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  1. Article: [Analysis of gene characteristics and core genome characteristics of carbapenem-resistant Enterobacter cloacae in rural residents of Weifang City, Shandong Province].

    Wang, A G / Wang, S / Liu, L / Sun, G X / Chen, Y Z / Qi, J X / Kou, Z Q / Bi, Z W

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

    2024  Volume 58, Issue 1, Page(s) 48–55

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Enterobacter cloacae/genetics ; Multilocus Sequence Typing ; beta-Lactamases/genetics ; Phylogeny ; Rural Population ; Carbapenems/pharmacology ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6) ; Carbapenems
    Language Chinese
    Publishing date 2024-01-17
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604575-3
    ISSN 0253-9624
    ISSN 0253-9624
    DOI 10.3760/cma.j.cn112150-20230412-00287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Facile one-step hydrothermal fabrication of Allium giganteum-like superhydrophobic coating on Mg alloy with self-cleaning and anti-corrosion properties

    Chu, J.H / Sun, G.X / Tong, L.B / Jiang, Z.H

    Colloids and surfaces. 2021 May 20, v. 617

    2021  

    Abstract: Superhydrophobic coating can act as the anti-corrosion layer for Mg alloy due to its water-repellency. The construction of such coating is dominated by the roughness and surface energy, which is expected to achieve in one-step to improve the weak ... ...

    Abstract Superhydrophobic coating can act as the anti-corrosion layer for Mg alloy due to its water-repellency. The construction of such coating is dominated by the roughness and surface energy, which is expected to achieve in one-step to improve the weak adsorption phenomenon of surface modification during traditional approaches. Therefore, a superhydrophobic coating composed of CeO₂ and cerium stearate (Ce(CH₃(CH₂)₁₆COO)₃) is fabricated via a facile hydrothermal method. The synthesis of Ce(CH₃(CH₂)₁₆COO)₃ passivates the surface of CeO₂ nanosheets, leading to a reduction of surface energy and the formation of an Allium giganteum-like structure which presents a micro-nano hierarchical roughness. This unique structure with high roughness and low surface energy is responsible for the excellent superhydrophobic behavior of coating which has high water contact angle (WCA) of 164° and low rolling angle (RA) of 4.1°. The superhydrophobic coating also displays an outstanding self-cleaning behavior due to its low surface adhesion. The corrosion rate of prepared coating in 3.5 wt% NaCl aqueous solution is approximately two orders of magnitude lower than that of bare Mg alloy. This remarkably enhanced corrosion resistance arises from the decrease in contact area between the corrosion solution and sample due to the water-repellency of coating.
    Keywords Allium ; adhesion ; adsorption ; alloys ; aqueous solutions ; cerium ; contact angle ; corrosion ; energy ; hot water treatment ; hydrophobicity ; nanosheets ; roughness ; stearic acid
    Language English
    Dates of publication 2021-0520
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1500517-3
    ISSN 0927-7757
    ISSN 0927-7757
    DOI 10.1016/j.colsurfa.2021.126370
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: [Protective repair of discolored breast cancer HE sections by color transfer].

    Wang, H Z / Sun, G X / Yan, X / Su, T H / Xu, J / Li, F / Liu, X / Wang, B D / Xin, L M / Zou, X

    Zhonghua bing li xue za zhi = Chinese journal of pathology

    2023  Volume 52, Issue 5, Page(s) 507–511

    MeSH term(s) Humans ; Female ; Breast Neoplasms
    Language Chinese
    Publishing date 2023-04-27
    Publishing country China
    Document type Journal Article
    ZDB-ID 784533-9
    ISSN 0529-5807
    ISSN 0529-5807
    DOI 10.3760/cma.j.cn112151-20230110-00019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of PPARγ agonist pioglitazone on cardiac fibrosis in diabetic mice by regulating PTEN/AKT/FAK pathway.

    Zhang, X-D / Sun, G-X / Guo, J-J / Hu, C-C / Sun, R-C / Yu, H-C

    European review for medical and pharmacological sciences

    2021  Volume 25, Issue 2, Page(s) 812–819

    Abstract: Objective: The aim of this study was to explore the role of pioglitazone (PIO), a peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, in cardiac fibrosis of diabetic mice.: Materials and methods: A total of 60 adult male C57/B6 mice ... ...

