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Article: Methods and Research Hotspots of Forensic Kinship Testing.

Li, Ran / Sun, Hong-Yu

Fa yi xue za zhi

2023 Volume 39, Issue 3, Page(s) 231–239

Abstract: Kinship testing is widely needed in forensic science practice. This paper reviews the definitions of common concepts, and summarizes the basic principles, advantages and disadvantages, and application scope of kinship analysis methods, including identity ...

Abstract	Kinship testing is widely needed in forensic science practice. This paper reviews the definitions of common concepts, and summarizes the basic principles, advantages and disadvantages, and application scope of kinship analysis methods, including identity by state (IBS) method, likelihood ratio (LR) method, method of moment (MoM), and identity by descent (IBD) segment method. This paper also discusses the research hotspots of challenging kinship testing, complex kinship testing, forensic genetic genealogy analysis, and non-human biological samples.
MeSH term(s)	DNA Fingerprinting ; Forensic Genetics/methods ; Forensic Sciences ; Pedigree ; Humans
Language	Chinese
Publishing date	2023-07-27
Publishing country	China
Document type	Review ; Journal Article
ISSN	1004-5619
ISSN	1004-5619
DOI	10.12116/j.issn.1004-5619.2023.530208
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Research Progresses of Tri-Allelic Patterns in Autosomal STR in Forensic DNA Analysis.

Ma, Xiao-Yan / Sun, Hong-Yu / Li, Qing

Fa yi xue za zhi

2023 Volume 39, Issue 3, Page(s) 240–246

Abstract: Tri-allelic pattern in autosomal STR is a common abnormal typing phenomenon in forensic DNA analysis, which brings difficulties and uncertainties to the evaluation of the evidence weight in actual cases. This paper reviews the types, formation mechanism, ...

Abstract	Tri-allelic pattern in autosomal STR is a common abnormal typing phenomenon in forensic DNA analysis, which brings difficulties and uncertainties to the evaluation of the evidence weight in actual cases. This paper reviews the types, formation mechanism, occurrence frequency, genetic pattern and quantitative evaluation of evidence of the tri-allelic pattern in autosomal STR in forensic DNA analysis. This paper mainly explains the formation mechanism and genetic patterns based on different types of tri-allelic pattern. This paper also discusses the determination of tri-allelic pattern and the quantitative method of evidence evaluation in paternity testing and individual identification. This paper aims to provide references for scientific and standardized analysis of this abnormal typing phenomenon in forensic DNA analysis.
MeSH term(s)	Alleles ; DNA/genetics ; Forensic Medicine ; Gene Frequency ; Microsatellite Repeats ; Humans
Chemical Substances	DNA (9007-49-2)
Language	Chinese
Publishing date	2023-07-25
Publishing country	China
Document type	Review ; Journal Article
ISSN	1004-5619
ISSN	1004-5619
DOI	10.12116/j.issn.1004-5619.2023.530210
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evaluation of Detection Efficiency for Trio Full Sibling Testing.

Chen, Hui / Li, Ran / Zang, Yu / Yang, Jing-Yi / Wu, Ri-Ga / Sun, Hong-Yu

Fa yi xue za zhi

2023 Volume 39, Issue 3, Page(s) 247–253

Abstract: Objectives: To study the detection efficiency of trio full sibling with another known full sibling reference added under different number of autosomal STR typing systems.: Methods: Based on 43 detection systems consisting of 13 to 55 representative ... ...

