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Article ; Online: The Enigma of Tau Protein Aggregation: Mechanistic Insights and Future Challenges.

Zheng, Huiting / Sun, Huimin / Cai, Qixu / Tai, Hwan-Ching

International journal of molecular sciences

2024 Volume 25, Issue 9

Abstract: Tau protein misfolding and aggregation are pathological hallmarks of Alzheimer's disease and over twenty neurodegenerative disorders. However, the molecular mechanisms of tau aggregation in vivo remain incompletely understood. There are two types of tau ... ...

Abstract	Tau protein misfolding and aggregation are pathological hallmarks of Alzheimer's disease and over twenty neurodegenerative disorders. However, the molecular mechanisms of tau aggregation in vivo remain incompletely understood. There are two types of tau aggregates in the brain: soluble aggregates (oligomers and protofibrils) and insoluble filaments (fibrils). Compared to filamentous aggregates, soluble aggregates are more toxic and exhibit prion-like transmission, providing seeds for templated misfolding. Curiously, in its native state, tau is a highly soluble, heat-stable protein that does not form fibrils by itself, not even when hyperphosphorylated. In vitro studies have found that negatively charged molecules such as heparin, RNA, or arachidonic acid are generally required to induce tau aggregation. Two recent breakthroughs have provided new insights into tau aggregation mechanisms. First, as an intrinsically disordered protein, tau is found to undergo liquid-liquid phase separation (LLPS) both in vitro and inside cells. Second, cryo-electron microscopy has revealed diverse fibrillar tau conformations associated with different neurodegenerative disorders. Nonetheless, only the fibrillar core is structurally resolved, and the remainder of the protein appears as a "fuzzy coat". From this review, it appears that further studies are required (1) to clarify the role of LLPS in tau aggregation; (2) to unveil the structural features of soluble tau aggregates; (3) to understand the involvement of fuzzy coat regions in oligomer and fibril formation.
MeSH term(s)	tau Proteins/chemistry ; tau Proteins/metabolism ; tau Proteins/ultrastructure ; Humans ; Protein Aggregation, Pathological/metabolism ; Animals ; Alzheimer Disease/metabolism ; Protein Aggregates
Chemical Substances	tau Proteins ; Protein Aggregates
Language	English
Publishing date	2024-05-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25094969
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Article ; Online: Highly sensitive surface acoustic wave biosensor for the detection of Hg

Sun, Huimin / Yang, Chunzhen / Wang, Hong

Analytical methods : advancing methods and applications

2023 Volume 15, Issue 36, Page(s) 4728–4735

Abstract: The detection of mercury ions ( ... ...

Abstract	The detection of mercury ions (Hg
MeSH term(s)	Thymine/chemistry ; Gold/chemistry ; Mercury/chemistry ; Biosensing Techniques/methods ; Ions/chemistry
Chemical Substances	Thymine (QR26YLT7LT) ; Gold (7440-57-5) ; Mercury (FXS1BY2PGL) ; Ions
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/d3ay01188g
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Article ; Online: Mindfulness meditation intervention improves the mindfulness awareness level of nurses' second victims to enhance their psychological support.

Li, Jieli / Yan, Xixi / Chen, Guiru / Sun, Huimin

SAGE open nursing

2023 Volume 9, Page(s) 23779608231178136

Abstract: Introduction: The medical staff involved in adverse events, referred to as second victims, usually suffer second victim syndrome endangering their health. Still, there are few organizational support projects in this area in China.: Objective: To ... ...

Abstract	Introduction: The medical staff involved in adverse events, referred to as second victims, usually suffer second victim syndrome endangering their health. Still, there are few organizational support projects in this area in China. Objective: To explore the effect of mindfulness meditation on the level and needs of organizational support, and mindfulness awareness among nurses as second victims. Methods: Forty-six nurses from a comprehensive tertiary hospital in Wuhan, China were selected to participate in the study. This study was conducted using a convenience sampling method for eight weeks of mindfulness meditation intervention. The Second Victim Experience and Support Tool and Mindfulness Attention Awareness Scale were used to assessing the need for support and mindfulness awareness of nurses prior to intervention, during the fourth and eighth weeks of intervention, and at the conclusion of the intervention course. Results: The difference between the scores measured before the intervention, in the fourth week, and in the eighth week of intervention showed that the need for the second victim support from work-related organizations was significant ( Conclusion: Mindfulness meditation intervention is applicable to the second victim population of nurses. It is an effective way to support second victim nurses and can effectively improve their level of mindfulness and awareness.
Language	English
Publishing date	2023-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2865437-7
ISSN	2377-9608 ; 2377-9608
ISSN (online)	2377-9608
ISSN	2377-9608
DOI	10.1177/23779608231178136
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Article ; Online: The association between character strengths and job crafting among nurses in tertiary hospitals: A cross-sectional survey.

