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  1. Article ; Online: Direct Access to Bowl-Like Nanostructures with Block Copolymer Anisotropic Truncated Microspheres.

    Sun, Cheng-Hao / Septani, Cindy Mutiara / Sun, Ya-Sen

    Langmuir : the ACS journal of surfaces and colloids

    2021  Volume 37, Issue 2, Page(s) 636–645

    Abstract: Bowl-like nanostructures have attracted significant scientific and technological interest due to their favorable characteristics, such as high specific surface area, interconnected porous channels, and conductivity. However, tailored synthesis of bowl- ... ...

    Abstract Bowl-like nanostructures have attracted significant scientific and technological interest due to their favorable characteristics, such as high specific surface area, interconnected porous channels, and conductivity. However, tailored synthesis of bowl-like nanostructures with well-defined and uniform morphology is still a challenge. Herein, we report a versatile microemulsion assembly approach to prepare bowl-like nanostructures of three different materials: polymer, carbon, and platinum. To this end, polystyrene-
    Language English
    Publishing date 2021-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.0c02298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Direct Access to Bowl-Like Nanostructures with Block Copolymer Anisotropic Truncated Microspheres

    Sun, Cheng-Hao / Septani, Cindy Mutiara / Sun, Ya-Sen

    Langmuir. 2021 Jan. 04, v. 37, no. 2

    2021  

    Abstract: Bowl-like nanostructures have attracted significant scientific and technological interest due to their favorable characteristics, such as high specific surface area, interconnected porous channels, and conductivity. However, tailored synthesis of bowl- ... ...

    Abstract Bowl-like nanostructures have attracted significant scientific and technological interest due to their favorable characteristics, such as high specific surface area, interconnected porous channels, and conductivity. However, tailored synthesis of bowl-like nanostructures with well-defined and uniform morphology is still a challenge. Herein, we report a versatile microemulsion assembly approach to prepare bowl-like nanostructures of three different materials: polymer, carbon, and platinum. To this end, polystyrene-block-poly(4vinylpyridine), PS-b-P4VP, block copolymer (BCP) microparticles with truncated-sphere shape and composed of stacks of parallel lamellae were used because those anisotropic microparticles play an important role in the design of bowl-like nanostructures. To form nanolamellae-within-microparticle morphology, a designed PS-b-P4VP/chloroform/CTAB microemulsion can be facilely obtained in the aqueous medium, where the morphology can be tailored by the interplay between macro-phase separations, BCP self-assembly, and interfacial energies of three phases in the presence of cetyltrimethylammonium bromide (CTAB). Finally, protonation or combination of cross-linking and pyrolysis of those truncated microparticles enables formation of polymer or carbon bowl-like nanostructures, respectively. Upon selective adsorption of Pt precursor salt ions with the pyridyl moieties followed by chemical reduction, subsequent calcination permits the synthesis of Pt bowl-like nanostructures. The microemulsion assembly approach opens up new ways to direct and template bowl-like nanostructures.
    Keywords adsorption ; anisotropy ; carbon ; cetyltrimethylammonium bromide ; chemical reduction ; composite polymers ; crosslinking ; emulsions ; microparticles ; platinum ; protonation ; pyrolysis ; surface area
    Language English
    Dates of publication 2021-0104
    Size p. 636-645.
    Publishing place American Chemical Society
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.0c02298
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Circular RNA circTTBK2 facilitates non-small-cell lung cancer malignancy through the miR-873-5p/TEAD1/DERL1 axis.

    Wei, Jin-Ying / Zhang, Qiang / Yao, Yue / He, Hai-Bin / Sun, Cheng-Hao / Dong, Ting-Ting / Meng, Guang-Ping / Zhang, Jie

    Epigenomics

    2022  Volume 14, Issue 16, Page(s) 931–949

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Apoptosis/genetics ; Carcinogenesis/genetics ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Membrane Proteins/genetics ; MicroRNAs/genetics ; Nuclear Proteins/genetics ; RNA, Circular/genetics ; TEA Domain Transcription Factors/genetics
    Chemical Substances DERL1 protein, human ; DNA-Binding Proteins ; MIRN873 microRNA, human ; Membrane Proteins ; MicroRNAs ; Nuclear Proteins ; RNA, Circular ; TEA Domain Transcription Factors ; TEAD1 protein, human
    Language English
    Publishing date 2022-08-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2537199-X
    ISSN 1750-192X ; 1750-1911
    ISSN (online) 1750-192X
    ISSN 1750-1911
    DOI 10.2217/epi-2021-0480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ochratoxin A mimotope from second-generation peptide library and its application in immunoassay.