Abstract	Objectives: To study the detection efficiency of trio full sibling with another known full sibling reference added under different number of autosomal STR typing systems. Methods: Based on 43 detection systems consisting of 13 to 55 representative autosomal STR loci, 10 000 true families (full sibling group) and 10 000 false families (unrelated individual group) were randomly simulated. The full sibling index (FSI) was calculated based on the method of family reconstruction. The cumulative sibling relationship index (CFSI) of 0.000 1 and 10 000 were used as the evaluation thresholds, and the detection efficiency parameters were calculated and compared with the identification of the duo full sibling testing. Results: With the increasing number of STR loci, the error rate and inability of judgement rate gradually decreased; the sensitivity, specificity, correct rate of judgment and other parameters gradually increased, and the system efficiency gradually improved. Under the same detection system, trio full sibling testing showed higher sensitivity, specificity, system efficiency and lower inability of judgement rate compared with duo full sibling testing. When the system efficiency was higher than 0.85 and inability of judgement rate was less than 0.01%, at least 20 STRs should be detected for trio full sibling testing, which was less than 29 STRs required by duo full sibling testing. Conclusions: The detection efficiency of trio full sibling testing is superior to that of duo full sibling testing with the same detection system, which is an effective identification scheme for laboratories with inadequate detection systems or for materials with limited conditions.
MeSH term(s)	Humans ; Siblings ; Microsatellite Repeats/genetics ; DNA Fingerprinting ; Gene Frequency
Language	Chinese
Publishing date	2023-07-27
Publishing country	China
Document type	Journal Article
ISSN	1004-5619
ISSN	1004-5619
DOI	10.12116/j.issn.1004-5619.2023.530203
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Article: Analysis of Trio Half Sibling Testing.

Li, Hai-Xia / Chen, Hui / Li, Ran / Zang, Yu / Sun, Hong-Yu

Fa yi xue za zhi

2023 Volume 39, Issue 3, Page(s) 254–261

Abstract: Objectives: To establish an analytical method for half sibling testing involving common three relatives' participation.: Methods: Based on the half sibling testing scenarios with the known biological mother, grandfather or uncle, and two unidentified ...

Abstract	Objectives: To establish an analytical method for half sibling testing involving common three relatives' participation. Methods: Based on the half sibling testing scenarios with the known biological mother, grandfather or uncle, and two unidentified controversial half siblings participating, two opposing hypotheses were set. Lineage reconstruction according to Mendel's law of heredity was carried out, and the calculation formula of the half sibling kinship index was derived. Verification of actual cases was carried out and the results were compared with duo half sibling testing. Results: In the scenarios of the known biological mother, grandfather and uncle participating in half sibling testing, the kinship calculation formulae of 54, 91 and 99 genotype combinations for kinship index calculation were deduced respectively. The actual cases showed higher kinship indexes in trio half sibling testing compared with duo half sibling testing. Conclusions: It is beneficial to obtain more genetic information for family reconstruction and improvement of the strength of genetic evidence for half sibling testing by adding known relatives.
MeSH term(s)	Female ; Humans ; Siblings ; Genotype ; Mothers ; Microsatellite Repeats
Language	Chinese
Publishing date	2023-07-27
Publishing country	China
Document type	Journal Article
ISSN	1004-5619
ISSN	1004-5619
DOI	10.12116/j.issn.1004-5619.2021.511202
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Article: [Effects of Exogenous Melatonin Treatment on the Growth and Antioxidant System of Rice Seedlings Under Antimony Stress].

Chu, Yu-Tan / Li, Yan / Huang, Yi-Zong / Bao, Qiong-Li / Sun, Hong-Yu / Huang, Yong-Chun

Huan jing ke xue= Huanjing kexue

2023 Volume 44, Issue 4, Page(s) 2356–2364

Abstract: To investigate the effect of exogenous application of melatonin (MT) on rice seedlings under antimony (Sb) stress, hydroponic experiments were carried out with rice seedlings (Huarun No.2). The fluorescent probe localization technology was used to locate ...

Abstract	To investigate the effect of exogenous application of melatonin (MT) on rice seedlings under antimony (Sb) stress, hydroponic experiments were carried out with rice seedlings (Huarun No.2). The fluorescent probe localization technology was used to locate the reactive oxygen species (ROS) in the root tips of rice seedlings, and the root viability, malondialdehyde (MDA) content, ROS (H
MeSH term(s)	Antioxidants/metabolism ; Melatonin/pharmacology ; Reactive Oxygen Species ; Seedlings ; Oryza/metabolism ; Antimony ; Oxidative Stress ; Hydrogen Peroxide/pharmacology
Chemical Substances	Antioxidants ; Melatonin (JL5DK93RCL) ; Reactive Oxygen Species ; Antimony (9IT35J3UV3) ; Hydrogen Peroxide (BBX060AN9V)
Language	Chinese
Publishing date	2023-02-15
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202205297
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Article: [Protective Effect of Mesenchymal Stem Cell Transplantation on Intestinal Injury in Septic Mice and Its Mechanism].