Li, Minli / Sun, Huimin / Zhou, Junhui

Nursing open

2023 Volume 10, Issue 8, Page(s) 5720–5727

Abstract: Aim: This study was to investigate the association between character strengths and job crafting among nurses in tertiary hospitals in China.: Design: A cross-sectional survey was conducted.: Methods: From February 2021 to April 2021, 1006 nurses ... ...

Abstract	Aim: This study was to investigate the association between character strengths and job crafting among nurses in tertiary hospitals in China. Design: A cross-sectional survey was conducted. Methods: From February 2021 to April 2021, 1006 nurses from four tertiary hospitals in China were recruited to complete a series of online questionnaires assessing their job crafting and character strengths. The analysis was conducted using structural equation modelling (SEM). Results: The mean scores for task crafting, cognitive crafting and relationship crafting were 3.19 ± 0.58, 3.50 ± 0.55 and 3.58 ± 0.51. There is a moderate level of job crafting and character strengths among Chinese nurses working at tertiary hospitals. Additionally, it was revealed by the SEM that character strengths contributed to 81% of the variance of job crafting and job crafting was positively correlated with nurses' character strengths. The study shows the need to develop nurses' character strengths to enhance job crafting behaviours.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Tertiary Care Centers ; Surveys and Questionnaires ; China ; Nurses
Language	English
Publishing date	2023-05-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2809556-X
ISSN	2054-1058 ; 2054-1058
ISSN (online)	2054-1058
ISSN	2054-1058
DOI	10.1002/nop2.1823
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Article ; Online: Association of Influenza Vaccination and Dementia Risk: A Meta-Analysis of Cohort Studies.

Sun, Huimin / Liu, Min / Liu, Jue

Journal of Alzheimer's disease : JAD

2023 Volume 92, Issue 2, Page(s) 667–678

Abstract: Background: Dementia is a critical global public health problem. Previous cohort studies have found that influenza vaccination can decrease the risk of dementia.: Objective: This meta-analysis aimed to systematically examine the relationship between ... ...

Abstract	Background: Dementia is a critical global public health problem. Previous cohort studies have found that influenza vaccination can decrease the risk of dementia. Objective: This meta-analysis aimed to systematically examine the relationship between influenza vaccination and dementia risk. Methods: We searched PubMed, Embase, Web of Science, ScienceDirect, medRxiv, and bioRxiv for studies investigating dementia risk based on influenza vaccination status, up to September 14, 2022. Relative risks (RRs) and 95% confidence intervals (95% CIs) were pooled in the meta-analysis. Subgroup analyses and sensitivity analyses were conducted as well. Results: Of the 4,087 articles initially reviewed, 6 cohort studies were included in the final meta-analysis, and all eligible studies were at low risk of bias. There were 2,087,195 participants without dementia at baseline (mean age: 61.8-75.5 years, 57.05% males), and 149,804 (7.18%) cases of dementia occurred during 4.00-13.00 years of follow-up. Pooled analysis of adjusted RRs found that influenza vaccination could reduce dementia risk by 31% (RR = 0.69, 95% CI: 0.57-0.83). Subgroup analyses showed that in the study with a mean age of 75-80 years or 75%-100% males, the association was generally weakened compared with studies with a mean age of 60-75 years or 25%-50% males. The results were stable in the sensitivity analyses, and no publication bias was observed. Conclusion: Influenza vaccination in older adults was markedly associated with a decreased risk of dementia. More mechanistic studies and epidemiological studies are needed to clarify the association between influenza vaccination and decreased dementia risk.
MeSH term(s)	Humans ; Aged ; Aged, 80 and over ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Cohort Studies ; Vaccination ; Dementia/epidemiology ; Dementia/prevention & control
Language	English
Publishing date	2023-02-06
Publishing country	Netherlands
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-221036
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Article ; Online: The FTO Mediated N6-Methyladenosine Modification of DDIT4 Regulation with Tumorigenesis and Metastasis in Prostate Cancer.

Zhao, Yue / Hu, Xin / Yu, Haoran / Sun, Huimin / Zhang, Lei / Shao, Chen

Research (Washington, D.C.)

