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  1. Book ; Online: Horizontal Gene Transfer Mediated Multidrug Resistance: A Global Crisis, 2nd Edition

    Sun, Dongchang / Jeannot, Katy / Xiao, Yonghong / Knapp, Charles W.

    2020  

    Keywords Science: general issues ; Medical microbiology & virology ; Microbiology (non-medical) ; multidrug resistance ; horizontal gene transfer ; antibiotic resistance gene ; plasmid ; transposition ; conjugation ; transformation ; recombination
    Size 1 electronic resource (223 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230195
    ISBN 9782889638802 ; 2889638804
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Horizontal Gene Transfer Mediated Multidrug Resistance: A Global Crisis

    Sun, Dongchang / Jeannot, Katy / Xiao, Yonghong / Knapp, Charles W.

    2019  

    Keywords Science: general issues ; Medical microbiology & virology ; Microbiology (non-medical) ; multidrug resistance ; horizontal gene transfer ; antibiotic resistance gene ; plasmid ; transposition ; conjugation ; transformation ; recombination
    Size 1 electronic resource (223 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230089
    ISBN 9782889631575 ; 2889631575
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: [Practice in fostering postgraduates' creativity through teaching the course of Modern Microbial Biotechnology].

    Sun, Dongchang

    Sheng wu gong cheng xue bao = Chinese journal of biotechnology

    2021  Volume 37, Issue 4, Page(s) 1450–1456

    Abstract: Improving the creativity is crucial to postgraduate training nowadays. The course of Modern Microbial Biotechnology is an optional specialized course for microbiology-related postgraduates. To explore a new teaching mode for improving the creativity of ... ...

    Abstract Improving the creativity is crucial to postgraduate training nowadays. The course of Modern Microbial Biotechnology is an optional specialized course for microbiology-related postgraduates. To explore a new teaching mode for improving the creativity of postgraduate students, we reformed the teaching content, the teaching method and the evaluation mode of this course. Through case study teaching, seminar-style classroom and implementation of a new assessment method, the students not only mastered professional knowledge and disciplinary frontiers of modern microbiology technology, but also improved their ability of discovering, analyzing and solving problems. The reformed course teaching mode is effective in fostering postgraduates' creativity.
    MeSH term(s) Biotechnology ; Humans ; Students
    Language Chinese
    Publishing date 2021-05-10
    Publishing country China
    Document type Journal Article
    ZDB-ID 1042206-7
    ISSN 1872-2075 ; 1042-749X
    ISSN (online) 1872-2075
    ISSN 1042-749X
    DOI 10.13345/j.cjb.200474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Pull in and Push Out: Mechanisms of Horizontal Gene Transfer in Bacteria.

    Sun, Dongchang

    Frontiers in microbiology

    2018  Volume 9, Page(s) 2154

    Abstract: Horizontal gene transfer (HGT) plays an important role in bacterial evolution. It is well accepted that DNA is pulled/pushed into recipient cells by conserved membrane-associated DNA transport systems, which allow the entry of only single-stranded DNA ( ... ...

    Abstract Horizontal gene transfer (HGT) plays an important role in bacterial evolution. It is well accepted that DNA is pulled/pushed into recipient cells by conserved membrane-associated DNA transport systems, which allow the entry of only single-stranded DNA (ssDNA). However, recent studies have uncovered a new type of natural bacterial transformation in which double-stranded DNA (dsDNA) is taken up into the cytoplasm, thus complementing the existing methods of DNA transfer among bacteria. Regulated by the stationary-phase regulators RpoS and cAMP receptor protein (CRP),
    Language English
    Publishing date 2018-09-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2018.02154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial: Horizontal gene transfer mediated bacterial antibiotic resistance, volume II.

    Sun, Dongchang / Sun, Xingmin / Hu, Yongfei / Yamaichi, Yoshiharu

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1221606

    Language English
    Publishing date 2023-06-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1221606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Two different routes for double-stranded DNA transfer in natural and artificial transformation of Escherichia coli.

