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  1. Article ; Online: Oligomeric Amyloid-β and Tau Alter Cell Adhesion Properties and Induce Inflammatory Responses in Cerebral Endothelial Cells Through the RhoA/ROCK Pathway.

    Hossen, Faruk / Geng, Xue / Sun, Grace Y / Yao, Xincheng / Lee, James C

    Molecular neurobiology

    2024  

    Abstract: Dysfunction of cerebral endothelial cells (CECs) has been implicated in the pathology of Alzheimer's disease (AD). Despite evidence showing cytotoxic effects of oligomeric amyloid-β (oAβ) and Tau (oTau) in the central nervous system, their direct effects ...

    Abstract Dysfunction of cerebral endothelial cells (CECs) has been implicated in the pathology of Alzheimer's disease (AD). Despite evidence showing cytotoxic effects of oligomeric amyloid-β (oAβ) and Tau (oTau) in the central nervous system, their direct effects on CECs have not been fully investigated. In this study, we examined the direct effects of oAβ, oTau, and their combination on cell adhesion properties and inflammatory responses in CECs. We found that both oAβ and oTau increased cell stiffness, as well as the p-selectin/Sialyl-Lewis
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-024-04138-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2411: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Book ; Conference proceedings: Molecular mechanisms of alcohol

    Sun, Grace Y.

    neurobiology and metabolism ; [the proceedings of the International Symposium for Biomedical Research on Alcoholism, July 4 - 6, 1988 Taipei, Taiwan, R. O. C.]

    (Experimental biology and medicine ; [21])

    1989  

    Event/congress International Symposium for Biomedical Research on Alcoholism (1988, Taipeh)
    Author's details ed. by Grace Y. Sun
    Series title Experimental biology and medicine ; [21]
    Collection
    Keywords Alcohol, Ethyl / pharmacology / congresses ; Brain Chemistry / drug effects / congresses ; Cells, Cultured / drug effects / congresses ; Metabolism / drug effects / congresses ; Alkohol ; Pathophysiologie
    Subject Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie
    Size XIV, 397 S. : Ill., graph. Darst.
    Publisher Humana Pr
    Publishing place Clifton, NJ
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003567175
    ISBN 0-89603-170-5 ; 978-0-89603-170-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 5035 order for loan Magazin

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  3. Article ; Online: Anti-Inflammatory Effects of Phytochemical Components of

    Ong, Wei-Yi / Herr, Deron R / Sun, Grace Y / Lin, Teng-Nan

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 11

    Abstract: Recent studies on the ethnomedicinal use ... ...

    Abstract Recent studies on the ethnomedicinal use of
    MeSH term(s) Acanthaceae/chemistry ; Anti-Inflammatory Agents/analysis ; Anti-Inflammatory Agents/pharmacology ; Phytochemicals/analysis ; Phytochemicals/pharmacology ; Plant Extracts/chemistry ; Plant Leaves/chemistry
    Chemical Substances Anti-Inflammatory Agents ; Phytochemicals ; Plant Extracts
    Language English
    Publishing date 2022-06-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27113607
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  4. Article ; Online: Glial Cell Line-Derived Neurotrophic Factor and Focal Ischemic Stroke.

    Zhang, Zhe / Sun, Grace Y / Ding, Shinghua

    Neurochemical research

    2021  Volume 46, Issue 10, Page(s) 2638–2650

    Abstract: Focal ischemic stroke (FIS) is a leading cause of human debilitation and death. Following the onset of a FIS, the brain experiences a series of spatiotemporal changes which are exemplified in different pathological processes. One prominent feature of FIS ...