Deng, Jie / Huang, Shang-Qing / Liu, Jiang-Tao / Li, Wei / Zeng, Jia-Rong / Shi, Hui-Qing / Sun, Hong-Yu

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

2023 Volume 54, Issue 3, Page(s) 565–573

Abstract: Objective: To explore the protective effect of placenta-derived mesenchymal stem cells (P-MSCs) transplantation on intestinal injury in septic mice and its mechanism.: Methods: A total of 24 mice were randomly assigned to 3 groups, a sham operation ... ...

Abstract	Objective: To explore the protective effect of placenta-derived mesenchymal stem cells (P-MSCs) transplantation on intestinal injury in septic mice and its mechanism. Methods: A total of 24 mice were randomly assigned to 3 groups, a sham operation group, a sepsis group that underwent cecal ligation and puncture (CLP) procedure, and a group that received CLP and P-MSCs treatment. Hereinafter, the three groups are referred to as the Sham group, the CLP group, and the CLP+P-MSCs group. For the mice in the Sham group, the abdomen was cut open and the cecum was exposed and then placed back in the abdomen. CLP was performed in the other two groups to establish the sepsis model. Mice in the Sham and the CLP groups received 0.1 mL of 0.9% NaCl injection in the tail vein 1 hour after operation, while mice in the CLP+P-MSCs group received 2×10 Results: The exogenous transplantation of P-MSCs could form colonies in the injured intestines of septic mice. Compared with those of the CLP group, the intestinal injury of the CLP+P-MSCs group was significantly alleviated, the serum concentrations of D-lactic acid, DAO, endotoxin, IL-1β, IL-6, and TNF-α were significantly decreased ( Conclusion: Exogenous transplantation of P-MSCs can significantly reduce inflammatory injury and improve the intestinal barrier function in septic mice with intestinal injury. Reduction in the infiltration of macrophages and promotion of the polarization of macrophages from M1 to M2 may be the mechanisms underlying the reduction of inflammation.
MeSH term(s)	Mice ; Animals ; Tumor Necrosis Factor-alpha ; Interleukin-10 ; Interleukin-6 ; Mesenchymal Stem Cell Transplantation ; Occludin ; Transforming Growth Factor beta ; Sepsis/therapy ; Lactic Acid
Chemical Substances	Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8) ; Interleukin-6 ; Occludin ; Transforming Growth Factor beta ; Lactic Acid (33X04XA5AT)
Language	Chinese
Publishing date	2023-05-29
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2106840-9
ISSN	1672-173X
ISSN	1672-173X
DOI	10.12182/20230560508
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Article: Epigallocatechin-3-gallate attenuates acute pancreatitis induced lung injury by targeting mitochondrial reactive oxygen species triggered NLRP3 inflammasome activation

Luo, Zhu-Lin / Sun, Hong-Yu / Wu, Xiao-Bo / Cheng, Long / Ren, Jian-Dong

Food & function. 2021 June 21, v. 12, no. 12

2021

Abstract: Green tea has been considered as a health-promoting beverage and is widely consumed worldwide. Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol derived from green tea leaves with potent antioxidative and chemopreventive activities, has ... ...