    Abstract Objective: The aim of this study was to explore the role of pioglitazone (PIO), a peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, in cardiac fibrosis of diabetic mice.
    Materials and methods: A total of 60 adult male C57/B6 mice were divided into 3 groups using a random number table, namely, control group (Sham group, n=20), diabetic cardiomyopathy group (DCM group, n=20), DCM + PIO group (n=20). Streptozocin (STZ) was injected into mice at a dose of 125 mg/Kg to induce the model of diabetes in vivo. After successful induction, mice in DCM + PIO group were intragastrically given PIO at 10 mg/kg/d once a day for 6 weeks. Meanwhile, those in Sham group and DCM group were given the same volume of normal saline. After 6 weeks, ejection fraction % (EF%), fraction shortening % (FS%) and heart rate of mice in each group were examined via echocardiography. Picrosirius red (PSR) staining assay was conducted to detect collagen deposition in myocardial tissues of mice in each group. The protein expression level of PPARγ in mouse myocardial tissues in each group was measured through Western blotting and immunohistochemical staining assays. Hematoxylin-eosin (H&E) staining assay was carried out to evaluate the myocardial hypertrophy of mice in each group. The protein expression level of transforming growth factor-β (TGF-β) in mouse myocardial tissues in each group was measured through immunohistochemical staining assay. In addition, Western blotting was employed to detect the expression of proteins related to the phosphate and tension homology deleted on chromsome ten (PTEN)/protein kinase B (AKT)/focal adhesion kinase (FAK) signaling pathway in myocardial tissues of mice in each group.
    Results: The messenger ribonucleic acid (mRNA) and protein expression levels of PPARγ in mouse myocardial tissues were significantly lower in DCM group than those in Sham group (p<0.05). PPARγ agonist PIO could significantly increase the protein expression of PPARγ in myocardial tissues of DCM mice. The results of cardiac Doppler ultrasound revealed that PIO significantly upregulated EF% and FS% in DCM mice (p<0.05). Besides, PIO remarkably reduced collagen deposition and TGF-β protein expression in myocardial tissues in DCM mice (p<0.05). H&E staining results showed that PIO notably attenuated myocardial hypertrophy in DCM mice (p<0.05). Furthermore, it was discovered that PIO markedly elevated PTEN protein in myocardial tissues of DCM mice and inhibited the phosphorylation of AKT and FAK proteins (p<0.05).
    Conclusions: The protective effect of PIO against cardiac fibrosis in diabetic mice may be related to its regulation on the PTEN/AKT/FAK signaling pathway. Our findings suggest that PIO is expected to become a targeted drug for the treatment of DCM in clinical practice.
    MeSH term(s) Animals ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Fibrosis/drug therapy ; Fibrosis/metabolism ; Focal Adhesion Kinase 1/antagonists & inhibitors ; Focal Adhesion Kinase 1/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; PPAR gamma/agonists ; PPAR gamma/genetics ; PTEN Phosphohydrolase/metabolism ; Phosphorylation/drug effects ; Pioglitazone/pharmacology ; Protective Agents/pharmacology ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/metabolism
    Chemical Substances PPAR gamma ; Protective Agents ; Focal Adhesion Kinase 1 (EC 2.7.10.2) ; Ptk2 protein, mouse (EC 2.7.10.2) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; Pten protein, mouse (EC 3.1.3.67) ; Pioglitazone (X4OV71U42S)
    Language English
    Publishing date 2021-02-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202101_24646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Sequentially bridged biomimetic graphene-based coating via covalent bonding with an effective anti-corrosion/wear protection for Mg alloy

    Chu, J.H / Tong, L.B / Wang, W / Jiang, Z.H / Sun, G.X / Zou, D.N / Wang, K.S / Zhang, H.J

    Colloids and surfaces. 2021 Feb. 05, v. 610

    2021  

    Abstract: The industrial applications of Mg and its alloys are restricted by their poor corrosion resistances, owing to the rapid dissolution and hydrogen evolution behaviors. In this study, a sequentially bridged reduced graphene oxide (RGO)/ ... ...

