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  1. Article ; Online: Enantioselective biomarkers of maize toxicity induced by hexabromocyclododecane based on submicroscopic structure, gene expression and molecular docking.

    Tian, Liu / Yang, Ronghe / Li, Die / Wu, Tong / Sun, Fengxia

    Environmental research

    2024  Volume 252, Issue Pt 4, Page(s) 119119

    Abstract: Hexabromocyclododecane (HBCD), as a monitored chemical of the Chemical Weapons Convention, the Stockholm Convention and the Action Plan for New Pollutants Treatment in China, raises significant concerns on its impact of human health and food security. ... ...

    Abstract Hexabromocyclododecane (HBCD), as a monitored chemical of the Chemical Weapons Convention, the Stockholm Convention and the Action Plan for New Pollutants Treatment in China, raises significant concerns on its impact of human health and food security. This study investigated enantiomer-specific biomarkers of HBCD in maize (Zea mays L.). Upon exposure to HBCD enantiomers, the maize root tip cell wall exhibited thinning, uneven cell gaps, and increased deposition on the cell outer wall. Elevated malondialdehyde (MDA) indicated lipid peroxidation, with higher mitochondrial membrane potential (MMP) inhibition in (+)-enantiomer treatments (47.2%-57.9%) than (-)-enantiomers (14.4%-37.4%). The cell death rate significantly increased by 37.7%-108.8% in roots and 16.4%-62.4% in shoots, accompanied by the upregulation of superoxide dismutase isoforms genes. Molecular docking presenting interactions between HBCD and target proteins, suggested that HBCD has an affinity for antioxidant enzyme receptors with higher binding energy for (+)-enantiomers, further confirming their stronger toxic effects. All indicators revealed that oxidative damage to maize seedlings was more severe after treatment with (+)-enantiomers compared to (-)-enantiomers. This study elucidates the biomarkers of phytotoxicity evolution induced by HBCD enantiomers, providing valuable insights for the formulation of more effective policies to safeguard environmental safety and human health in the future.
    Language English
    Publishing date 2024-05-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.119119
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  2. Article ; Online: Highly Sensitive Fluorescence Detection of Three Organophosphorus Pesticides Based on Highly Bright DNA-Templated Silver Nanoclusters.

    Li, Guowen / Huang, Xiufang / Peng, Chifang / Sun, Fengxia

    Biosensors

    2023  Volume 13, Issue 5

    Abstract: It is still challenging to achieve simultaneous and sensitive detection of multiple organophosphorus pesticides (OPs). Herein, we optimized the ssDNA templates for the synthesis of silver nanoclusters (Ag NCs). For the first time, we found that the ... ...

    Abstract It is still challenging to achieve simultaneous and sensitive detection of multiple organophosphorus pesticides (OPs). Herein, we optimized the ssDNA templates for the synthesis of silver nanoclusters (Ag NCs). For the first time, we found that the fluorescence intensity of T base-extended DNA-templated Ag NCs was over three times higher than the original C-riched DNA-templated Ag NCs. Moreover, a "turn-off" fluorescence sensor based on the brightest DNA-Ag NCs was constructed for the sensitive detection of dimethoate, ethion and phorate. Under strong alkaline conditions, the P-S bonds in three pesticides were broken, and the corresponding hydrolysates were obtained. The sulfhydryl groups in the hydrolyzed products formed Ag-S bonds with the silver atoms on the surface of Ag NCs, which resulted in the aggregation of Ag NCs, following the fluorescence quenching. The fluorescence sensor showed that the linear ranges were 0.1-4 ng/mL for dimethoate with a limit of detection (LOD) of 0.05 ng/mL, 0.3-2 µg/mL for ethion with a LOD of 30 ng/mL, and 0.03-0.25 µg/mL for phorate with a LOD of 3 ng/mL. Moreover, the developed method was successfully applied to the detection of dimethoate, ethion and phorate in lake water samples, indicating a potential application in OP detection.
    MeSH term(s) Silver/chemistry ; Organophosphorus Compounds ; Pesticides ; Fluorescence ; Dimethoate ; Phorate ; Metal Nanoparticles/chemistry ; DNA/chemistry ; Spectrometry, Fluorescence
    Chemical Substances ethion (2TI07NO12Y) ; Silver (3M4G523W1G) ; Organophosphorus Compounds ; Pesticides ; Dimethoate (W6U08B045O) ; Phorate (3W54X3W9IV) ; DNA (9007-49-2)
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios13050520
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  3. Article ; Online: Indole-containing pharmaceuticals: targets, pharmacological activities, and SAR studies.

    Zeng, Wei / Han, Chi / Mohammed, Sarah / Li, Shanshan / Song, Yixuan / Sun, Fengxia / Du, Yunfei

    RSC medicinal chemistry

    2024  Volume 15, Issue 3, Page(s) 788–808

    Abstract: Indole is a prestigious heterocyclic skeleton widely found in both naturally-occurring and biologically-active compounds. Pharmaceutical agents containing an indole skeleton in their framework possess a wide range of pharmacological properties, including ...