    Abstract Focal ischemic stroke (FIS) is a leading cause of human debilitation and death. Following the onset of a FIS, the brain experiences a series of spatiotemporal changes which are exemplified in different pathological processes. One prominent feature of FIS is the development of reactive astrogliosis and glial scar formation in the peri-infarct region (PIR). During the subacute phase, astrocytes in PIR are activated, referred to as reactive astrocytes (RAs), exhibit changes in morphology (hypotrophy), show an increased proliferation capacity, and altered gene expression profile, a phenomenon known as reactive astrogliosis. Subsequently, the morphology of RAs remains stable, and proliferation starts to decline together with the formation of glial scars. Reactive astrogliosis and glial scar formation eventually cause substantial tissue remodeling and changes in permanent structure around the PIR. Glial cell line-derived neurotrophic factor (GDNF) was originally isolated from a rat glioma cell-line and regarded as a potent survival neurotrophic factor. Under normal conditions, GDNF is expressed in neurons but is upregulated in RAs after FIS. This review briefly describes properties of GDNF, its receptor-mediated signaling pathways, as well as recent studies regarding the role of RAs-derived GDNF in neuronal protection and brain recovery. These results provide evidence suggesting an important role of RA-derived GDNF in intrinsic brain repair and recovery after FIS, and thus targeting GDNF in RAs may be effective for stroke therapy.
    MeSH term(s) Animals ; Astrocytes/metabolism ; Brain/metabolism ; Glial Cell Line-Derived Neurotrophic Factor/metabolism ; Glial Cell Line-Derived Neurotrophic Factor Receptors/metabolism ; Humans ; Ischemic Stroke/metabolism ; Neurons/metabolism ; Neuroprotection/physiology ; Recovery of Function/physiology ; Signal Transduction/physiology
    Chemical Substances Glial Cell Line-Derived Neurotrophic Factor ; Glial Cell Line-Derived Neurotrophic Factor Receptors
    Language English
    Publishing date 2021-02-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 199335-5
    ISSN 1573-6903 ; 0364-3190
    ISSN (online) 1573-6903
    ISSN 0364-3190
    DOI 10.1007/s11064-021-03266-5
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    Zs.A 1368: Show issues Location:
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  5. Article ; Online: Microglia Signaling Pathway Reporters Unveiled Manganese Activation of the Interferon/STAT1 Pathway and Its Mitigation by Flavonoids.

    Mossine, Valeri V / Waters, James K / Sun, Grace Y / Gu, Zezong / Mawhinney, Thomas P

    Molecular neurobiology

    2023  Volume 60, Issue 8, Page(s) 4679–4692

    Abstract: Neuroinflammatory responses to neurotoxic manganese (Mn) in CNS have been associated with the Mn-induced Parkinson-like syndromes. However, the framework of molecular mechanisms contributing to manganism is still unclear. Using an in vitro ... ...

    Abstract Neuroinflammatory responses to neurotoxic manganese (Mn) in CNS have been associated with the Mn-induced Parkinson-like syndromes. However, the framework of molecular mechanisms contributing to manganism is still unclear. Using an in vitro neuroinflammation model based on the insulated signaling pathway reporter transposon constructs stably transfected into a murine BV-2 microglia line, we tested effects of manganese (II) together with a set of 12 metal salts on the transcriptional activities of the NF-κB, activator protein-1 (AP-1), signal transducer and activator of transcription 1 (STAT1), STAT1/STAT2, STAT3, Nrf2, and metal-responsive transcription factor-1 (MTF-1) via luciferase assay, while concatenated destabilized green fluorescent protein expression provided for simultaneous evaluation of cellular viability. This experiment revealed specific and strong responses to manganese (II) in reporters of the type I and type II interferon-induced signaling pathways, while weaker activation of the NF-κB in the microglia was detected upon treatment of cells with Mn(II) and Ba(II). There was a similarity between Mn(II) and interferon-γ in the temporal STAT1 activation profile and in their antagonism to bacterial LPS. Sixty-four natural and synthetic flavonoids differentially affected both cytotoxicity and the pro-inflammatory activity of Mn (II) in the microglia. Whereas flavan-3-ols, flavanones, flavones, and flavonols were cytoprotective, isoflavones enhanced the cytotoxicity of Mn(II). Furthermore, about half of the tested flavonoids at 10-50 μM could attenuate both basal and 100-200 μM Mn(II)-induced activity at the gamma-interferon activated DNA sequence (GAS) in the cells, suggesting no critical roles for the metal chelation or antioxidant activity in the protective potential of flavonoids against manganese in microglia. In summary, results of the study identified Mn as a specific elicitor of the interferon-dependent pathways that can be mitigated by dietary polyphenols.
    MeSH term(s) Mice ; Animals ; NF-kappa B/metabolism ; Interferons/metabolism ; Manganese/toxicity ; Flavonoids/pharmacology ; Microglia/metabolism ; Signal Transduction ; Interferon-gamma/pharmacology ; Interferon-gamma/metabolism ; STAT1 Transcription Factor/metabolism
    Chemical Substances NF-kappa B ; Interferons (9008-11-1) ; Manganese (42Z2K6ZL8P) ; Flavonoids ; Interferon-gamma (82115-62-6) ; STAT1 Transcription Factor
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03369-w
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    Zs.A 2411: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Book ; Conference proceedings: NEURAL MEMBRANES

