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Article ; Online: For COVID-19, what are the priorities of normalized prevention and control strategies?

Luo, Mingyu / Gong, Fuzhe / Sun, Jimin / Gong, Zhenyu

2023 Volume 17, Issue 1, Page(s) 63–67

Abstract: The COVID-19 pandemic has ravaged the world for three years. Most countries have adjusted policies and strategies in response to the burden of COVID-19. The severity of COVID-19 seems to be diminishing as the case fatality rate has declined and the ... ...

Abstract	The COVID-19 pandemic has ravaged the world for three years. Most countries have adjusted policies and strategies in response to the burden of COVID-19. The severity of COVID-19 seems to be diminishing as the case fatality rate has declined and the number of vaccinated people has increased markedly. Given the large population worldwide, we need to pay attention to the continuing COVID-19 burden. Globally, the number of cases remains at a certain level, and the number of cases is still increasing in China. We also need to deal with shortages of medical resources, antipyretics, and home nursing facilities. SARS-CoV-2 will coexist with humans for a long time, and predicting viral mutations and pandemic trends will be difficult. The reform of the whole public health system is imperative. A comprehensive surveillance system should be created to determine the proportion of various pathogens and to guard against mixed infections of respiratory infectious diseases. A comprehensive response mechanism, including preventive measures and medical treatments, should be created as soon as possible to monitor the status of the epidemic and to deal with the long-term health burden of SARS-CoV-2.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Pandemics ; China ; Mutation
Language	English
Publishing date	2023-01-16
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2543899-2
ISSN	1881-7823 ; 1881-7823
ISSN (online)	1881-7823
ISSN	1881-7823
DOI	10.5582/bst.2023.01005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chikungunya in Zhejiang Province, Southeast China.

Ren, Jiangping / Ling, Feng / Liu, Ying / Sun, Jimin

Infectious medicine

2023 Volume 2, Issue 4, Page(s) 315–323

Abstract: Background: Chikungunya is emerging and reemerging word-widely in the past decades. It is non-endemic in Zhejiang Province, Southeast China. Aedes albopictus, one of major vectors of chikungunya, is widely-distribution in Zhejiang, and autochthonous ... ...

Abstract	Background: Chikungunya is emerging and reemerging word-widely in the past decades. It is non-endemic in Zhejiang Province, Southeast China. Aedes albopictus, one of major vectors of chikungunya, is widely-distribution in Zhejiang, and autochthonous transmission is possible after introducing chikungunya virus. Methods: Retrospectively collected the epidemiological, clinical and genetic data of chikungunya and conducted the descriptive analysis and gene sequence analysis. Results: From 2008 to 2022, 29 chikungunya cases, including 26 overseas imported and 3 local cases, were reported and no cases died of chikungunya. More than half of the imported cases (53.85%) were from Southeast Asia. Seasonal peak of the imported cases was noted between August and September, and 42.31% cases onset in those 2 months. Eight prefecture-level cities and 16 counties reported cases during the study period, with Jinghua (27.59%) and Hangzhou (24.14%) reporting the largest number of cases. The 3 local cases were all reported in Qujiang, Quzhou in 2017. For imported cases, the male-female gender ratio was 2.71:1, 20-30 years old cases (46.15%) and commercial service (42.31%) accounted for the highest proportion. Clinically, fever (100%), fatigue (94.44%), arthralgia (79.17%), headache (71.43%) and erythra (65.22%) were the most common reported symptoms. Eight whole-genome sequences were obtained and belonged to East/Central/South African (ECSA) or Asian genotype. Conclusions: With the change of immigration policy, the surveillance of chikungunya should be strengthened and the ability of the case discovery and diagnosis should be improved in Zhejiang in the post-COVID-19 era.
Language	English
Publishing date	2023-11-17
Publishing country	China
Document type	Journal Article
ISSN	2772-431X
ISSN (online)	2772-431X
DOI	10.1016/j.imj.2023.11.005
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Article ; Online: Epidemiology of Hemorrhagic Fever with Renal Syndrome and Host Surveillance in Zhejiang Province, China, 1990-2021.