    Abstract Indole is a prestigious heterocyclic skeleton widely found in both naturally-occurring and biologically-active compounds. Pharmaceutical agents containing an indole skeleton in their framework possess a wide range of pharmacological properties, including antiviral, antitumor, analgesic, and other therapeutic activities, and many indole-containing drugs have been proven to have excellent pharmacokinetic and pharmacological effects. Over the past few decades, the FDA has approved over 40 indole-containing drugs for the treatment of various clinical conditions, and the development of indole-related drugs has attracted significant attention from medicinal chemists. This review aims to provide an overview of all the approved drugs that contain an indole nucleus, focusing on their targets, pharmacological activities, and SAR studies.
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2632-8682
    ISSN (online) 2632-8682
    DOI 10.1039/d3md00677h
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  4. Article ; Online: Synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines and isocoumarins enabled by multi-component reagents system (MCRS).

    Li, Xuemin / Shi, Haofeng / He, Jiaxin / Wu, Jialiang / Sun, Fengxia / Du, Yunfei

    Organic & biomolecular chemistry

    2024  Volume 22, Issue 19, Page(s) 3882–3886

    Abstract: The combining use of ... ...

    Abstract The combining use of BnSCF
    Language English
    Publishing date 2024-05-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d4ob00328d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Determination of tetrabromobisphenol A and its brominated derivatives in water, sediment and soil by high performance liquid chromatography-tandem mass spectrometry.

    Xie, Hui / Xu, Yuxin / Sun, Fengxia / Li, Jinling / Liu, Ruiyuan

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    2023  Volume 39, Issue 11, Page(s) 1875–1888

    Abstract: Tetrabromobisphenol A (TBBPA) was typical brominated flame retardant and potential environmental endocrine disruptor, and it had persistence, bioaccumulation and chronic toxicity. Simultaneous determination of ultra-trace TBBPA, tribromobiphenol A (tri- ... ...

    Abstract Tetrabromobisphenol A (TBBPA) was typical brominated flame retardant and potential environmental endocrine disruptor, and it had persistence, bioaccumulation and chronic toxicity. Simultaneous determination of ultra-trace TBBPA, tribromobiphenol A (tri-BBPA), dibromobiphenol A (di-BBPA), monobromobisphenol A (mono-BBPA) and bisphenol A (BPA) was developed by high performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS), the parent ion charge ratios (m/z) had been optimized. The linear range was wider and the limit of detection was (LOD) 0.09 ~ 0.21 ng mL
    Language English
    Publishing date 2023-07-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1483376-1
    ISSN 1348-2246 ; 1348-2246
    ISSN (online) 1348-2246
    ISSN 1348-2246
    DOI 10.1007/s44211-023-00393-7
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  6. Article ; Online: Significant Effects of Long-Term Application of Straw and Manure Combined with NPK Fertilizers on Olsen P and PAC in Red Soil

    Sun, Fengxia / Sun, Nan / Wang, Boren / Cai, Zejiang / Xu, Minggang

    Agronomy. 2023 June 19, v. 13, no. 6

    2023  

    Abstract: The application of manure (M) and straw (S) will increase the Olsen P and phosphorus activation coefficient (PAC) in soil. Clarifying the increasing trend of Olsen P and PAC is crucial for rational fertilization. This study fitted the equation between ... ...

    Abstract The application of manure (M) and straw (S) will increase the Olsen P and phosphorus activation coefficient (PAC) in soil. Clarifying the increasing trend of Olsen P and PAC is crucial for rational fertilization. This study fitted the equation between the accumulated P surplus, Olsen P, and PAC in four treatments for 28 years and analyzed the changes and rates of P fractions. The results showed Olsen P and PAC increase linearly with NPK and NPKS treatments; for every 100 kg ha⁻¹ of P surplus, Olsen P increased by 5.9 and 6.7 mg kg⁻¹, and PAC increased by 0.52% and 0.50%. With M and MNPK treatments, the sigmoid curve equation was the best fitting method. The equilibrium values were 167 and 164 mg kg⁻¹ for Olsen P, and 10.4 and 10.2 mg kg⁻¹ for PAC. There was a correlation between Al-P, Ca₂-P, Resin-P, NaOH-Pᵢ, C/N, SOC, and pH, which had the highest interpretation rates for Olsen P and PAC. Manure is significantly better than straw in improving Olsen P in red soil. It is recommended to reduce the amount of manure applied for a long time to avoid a zero increase in Olsen P.
    Keywords agronomy ; equations ; pH ; phosphorus ; soil ; straw
    Language English
    Dates of publication 2023-0619
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2607043-1
    ISSN 2073-4395
    ISSN 2073-4395
    DOI 10.3390/agronomy13061647
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  7. Article ; Online: Intramolecular Heterocyclization/Fluoromethylthiolation of Alkynes Enabled by a Multicomponent Reagent System.

