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  1. Article: [Initiative and vigorous promotion for applying big data in pediatric multi-center clinical research].

    Sun, K

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2021  Volume 59, Issue 8, Page(s) 621–623

    MeSH term(s) Big Data ; Child ; Humans
    Language Chinese
    Publishing date 2021-07-31
    Publishing country China
    Document type Journal Article
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
    DOI 10.3760/cma.j.cn112140-20210204-00107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3292: Show issues Location:
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  2. Article: [Segmental atrophy of liver: a clinicopathological analysis of six cases].

    Deng, R X / Sun, K

    Zhonghua bing li xue za zhi = Chinese journal of pathology

    2023  Volume 52, Issue 12, Page(s) 1272–1274

    MeSH term(s) Humans ; Liver/pathology ; Atrophy/pathology
    Language Chinese
    Publishing date 2023-12-06
    Publishing country China
    Document type Journal Article
    ZDB-ID 784533-9
    ISSN 0529-5807
    ISSN 0529-5807
    DOI 10.3760/cma.j.cn112151-20230726-00029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Colloquialization as a key factor in historical changes of rational and emotional words.

    Sun, Kun

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 26, Page(s) e2205563119

    MeSH term(s) Emotions ; Humans ; Semantics ; Speech
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2205563119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  4. Article ; Online: The effects of childhood maltreatment, recent interpersonal and noninterpersonal stress, and HPA-axis multilocus genetic variation on prospective changes in adolescent depressive symptoms: A multiwave longitudinal study.

    Sun, Kexin / Cao, Cong

    Development and psychopathology

    2024  , Page(s) 1–12

    Abstract: Based on a multiwave, two-year prospective design, this study is the first to examine the extent to which multilocus hypothalamic-pituitary-adrenal axis (HPA axis)-related genetic variants, childhood maltreatment, and recent stress jointly predicted ... ...

    Abstract Based on a multiwave, two-year prospective design, this study is the first to examine the extent to which multilocus hypothalamic-pituitary-adrenal axis (HPA axis)-related genetic variants, childhood maltreatment, and recent stress jointly predicted prospective changes in adolescent depressive symptoms. A theory-driven multilocus genetic profile score (MGPS) was calculated to combine the effects of six common polymorphisms within HPA-axis related genes (
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1036173-x
    ISSN 1469-2198 ; 0954-5794
    ISSN (online) 1469-2198
    ISSN 0954-5794
    DOI 10.1017/S0954579424000269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Theoretical formulation of chemical equilibrium under vibrational strong coupling.

    Sun, Kaihong / Ribeiro, Raphael F

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2405

    Abstract: Experiments have suggested that strong interactions between molecular ensembles and infrared microcavities can be employed to control chemical equilibria. Nevertheless, the primary mechanism and key features of the effect remain largely unexplored. In ... ...

    Abstract Experiments have suggested that strong interactions between molecular ensembles and infrared microcavities can be employed to control chemical equilibria. Nevertheless, the primary mechanism and key features of the effect remain largely unexplored. In this work, we develop a theory of chemical equilibrium in optical microcavities, which allows us to relate the equilibrium composition of a mixture in different electromagnetic environments. Our theory shows that in planar microcavities under strong coupling with polyatomic molecules, hybrid modes formed between all dipole-active vibrations and cavity resonances contribute to polariton-assisted chemical equilibrium shifts. To illustrate key aspects of our formalism, we explore a model S
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46442-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Genetic predisposition of

    Sun, Kai / Liu, Ruiyu

    Cell cycle (Georgetown, Tex.)

    2024  , Page(s) 1–12

    Abstract: Bone morphogenetic protein 7 (BMP7) can induce skeletal formation, promote the differentiation of chondrocytes and osteoblasts, and ameliorate intervertebral disc degeneration. The study was designed to evaluate the relationship ... ...

    Abstract Bone morphogenetic protein 7 (BMP7) can induce skeletal formation, promote the differentiation of chondrocytes and osteoblasts, and ameliorate intervertebral disc degeneration. The study was designed to evaluate the relationship of
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2024.2342703
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
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  7. Article ; Online: Antiosteoporosis effect of bryodulcosigenin on ovariectomy-induced osteoporosis in experimental rats.

    Sun, Kai / Qin, Lin

    Acta cirurgica brasileira

    2024  Volume 39, Page(s) e391024

    Abstract: Purpose: Osteoporosis is a bone disease which commonly occurred in postmenopausal women. Almost 10 percent of world population and approximately 30% of women (postmenopausal) suffer from this disease. Alternative medicine has great success in the ... ...

