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  1. Article ; Online: Correction to: Shen Qi Li Xin formula improves chronic heart failure through balancing mitochondrial fission and fusion via upregulation of PGC-1α.

    Sui, Yan-Bo / Xiu, Jian / Wei, Jin-Xuan / Pan, Pei-Pei / Sun, Bi-Hong / Liu, Li

    The journal of physiological sciences : JPS

    2022  Volume 72, Issue 1, Page(s) 25

    Language English
    Publishing date 2022-10-03
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 2234472-X
    ISSN 1880-6562 ; 1880-6546
    ISSN (online) 1880-6562
    ISSN 1880-6546
    DOI 10.1186/s12576-022-00840-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Shen Qi Li Xin formula improves chronic heart failure through balancing mitochondrial fission and fusion via upregulation of PGC-1α.

    Sui, Yan-Bo / Xiu, Jian / Wei, Jin-Xuan / Pan, Pei-Pei / Sun, Bi-Hong / Liu, Li

    The journal of physiological sciences : JPS

    2021  Volume 71, Issue 1, Page(s) 32

    Abstract: Background: Our previous study proved that Shen Qi Li Xin formula (SQLXF) improved the heart function of chronic heart failure (CHF) patients, while the action mechanism remains unclear.: Methods: H&E staining and TUNEL staining were performed to ... ...

    Abstract Background: Our previous study proved that Shen Qi Li Xin formula (SQLXF) improved the heart function of chronic heart failure (CHF) patients, while the action mechanism remains unclear.
    Methods: H&E staining and TUNEL staining were performed to measure myocardial damages. Western blot was used to examine the expression of proteins. Moreover, CCK-8 assay and flow cytometry were used to measure cell viability and cell apoptosis, respectively. Concentrations of ATP and ROS in cells, and mitochondrial membrane potential (MMP) were detected to estimate oxidative stress.
    Results: In vivo, we found that SQLXF improved cardiac hemodynamic parameters, reduced LDH, CK-MB and BNP production, and attenuated myocardial damages in CHF rats. Besides, SQLXF promoted mitochondrial fusion-related proteins expression and inhibited fission-related proteins expression in CHF rats and oxygen glucose deprivation/reoxygenation (OGD/R)-induced cardiac myocytes (CMs). In vitro, our data show that certain dose of SQLXF inhibited OGD/R-induced CMs apoptosis, cell viability decreasing and oxidative stress.
    Conclusion: Overall, certain dose of SQLXF could effectively improve the cardiac function of CHF rats through inhibition of CMs apoptosis via balancing mitochondrial fission and fusion. Our data proved a novel action mechanism of SQLXF in CHF improvement, and provided a reference for clinical.
    MeSH term(s) Animals ; Apoptosis ; Heart Failure/drug therapy ; Heart Failure/metabolism ; Humans ; Membrane Potential, Mitochondrial ; Mitochondrial Dynamics ; Myocytes, Cardiac/metabolism ; Rats ; Up-Regulation
    Language English
    Publishing date 2021-10-18
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2234472-X
    ISSN 1880-6562 ; 1880-6546
    ISSN (online) 1880-6562
    ISSN 1880-6546
    DOI 10.1186/s12576-021-00816-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.360: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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