    He, Zhen-yun / He, Qing-hua / Xu, Yang / Li, Yan-ping / Liu, Xing / Chen, Bo / Lei, Da / Sun, Cheng-hao

    Analytical chemistry

    2013  Volume 85, Issue 21, Page(s) 10304–10311

    Abstract: With the advantage of replacing mycotoxins and their conjugates, mimotopes have been applied to immunoassays, the most common of which were seleted from random phage displayed peptide libraries. However, these mimotopes were limited by the diversities of ...

    Abstract With the advantage of replacing mycotoxins and their conjugates, mimotopes have been applied to immunoassays, the most common of which were seleted from random phage displayed peptide libraries. However, these mimotopes were limited by the diversities of the peptide libraries. The aim of this study was to demonstrate that a variety of mimotopes can be obtained by constructing a second-generation peptide library. Using mycotoxin ochratoxin A as a model system, a dodecapeptide mimotope was isolated after panning the second-generation peptide library. The half inhibition concentration of the chemiluminescent enzyme-linked immunosorbent assay setup with this mimotope was 0.04 ng/mL, and the linear range was 0.006-0.245 ng/mL. The mimotope was also used to develop a qualitative dipstick assay with a cutoff level of 1 ng/mL. The method not only presents a high sensitivity but also contributes to the development of mimotope-based assays for mycotoxins avoiding the need of synthesizing toxic mycotoxin conjugates.
    MeSH term(s) Amino Acid Sequence ; Base Sequence ; Enzyme-Linked Immunosorbent Assay/methods ; Luminescence ; Molecular Sequence Data ; Mycotoxins/chemistry ; Ochratoxins/chemistry ; Peptide Library
    Chemical Substances Mycotoxins ; Ochratoxins ; Peptide Library ; ochratoxin A (1779SX6LUY)
    Language English
    Publishing date 2013-11-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Studies
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/ac402127t
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Ochratoxin A Mimotope from Second-Generation Peptide Library and Its Application in Immunoassay

    He, Zhen-yun / Chen Bo / He Qing-hua / Lei Da / Li Yan-ping / Liu Xing / Sun Cheng-hao / Xu Yang

    Analytical chemistry. 2013 Nov. 05, v. 85, no. 21

    2013  

    Abstract: With the advantage of replacing mycotoxins and their conjugates, mimotopes have been applied to immunoassays, the most common of which were seleted from random phage displayed peptide libraries. However, these mimotopes were limited by the diversities of ...

    Abstract With the advantage of replacing mycotoxins and their conjugates, mimotopes have been applied to immunoassays, the most common of which were seleted from random phage displayed peptide libraries. However, these mimotopes were limited by the diversities of the peptide libraries. The aim of this study was to demonstrate that a variety of mimotopes can be obtained by constructing a second-generation peptide library. Using mycotoxin ochratoxin A as a model system, a dodecapeptide mimotope was isolated after panning the second-generation peptide library. The half inhibition concentration of the chemiluminescent enzyme-linked immunosorbent assay setup with this mimotope was 0.04 ng/mL, and the linear range was 0.006–0.245 ng/mL. The mimotope was also used to develop a qualitative dipstick assay with a cutoff level of 1 ng/mL. The method not only presents a high sensitivity but also contributes to the development of mimotope-based assays for mycotoxins avoiding the need of synthesizing toxic mycotoxin conjugates.
    Keywords bacteriophages ; chemiluminescence ; enzyme-linked immunosorbent assay ; ochratoxin A ; peptide libraries ; toxicity
    Language English
    Dates of publication 2013-1105
    Size p. 10304-10311.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021%2Fac402127t
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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