    Sun, Dongchang

    Biochemical and biophysical research communications

    2016  Volume 471, Issue 1, Page(s) 213–218

    Abstract: Escherichia coli is naturally transformable, independent on the conserved DNA uptake machinery for single-stranded DNA (ssDNA) integration. The transfer of double-stranded DNA (dsDNA) during natural transformation of E. coli is regulated by the ... ...

    Abstract Escherichia coli is naturally transformable, independent on the conserved DNA uptake machinery for single-stranded DNA (ssDNA) integration. The transfer of double-stranded DNA (dsDNA) during natural transformation of E. coli is regulated by the alternative sigma factor σ(S). However, it remains mysterious how dsDNA transfers across the membranes and how σ(S) regulates natural transformation of E. coli. Here, I screened for σ(S)-regulated genes for dsDNA transfer in E. coli. The screening identified the σ(S)-regulated genes ydcS and ydcV, both locate on the putative ABC transporter ydcSTUV operon. Considering that ydcS and ydcV are predicted to encode a periplasmic protein and an inner membrane protein for substrate binding and translocation respectively, I propose that they may mediate dsDNA translocation across the inner membrane during natural transformation. In chemical transformation of E. coli, ydcS was but ydcV was not required. Thus, YdcV should not be the channel for dsDNA translocation in artificial transformation. Together with the previous observation that the outer membrane porin OmpA mediates dsDNA transfer across the outer membrane in chemical transformation but not in natural transformation, I conclude that dsDNA transfers across the two membranes through different routes in natural and artificial transformation of E. coli.
    MeSH term(s) ATP-Binding Cassette Transporters/metabolism ; Acyltransferases/metabolism ; Cell Membrane/metabolism ; DNA/administration & dosage ; DNA/physiology ; Escherichia coli/physiology ; Escherichia coli Proteins/metabolism ; Transfection/methods ; Transformation, Bacterial/physiology
    Chemical Substances Escherichia coli Proteins ; YdcV protein, E coli ; DNA (9007-49-2) ; Acyltransferases (EC 2.3.-) ; YdcS protein, E coli (EC 2.3.1.-)
    Language English
    Publishing date 2016-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2016.01.137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dynamically Regulating Glucose Uptake to Reduce Overflow Metabolism with a Quorum-Sensing Circuit for the Efficient Synthesis of d-Pantothenic Acid in

    Yuan, Panhong / Xu, Mengtao / Mao, Chengyao / Zheng, Han / Sun, Dongchang

    ACS synthetic biology

    2023  Volume 12, Issue 10, Page(s) 2983–2995

    Abstract: In response to a high concentration of glucose, ...

    Abstract In response to a high concentration of glucose,
    MeSH term(s) Bacillus subtilis/metabolism ; Pantothenic Acid/metabolism ; Quorum Sensing ; Carbohydrate Metabolism ; Glucose/metabolism ; Metabolic Engineering
    Chemical Substances Pantothenic Acid (19F5HK2737) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-09-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2161-5063
    ISSN (online) 2161-5063
    DOI 10.1021/acssynbio.3c00315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Engineering Escherichia coli Nissle 1917 as a microbial chassis for therapeutic and industrial applications.

    Yu, Mingjing / Hu, Shilong / Tang, Biao / Yang, Hua / Sun, Dongchang

    Biotechnology advances

    2023  Volume 67, Page(s) 108202

    Abstract: Genetically engineered microbes, especially Escherichia coli, have been widely used in the biosynthesis of proteins and metabolites for medical and industrial applications. As a traditional probiotic with a well-established safety record, E. coli Nissle ... ...

    Abstract Genetically engineered microbes, especially Escherichia coli, have been widely used in the biosynthesis of proteins and metabolites for medical and industrial applications. As a traditional probiotic with a well-established safety record, E. coli Nissle 1917 (EcN) has recently emerged as a microbial chassis for generating living therapeutics, drug delivery vehicles, and microbial platforms for industrial production. Despite the availability of genetic tools for engineering laboratory E. coli K-12 and B strains, new genetic engineering systems are still greatly needed to expand the application range of EcN. In this review, we have summarized the latest progress in the development of genetic engineering systems in EcN, as well as their applications in the biosynthesis and delivery of valuable small molecules and biomacromolecules of medical and/or industrial interest, followed by a glimpse of how this rapidly growing field will evolve in the future.
    MeSH term(s) Escherichia coli/genetics ; Escherichia coli/metabolism ; Drug Delivery Systems ; Genetic Engineering
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 47165-3
    ISSN 1873-1899 ; 0734-9750
    ISSN (online) 1873-1899
    ISSN 0734-9750
    DOI 10.1016/j.biotechadv.2023.108202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Engineering Escherichia coli Nissle 1917 as a microbial chassis for therapeutic and industrial applications