Abstract	Green tea has been considered as a health-promoting beverage and is widely consumed worldwide. Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol derived from green tea leaves with potent antioxidative and chemopreventive activities, has been reported to offer protection against inflammation-driven tissue damage. Here, we evaluated the protective effects of EGCG against lung injury during acute pancreatitis (AP) and further revealed the detailed mechanism. The results showed that EGCG significantly attenuated l-arginine-induced AP and the consequent pulmonary damage in mice. Moreover, EGCG substantially attenuated oxidative stress and concurrently suppressed NOD-like receptor protein 3 (NLRP3) inflammasome activation in the lung. In vitro, EGCG considerably reduced the production of mitochondrial reactive oxygen species (mtROS) and oxidized mitochondrial DNA (ox-mtDNA) in alveolar macrophages (AMs) challenged with AP-conditioned plasma. Meanwhile, the amount of ox-mtDNA bound to NLRP3 decreased significantly by the treatment with EGCG, resulting in impaired NLRP3 inflammasome activation. In addition, the antagonism of NLRP3 signaling by EGCG was affected in the presence of the mtROS stimulant rotenone or scavenger Mito-TEMPO. Altogether, EGCG possesses potent activity to attenuate lung injury during AP progression by inhibiting NLRP3 inflammasome activation. As for the mechanism, the EGCG-conferred restriction of NLRP3 inflammasome activation probably arises from the elimination of mtROS as well as its oxidative product ox-mtDNA, which consequently enables the protection against AP-associated lung injury.
Keywords	antagonism ; beverages ; chemoprevention ; epigallocatechin gallate ; green tea ; health promotion ; inflammasomes ; lungs ; macrophages ; mitochondria ; mitochondrial DNA ; oxidative stress ; pancreatitis ; polyphenols ; reactive oxygen species ; rotenone
Language	English
Dates of publication	2021-0621
Size	p. 5658-5667.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d1fo01154e
Database	NAL-Catalogue (AGRICOLA)

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Article: Ethical issues of the research and practice in forensic genetics.

Liu, Zhi-Yong / Wu, Ri-Ga / Li, Ran / Wang, Qiang-Wei / Sun, Hong-Yu

Yi chuan = Hereditas

2021 Volume 43, Issue 10, Page(s) 994–1002

Abstract: Forensic genetics mainly uses human biological samples as the objects, solves the identification of biological materials related to law by detecting genetic information, provides clues for investigation and evidences for trial, thus facing many ethical ... ...

Abstract	Forensic genetics mainly uses human biological samples as the objects, solves the identification of biological materials related to law by detecting genetic information, provides clues for investigation and evidences for trial, thus facing many ethical issues. This paper put forward the ethical principles in forensic genetics research and practice, and discussed the ethical issues in sample collection, forensic DNA phenotyping, forensic genetic genealogy analysis, forensic DNA database development, paternity and kinship testing, and research data sharing. We suggest that specific ethical requirements should be formulated, the ethical review system should be established for forensic genetics and ethical training for practitioners should be strengthened.
MeSH term(s)	DNA ; Databases, Nucleic Acid ; Forensic Genetics ; Humans
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2021-10-20
Publishing country	China
Document type	Journal Article
ISSN	0253-9772
ISSN	0253-9772
DOI	10.16288/j.yczz.21-202
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Article ; Online: Epigallocatechin-3-gallate attenuates acute pancreatitis induced lung injury by targeting mitochondrial reactive oxygen species triggered NLRP3 inflammasome activation.