2024 Volume 7, Page(s) 313

Abstract: The progression of numerous malignancies has been linked to N6-methyladenosine (m6A) alteration. However, the opposite trend of m6A levels in the development and metastasis of cancer has not been reported. This study aimed to evaluate the biological ... ...

Abstract	The progression of numerous malignancies has been linked to N6-methyladenosine (m6A) alteration. However, the opposite trend of m6A levels in the development and metastasis of cancer has not been reported. This study aimed to evaluate the biological function and mechanism of fat mass and obesity-associated protein (FTO) in regulating m6A modification in prostate cancer development and epithelial-mesenchymal transition (EMT). An EMT model of LNCaP and PC-3 cells was established with transforming growth factor-β treatment, and FTO knockout cell line was established in prostate cancer cells using the CRISPR/Cas9 gene editing technology. The level of m6A modification in tumor tissues was higher than that in normal prostate tissues; m6A levels were decreased after EMT. FTO deletion increased m6A expression and enhanced PC-3 cell motility, invasion, and EMT both in vitro and in vivo. RNA sequencing and functional investigations suggested that DDIT4, a novel EMT target gene, plays a role in m6A-regulated EMT, which was recognized and stabilized by the m6A effector IGF2BP2/3. Decreased FTO expression was an independent indicator of worse survival, and the level of DDIT4 was considerably elevated in patients with bone metastasis. Thus, this study revealed that the m6A demethylase FTO can play different roles in prostate cancer as a regulator of EMT and an inhibitor of m6A modification. Moreover, DDIT4 can be suggested as a possible biomarker for prostate cancer metastasis prediction.
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ISSN	2639-5274
ISSN (online)	2639-5274
DOI	10.34133/research.0313
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Article ; Online: Transport of polyethylene and polypropylene microplastics under the action of agricultural chemicals: Role of pesticide adjuvants and neonicotinoid active ingredients.

Zhou, Shi / Song, Jie / Sun, Huimin / Jiang, Yanji / Jia, Hongtao / Wang, Jun / Yin, Xianqiang

Environmental research

2024 Volume 252, Issue Pt 2, Page(s) 118975

Abstract: Understanding the impact of various agricultural chemical components on the fate and transport of microplastics (MPs) in the subsurface is essential. In this study, column experiments on saturated porous media were conducted to explore the influence of ... ...

Abstract	Understanding the impact of various agricultural chemical components on the fate and transport of microplastics (MPs) in the subsurface is essential. In this study, column experiments on saturated porous media were conducted to explore the influence of the coexistence environment of pesticide adjuvants (surfactants) and active ingredients (neonicotinoids) on the transport of polyethylene (PE) and polypropylene (PP) MPs. An anionic surfactant (sodium dodecyl sulfate (SDS)), a nonionic surfactant (nonylphenol ethoxylate (NP-40)), and three neonicotinoid insecticides (acetamiprid, dinotefuran, and nitenpyram) could independently increase MP migration by 9.31%-61.01% by improving the hydrophilicity. Acetamiprid or dinotefuran reduced the adhesion work of the binary system by competing with SDS for adsorption sites, thereby inhibiting PE mobility. However, nitenpyram in the mixture was not easily adsorbed on the surface of PE MPs together with SDS because of nitenpyram's high hydrophilicity. Neonicotinoid molecules could not reduce the hydrophilic modification of SDS on PP MPs by competing for adsorption sites. Owing to their weak charge and adhesion work of nonionic surfactants (-4.80 mV and 28.45 kT for PE and -8.21 mV and 17.64 kT for PP), neonicotinoids tended to occupy the adsorption sites originally belonging to NP-40. The long molecular chain of NP-40 made it difficult for high-concentration neonicotinoids to affect the adhesion on MPs. In addition, NP-40 was harder to peel off from the MP surface than SDS, leading to a larger MP transport ability in the sand column.
Language	English
Publishing date	2024-04-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118975
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Article: Aberrant brain topological organization and granger causality connectivity in Parkinson's disease with impulse control disorders.

Gan, Caiting / Zhang, Heng / Sun, Huimin / Cao, Xingyue / Wang, Lina / Zhang, Kezhong / Yuan, Yongsheng

Frontiers in aging neuroscience

2024 Volume 16, Page(s) 1364402

Abstract: Introduction: Impulse control disorders (ICDs) refer to the common neuropsychiatric complication of Parkinson's disease (PD). The white matter (WM) topological organization and its impact on brain networks remain to be established.: Methods: A total ... ...