    Abstract The industrial applications of Mg and its alloys are restricted by their poor corrosion resistances, owing to the rapid dissolution and hydrogen evolution behaviors. In this study, a sequentially bridged reduced graphene oxide (RGO)/bistriethoxysilylethane (BTSE) coating is successfully grafted on the surface of Mg alloy substrate, to simultaneously inhibit the corrosion and wear behaviors. It exhibits well-aligned biomimetic nacre-like “bricks and mortar” structure connected by covalent bonding networks, consisting of the Si-O-C bonds between the RGO sheets and the Si-O-Si bonds derived from BTSE self-crosslinking reactions. The reduced porosity and defects lead to a high continuity and integrity of the RGO/BTSE coating, which decreases the corrosion rate by an order of magnitude compared with bare Mg substrate and RGO coated sample, owing to the enhanced barrier effect and weakened galvanic corrosion. In addition, the hybrid coating also performs well anti-wear property due to the intrinsic lubrication of RGO sheets, which can protect the substrate from friction and wear. The wear rate decreases from 3.5 × 10⁻³ mm³N⁻¹ m⁻¹ of bare Mg alloy to 5.13 × 10⁻⁵ mm³N⁻¹ m⁻¹ of RGO/BTSE coated sample. The interlayer slipping between the RGO sheets effectively decreases friction resistance, although the incorporation of BTSE slightly increases their shear resistance.
    Keywords alloys ; biomimetic materials ; biomimetics ; chemical bonding ; coatings ; corrosion ; friction ; graphene ; graphene oxide ; hydrogen production ; lubrication ; magnesium ; porosity ; shear strength ; silicon
    Language English
    Dates of publication 2021-0205
    Publishing place Elsevier B.V.
    Document type Article
    Note golden set
    ZDB-ID 1500517-3
    ISSN 0927-7757
    ISSN 0927-7757
    DOI 10.1016/j.colsurfa.2020.125707
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Study of expression levels and clinical significance of miR-503 and miR-375 in patients with esophageal squamous cell carcinoma.

    Liu, Z H / Chen, L D / He, Y B / Xu, B / Wang, K B / Sun, G X / Zhang, Z H

    European review for medical and pharmacological sciences

    2019  Volume 23, Issue 9, Page(s) 3799–3805

    Abstract: Objective: This study aims to investigate the expression levels and clinical significance of miR-503 and miR-375 in patients with esophageal squamous cell carcinoma.: Patients and methods: 40 cases of cancer tissues and adjacent tissues in patients ... ...

    Abstract Objective: This study aims to investigate the expression levels and clinical significance of miR-503 and miR-375 in patients with esophageal squamous cell carcinoma.
    Patients and methods: 40 cases of cancer tissues and adjacent tissues in patients with esophageal squamous cell carcinoma were collected from March 2017 to September 2017 in the Department of Gastroenterology in the First Affiliated Hospital of Henan Polytechnic University. qRT-PCR was used to analyze the expressions of miR-503 and miR-375 in cancer tissues and adjacent normal tissues. The association between their expressions and the gender, age, degree of tumor differentiation, TNM staging, presence or absence of lymph node metastasis, and other clinicopathological characteristics of patients with esophageal squamous cell carcinoma was analyzed.
    Results: The results showed that the expression level of miR-503 in esophageal squamous cell carcinoma tissues (6.83±2.14) was significantly higher than that in adjacent tissues (2.45±1.13). The expression level of miR-375 in esophageal squamous cell carcinoma tissues (3.75±1.06) was significantly lower than that in adjacent tissues (7.45±1.13). The expression levels of miR-503 and miR-375 in esophageal squamous cell carcinoma were related to the existence of lymph node metastasis, degree of differentiation of esophageal squamous cell carcinoma and TNM staging (p<0.001). There was no correlation between the expressions of miR-503 and miR-375 and the age, gender and tumor size of patients (p>0.05).
    Conclusions: miR-503 was highly expressed in esophageal squamous cell carcinoma and miR-375 was lowly expressed in esophageal squamous cell carcinoma. miR-503 and miR-375 were closely related to the lymphatic metastasis, degree of differentiation and TNM staging of the tumor.
    MeSH term(s) Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Down-Regulation ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/pathology ; Esophagus/metabolism ; Esophagus/pathology ; Female ; Humans ; Lymphatic Metastasis ; Male ; MicroRNAs/metabolism ; Middle Aged ; Neoplasm Staging
    Chemical Substances MIRN375 microRNA, human ; MIRN503 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2019-05-15
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_201905_17806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Effect of Selenium Against Lead-Induced Damage on the Gene Expression of Heat Shock Proteins and Inflammatory Cytokines in Peripheral Blood Lymphocytes of Chickens

    Sun, G.X / Y. Chen / C. P. Liu / S. Li / J. Fu

    Biological trace element research. 2016 Aug., v. 172, no. 2

    2016  

    Abstract: The possible beneficial role of selenium (Se) in heat shock proteins (HSPs) and inflammation damage induced by lead (Pb) in chickens is unclear. Therefore, the aim of this study was to investigate the effect of Se against Pb on the messenger RNA (mRNA) ... ...