Luo, Zhu-Lin / Sun, Hong-Yu / Wu, Xiao-Bo / Cheng, Long / Ren, Jian-Dong

Food & function

2021 Volume 12, Issue 12, Page(s) 5658–5667

Abstract	Green tea has been considered as a health-promoting beverage and is widely consumed worldwide. Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol derived from green tea leaves with potent antioxidative and chemopreventive activities, has been reported to offer protection against inflammation-driven tissue damage. Here, we evaluated the protective effects of EGCG against lung injury during acute pancreatitis (AP) and further revealed the detailed mechanism. The results showed that EGCG significantly attenuated l-arginine-induced AP and the consequent pulmonary damage in mice. Moreover, EGCG substantially attenuated oxidative stress and concurrently suppressed NOD-like receptor protein 3 (NLRP3) inflammasome activation in the lung. In vitro, EGCG considerably reduced the production of mitochondrial reactive oxygen species (mtROS) and oxidized mitochondrial DNA (ox-mtDNA) in alveolar macrophages (AMs) challenged with AP-conditioned plasma. Meanwhile, the amount of ox-mtDNA bound to NLRP3 decreased significantly by the treatment with EGCG, resulting in impaired NLRP3 inflammasome activation. In addition, the antagonism of NLRP3 signaling by EGCG was affected in the presence of the mtROS stimulant rotenone or scavenger Mito-TEMPO. Altogether, EGCG possesses potent activity to attenuate lung injury during AP progression by inhibiting NLRP3 inflammasome activation. As for the mechanism, the EGCG-conferred restriction of NLRP3 inflammasome activation probably arises from the elimination of mtROS as well as its oxidative product ox-mtDNA, which consequently enables the protection against AP-associated lung injury.
MeSH term(s)	Acute Lung Injury/metabolism ; Animals ; Antioxidants/pharmacology ; Catechin/analogs & derivatives ; Catechin/pharmacology ; DNA, Mitochondrial/metabolism ; Disease Models, Animal ; Inflammasomes/drug effects ; Inflammasomes/metabolism ; Inflammation/metabolism ; Lung/pathology ; Lung Injury/drug therapy ; Lung Injury/pathology ; Male ; Mice ; Mitochondria/drug effects ; NLR Family, Pyrin Domain-Containing 3 Protein/drug effects ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Pancreatitis/drug therapy ; Reactive Oxygen Species/metabolism ; Tea/chemistry
Chemical Substances	Antioxidants ; DNA, Mitochondrial ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, mouse ; Reactive Oxygen Species ; Tea ; Catechin (8R1V1STN48) ; epigallocatechin gallate (BQM438CTEL)
Language	English
Publishing date	2021-05-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d1fo01154e
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of abdominal paracentesis drainage on TLR4 expression in liver of rats with early severe acute pancreatitis

CHEN Zhen-yu / HUANG Qi-lin / SUN Hong-yu / LIU Li-ye / WEN Yi

Jichu yixue yu linchuang, Vol 40, Iss 10, Pp 1342-

2020 Volume 1347

Abstract: Objective To investigate the effect of abdominal paracentesis drainage (APD) on TLR4 expression in the liver of rats with early severe acute pancreatitis (SAP) and its significance. Methods The rats were randomly divided into sham operation group (sham ... ...

Abstract	Objective To investigate the effect of abdominal paracentesis drainage (APD) on TLR4 expression in the liver of rats with early severe acute pancreatitis (SAP) and its significance. Methods The rats were randomly divided into sham operation group (sham group), SAP group(SAP model was established by retrograde injection of 5% sodium trasulfide cholate into the pancreatic bile duct) and SAP+APD group(drainage tube was placed and fixed on the basis of SAP). HE staining, automatic biochemical analyzer, ELISA, real-time PCR and Western blot were used to detect relevant indexes. Results Compared with sham group, the pathological injury of liver and pancreas were significantly worse and the pathological scores were significantly increased in the SAP group (P＜0.05), the activityies of serum amylase and lipase, serum indicators related to liver function, and serum levels of TNF-α, IL-1β were also significantly increased (P＜0.05); The mRNA and protein expressions of TLR4, the protein expression of NF-κB p65, TNF-α, IL-1β , and the phosphorylation levels of NF-κB p65 in liver tissues in the SAP group were significantly up-regulated than those in the sham group (P＜0.05); After APD intervention,the above indicators were significantly alleviated (P＜0.05). Conclusions Implementation of APD can significantly decrease the expression of TLR4 in liver tissue of rats with early SAP, inhibit the activation of downstream NF-κB signaling pathway, thus relieve the degree of liver injury.
Keywords	severe acute pancreatitis\|abdominal paracentesis drainage\|liver injury\|toll-like receptor 4\|high mobility group box-1 protein ; Medicine ; R
Subject code	610
Language	Chinese
Publishing date	2020-10-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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