Su, Fan / Liu, Ying / Ling, Feng / Zhang, Rong / Wang, Zhen / Sun, Jimin

Viruses

2024 Volume 16, Issue 1

Abstract: Hemorrhagic fever with renal syndrome (HFRS) is caused by hantaviruses (HVs) and is endemic in Zhejiang Province, China. In this study, we aimed to explore the changing epidemiology of HFRS cases and the dynamics of hantavirus hosts in Zhejiang Province. ...

Abstract	Hemorrhagic fever with renal syndrome (HFRS) is caused by hantaviruses (HVs) and is endemic in Zhejiang Province, China. In this study, we aimed to explore the changing epidemiology of HFRS cases and the dynamics of hantavirus hosts in Zhejiang Province. Joinpoint regression was used to analyze long-term trends in the incidence of HFRS. The comparison of animal density at different stages was conducted using the Mann-Whitney Test. A comparison of HV carriage rates between stages and species was performed using the chi-square test. The incidence of HFRS shows a continuous downward trend. Cases are widely distributed in all counties of Zhejiang Province except Shengsi County. There was a high incidence belt from west to east, with low incidence in the south and north. The HFRS epidemic showed two seasonal peaks in Zhejiang Province, which were winter and summer. It showed a marked increase in the age of the incidence population. A total of 23,073 minibeasts from 21 species were captured. Positive results were detected in the lung tissues of 14 rodent species and 1 shrew species. A total of 80% of the positive results were from striped field mice and brown rats. No difference in HV carriage rates between striped field mice and brown rats was observed (
MeSH term(s)	Mice ; Rats ; Animals ; Hemorrhagic Fever with Renal Syndrome/epidemiology ; Seasons ; Orthohantavirus ; China/epidemiology ; Incidence ; Shrews ; Murinae
Language	English
Publishing date	2024-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v16010145
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Article ; Online: Ultrasound-Assisted Extraction of

Liang, Minjie / Wu, Yayun / Sun, Jimin / Zhao, Ya / Liu, Lijuan / Zhao, Ruizhi / Wang, Yan

ACS omega

2024 Volume 9, Issue 16, Page(s) 18375–18384

Abstract: Oxaliplatin (OXA) is recognized as a first-line drug for gastric cancer. However, low accumulation of the OXA in the target site and the development of drug resistance directly led to treatment failure. In the present study, an ultrasonic extraction ... ...

Abstract	Oxaliplatin (OXA) is recognized as a first-line drug for gastric cancer. However, low accumulation of the OXA in the target site and the development of drug resistance directly led to treatment failure. In the present study, an ultrasonic extraction method for
Language	English
Publishing date	2024-04-14
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.4c00364
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Article ; Online: Epidemiological Characteristics and Economic Burden of Dengue in Zhejiang Province, China.

Yu, Yi / Liu, Ying / Ling, Feng / Sun, Jimin / Jiang, Jianmin

Viruses

2023 Volume 15, Issue 8

Abstract: Dengue imposes a heavy economic burden on families and society. We used surveillance data reported in 2019 to characterize the dengue epidemic in Zhejiang Province, China, which provided guidance for dengue prevention and control. Dengue epidemics mostly ...