    Sun, Grace Y.

    (PROC. OF THE INTERNATIONAL SYMPOSIUM ON NEURAL MEMBRANES ... TAIPEI, TAIWAN, ROC, AUGUST 2-5, 1982)

    (EXPERIMENTAL AND CLINICAL NEUROSCIENCE)

    1983  

    Author's details ED. BY GRACE Y. SUN
    Series title EXPERIMENTAL AND CLINICAL NEUROSCIENCE
    Keywords CELL MEMBRANE / CONGRESSES ; NEURONS / CONGRESSES ; Nervensystem ; Biomembran ; Nervenzelle ; Plasmamembran
    Subject Zellmembran ; Plasmalemma ; Zelle ; Ganglienzelle ; Neurozyt ; Neuron ; Biologische Membran ; Einheitsmembran ; Systema nervosum ; NS
    Size XII, 584 S. : ILL., GRAPH. DARST.
    Publisher HUMANA PR
    Publishing place CLIFTON, N.J
    Document type Book ; Conference proceedings
    HBZ-ID HT002743043
    ISBN 0-89603-052-0 ; 978-0-89603-052-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1984 A 3093 order for loan Magazin

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  7. Article ; Online: Bidirectional Responses of Eight Neuroinflammation-Related Transcriptional Factors to 64 Flavonoids in Astrocytes with Transposable Insulated Signaling Pathway Reporters.

    Mossine, Valeri V / Waters, James K / Gu, Zezong / Sun, Grace Y / Mawhinney, Thomas P

    ACS chemical neuroscience

    2022  Volume 13, Issue 5, Page(s) 613–623

    Abstract: Neuroinflammation is implicated in a variety of pathologies and is mechanistically linked to hyperactivation of glial cells in the central nervous system (CNS), predominantly in response to external stimuli. Multiple dietary factors were reported to ... ...

    Abstract Neuroinflammation is implicated in a variety of pathologies and is mechanistically linked to hyperactivation of glial cells in the central nervous system (CNS), predominantly in response to external stimuli. Multiple dietary factors were reported to alter neuroinflammation, but their actions on the relevant transcription factors in glia are not sufficiently understood. Here, an in vitro protocol employing cultured astroglial cells, which carry reporters of multiple signaling pathways associated with inflammation, was developed for screening environmental factors and synthetic drugs. Immortalized rat astrocyte line DI TNC1 was stably transfected with
    MeSH term(s) Animals ; Astrocytes/metabolism ; Flavonoids/metabolism ; Flavonoids/pharmacology ; NF-kappa B/metabolism ; Neuroinflammatory Diseases ; Rats ; Signal Transduction
    Chemical Substances Flavonoids ; NF-kappa B
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.1c00750
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  8. Article ; Online: Neuroprotective effects of DHA-derived peroxidation product 4(RS)-4-F4t-neuroprostane on microglia.

    Geng, Xue / Galano, Jean-Marie / Oger, Camille / Sun, Grace Y / Durand, Thierry / Lee, James C

    Free radical biology & medicine

    2022  Volume 185, Page(s) 1–5

    Abstract: The abundance of docosahexaenoic acid (DHA) in brain membrane phospholipids has stimulated studies to explore its role in neurological functions. Upon released from phospholipids, DHA undergoes enzymatic reactions resulting in synthesis of bioactive ... ...

