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Article: Spatial-temporal changes of landscape and habitat quality in typical ecologically fragile areas of western China over the past 40 years: A case study of the Ningxia Hui Autonomous Region.

Wang, Ding / Hao, Haiguang / Liu, Hao / Sun, Lihui / Li, Yuyang

2024 Volume 14, Issue 1, Page(s) e10847

Abstract: In this paper, we use the InVEST model and five periods of land use data from 1980 to 2020 to assess the habitat quality of the Ningxia Hui Autonomous Region in Western China, which has characteristics of a typical fragile ecosystem. We further analyse ... ...

Abstract	In this paper, we use the InVEST model and five periods of land use data from 1980 to 2020 to assess the habitat quality of the Ningxia Hui Autonomous Region in Western China, which has characteristics of a typical fragile ecosystem. We further analyse the spatial and temporal characteristics of habitat quality evolution and its relationship with land use and landscape pattern indices to explore the close relationship between regional habitat quality changes and human natural resource conservation and utilization. The research results show that the overall habitat quality of Ningxia Hui Autonomous Region was stable and at a moderate level (0.57-0.60) during the 40 years from 1980 to 2020; Habitat patches (2020) with low (24.89%), high (22.45%) and very high (29.81%) quality occupy a larger proportion of the area, followed by very low (13.31%) and moderate levels (9.54%). Over the past 40 years, there have been 275 sample sites in Ningxia where habitat quality has deteriorated, 1593 sample sites where the habitat quality has remained stable, and 184 sample sites where the habitat quality has increased. From 1980 to 2020, the Mean Patch Area of landscape types in Ningxia decreased by 25.9 hm
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.10847
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Article ; Online: TRIM29 knockdown prevented the colon cancer progression through decreasing the ubiquitination levels of KRT5.

Sun, Lihui / Wang, Dawei / Chen, Zhenyu / Zhu, Xu

Open life sciences

2023 Volume 18, Issue 1, Page(s) 20220711

Abstract: To investigate the specific role of TRIM29 in colon cancer progression, bioinformatic analysis was performed on TRIM29. Colon cancer tissues were collected and colon cancer cells were cultured for further experiments. Cell viability and proliferation ... ...

Abstract	To investigate the specific role of TRIM29 in colon cancer progression, bioinformatic analysis was performed on TRIM29. Colon cancer tissues were collected and colon cancer cells were cultured for further experiments. Cell viability and proliferation were determined using CCK-8, colony formation, and EDU staining assays. The mRNA and protein levels of TRIM29 and KRT5 were determined using quantitative real-time PCR and western blotting, respectively. The interaction between TRIM29 and KRT5 was detected using a co-immunoprecipitation (CO-IP) assay. Cycloheximide treatment was performed to analyse the stability of KRT5. TRIM29 was upregulated in colon cancer tissues and cells. TRIM29 knockdown decreased the cell viability and proliferation and ubiquitination levels of KRT5 and enhanced the protein stability and expression of KRT5. The CO-IP assay confirmed that TRIM29 and KRT5 binded to each other. KRT5 knockdown neutralises the inhibitory effect of sh-TRIM29 on colon cancer cell growth and TRIM29 knockdown prevented the proliferation of colon cancer cells by decreasing ubiquitination of KRT5, which enhanced the protein stability and expression of KRT5 in cancer cells. Thus, targeting TRIM29-mediated ubiquitination levels of KRT5 might be a new direction for colon cancer therapy.
Language	English
Publishing date	2023-08-30
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2817958-4
ISSN	2391-5412 ; 2391-5412
ISSN (online)	2391-5412
ISSN	2391-5412
DOI	10.1515/biol-2022-0711
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Article ; Online: ABCE1 selectively promotes HIF-1α transactivation of angiogenic gene expression.

Sun, Lihui / Ding, Xueqin / Kang, Y James

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

2023 Volume 80, Page(s) 127307

Abstract: Background: Copper (Cu), by inhibiting the factor inhibiting HIF-1 (FIH-1), promotes the transcriptional activity of hypoxia-inducible factor-1 (HIF-1).: Objective: The present study was undertaken to understand the molecular mechanism by which Cu ... ...

