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Article ; Online: COVID-19 MIS-C (Multisystem Inflammatory Syndrome in Children) Cases with Significant Echocardiographic Abnormality

Sumanta Laha / Amaresh Roy / Sushama Saren / Tarak Nath Ghosh

Journal of Medical Sciences and Health, Vol 8, Iss 2, Pp 162-

A Case Series

2022 Volume 165

Abstract: Post COVID-19 MIS-C cases are on the rise recently and various cardiac abnormalities are reported among them in different literature. Here we have presented six cases of MIS-C with significant echocardiographic abnormality. They have a varied ... ...

Abstract	Post COVID-19 MIS-C cases are on the rise recently and various cardiac abnormalities are reported among them in different literature. Here we have presented six cases of MIS-C with significant echocardiographic abnormality. They have a varied presentation like acute encephalitis, acute renal failure, incomplete Kawasaki, shock or acute gastroenteritis along with fever. Our cases have raised inflammatory markers like ESR, CRP, IL-6 with increased D-dimer, CPK-MB and positive COVID serology. Except case5, none has any cardiovascular presentation but every case has some important echocardiographic finding. Mild pericardial effusion was present in two cases, gross LV systolic dysfunction with LVEF 40-45% in one case, significant coronary artery dilatation in three cases and valvular abnormality like MR or TR in three cases. So it is extremely important to evaluate every case of MIS-C with proper echocardiography even if they had no cardiac manifestation at presentation to prevent complication afterwards. Keywords: COVID -19, MIS-C, Echocardiography
Keywords	Medicine ; R
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	ADICHUNCHANAGIRI INSTITUTE OF MEDICAL SCIENCES
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neonatal acute kidney injury - how mortality is related to its stage and the common co-morbidity among expired? A hospital based study

Sumanta Laha / Krishnendu Karmakar / Bhaswati Ghoshal

Journal of Medical and Allied Sciences, Vol 11, Iss 1, Pp 97-

2021 Volume 100

Abstract: Objective of our study was to find out the incidence of Acute Kidney Injury (AKI) in neonates with their immediate outcome, how stages of AKI is related to mortality and what are the common co-morbid conditions among AKI deaths. In this observational ... ...

Abstract	Objective of our study was to find out the incidence of Acute Kidney Injury (AKI) in neonates with their immediate outcome, how stages of AKI is related to mortality and what are the common co-morbid conditions among AKI deaths. In this observational prospective study we included the newborns with features suggestive of AKI with exclusion criteria of major congenital anomaly and extreme prematurity. AKI was diagnosed and classified according to the KDIGO (Kidney Disease: Improving Global Outcome) guideline taking serum creatinine and urine output as determinant. Cases were followed up till discharge or death. Now we have figured out the incidence of AKI in different stages, its immediate outcome and what are the percentage of mortality within each stage. Among the AKI deaths, we sort out the associated co-morbid conditions like perinatal asphyxia, sepsis, shock, prematurity, etc. and analyzed all the results statistically. Out of total 1923 neonates admitted during the 18 months study period we found AKI in 119 neonates (6.18%). Among them 75(63.03%), 26(21.85%) and 18(15.12%) neonates were in KDIGO stage 1, 2 and 3 respectively. We were able to discharge 68 neonates, 30 expired and the rest were referred out or LAMA. When we compare mortality among different stage, we found that it was 9.33% in stage 1 and 38.46% and 72.22% in stage 2 and 3 respectively. Among the various co-morbid conditions present among the expired neonates, sepsis(13) and perinatal asphyxia(12) were the leading ones followed by prematurity(3)and PPHN(2). So the conclusion is, if we can identify AKI early then chance of survival is better as we have shown in our study that mortality increases with the advancement of AKI stage. Sepsis and asphyxia ware the two most common co-morbid conditions among AKI deaths in our study. [J Med Allied Sci 2021; 11(1): 97-100]
Keywords	acute kidney injury (aki) ; co-morbidity ; mortality ; neonate ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Deccan College of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Japanese encephalitis in children from an endemic district of West Bengal, India

Abhishek Gupta / Sumanta Laha / Kanai Lal Barik

Asian Journal of Medical Sciences, Vol 12, Iss 10, Pp 34-

A hospital based observational study

2021 Volume 38

Abstract: Background: Japanese encephalitis (JE) is an important cause of viral encephalitis in children in South East Asian countries including India. Aims and Objective: We have done this study in an JE endemic district of India to know the demographic profile, ... ...