    Abstract The possible beneficial role of selenium (Se) in heat shock proteins (HSPs) and inflammation damage induced by lead (Pb) in chickens is unclear. Therefore, the aim of this study was to investigate the effect of Se against Pb on the messenger RNA (mRNA) expression levels of HSPs (HSP 27, 40, 60, 70, and 90); heme oxygenase-1 (HO-1); and the inflammatory cytokines nuclear factor kappa B (NF-κB), tumor necrosis factor alpha (TNF-α), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) in the peripheral blood lymphocytes of chickens. A total of 360 1-day-old broiler chickens were randomly allocated into four groups (n = 90/group). The control group was fed a basic diet containing 0.2 mg/kg Se and 0.5 mg/kg Pb; the Se supplementation group (+Se group) was fed a Se-adequate (sodium selenite) diet containing 1 mg/kg Se and 0.5 mg/kg Pb; the Pb-supplemented group (+Pb group) was fed a Pb acetate diet containing 0.2 mg/kg Se and 350 mg/kg Pb; and the Se and Pb compound group (Se + Pb group) was fed a diet containing 1 mg/kg Se and 350 mg/kg Pb. The blood was collected and examined for the mRNA levels of HSP and inflammatory cytokine genes at 30 and 60 days old. The results showed that Pb poisoning induced the mRNA expression of HSPs and inflammatory cytokines in the peripheral blood lymphocytes of chickens. In addition, Se alleviated the Pb-induced increase in HSP and inflammatory cytokine mRNA levels in chicken peripheral blood lymphocytes. In conclusion, Se can antagonize the toxic effects of Pb on chickens and protect the chickens’ peripheral blood lymphocytes in normal physiological function.
    Keywords acetates ; broiler chickens ; diet ; gene expression ; genes ; heat shock proteins ; heme oxygenase (biliverdin-producing) ; inducible nitric oxide synthase ; inflammation ; lead ; lymphocytes ; messenger RNA ; poisoning ; prostaglandin synthase ; selenium ; sodium selenite ; toxicity ; transcription factor NF-kappa B ; tumor necrosis factor-alpha
    Language English
    Dates of publication 2016-08
    Size p. 474-480.
    Publishing place Springer US
    Document type Article
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-015-0602-2
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Bio-inspired graphene-based coatings on Mg alloy surfaces and their integrations of anti-corrosive/wearable performances

    Chu, J.H / Tong, L.B / Zhang, J.B / Kamado, S / Jiang, Z.H / Zhang, H.J / Sun, G.X

    Carbon. 2019 Jan., v. 141

    2019  

    Abstract: Mg and its alloys generally exhibit the poor corrosion and wear resistances, which greatly limits their industrial applications. Inspired from an ordered layered structure within natural nacre, the homogeneous reduced graphene oxide/poly (vinyl alcohol) ( ...

    Abstract Mg and its alloys generally exhibit the poor corrosion and wear resistances, which greatly limits their industrial applications. Inspired from an ordered layered structure within natural nacre, the homogeneous reduced graphene oxide/poly (vinyl alcohol) (RGO/PVA) coating is successfully fabricated on Mg alloy surface in the current study, through a facile spin-assisted layer-by-layer assembly (SA-LBL) technology. The hybrid hydrogen/covalent bond networks form between PVA chains and RGO sheets, resulting in a compact lamellar “bricks-and-mortar” structure. The microstructure of hybrid coating is strongly influenced by the cross-linking effect of PVA molecule, whose suitable content is beneficial to generating the densely stacked lamellar coating with excellent binding strength and reduced intrinsic defects, which can significantly improve its corrosion resistance. And the water molecules can hardly diffuse into the hybrid coating, leading to a long-term stability of samples in aqueous solution, ethanol and N, N-dimethylformamide. Besides, the high hardness and good lubricant effect of RGO sheets confer the hybrid coatings outstanding wear-resistant properties. Therefore, the bio-inspired RGO coating with a certain amount of PVA allows it to have a superior barrier effect and maintain the lubrication, which can provide an integrated protection for the corrosion and wear behaviors of Mg alloy.
    Keywords alloys ; aqueous solutions ; chemical bonding ; coatings ; corrosion ; crosslinking ; ethanol ; graphene ; graphene oxide ; hardness ; hydrogen ; industrial applications ; lubricants ; lubrication ; magnesium ; microstructure ; polyvinyl alcohol
    Language English
    Dates of publication 2019-01
    Size p. 154-168.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0008-6223
    DOI 10.1016/j.carbon.2018.09.047
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Effect of Selenium Against Lead-Induced Damage on the Gene Expression of Heat Shock Proteins and Inflammatory Cytokines in Peripheral Blood Lymphocytes of Chickens.