Abstract	Background: Copper (Cu), by inhibiting the factor inhibiting HIF-1 (FIH-1), promotes the transcriptional activity of hypoxia-inducible factor-1 (HIF-1). Objective: The present study was undertaken to understand the molecular mechanism by which Cu inhibits FIH-1. Methods: Human umbilical vein endothelial cells (HUVECs) were treated with dimethyloxalylglycine (DMOG) resulting in HIF-1α accumulation and the FIH-1 protein complexes were pulled down for candidate protein analysis. The metal binding sites were predicted by both MetalDetector V2.0 and Metal Ion-Binding Site Prediction Server, and then the actual ability to bind to Cu in vitro was tested by both Copper-Immobilized metal affinity chromatography (Cu-IMAC) and Isothermal Titration Calorimetry (ITC). Subsequently, subcellular localization was monitored by immunocytochemistry, GFP-fusion protein expression plasmid and Western blotting in the nuclear extract. The interaction of candidate protein with HIF-1α and FIH-1 was validated by Co-Immunoprecipitation (Co-IP). Finally, the effect of candidate protein on the FIH-1 structure and HIF-1α transcriptional activity was analyzed by the InterEvDock3 web server and real-time quantitative RT-PCR. Results: ATP-binding cassette E1 (ABCE1) was present in the FIH-1 complexes and identified as a leading Cu-binding protein as indicated by a number of possible Cu binding sites. The ability of ABCE1 to bind Cu was demonstrated in vitro. ABCE1 entered the nucleus along with FIH-1 under hypoxic conditions. Protein interaction analysis revealed that ABCE1 prevented FIH-1 to bind iron ions, inhibiting FIH-1 enzymatic activity. ABCE1 silencing suppressed the expression of Cu-dependent HIF-1 target gene BNIP3, not that of Cu-independent IGF-2. Conclusion: The results demonstrate that ABCE1, as a Cu-binding protein, enters the nucleus under hypoxic conditions and inhibits FIH-1degradation of HIF-1α, thus promoting HIF-1 transactivation of angiogenic gene expression.
MeSH term(s)	Humans ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Carrier Proteins/metabolism ; Copper/pharmacology ; Copper/metabolism ; Endothelial Cells/metabolism ; Gene Expression ; Hypoxia ; Mixed Function Oxygenases/genetics ; Mixed Function Oxygenases/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Transcriptional Activation
Chemical Substances	ABCE1 protein, human ; ATP-Binding Cassette Transporters ; Carrier Proteins ; Copper (789U1901C5) ; Mixed Function Oxygenases (EC 1.-) ; Repressor Proteins ; HIF1A protein, human
Language	English
Publishing date	2023-09-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1236267-0
ISSN	1878-3252 ; 1611-602X ; 0946-672X
ISSN (online)	1878-3252 ; 1611-602X
ISSN	0946-672X
DOI	10.1016/j.jtemb.2023.127307
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Article ; Online: Developing pre-service teachers' computational thinking: a systematic literature review.

Dong, Wei / Li, Yongjie / Sun, Lihui / Liu, Yiran

International journal of technology and design education

2023 , Page(s) 1–37

Abstract: Recently, computational thinking (CT) has gained importance in education systems worldwide, specifically the CT training of pre-service teachers. This study conducted a systematic literature analysis (2011-2021) of 38 works on pre-service teachers' CT ... ...

Abstract	Recently, computational thinking (CT) has gained importance in education systems worldwide, specifically the CT training of pre-service teachers. This study conducted a systematic literature analysis (2011-2021) of 38 works on pre-service teachers' CT based on Web of Science, Science Direct, and Google Scholar databases. The results were as follows: (1) Six training methods were found, (2) CT training effectively improved pre-service teachers' CT, (3) A positive relationship was found between pre-service teachers' CT ability and the five factors affecting the ability, (4) A mode of training to improve CT ability of pre-service teachers and the relationship between CT ability and teaching methods were considered. This study suggested ideas for designing training modules of CT ability and a reference for realizing the best training effect. Finally, future research trends and a general model of training were presented as references for researchers, instructors, and policy makers to promote the CT of pre-service teachers.
Language	English
Publishing date	2023-02-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2016164-5
ISSN	1573-1804 ; 0957-7572
ISSN (online)	1573-1804
ISSN	0957-7572
DOI	10.1007/s10798-023-09811-3
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Article ; Online: A new perspective on anthropogenic nitrogen loss mitigation strategies: Integrated control via sustainable regional integration.

Zhang, Zeqian / Sun, Lihui / Deng, Chenning / Dong, Li / Xu, Rui / Nie, Chong / Yang, Queping

The Science of the total environment

2024 Volume 916, Page(s) 170188

Abstract: Unregulated regional integrated development disrupts the reactive nitrogen (Nr) cycle, adding complexity to anthropogenic Nr environmental losses. The objective of this study was to establish a framework for mitigating anthropogenic Nr loss through a new ...