Abstract	Background: Japanese encephalitis (JE) is an important cause of viral encephalitis in children in South East Asian countries including India. Aims and Objective: We have done this study in an JE endemic district of India to know the demographic profile, clinical presentation, seasonal variation, outcome and about the vaccination status of the JE cases. Materials and Methods: This observational, cross sectional study was done for a period of one year in the Pediatric department of Burdwan Medical College, West Bengal in children up to the age of 12 year, presented with acute encephalitis syndrome (AES). Demographic data, clinical presentation and JE vaccination status were recorded and confirmed JE cases were detected by either serum or CSF JE IgM antibody. Outcome of the JE cases were noted as discharge, death or leave against medical advice (LAMA). Results: We have found confirmed JE in 18 children out of total 125 AES cases (14.4%). 61.1% of them were within 6 to 12 year age, mostly from low socioeconomic status and 100% case occurred during monsoon and post monsoon period. History, was of JE vaccination were present in only 11.1% case of JE. Most common presenting symptoms were high fever (100%), convulsion (94.4%) and altered sensorium (72.2%). 77.8% JE case were discharged and 11.1% expired. Conclusion: We must consider JE whenever a child from any endemic district comes with AES and we should try to bring every child under the JE vaccination coverage in the endemic regions globally to reduce the burden of this preventable encephalitis.
Keywords	japanese encephalitis ; children ; west bengal ; Medicine ; R
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Usefulness of Urine Uric Acid/Creatinine Ratio in Neonate as an Early Detector of Perinatal Hypoxia

Saikat Mondal / Kanai Lal Barik / Sudipto Paul / Sumanta Laha* / Sayan Bera

SVU - International Journal of Medical Sciences, Vol 6, Iss 2, Pp 206-

A Hospital-Based Observational Study

2023 Volume 214

Abstract: Background: When a neonate is born under a hypoxic state, there is increased production of uric acid due to hypoxic tissue damage, which is excreted via the kidney, and the ratio of uric acid and creatinine (UA/Cr) in urine is used as an early predictor ... ...

Abstract	Background: When a neonate is born under a hypoxic state, there is increased production of uric acid due to hypoxic tissue damage, which is excreted via the kidney, and the ratio of uric acid and creatinine (UA/Cr) in urine is used as an early predictor of perinatal hypoxia. Objectives: We conducted this study to compare urine UA/Cr ratio between normal and asphyxiated newborns and between different stages of HIE to evaluate its usefulness as a diagnostic and prognostic marker of perinatal asphyxia. Patients and method: This observational cross-sectional study is conducted for one year with 75 asphyxiated neonates in different stages of HIE and 75 healthy neonates as control. Uric acid and creatinine values are measured with an auto-analyzer from a single urine sample taken between 6 to 24 hours of birth. Results: We found urine UA(38 ±2.81 mg/dl vs 19.24±0.75 mg/dl ) and urine UA/Cr value (2.81±0.32 vs 1.40±0.13 ) significantly high in cases compared to control. Also, the urine UA and UA/Cr values are increasing with advanced stages of HIE (p <0.001). The optimal cut point value to predict HIE was at urine UA/Cr ratio of >2.45 with an AUC of 0.96, accuracy of 90%, sensitivity of 98.07% , specificity of 85.70% , PPV 78.46%, and NPV 98.82%. Conclusion: Urine UA/Cr appears to be a simple, inexpensive and reliable indicator of perinatal hypoxia for risk stratification based on functional impairment in the HIE babies.
Keywords	hypoxic ischemic encephalopathy ; neonate ; perinatal hypoxia ; uric acid ; creatinine ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	South Valley University, Faculty of Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An observational study to evaluate the outcome of patients admitted in pediatric intensive care unit (PICU) using pediatric risk of mortality (PRISM-III) score in a tertiary care hospital of West Bengal