    Sun, G X / Chen, Y / Liu, C P / Li, S / Fu, J

    Biological trace element research

    2016  Volume 172, Issue 2, Page(s) 474–480

    Abstract: The possible beneficial role of selenium (Se) in heat shock proteins (HSPs) and inflammation damage induced by lead (Pb) in chickens is unclear. Therefore, the aim of this study was to investigate the effect of Se against Pb on the messenger RNA (mRNA) ... ...

    Abstract The possible beneficial role of selenium (Se) in heat shock proteins (HSPs) and inflammation damage induced by lead (Pb) in chickens is unclear. Therefore, the aim of this study was to investigate the effect of Se against Pb on the messenger RNA (mRNA) expression levels of HSPs (HSP 27, 40, 60, 70, and 90); heme oxygenase-1 (HO-1); and the inflammatory cytokines nuclear factor kappa B (NF-κB), tumor necrosis factor alpha (TNF-α), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) in the peripheral blood lymphocytes of chickens. A total of 360 1-day-old broiler chickens were randomly allocated into four groups (n = 90/group). The control group was fed a basic diet containing 0.2 mg/kg Se and 0.5 mg/kg Pb; the Se supplementation group (+Se group) was fed a Se-adequate (sodium selenite) diet containing 1 mg/kg Se and 0.5 mg/kg Pb; the Pb-supplemented group (+Pb group) was fed a Pb acetate diet containing 0.2 mg/kg Se and 350 mg/kg Pb; and the Se and Pb compound group (Se + Pb group) was fed a diet containing 1 mg/kg Se and 350 mg/kg Pb. The blood was collected and examined for the mRNA levels of HSP and inflammatory cytokine genes at 30 and 60 days old. The results showed that Pb poisoning induced the mRNA expression of HSPs and inflammatory cytokines in the peripheral blood lymphocytes of chickens. In addition, Se alleviated the Pb-induced increase in HSP and inflammatory cytokine mRNA levels in chicken peripheral blood lymphocytes. In conclusion, Se can antagonize the toxic effects of Pb on chickens and protect the chickens' peripheral blood lymphocytes in normal physiological function.
    MeSH term(s) Animals ; Chickens/blood ; Chickens/genetics ; Cytokines/genetics ; Cytokines/metabolism ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Inflammation/genetics ; Inflammation/metabolism ; Lead/administration & dosage ; Lead/toxicity ; Lymphocytes/drug effects ; Lymphocytes/metabolism ; Male ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Selenium/administration & dosage ; Selenium/pharmacology
    Chemical Substances Cytokines ; Heat-Shock Proteins ; RNA, Messenger ; Lead (2P299V784P) ; Selenium (H6241UJ22B)
    Language English
    Publishing date 2016-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-015-0602-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Curative effect of combined traditional Chinese medicine with Western medicine therapy on chronic nephritis and its correlation with hemorheology and microcirculation].

    Sun, G X

    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

    1993  Volume 13, Issue 2, Page(s) 80–3, 67–8

    Abstract: Patients were divided into two groups, 89 cases treated by combined traditional Chinese and Western medicine (TCM-WM) therapy, the other 36 served as control. Each of two groups was further subdivided into 4 clinical types and 5 Syndromes of TCM. ... ...

    Abstract Patients were divided into two groups, 89 cases treated by combined traditional Chinese and Western medicine (TCM-WM) therapy, the other 36 served as control. Each of two groups was further subdivided into 4 clinical types and 5 Syndromes of TCM. Hemorheology and microcirculation were tested before and after treatment, the clinical curative effects of both groups were compared and correlation analysis between clinical curative effect and improvement of hemorheology and microcirculation was made. The results showed that the remission rate and total effective rate were 79.8% and 92.1% respectively in testing group, significantly higher than those (25% and 50%) of control (P < 0.05-0.01). The curative effect on each clinical type and Syndrome of TCM was better than that on corresponding type and Syndrome of control (P < 0.05-0.01). The improvement of hemorheology and microcirculation was more significant in testing group than that in control. It was very significant in complete and partial remission of both group (P < 0.05-0.01) but not marked in the cases of improved and ineffective cases (P > 0.05). Therefore clinical curative effect was closely related with them. So any treatment which could improve hemorheology and microcirculation would be useful in treating chronic nephritis.
    MeSH term(s) Adult ; Blood Viscosity/drug effects ; Chronic Disease ; Dipyridamole/therapeutic use ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Male ; Microcirculation/drug effects ; Nails/blood supply ; Nephritis/blood ; Nephritis/drug therapy ; Nephritis/physiopathology ; Rheology
    Chemical Substances Drugs, Chinese Herbal ; Dipyridamole (64ALC7F90C)
    Language Chinese
    Publishing date 1993-02
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1195456-5
    ISSN 1003-5370
    ISSN 1003-5370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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