Abstract	Unregulated regional integrated development disrupts the reactive nitrogen (Nr) cycle, adding complexity to anthropogenic Nr environmental losses. The objective of this study was to establish a framework for mitigating anthropogenic Nr loss through a new regional integration perspective by analyzing anthropogenic Nr loss and integrated control strategies in the Yangtze River Delta (YRD) region from 2011 to 2020. The results revealed that the total Nr loss in the YRD ranged from 1780.7 to 1972.0 Gg N yr
Language	English
Publishing date	2024-01-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.170188
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Zs.A 949: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Life cycle assessment of rice bran oil production: a case study in China.

Sun, Li-Hui / Wang, Yu-Ying / Gong, Yu-Qing

Environmental science and pollution research international

2022 Volume 29, Issue 26, Page(s) 39847–39859

Abstract: Environmental problems caused by the food processing industry have always been one of the concerns for the public. Herein, for the first time, a gate-to-gate life cycle assessment (LCA) was employed to evaluate the environmental impact of rice bran oil ... ...

Abstract	Environmental problems caused by the food processing industry have always been one of the concerns for the public. Herein, for the first time, a gate-to-gate life cycle assessment (LCA) was employed to evaluate the environmental impact of rice bran oil production. Four subsystems, namely, transportation of the raw rice bran to oil factory, crude oil extraction, oil refining, and oil storage, were established. The product sustainability software GaBi and the method CML 2001-Jan. 2016 were used to calculate and analyze the environmental burdens at each stage of the rice bran oil production chain. The results show the oil refining stage had the greatest environmental impact, followed by the oil extraction stage. High demands for coal and electricity make a critical difference in generating vast majority of environmental impacts. Modifying the electricity source and replacing traditional fuels with cleaner ones will do bring benefits to the sustainable development of the industry.
MeSH term(s)	Animals ; Electricity ; Environment ; Life Cycle Stages ; Oryza ; Petroleum ; Rice Bran Oil
Chemical Substances	Petroleum ; Rice Bran Oil (LZO6K1506A)
Language	English
Publishing date	2022-02-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-18172-0
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Article ; Online: Dynamic change of habitat quality and its key driving factors in Ningxia Hui Autonomous Region, China

Wang, Ding / Hao, Haiguang / Liu, Hao / Sun, Lihui / Li, Yuyang

Nature Conservation. 2023 Aug. 16, v. 53 p.125-155

2023

Abstract: AbstractHabitat quality reflects the level of biodiversity, and habitat maintenance functions are related to human well-being and ecosystem stability. Ningxia Hui Autonomous Region is a typical ecologically fragile region in Western China with complex ... ...

Abstract	AbstractHabitat quality reflects the level of biodiversity, and habitat maintenance functions are related to human well-being and ecosystem stability. Ningxia Hui Autonomous Region is a typical ecologically fragile region in Western China with complex human-nature relationships. Maintaining good habitat is not only a fundamental requirement for biodiversity conservation but also a necessary path for sustainable regional development. In this study, we assessed and analysed the spatial and temporal patterns and changes in habitat quality in Ningxia from 2000 to 2020, and explored the driving factors of habitat quality using a geographically weighted regression (GWR) model. The results indicated: (1) The overall habitat quality level in Ningxia was low to intermediate, with an upwards and then downwards trend during the past 20 years, showing a small change in overall magnitude. (2) The high- and higher-level habitat quality patches in Ningxia were mainly distributed in areas with high vegetation cover, such as the Helan Mountain and Liupan Mountain. The patches of moderate-level habitat quality mainly included cultivated land, while the low- and lower-level patches were mainly distributed in areas subjected to more frequent human activities, such as cultivated land and construction land. (3) The spatial and temporal distribution patterns and changes in habitat quality in Ningxia from 2000 to 2020 were mainly influenced by fractional vegetation cover (FVC), soil moisture content (SMC), proportion of construction land area (PCL), and proportion of cultivated land area (CLP). Among them, FVC and SMC were positive driving factors, and PCL and CLP were negative driving factors. The results support that increasing vegetation cover and reducing anthropogenic disturbance to natural habitats are important measures to maintain fragile habitats and that key ecological function areas such as nature reserves are crucial for habitat quality protection in ecologically fragile areas.
Keywords	agricultural land ; anthropogenic activities ; biodiversity ; biodiversity conservation ; ecological balance ; ecological function ; fractional vegetation cover ; habitats ; humans ; models ; social welfare ; soil water content ; China ; Driving factors ; geographically weighted regression (GWR) ; habitat quality ; Ningxia Hui Autonomous Region ; spatiotemporal pattern
Language	English
Dates of publication	2023-0816
Size	p. 125-155.
Publishing place	Pensoft Publishers
Document type	Article ; Online
ZDB-ID	2667603-5
ISSN	1314-3301
ISSN	1314-3301
DOI	10.3897/natureconservation.53.102810
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Enhancement of Optomechanical Squeezing of Light Using the Optical Coherent Feedback.