Abstract	Dengue imposes a heavy economic burden on families and society. We used surveillance data reported in 2019 to characterize the dengue epidemic in Zhejiang Province, China, which provided guidance for dengue prevention and control. Dengue epidemics mostly occurred in July to October. People aged 30-44 years, males, and commercial service workers were more likely to suffer from dengue. The epidemic areas were mainly in Hangzhou and Wenzhou. Meanwhile, we assessed the economic cost of dengue in the province from both family and organizational perspectives. The direct economic burden of dengue patients was estimated to be USD 405,038.25, and the indirect economic burden was USD 140,364.90, for a total economic burden of USD 543,213.00. The direct economic burden of dengue patients should be reduced by increasing the coverage and reimbursement of health insurance. Additionally, the total annual cost of dengue prevention and control for the government and organizational sectors was estimated to be USD 7075,654.83. Quantifying the dengue burden is critical for developing disease control strategies, allocating public health resources, and setting health policy priorities.
MeSH term(s)	Male ; Humans ; Financial Stress ; China/epidemiology ; Public Health ; Epidemics ; Dengue/epidemiology
Language	English
Publishing date	2023-08-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15081731
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Article ; Online: Modeling the effects of global cooling and the Tethyan Seaway closure on North African and South Asian climates during the Middle Miocene Climate Transition

Zhang, Jian / Hu, Yongyun / Zhu, Chenguang / Flögel, Sascha / Fang, Xiaomin / Sun, Jimin

Palaeogeography, Palaeoclimatology, Palaeoecology. 2023 June, v. 619 p.111541-

2023

Abstract: The Middle Miocene was a period of prominent climatic change, marked by the Mid-Miocene Climatic Optimum (MMCO) and the subsequent global cooling due to a decline of the atmospheric CO₂ concentrations (pCO₂). In addition to this, the closure of the ... ...

Abstract	The Middle Miocene was a period of prominent climatic change, marked by the Mid-Miocene Climatic Optimum (MMCO) and the subsequent global cooling due to a decline of the atmospheric CO₂ concentrations (pCO₂). In addition to this, the closure of the Tethyan Seaway driven by the Arab-Eurasia collision also had an important effect on the paleoclimatic changes during this period. In this study, we use the Community Earth System Model 1.2.2 (CESM 1.2.2) to simulate the effects of global cooling (i.e. pCO₂ decline) and the closure of the Tethyan Seaway on the North African and South Asian climates. Our results show that the global cooling led to a precipitation decrease over both North Africa and South Asia, whereas the closure of the Tethyan Seaway resulted in a precipitation decrease over North Africa but an increase over South Asia. The opposite effects over North Africa and South Asia are due to an increased moisture transport from North Africa to South Asia induced by stronger summer atmospheric circulation when the Tethyan Seaway is closed. We further show that the reconstructed records of drying conditions over North Africa during the warming period from the late Early Miocene to the early Middle Miocene from previous studies can be partly explained by the narrowing of the Tethyan Seaway and its climatic continuing deterioration due to the subsequent final closure and global cooling. Both are precursory conditions for the formation of the Sahara desert. The stronger South Asian monsoon during the Middle Miocene transient cooling period found in previous studies can be partially attributed to the final closure of the Tethyan Seaway.
Keywords	Miocene epoch ; atmospheric circulation ; carbon dioxide ; climate ; decline ; global cooling ; models ; moisture diffusivity ; monsoon season ; palaeogeography ; paleoclimatology ; paleoecology ; summer ; Northern Africa ; Sahara Desert ; South Asia ; South Asian monsoon ; Middle Miocene Climate Optimum ; Paleoclimate modeling
Language	English
Dates of publication	2023-06
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	417718-6
ISSN	0031-0182
ISSN	0031-0182
DOI	10.1016/j.palaeo.2023.111541
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The impact of EV71 vaccination program on hand, foot and mouth disease in Zhejiang Province, China: A negative control study.

Zheng, Dashan / Shen, Lingzhi / Wen, Wanqi / Ling, Feng / Miao, Ziping / Sun, Jimin / Lin, Hualiang

Infectious Disease Modelling

2023 Volume 8, Issue 4, Page(s) 1088–1096

Abstract: Objective: To estimate the potential causal impact of Enterovirus A71 (EV71) vaccination program on the reduction of EV71-infected hand, foot, and mouth disease (HFMD) in Zhejiang Province.: Methods: We utilized the longitudinal surveillance dataset ... ...