Sudipto Paul / Kanai Lal Barik / Nilanjan Ghosh / Sumanta Laha / Sayan Bera / Sukanya Nath

Asian Journal of Medical Sciences, Vol 14, Iss 7, Pp 171-

2023 Volume 177

Abstract: Background: Pediatric risk of mortality (PRISM III) score is used across the globe to predict the mortality of hospitalized children by an objective method based on 17 variables measured during first 24 h of admission in pediatric intensive care unit ( ... ...

Abstract	Background: Pediatric risk of mortality (PRISM III) score is used across the globe to predict the mortality of hospitalized children by an objective method based on 17 variables measured during first 24 h of admission in pediatric intensive care unit (PICU). Aims and Objectives: We have done this study to evaluate the cause, management and outcome of PICU admissions and also to find out the statistical significance of PRISM III score in predicting mortality. Materials and Methods: This observational prospective study was conducted for a period of 1 year in the PICU of a district Medical College of West Bengal among children 1–12 years age. They were divided into 4 groups according to the PRISM III scores of 1–10, 11–20, 21–30, and >30 and outcome in all the groups were recorded and analyzed. Results: Respiratory (25%), neurological (20.1%), and infectious (17.3%) etiology were major cause of PICU admission. About 17.4% patients needed mechanical ventilation, 31.2% Continuous Positive Airway Pressure and 66% patients inotropic support. Out of 144 cases, 117 discharged and 27 expired. Percentage of death is 100%, 44.4%, 21.6%, and 4.6% among child with PRISM III score of >30, 21–30, 11–21, and ≤10, respectively. Significant increase in mortality noted with increase in number of organ failures. Specificity and positive predictive value increases with higher PRISM III score and sensitivity and negative predictive value is more with low PRISM III score. Conclusion: PRISM III score can be used as a triage tool in limited resource settings for early initiation of intense management to high risk and salvageable cases.
Keywords	child mortality ; pediatric intensive care units ; pediatric risk of mortality score ; Medicine ; R
Subject code	310
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bacteriological profile, antibiotic susceptibility pattern and other factors related to neonatal meningitis

Kanai Lal Barik / Projesh Biswas / Kuntal Kanti Das / Sumanta Laha / Sudipto Paul / Saikat Mondal

Asian Journal of Medical Sciences, Vol 13, Iss 1, Pp 93-

A cross-sectional hospital-based study from West Bengal

2022 Volume 98

Abstract: Background: Neonatal sepsis and meningitis is an important cause of neonatal mortality and morbidity especially in the developing countries. Bacteriological profile of meningitis and antibiotic sensitivity pattern may vary from one region to another. ... ...

Abstract	Background: Neonatal sepsis and meningitis is an important cause of neonatal mortality and morbidity especially in the developing countries. Bacteriological profile of meningitis and antibiotic sensitivity pattern may vary from one region to another. Aims and Objectives: We have planned this study to know the etiological agent of neonatal meningitis with its antibiotic sensitivity profile and to evaluate some other associated risk factors of meningitis. Materials and Methods: This observational, cross-sectional study was done for a period of 1 year in the SNCU and NICU of a district Medical College of West Bengal in neonates presented with clinical sepsis and meningitis. Sepsis screen, blood culture, cerebrospinal fluid (CSF) study, and culture sensitivity was done and recorded along with demographic data, clinical presentation, outcome, and other associated factors. Results: We found meningitis in 55 neonates out of 250 clinical sepsis. CSF culture was positive in 42 cases with Escherichia coli (30.9%), Klebsiella (26.1%), Staphylococcus aureus (16.6%), Acinetobacter (14.2%) and Coagulase negative Staphylococcus (CoNS 11.9%) as prevalent organism. E. coli and Klebsiella were mostly sensitive to Amikacin, Levofloxacin, and Colistin whereas less sensitive to Cefotaxime, Pipercilin-tazobactam or Meropenem and Acinetobacter showed good sensitivity only to Levofloxacin. Among the gram-positive organism, S. aureus and CoNS were only sensitive to Linezolid, Vancomycin, and Teicoplanin. Conclusion: This type of study should help to make a proper antibiotic policy for an institution so that the empirical first-line antibiotic can be started with good effect in cases of neonatal sepsis and meningitis before the arrival of culture sensitivity report.
Keywords	antimicrobial susceptibility ; etiology ; meningitis ; neonates ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A comparative study between glucose 6-phosphate dehydrogenase deficient and normal term neonates with indirect hyperbilirubinemia in a rural tertiary care hospital of Eastern India