Wu, Zhenhua / Yi, Zhen / Gu, Wenju / Sun, Lihui / Ficek, Zbigniew

Entropy (Basel, Switzerland)

2022 Volume 24, Issue 12

Abstract: A coherent feedback scheme is used to enhance the degree of squeezing of the output field in a cavity optomechanical system. In the feedback loop, a beam splitter (BS) plays the roles of both a feedback controller and an input-output port. To realize ... ...

Abstract	A coherent feedback scheme is used to enhance the degree of squeezing of the output field in a cavity optomechanical system. In the feedback loop, a beam splitter (BS) plays the roles of both a feedback controller and an input-output port. To realize effective enhancement, the output quadrature should take the same form as the input quadrature, and the system should operate at the deamplification situation in the meantime. This can be realized by choosing an appropriate frequency-dependent phase angle for the generalized quadrature. Additionally, both the transmissivity of the BS and the phase factor induced by time delays in the loop affect optical squeezing. For the fixed frequency, the optimal values of transmissivity and phase factor can be used to achieve the enhanced optical squeezing. The effect of optical losses on squeezing is also discussed. Optical squeezing is degraded by the introduced vacuum noise owing to the inefficient transmission in the loop. We show that the enhancement of squeezing is achievable with the parameters of the current experiments.
Language	English
Publishing date	2022-11-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e24121741
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Article ; Online: Zoning method of aquatic ecosystem functional management fourth-level region in the Daqing River Basin, China.

Sun, Lihui / Shu, Chang / Ding, Lin / Tian, Ziqiang / Liu, Hao

Journal of environmental management

2022 Volume 327, Page(s) 116870

Abstract: Watershed management needs more information on ecological function and services in large regions. Spatial units are particularly important for the watershed management. Zoning of aquatic ecosystem functional management region refers to the zoning of ... ...

Abstract	Watershed management needs more information on ecological function and services in large regions. Spatial units are particularly important for the watershed management. Zoning of aquatic ecosystem functional management region refers to the zoning of terrestrial ecosystems as per the characteristics of aquatic ecosystems, providing an ecological background and basic spatial units for water environment management in basins. Although basin water environment management based on aquatic ecosystem functional management region and control unit is highly effective in practice, the current need for refined management of water environments cannot be met by existing zoning schemes of aquatic ecosystem functional management regions and control units. In response to the need to protect basin water environments, which is raised in the 14th Five-Year plan, a zoning method of aquatic ecosystem functional management fourth-level region for basins is proposed in this study. It features an effective integration of aquatic ecosystem functional management regions and control units and township-level administrative divisions, thus contributing to the implementation of a basin water environment management system that fulfils the zoning, grading, classification and period goals of aquatic ecosystem functional management. In this way, it can satisfy the business application of administrative management and refined management of water environments, which features coupling terrestrial and aquatic ecosystems and unification of water resources, water environments and aquatic ecology. The feasibility and effectiveness of the proposed zoning method were verified by using the Daqing River Basin, Beijing-Tianjin-Hebei region, China, as a case study. The results were accepted by the Ministry of Ecology and Environment and the Haihe River Water Conservancy Commission of the Ministry of Water Resources, which can provide scientific rationale and technical support for the accurate and differentiated watershed water environments management and ecological restoration of coastal wetlands in the Haihe River Basin based on aquatic ecosystem functional management fourth-level region with clear responsibility for the local government during the period of the 14th Five-Year plan.
Language	English
Publishing date	2022-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2022.116870
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Article: Molecular mechanism of Cuscutae semen-radix rehmanniae praeparata in relieving reproductive injury of male rats induced with tripterygium wilfordii multiglycosides: A tandem mass tag-based proteomics analysis.

Han, Shanshan / Dai, Yanlin / Sun, Lihui / Xing, Yaping / Ding, Ying / Zhang, Xia / Xu, Shanshan

Frontiers in pharmacology

2023 Volume 14, Page(s) 1050907

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1050907
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