    Abstract The abundance of docosahexaenoic acid (DHA) in brain membrane phospholipids has stimulated studies to explore its role in neurological functions. Upon released from phospholipids, DHA undergoes enzymatic reactions resulting in synthesis of bioactive docosanoids and prostanoids. However, these phospholipids are also prone to non-enzymatic reactions leading to more complex pattern of metabolites. A non-enzymatic oxidized product of DHA, 4(RS)-4-F
    MeSH term(s) Docosahexaenoic Acids/metabolism ; Lipopolysaccharides/pharmacology ; Microglia ; Neuroprostanes ; Neuroprotective Agents/pharmacology ; Phospholipids/metabolism
    Chemical Substances 4-F4t-neuroprostane ; Lipopolysaccharides ; Neuroprostanes ; Neuroprotective Agents ; Phospholipids ; Docosahexaenoic Acids (25167-62-8)
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2022.04.002
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    Zs.A 2109: Show issues Location:
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  9. Article: COVID-19, Blood Lipid Changes, and Thrombosis.

    Farooqui, Akhlaq A / Farooqui, Tahira / Sun, Grace Y / Lin, Teng-Nan / Teh, Daniel B L / Ong, Wei-Yi

    Biomedicines

    2023  Volume 11, Issue 4

    Abstract: Although there is increasing evidence that oxidative stress and inflammation induced by COVID-19 may contribute to increased risk and severity of thromboses, the underlying mechanism(s) remain to be understood. The purpose of this review is to highlight ... ...

    Abstract Although there is increasing evidence that oxidative stress and inflammation induced by COVID-19 may contribute to increased risk and severity of thromboses, the underlying mechanism(s) remain to be understood. The purpose of this review is to highlight the role of blood lipids in association with thrombosis events observed in COVID-19 patients. Among different types of phospholipases A
    Language English
    Publishing date 2023-04-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11041181
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  10. Article ; Online: Long-Term Effects of Low-Intensity Blast Non-Inertial Brain Injury on Anxiety-Like Behaviors in Mice: Home-Cage Monitoring Assessments.

    Siedhoff, Heather R / Chen, Shanyan / Balderrama, Ashley / Sun, Grace Y / Koopmans, Bastijn / DePalma, Ralph G / Cui, Jiankun / Gu, Zezong

    Neurotrauma reports

    2022  Volume 3, Issue 1, Page(s) 27–38

    Abstract: Mild traumatic brain injury induced by low-intensity blast (LIB) exposure poses concerns in military personnel. Using an open-field, non-inertial blast model and assessments by conventional behavioral tests, our previous studies revealed early-phase ... ...

    Abstract Mild traumatic brain injury induced by low-intensity blast (LIB) exposure poses concerns in military personnel. Using an open-field, non-inertial blast model and assessments by conventional behavioral tests, our previous studies revealed early-phase anxiety-like behaviors in LIB-exposed mice. However, the impact of LIB upon long-term anxiety-like behaviors requires clarification. This study applied a highly sensitive automated home-cage monitoring (HCM) system, which minimized human intervention and environmental changes, to assess anxiety-like responses in mice 3 months after LIB exposure. Initial assessment of 72-h spontaneous activities in a natural cage condition over multiple light and dark phases showed altered sheltering behaviors. LIB-exposed mice exhibited a subtle, but significantly decreased, duration of short shelter visits as compared to sham controls. Other measured responses between LIB-exposed mice and sham controls were insignificant. When behavioral assessments were performed in a challenged condition using an aversive spotlight, LIB-exposed mice demonstrated a significantly higher frequency of movements of shorter distance and duration per movement. Taken together, these findings demonstrated the presence of chronic anxiety-like behaviors assessed by the HCM system under both natural and challenged conditions in mice occurring post-LIB exposure. This model thus provides a platform to test for screening and interventions on anxiety disorders occurring after LIB non-inertial brain injury.
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article
    ISSN 2689-288X
    ISSN (online) 2689-288X
    DOI 10.1089/neur.2021.0063
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