    Abstract Purpose: Osteoporosis is a bone disease which commonly occurred in postmenopausal women. Almost 10 percent of world population and approximately 30% of women (postmenopausal) suffer from this disease. Alternative medicine has great success in the treatment of osteoporosis disease. Bryodulcosigenin, a potent phytoconstituent, already displayed the anti-inflammatory and antioxidant effect. In this study, we made effort to analyze the antiosteoporosis effect of bryodulcosigenin against ovariectomy (OVX) induced osteoporosis in rats.
    Methods: Swiss albino Wistar rats were grouped into fIve groups and given an oral dose of bryodulcosigenin (10, 20 and 30 mg/kg) for eight weeks. Body weight, uterus, bone mineral density, cytokines, hormones parameters, transforming growth factor (TGF)-β, insulin-like growth factor (IGF), osteoprotegerin (OPG), receptor activator of nuclear factor kappa-Β ligand (RANKL), and its ratio were estimated.
    Results: Bryodulcosigenin significantly (p < 0.001) suppressed the body weight and enhanced the uterine weight and significantly (p < 0.001) increased the bone mineral density in whole femur, caput femoris, distal femur and proximal femur. Bryodulcosigenin significantly (P < 0.001) altered the level of biochemical parameters at dose dependent manner, significantly (P < 0.001) improved the level of estrogen and suppressed the level of follicle stimulating hormone and luteinizing hormone. Bryodulcosigenin significantly (P < 0.001) improved the level of OPG and suppressed the level of RANKL.
    Conclusions: Bryodulcosigenin reduced the cytokines level and suppressed the TGF-β and IGF. We concluded that bryodulcosigenin is an antiosteoporosis medication based on the findings.
    MeSH term(s) Animals ; Female ; Rats, Wistar ; Ovariectomy ; Bone Density/drug effects ; Osteoporosis/drug therapy ; Osteoporosis/prevention & control ; Osteoporosis/etiology ; Rats ; Body Weight/drug effects ; Disease Models, Animal ; Uterus/drug effects ; Cytokines/blood ; Cytokines/drug effects ; Femur/drug effects ; Treatment Outcome
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-04-22
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2012156-8
    ISSN 1678-2674 ; 1678-2674
    ISSN (online) 1678-2674
    ISSN 1678-2674
    DOI 10.1590/acb391024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Historical Patterns and Recent Impacts of Chinese Investors in United States Real Estate

    Sun, Kevin

    2022  

    Abstract: Since supplanting Canada in 2014, Chinese investors have been the lead foreign buyers of U.S. real estate, concentrating their purchases in urban areas with higher Chinese populations like California. The reasons for investment include prestige, freedom ... ...

    Abstract Since supplanting Canada in 2014, Chinese investors have been the lead foreign buyers of U.S. real estate, concentrating their purchases in urban areas with higher Chinese populations like California. The reasons for investment include prestige, freedom from capital confiscation, and safe, diversified opportunities from abroad simply being more lucrative and available than in their home country, where the market is eroding. Interestingly, since 2019, Chinese investors have sold a net 23.6 billion dollars of U.S. commercial real estate, a stark contrast to past acquisitions between 2013 to 2018 where they were net buyers of almost 52 billion dollars worth of properties. A similar trend appears in the residential real estate segment too. In both 2017 and 2018, Chinese buyers purchased over 40,000 U.S. residential properties which were halved in 2019 and steadily declined to only 6,700 in the past year. This turnaround in Chinese investment can be attributed to a deteriorating relationship between the U.S. and China during the Trump Presidency, financial distress in China, and new Chinese government regulations prohibiting outbound investments. Additionally, while Chinese investment is a small share of U.S. real estate (~1.5% at its peak), it has outsized impacts on market valuations of home prices in U.S. zip codes with higher populations of foreign-born Chinese, increasing property prices and exacerbating the issue of housing affordability in these areas. This paper investigates the rapid growth and decline of Chinese investment in U.S. real estate and its effect on U.S. home prices in certain demographics.

    Comment: 23 pages, 4 figures, presented at the 2022 Southern California Conference for Undergraduate Research (SCCUR), preprint for publishing in research journal, currently in the peer-review process
    Keywords Economics - General Economics
    Subject code 303
    Publishing date 2022-12-28
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Clonal hematopoiesis: background player in plasma cell-free DNA variants.

    Sun, Kun

    Annals of translational medicine

    2020  Volume 7, Issue Suppl 8, Page(s) S384

    Language English
    Publishing date 2020-01-03
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2019.12.97
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Ktrim: an extra-fast and accurate adapter- and quality-trimmer for sequencing data.

    Sun, Kun

    Bioinformatics (Oxford, England)

    2020  Volume 36, Issue 11, Page(s) 3561–3562

    Abstract: Motivation: Next-generation sequencing (NGS) data frequently suffer from poor-quality cycles and adapter contaminations therefore need to be preprocessed before downstream analyses. With the ever-growing throughput and read length of modern sequencers, ... ...

    Abstract Motivation: Next-generation sequencing (NGS) data frequently suffer from poor-quality cycles and adapter contaminations therefore need to be preprocessed before downstream analyses. With the ever-growing throughput and read length of modern sequencers, the preprocessing step turns to be a bottleneck in data analysis due to unmet performance of current tools. Extra-fast and accurate adapter- and quality-trimming tools for sequencing data preprocessing are therefore still of urgent demand.
    Results: Ktrim was developed in this work. Key features of Ktrim include: built-in support to adapters of common library preparation kits; supports user-supplied, customized adapter sequences; supports both paired-end and single-end data; supports parallelization to accelerate the analysis. Ktrim was ∼2-18 times faster than current tools and also showed high accuracy when applied on the testing datasets. Ktrim could thus serve as a valuable and efficient tool for short-read NGS data preprocessing.
    Availability and implementation: Source codes and scripts to reproduce the results descripted in this article are freely available at https://github.com/hellosunking/Ktrim/, distributed under the GPL v3 license.
    Contact: sunkun@szbl.ac.cn.
    Supplementary information: Supplementary data are available at Bioinformatics online.
    MeSH term(s) Data Analysis ; High-Throughput Nucleotide Sequencing ; Licensure ; Software
    Language English
    Publishing date 2020-03-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btaa171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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