    Li, Xuemin / Sun, Fengxia / Shi, Haofeng / Zhang, Beibei / He, Jiaxin / Wu, Jialiang / Du, Yunfei

    Organic letters

    2023  Volume 25, Issue 19, Page(s) 3517–3521

    Abstract: ... The ... ...

    Abstract The BnSR
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c01095
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  8. Article ; Online: DMSO/SOCl

    Li, Xuemin / Cheng, Yifu / Li, Yue / Sun, Fengxia / Zhan, Xiangyu / Yang, Zhifang / Yang, Jingyue / Du, Yunfei

    The Journal of organic chemistry

    2024  Volume 89, Issue 3, Page(s) 2039–2049

    Abstract: The application of the DMSO/ ... ...

    Abstract The application of the DMSO/SOCl
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02471
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  9. Article: Research progress in the correlation between SREBP/PCSK9 pathway and lipid metabolism disorders induced by antipsychotics.

    Ma, Jiashu / Zheng, Yunshao / Sun, Fengxia / Fan, Yunli / Fan, Yunming / Su, Xianbiao / Wang, Zhongbao / Weng, Ning / Li, Ranran

    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

    2024  Volume 48, Issue 10, Page(s) 1529–1538

    Abstract: Antipsychotic medications are commonly used to treat schizophrenia, but they can have negative effects on lipid metabolism, leading to an increased risk of cardiovascular diseases, reduced life expectancy, and difficulties with treatment adherence. The ... ...

    Title translation SREBP/PCSK9通路与抗精神病药物所致脂代谢紊乱相关性的研究进展.
    Abstract Antipsychotic medications are commonly used to treat schizophrenia, but they can have negative effects on lipid metabolism, leading to an increased risk of cardiovascular diseases, reduced life expectancy, and difficulties with treatment adherence. The specific mechanisms by which antipsychotics disrupt lipid metabolism are not well understood. Sterol regulatory element-binding proteins (SREBPs) are important transcriptional factors that regulate lipid metabolism. Proprotein convertase subtilisin/kexin type 9 (
    MeSH term(s) Humans ; Antipsychotic Agents/adverse effects ; Lipid Metabolism ; Lipid Metabolism Disorders ; Proprotein Convertase 9/genetics ; Sterol Regulatory Element Binding Protein 1
    Chemical Substances Antipsychotic Agents ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Sterol Regulatory Element Binding Protein 1
    Language Chinese
    Publishing date 2024-03-01
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2168533-2
    ISSN 1672-7347
    ISSN 1672-7347
    DOI 10.11817/j.issn.1672-7347.2023.230029
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  10. Article ; Online: A colorimetric sensor array based on nanoceria crosslinked and heteroatom-doped graphene oxide nanoribbons for the detection and discrimination of multiple pesticides.

    Tai, Shengmei / Wang, Jun / Sun, Fengxia / Pan, Qiuli / Peng, Chifang / Wang, Zhouping

    Analytica chimica acta

    2023  Volume 1283, Page(s) 341929

    Abstract: Nanozymes have demonstrated high potential in constructing colorimetric sensor array for pesticides. However, rarely array for pesticides constructed without bio-enzyme were reported. Herein, nanoceria crosslinked graphene oxide nanoribbons (Ce-GONRs) ... ...

    Abstract Nanozymes have demonstrated high potential in constructing colorimetric sensor array for pesticides. However, rarely array for pesticides constructed without bio-enzyme were reported. Herein, nanoceria crosslinked graphene oxide nanoribbons (Ce-GONRs) and heteroatom-doped graphene oxide nanoribbons (Ce-BGONRs and Ce-NGONRs) were prepared, demonstrating excellent peroxidase-like activities. A colorimetric sensor array was developed based on directly inhibiting the peroxidase-like activities of the above three nanozymes, which realized the discrimination and quantitative analysis of six pesticides. In the presence of pesticides including carbaryl (Car), fluroxypyr-mepthyl (Flu), thiophanate-methyl (Thio), thiram (Thir), diafenthiuron (Dia) and fomesafen (Fom), the peroxidase-like activities of three nanozymes were inhibited to different degrees, resulting in different fingerprint responses. The six pesticides in the concentration range of 0.1-50 μg/mL and two pesticides mixtures at varied ratios could be detected and discriminated, and minimum detection limit for pesticides was 0.022 μg/mL. In addition, this sensor array has been successfully applied for pesticides discrimination in lake water and apple samples. This work provided a new strategy of constructing simple and sensitive colorimetric sensor array for pesticides based on directly inhibiting the catalytic activities of nanozymes.
    MeSH term(s) Pesticides/analysis ; Nanotubes, Carbon ; Colorimetry/methods ; Antioxidants ; Peroxidases ; Hydrogen Peroxide/analysis
    Chemical Substances Pesticides ; graphene oxide ; ceric oxide (619G5K328Y) ; Nanotubes, Carbon ; Antioxidants ; Peroxidases (EC 1.11.1.-) ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2023-10-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2023.341929
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