Kanai Lal Barik / Puja Kumari Singh / Sudipto Paul / Sumanta Laha / Saikat Mondal

Asian Journal of Medical Sciences, Vol 13, Iss 9, Pp 77-

2022 Volume 82

Abstract: Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an important cause of neonatal indirect hyperbilirubinemia or even kernicterus leading to long-term neurological sequelae specially in countries like India where G6PD deficiency is quite ... ...

Abstract	Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an important cause of neonatal indirect hyperbilirubinemia or even kernicterus leading to long-term neurological sequelae specially in countries like India where G6PD deficiency is quite prevalent. Aims and Objectives: We have planned this study to know the prevalence of G6PD deficiency among cases of neonatal jaundice and also to evaluate the difference between G6PD deficient and normal neonates with indirect hyperbilirubinemia in terms of laboratory parameters and need of phototherapy or exchange transfusion. Materials and Methods: This observational and cross-sectional study was done for a period of 1 year in the SNCU and NICU of a district Medical College of West Bengal among 200 term neonates presented with indirect hyperbilirubinemia. Birth weight, sex, hemoglobin, G6PD level, serum bilirubin at admission, phototherapy duration, and need for exchange transfusion were recorded along with other necessary parameters. Results: We found G6PD deficiency in 24 neonates (12%) out of 200 cases of neonatal jaundice, 20 of whom were male. There is a statistically significant difference in hemoglobin and serum bilirubin level between two groups. Difference in early presentation of jaundice within 24–48 h (66.7% vs. 34.1%) and need of prolonged phototherapy 72–96 h (45.83% vs. 7.4%) between G6PD deficient and normal group were statistically significant. Difference in requirement of exchange transfusion is not statistically significant. Conclusion: Early screening for G6PD deficiency should be considered in every neonates of G6PD deficient endemic countries so that we can predict the natural course of the jaundice in those G6PD deficient neonate and prevent complication by early initiation of phototherapy or exchange transfusion.
Keywords	glucose-6-phosphate dehydrogenase ; hyperbilirubinemia ; jaundice ; neonates ; Medicine ; R
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Direct genital manipulation is rare a manifestation of childhood gratification behaviour below 5 years of age

Biswajit Biswas / Sumanta Laha / Archan Sil / Mousumi Das / Shibnath Mondal / Raveesh Kumar / Priyanka Biswas / Santi Sarkar

Asian Journal of Medical Sciences, Vol 11, Iss 5, Pp 108-

A case series

2020 Volume 111

Abstract: Childhood masturbation/self-gratification behaviour means self-stimulation of the genitals by an immature child. Literature on this topic is scarce and scattered. Though most of the paediatricians seem to know about this entity, precise knowledge on ... ...

Abstract	Childhood masturbation/self-gratification behaviour means self-stimulation of the genitals by an immature child. Literature on this topic is scarce and scattered. Though most of the paediatricians seem to know about this entity, precise knowledge on spectrum of different behavioural patterns these children may show is lacking. Masturbatory activity in infants and young children is difficult to recognise because it often does not involve manual stimulation of the genitalia at all. We hereby report a series of 3 cases of childhood masturbation where direct genital manipulation, a very rare manifestation, was evident during gratification spells.
Keywords	childhood masturbation ; self-gratification behaviour ; children ; Medicine ; R
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A study on effect of phototherapy on platelet count in neonates with unconjugated hyperbilirubinemia