Abstract	Objective: To estimate the potential causal impact of Enterovirus A71 (EV71) vaccination program on the reduction of EV71-infected hand, foot, and mouth disease (HFMD) in Zhejiang Province. Methods: We utilized the longitudinal surveillance dataset of HFMD and EV71 vaccination in Zhejiang Province during 2010-2019. We estimated vaccine efficacy using a Bayesian structured time series (BSTS) model, and employed a negative control outcome (NCO) model to detect unmeasured confounding and reveal potential causal association. Results: We estimated that 20,132 EV71 cases (95% CI: 16,733, 23,532) were prevented by vaccination program during 2017-2019, corresponding to a reduction of 29% (95% CI: 24%, 34%). The effectiveness of vaccination increased annually, with reductions of 11% (95% CI: 6%, 16%) in 2017 and 66% (95% CI: 61%, 71%) in 2019. Children under 5 years old obtained greater benefits compared to those over 5 years. Cities with higher vaccination coverage experienced a sharper EV71 reduction compared to those with lower coverage. The NCO model detected no confounding factors in the association between vaccination and EV71 cases reduction. Conclusions: This study suggested a potential causal effect of the EV71 vaccination, highlighting the importance of achieving higher vaccine coverage to control the HFMD.
Language	English
Publishing date	2023-09-05
Publishing country	China
Document type	Journal Article
ZDB-ID	3015225-2
ISSN	2468-0427 ; 2468-2152
ISSN (online)	2468-0427
ISSN	2468-2152
DOI	10.1016/j.idm.2023.09.001
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Article ; Online: What is always necessary throughout efforts to prevent and control COVID-19 and other infectious diseases? A physical containment strategy and public mobilization and management.

Luo, Mingyu / Sun, Jimin / Gong, Zhenyu / Wang, Zhen

Bioscience trends

2021 Volume 15, Issue 3, Page(s) 188–191

Abstract: The COVID-19 pandemic continues to ravage the world. As many countries have entered the postpandemic period, current efforts to prevent and control COVID-19 have gradually been normalized in many countries. Although the focus is on vaccines to achieve ... ...

Abstract	The COVID-19 pandemic continues to ravage the world. As many countries have entered the postpandemic period, current efforts to prevent and control COVID-19 have gradually been normalized in many countries. Although the focus is on vaccines to achieve herd immunity, conventional physical containment strategies should be reassessed as part of efforts to prevent and control infectious diseases. Continued respiratory protective measures such as social distancing and the wearing of masks have been extensively accepted by the public in most countries. A point worth noticing is that the activities of influenza and other respiratory diseases have decreased as these strategies have been implemented. Public mobilization and large-scale campaigns to promote health are also important to interrupting the transmission of pathogens. A good example can be found in the achievements of China's Patriotic Public Health Campaign. These practices underscore the importance of enhancing physical containment strategies and public mobilization and management, with support from the legal system, to respond to any potential emerging infectious diseases.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/virology ; Humans ; Influenza, Human/epidemiology ; Public Health ; SARS-CoV-2/physiology
Language	English
Publishing date	2021-06-16
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2543899-2
ISSN	1881-7823 ; 1881-7815
ISSN (online)	1881-7823
ISSN	1881-7815
DOI	10.5582/bst.2021.01218
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Article ; Online: Improving explainable AI with patch perturbation-based evaluation pipeline: a COVID-19 X-ray image analysis case study.

Sun, Jimin / Shi, Wenqi / Giuste, Felipe O / Vaghani, Yog S / Tang, Lingzi / Wang, May D

Scientific reports

2023 Volume 13, Issue 1, Page(s) 19488

Abstract: Recent advances in artificial intelligence (AI) have sparked interest in developing explainable AI (XAI) methods for clinical decision support systems, especially in translational research. Although using XAI methods may enhance trust in black-box models, ...