Abstract	Introduction: Impulse control disorders (ICDs) refer to the common neuropsychiatric complication of Parkinson's disease (PD). The white matter (WM) topological organization and its impact on brain networks remain to be established. Methods: A total of 17 PD patients with ICD (PD-ICD), 17 without ICD (PD-NICD), and 18 healthy controls (HCs) were recruited. Graph theoretic analyses and Granger causality analyses were combined to investigate WM topological organization and the directional connection patterns of key regions. Results: Compared to PD-NICD, ICD patients showed abnormal global properties, including decreased shortest path length (Lp) and increased global efficiency (Eg). Locally, the ICD group manifested abnormal nodal topological parameters predominantly in the left middle cingulate gyrus (MCG) and left superior cerebellum. Decreased directional connectivity from the left MCG to the right medial superior frontal gyrus was observed in the PD-ICD group. ICD severity was significantly correlated with Lp and Eg. Discussion: Our findings reflected that ICD patients had excessively optimized WM topological organization, abnormally strengthened nodal structure connections within the reward network, and aberrant causal connectivity in specific cortical- limbic circuits. We hypothesized that the aberrant reward and motor inhibition circuit could play a crucial role in the emergence of ICDs.
Language	English
Publishing date	2024-04-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2024.1364402
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Article ; Online: Dynamic ion exchange engineering bismuth ferrite-derived Bi

Ai, Luchen / Yin, Huanshun / Wang, Jun / Yin, Xianqiang / Li, Yanyong / Sun, Huimin

Journal of colloid and interface science

2024 Volume 661, Page(s) 815–830

Abstract: Piezoelectric materials can generate the built-in electric field under ultrasound assistance, which is beneficial to the separation of the photogenerated electron-hole pairs in photocatalysis. Meanwhile, the ultrasound stress usually leads to accelerate ... ...

Abstract	Piezoelectric materials can generate the built-in electric field under ultrasound assistance, which is beneficial to the separation of the photogenerated electron-hole pairs in photocatalysis. Meanwhile, the ultrasound stress usually leads to accelerate electron transfer and enhance catalytic activity. Thus, piezo-photocatalysis technique is believed to be one of the effective techniques for organic pollutant degradation. In this work, a binary piezoelectric integrated piezo-photocatalytic Z-Scheme heterojunction with bismuth ferrite (BFO) and bismuth oxycarbonate (Bi
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2024.01.187
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Article ; Online: The synergistic effect of typical chiral organic acids and solution chemistry conditions on the transport of 2-arylpropionic acid chiral derivatives in porous media.

Xu, Duo / Ji, Yantian / Du, Bowen / He, Bo / Chen, Hongyang / Sun, Huimin / Yin, Xianqiang

Environmental pollution (Barking, Essex : 1987)

2024 Volume 351, Page(s) 124059

Abstract: The hazards of man-made chiral compounds are of great public concern, with reports of worrying stereoselective compounds and an urgent need to assess their transport. This study evaluated the transport of 2-arylpropionic acid derivatives enantiomers (2- ... ...

Abstract	The hazards of man-made chiral compounds are of great public concern, with reports of worrying stereoselective compounds and an urgent need to assess their transport. This study evaluated the transport of 2-arylpropionic acid derivatives enantiomers (2-APA) in porous media under a variety of solution chemistry conditions via column packing assays. The results revealed the introduction of Malic acid (MA) enantiomers enhanced the mobility of 2-APA enantiomers, but the enhancement effect was different for different 2-APA enantiomers. Batch sorption experiments confirmed that the MA enantiomers occupied the sorption site of the quartz sand, thus reducing the deposition of the 2-APA enantiomer. Homo- or heterochirality between 2-APA and MA dominates the transport of 2-APA enantiomers, with homochirality between them triggering stronger retention and vice versa. Further evaluating the effect of solution chemistry conditions on the transport of 2-APA enantiomers, increased ionic strength attenuated the mobility of 2-APA enantiomers, whereas introduced coexisting cations enhanced the retention of 2-APA enantiomers in the column. The redundancy analyses corroborated these solution chemistry conditions were negatively correlated with the transport of 2-APA enantiomers. The coupling of pH and these conditions reveals electrostatic forces dominate the transport behavior and stereoselective interactions of 2-APA enantiomers. Distinguishing the transport of enantiomeric pair helps to understand the difference in stereoselectivity of enantiomers and promises to remove the more hazardous one.
Language	English
Publishing date	2024-05-02
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2024.124059
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