    Yu, Mingjing / Hu, Shilong / Tang, Biao / Yang, Hua / Sun, Dongchang

    Biotechnology Advances. 2023 Oct., v. 67 p.108202-

    2023  

    Abstract: Genetically engineered microbes, especially Escherichia coli, have been widely used in the biosynthesis of proteins and metabolites for medical and industrial applications. As a traditional probiotic with a well-established safety record, E. coli Nissle ... ...

    Abstract Genetically engineered microbes, especially Escherichia coli, have been widely used in the biosynthesis of proteins and metabolites for medical and industrial applications. As a traditional probiotic with a well-established safety record, E. coli Nissle 1917 (EcN) has recently emerged as a microbial chassis for generating living therapeutics, drug delivery vehicles, and microbial platforms for industrial production. Despite the availability of genetic tools for engineering laboratory E. coli K-12 and B strains, new genetic engineering systems are still greatly needed to expand the application range of EcN. In this review, we have summarized the latest progress in the development of genetic engineering systems in EcN, as well as their applications in the biosynthesis and delivery of valuable small molecules and biomacromolecules of medical and/or industrial interest, followed by a glimpse of how this rapidly growing field will evolve in the future.
    Keywords Escherichia coli K12 ; biosynthesis ; biotechnology ; drugs ; genetic engineering ; metabolites ; probiotics ; therapeutics ; Escherichia coli Nissle 1917 ; Living therapeutics ; CRISPR-Cas ; Light-controlled gene expression ; 'Suicide' systems ; Minicells ; Bacterial ghosts
    Language English
    Dates of publication 2023-10
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 47165-3
    ISSN 0734-9750
    ISSN 0734-9750
    DOI 10.1016/j.biotechadv.2023.108202
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: [Prevention and control of antimicrobial resistance using CRISPR-Cas system: a review].

    Wang, Chenyu / Liu, Zhizhi / Tang, Biao / Yang, Hua / Sun, Dongchang

    Sheng wu gong cheng xue bao = Chinese journal of biotechnology

    2022  Volume 38, Issue 4, Page(s) 1432–1445

    Abstract: Bacterial multi-drug resistance (MDR) is a global challenge in the fields of medicine and health, agriculture and fishery, ecology and environment. The cross-region spread of antibiotic resistance genes (ARGs) among different species is one of the main ... ...

    Abstract Bacterial multi-drug resistance (MDR) is a global challenge in the fields of medicine and health, agriculture and fishery, ecology and environment. The cross-region spread of antibiotic resistance genes (ARGs) among different species is one of the main cause of bacterial MDR. However, there is no effective strategies for addressing the intensifying bacterial MDR. The CRISPR-Cas system, consisting of clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR associated proteins, can targetedly degrade exogenous nucleic acids, thus exhibiting high application potential in preventing and controlling bacterial MDR caused by ARGs. This review briefly introduced the working mechanism of CRISPR-Cas systems, followed by discussing recent advances in reducing ARGs by CRISPR-Cas systems delivered through mediators (e.g. plasmids, bacteriophages and nanoparticle). Moreover, the trends of this research field were envisioned, providing a new perspective on preventing and controlling MDR.
    MeSH term(s) Anti-Bacterial Agents ; Bacteriophages/genetics ; CRISPR-Cas Systems ; Drug Resistance, Bacterial/genetics ; Plasmids/genetics
    Chemical Substances Anti-Bacterial Agents
    Language Chinese
    Publishing date 2022-04-25
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 1042206-7
    ISSN 1872-2075 ; 1042-749X
    ISSN (online) 1872-2075
    ISSN 1042-749X
    DOI 10.13345/j.cjb.210348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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