Santi Kumar Sarkar / Biswajit Biswas / Sumanta Laha / Nirban Sarkar / Monojit Mondal / Jasni Angel / Veeresh Dr / Kumar Abhisek / Vinay Kumar / Arkaprava Acharya / Priyanka Biswas / Subhamoy Mal / Debashis Ghosh / Trishita Mukherjee

Asian Journal of Medical Sciences, Vol 12, Iss 5, Pp 41-

a hospital based prospective observational study

2021 Volume 46

Abstract: Background: Thrombocytopenia as a side effect of phototherapy has not been mentioned in standard literature and textbooks. Though there are few studies in this regard, but results are conflicting. Aims and Objective: Hence, the present study is ... ...

Abstract	Background: Thrombocytopenia as a side effect of phototherapy has not been mentioned in standard literature and textbooks. Though there are few studies in this regard, but results are conflicting. Aims and Objective: Hence, the present study is undertaken to find out whether any significant change in platelet count occurs following phototherapy, and if there be any, to see whether the changes are transient or not. Materials and Methods: This prospective and observational study was carried out over a period of one and half years (1st March 2019 to 31st August 2020) on 190 new-borns admitted with idiopathic unconjugated hyperbilirubinemia needing phototherapy through consecutive enrolment. Serum bilirubin (total, conjugated and unconjugated) and platelet count were done before initiation and just after completion of phototherapy, and seven days after completion of phototherapy. Appropriate statistical tests were used to make statistical comparisons with a p-value of < 0.05 taken as significant. Results: Among 190 neonates, 108(56.8%) were male and 82(43.2%) were female; 90(47.4%) were preterm and 100(52.6%) were term. Mean birth weight was (2.4725 ± 0.4782) kg. Mean gestational age was (36.4316 ± 2.4802) weeks. Mean haemoglobin level was (17.3816± 1.0784) gm/dl. Mean age at presentation was (4.5737± 1.5811) days. Mean total serum bilirubin (TSB) before initiation, after completion, and 7 days after completion of phototherapy were (17.8595 ± 3.7034) mg/dl, (8.1726 ± 2.2586) mg/dl and (5.7279± 1.5918) mg/dl respectively. The mean duration of phototherapy required was (48.1895 ± 13.6054) hours. Mean platelet count before initiation and just after completion of phototherapy were (2,49,321.0526± 89,460.2101)/μL and (2,22,436.8421 ± 88,538.7173)/μL respectively. Mean platelet count 7days after completion of phototherapy was (2,46,210.5263 ± 87,442.3038)/μL. Decrease in platelet count just after completion of phototherapy was statistically significant. Fifty-nine (31.1%) out of 190 neonates developed mild ...
Keywords	thrombocytopenia ; phototherapy ; neonatal jaundice ; Medicine ; R
Subject code	630
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bilateral nephromegaly and arthritis

Tapas Kumar Sabui / Syamal Sardar / Sumanta Laha / Abhishek Roy

Open Journal of Pediatrics, Vol 03, Iss 03, Pp 257-

A rare presentation of acute lymphoblastic leukemia

2013 Volume 259

Abstract: A 2.5 years old boy presented with fever, intermittent s mall joint arthritis of hands and feet, bilateral nephro megaly with normal hemogram and uric acid level. Bone marrow aspiration revealed pre-B acute lymphoblastic leukemia without leukemic ... ...

Abstract	A 2.5 years old boy presented with fever, intermittent s mall joint arthritis of hands and feet, bilateral nephro megaly with normal hemogram and uric acid level. Bone marrow aspiration revealed pre-B acute lymphoblastic leukemia without leukemic infiltration of kidneys. Leukemia should be suspected in any patient with arthritis and nephromegaly.
Keywords	Acute Lymphoblastic Leukemia ; Nephromegaly ; Arthritis ; Pediatrics ; RJ1-570 ; Medicine ; R ; DOAJ:Pediatrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2013-08-01T00:00:00Z
Publisher	Scientific Research Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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