Publishing date 2017--02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2484394-5
    ISSN 1756-994X ; 1756-994X
    ISSN (online) 1756-994X
    ISSN 1756-994X
    DOI 10.1186/s13073-017-0416-2
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  4. Article ; Online: How Good Were Candidate Gene Guesses in Schizophrenia Genetics?

    Sullivan, Patrick F

    Biological psychiatry

    2017  Volume 82, Issue 10, Page(s) 696–697

    MeSH term(s) Genetic Predisposition to Disease ; Humans ; Schizophrenia
    Language English
    Publishing date 2017-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2017.09.004
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  5. Article ; Online: Evidence of soil nutrient availability as the proximate constraint on growth of treeline trees in northwest Alaska: reply.

    Sullivan, Patrick F

    Ecology

    2016  Volume 97, Issue 3, Page(s) 803–808

    MeSH term(s) Picea/growth & development ; Soil/chemistry ; Trees/growth & development
    Chemical Substances Soil
    Language English
    Publishing date 2016-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 2010140-5
    ISSN 1939-9170 ; 0012-9658
    ISSN (online) 1939-9170
    ISSN 0012-9658
    DOI 10.1890/15-1734.1
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  6. Article ; Online: Arctic sea ice retreat fuels boreal forest advance.

    Dial, Roman J / Maher, Colin T / Hewitt, Rebecca E / Wockenfuss, Amy M / Wong, Russell E / Crawford, Daniel J / Zietlow, Madeline G / Sullivan, Patrick F

    Science (New York, N.Y.)

    2024  Volume 383, Issue 6685, Page(s) 877–884

    Abstract: Climate-induced northward advance of boreal forest is expected to lessen albedo, alter carbon stocks, and replace tundra, but where and when this advance will occur remains largely unknown. Using data from 19 sites across 22 degrees of longitude along ... ...

    Abstract Climate-induced northward advance of boreal forest is expected to lessen albedo, alter carbon stocks, and replace tundra, but where and when this advance will occur remains largely unknown. Using data from 19 sites across 22 degrees of longitude along the tree line of northern Alaska, we show a stronger temporal correlation of tree ring growth with open water uncovered by retreating Arctic sea ice than with air temperature. Spatially, our results suggest that tree growth, recruitment, and range expansion are causally linked to open water through associated warmer temperatures, deeper snowpacks, and improved nutrient availability. We apply a meta-analysis to 82 circumarctic sites, finding that proportionally more tree lines have advanced where proximal to ongoing sea ice loss. Taken together, these findings underpin how and where changing sea ice conditions facilitate high-latitude forest advance.
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adh2339
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  7. Article: Schizophrenia: Hope on the Horizon.

    Sullivan, Patrick F

    Cerebrum : the Dana forum on brain science

    2015  Volume 2015

    Abstract: In July 2014, an international consortium of schizophrenia researchers co-founded by the author mounted the largest biological experiment in the history of psychiatry and found eighty new regions in the genome associated with the illness. With many more ... ...

    Abstract In July 2014, an international consortium of schizophrenia researchers co-founded by the author mounted the largest biological experiment in the history of psychiatry and found eighty new regions in the genome associated with the illness. With many more avenues for exploring the biological underpinnings of schizophrenia now available to neuroscientists, hope may be on the way for the estimated 2.4 million Americans and 1 in 100 people worldwide affected by the illness, one in which drugs have limited impact and there is no known cure.
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2251230-5
    ISSN 1524-6205
    ISSN 1524-6205
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  8. Article ; Online: Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders.

    Sullivan, Patrick F / Geschwind, Daniel H

    Cell

    2019  Volume 177, Issue 1, Page(s) 162–183

    Abstract: Studies of the genetics of psychiatric disorders have become one of the most exciting and fast-moving areas in human genetics. A decade ago, there were few reproducible findings, and now there are hundreds. In this review, we focus on the findings that ... ...

    Abstract Studies of the genetics of psychiatric disorders have become one of the most exciting and fast-moving areas in human genetics. A decade ago, there were few reproducible findings, and now there are hundreds. In this review, we focus on the findings that have illuminated the genetic architecture of psychiatric disorders and the challenges of using these findings to inform our understanding of pathophysiology. The evidence is now overwhelming that psychiatric disorders are "polygenic"-that many genetic loci contribute to risk. With the exception of a subset of those with ASD, few individuals with a psychiatric disorder have a single, deterministic genetic cause; rather, developing a psychiatric disorder is influenced by hundreds of different genetic variants, consistent with a polygenic model. As progressively larger studies have uncovered more about their genetic architecture, the need to elucidate additional architectures has become clear. Even if we were to have complete knowledge of the genetic architecture of a psychiatric disorder, full understanding requires deep knowledge of the functional genomic architecture-the implicated loci impact regulatory processes that influence gene expression and the functional coordination of genes that control biological processes. Following from this is cellular architecture: of all brain regions, cell types, and developmental stages, where and when are the functional architectures operative? Given that the genetic architectures of different psychiatric disorders often strongly overlap, we are challenged to re-evaluate and refine the diagnostic architectures of psychiatric disorders using fundamental genetic and neurobiological data.
    MeSH term(s) Alleles ; Gene Frequency/genetics ; Genetic Predisposition to Disease ; Genetic Variation/genetics ; Genome-Wide Association Study ; Genomics/methods ; Humans ; Mental Disorders/epidemiology ; Mental Disorders/genetics ; Mental Health ; Multifactorial Inheritance/genetics
    Language English
    Publishing date 2019-02-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2019.01.015
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  9. Article ; Online: Increasing the Clinical Psychiatric Knowledge Base About Pathogenic Copy Number Variation.

    Sullivan, Patrick F / Owen, Michael J

    The American journal of psychiatry

    2019  Volume 177, Issue 3, Page(s) 204–209

    MeSH term(s) DNA Copy Number Variations ; Genotype ; Humans ; Knowledge Bases ; Mental Disorders/genetics
    Language English
    Publishing date 2019-10-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2019.19040335
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  10. Article ; Online: Sufficient conditions for rapid range expansion of a boreal conifer.

    Dial, Roman J / Maher, Colin T / Hewitt, Rebecca E / Sullivan, Patrick F

    Nature

    2022  Volume 608, Issue 7923, Page(s) 546–551

    Abstract: Unprecedented modern rates of warming are expected to advance boreal forest into Arctic ... ...

    Abstract Unprecedented modern rates of warming are expected to advance boreal forest into Arctic tundra
    MeSH term(s) Acclimatization ; Arctic Regions ; Climate Models ; Global Warming/statistics & numerical data ; Models, Biological ; Picea/growth & development ; Picea/metabolism ; Seasons ; Snow ; Soil/chemistry ; Taiga ; Temperature ; Trees/growth & development ; Trees/metabolism ; Tundra ; Wind
    Chemical Substances Soil
    Language English
    Publishing date 2022-08-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-022-05093-2
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