Abstract	Recent advances in artificial intelligence (AI) have sparked interest in developing explainable AI (XAI) methods for clinical decision support systems, especially in translational research. Although using XAI methods may enhance trust in black-box models, evaluating their effectiveness has been challenging, primarily due to the absence of human (expert) intervention, additional annotations, and automated strategies. In order to conduct a thorough assessment, we propose a patch perturbation-based approach to automatically evaluate the quality of explanations in medical imaging analysis. To eliminate the need for human efforts in conventional evaluation methods, our approach executes poisoning attacks during model retraining by generating both static and dynamic triggers. We then propose a comprehensive set of evaluation metrics during the model inference stage to facilitate the evaluation from multiple perspectives, covering a wide range of correctness, completeness, consistency, and complexity. In addition, we include an extensive case study to showcase the proposed evaluation strategy by applying widely-used XAI methods on COVID-19 X-ray imaging classification tasks, as well as a thorough review of existing XAI methods in medical imaging analysis with evaluation availability. The proposed patch perturbation-based workflow offers model developers an automated and generalizable evaluation strategy to identify potential pitfalls and optimize their proposed explainable solutions, while also aiding end-users in comparing and selecting appropriate XAI methods that meet specific clinical needs in real-world clinical research and practice.
MeSH term(s)	Humans ; Artificial Intelligence ; COVID-19/diagnostic imaging ; X-Rays ; Benchmarking ; Decision Support Systems, Clinical
Language	English
Publishing date	2023-11-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-46493-2
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Article: Enhanced aridification across the Eocene/Oligocene transition evidenced by geochemical record in the Tajik Basin, Central Asia

Sun, Jimin / Liu, Weiguo / Guo, Zhengtang / Qi, Liang / Zhang, Zhiliang

Global and planetary change. 2022 Apr., v. 211

2022

Abstract: The Tajik Basin is an intermontane depression between the mountain ranges of Tian Shan, Pamir, and Hindukush, which is located in the northwestern part of the India-Asia collision zone. Due to the westward retreat of the Neotethys Sea, the ... ...

Abstract	The Tajik Basin is an intermontane depression between the mountain ranges of Tian Shan, Pamir, and Hindukush, which is located in the northwestern part of the India-Asia collision zone. Due to the westward retreat of the Neotethys Sea, the paleoenvironment of the Tajik Basin has underwent change from a shallow-sea to a continental semiarid land during the Cenozoic era. This implies that the long-term climatic record in the Tajik Basin can potentially reflect the environmental effects of the changed land-sea distributions controlled by plate collision and global eustatic sea-level changes. In this paper, we present new results of stable oxygen and carbon isotopes of carbonates and chemical weathering indices of bulk samples from the Eocene-Oligocene terrestrial strata (ca. 39–30 Ma) in the center of the Tajik Basin. The temporal variations of oxygen and carbon isotopes of carbonates indicate an isotopic shift across the Eocene-Oligocene transition (~34 Ma), characterized by a relatively positive shift due to the isotopic enrichment in authigenic carbonates in an enhanced aridification episode in the Tajik Basin. This shift was also mirrored by the weakened chemical weathering indicated by the ratios of major oxides across the Eocene-Oligocene transition. Such a regional climatic shift was generally coincident with a remarkable global scale sea-level drop. We suggest that the isolated Paratethys Sea, which was mainly driven by global cooling due to the initial formation of the Antarctica Ice-sheet, together with the decreased seawater evaporation due to lower sea surface temperature, reduced water vapor transport by westerlies to the downwind region, and thus intensified the aridification in the Tajik Basin began at ~34 Ma.
Keywords	Eocene epoch ; Oligocene epoch ; arid lands ; basins ; evaporation ; isotopic enrichment ; oxygen ; paleoecology ; sea level ; seawater ; surface water temperature ; water vapor ; Antarctica ; Central Asia
Language	English
Dates of publication	2022-04
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2016967-X
ISSN	0921-8181
ISSN	0921-8181
DOI	10.1016/j.gloplacha.2022.103789
Database	NAL-Catalogue (AGRICOLA)

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