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Article: Associations among Stroke, Myocardial Infarction, and Amaurosis Fugax in a Tertiary Referral Hospital in Taiwan.

Sun, Ming-Hui / Ognoo, Nomin-Erdene

2022 Volume 11, Issue 17

Abstract: Background: To determine the associations among carotid stenosis, stroke, and myocardial infarction (MI) in patients with amaurosis fugax (AF).: Methods: We retrospectively reviewed the records of patients diagnosed as having AF between January 2000 ... ...

Abstract	Background: To determine the associations among carotid stenosis, stroke, and myocardial infarction (MI) in patients with amaurosis fugax (AF). Methods: We retrospectively reviewed the records of patients diagnosed as having AF between January 2000 and December 2019. Among 14,857 patients with AF initially reviewed in the database, only 173 were ultimately enrolled, after excluding patients with wrong diagnosis, insufficient medical records, or loss of follow-up. Results: Of the 173 patients with AF, 61 (35.3%) had carotid stenosis, and among them, 18 (10.4%) had severe stenosis. In multivariate regression analysis, carotid stenosis was significantly associated with age ( Conclusions: A high incidence of internal carotid artery stenosis was observed after AF attack and was significantly associated with stroke. The incidence of MI and CRAO after AF was low. Among them, only CRAO was associated with carotid artery stenosis.
Language	English
Publishing date	2022-08-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11175088
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Article ; Online: Endogenous Staphylococcus aureus endophthalmitis: Clinical features, treatments, and visual outcomes.

Chen, Kuan-Jen / Sun, Ming-Hui / Wu, Wei-Chi / Lai, Chi-Chun

Clinical & experimental ophthalmology

2024

Language	English
Publishing date	2024-02-13
Publishing country	Australia
Document type	Letter
ZDB-ID	2014008-3
ISSN	1442-9071 ; 1442-6404
ISSN (online)	1442-9071
ISSN	1442-6404
DOI	10.1111/ceo.14361
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Zs.A 1064: Show issues

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Article ; Online: LHPE-nets: A lightweight 2D and 3D human pose estimation model with well-structural deep networks and multi-view pose sample simplification method.

Wang, Hao / Sun, Ming-Hui / Zhang, Hao / Dong, Li-Yan

PloS one

2022 Volume 17, Issue 2, Page(s) e0264302

Abstract: The cross-view 3D human pose estimation model has made significant progress, it better completed the task of human joint positioning and skeleton modeling in 3D through multi-view fusion method. The multi-view 2D pose estimation part of this model is ... ...

Abstract	The cross-view 3D human pose estimation model has made significant progress, it better completed the task of human joint positioning and skeleton modeling in 3D through multi-view fusion method. The multi-view 2D pose estimation part of this model is very important, but its training cost is also very high. It uses some deep learning networks to generate heatmaps for each view. Therefore, in this article, we tested some new deep learning networks for pose estimation tasks. These deep networks include Mobilenetv2, Mobilenetv3, Efficientnetv2 and Resnet. Then, based on the performance and drawbacks of these networks, we built multiple deep learning networks with better performance. We call our network in this article LHPE-nets, which mainly includes Low-Span network and RDNS network. LHPE-nets uses a network structure with evenly distributed channels, inverted residuals, external residual blocks and a framework for processing small-resolution samples to achieve training saturation faster. And we also designed a static pose sample simplification method for 3D pose data. It implemented low-cost sample storage, and it was also convenient for models to read these samples. In the experiment, we used several recent models and two public estimation indicators. The experimental results show the superiority of this work in fast start-up and network lightweight, it is about 1-5 epochs faster than the Resnet-34 during training. And they also show the accuracy improvement of this work in estimating different joints, the estimated performance of approximately 60% of the joints is improved. Its performance in the overall human pose estimation exceeds other networks by more than 7mm. The experiment analyzes the network size, fast start-up and the performance in 2D and 3D pose estimation of the model in this paper in detail. Compared with other pose estimation models, its performance has also reached a higher level of application.
MeSH term(s)	Biometric Identification/methods ; Deep Learning ; Humans ; Imaging, Three-Dimensional/methods ; Posture
Language	English
Publishing date	2022-02-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0264302
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Article ; Online: Adult Woman With Tunnel Vision.

Chen, Kuan-Jen / Chen, Yen-Po / Chen, Yen-Ting / Sun, Ming-Hui

Annals of emergency medicine

2022 Volume 81, Issue 1, Page(s) 101–111

MeSH term(s)	Adult ; Female ; Humans ; Vision Disorders
Language	English
Publishing date	2022-12-18
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	603080-4
ISSN	1097-6760 ; 0196-0644
ISSN (online)	1097-6760
ISSN	0196-0644
DOI	10.1016/j.annemergmed.2022.07.009
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Article: Effect of potassium-competitive acid blockers on human gut microbiota: a systematic review and meta-analysis.

Ouyang, Meng-Ling / Zou, Shu-Peng / Cheng, Qian / Shi, Xuan / Zhao, Ya-Zheng / Sun, Ming-Hui

Frontiers in pharmacology

2023 Volume 14, Page(s) 1269125

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-12-13
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1269125
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Article: [Correlation between spatial inclination of Blumensaat line and anterior cruciate ligament injury based on EOS biplanar 3D imaging system].

Li, Jian / Wang, Wei-Jun / Sun, Ming-Hui / Jiang, Qing / Weng, Wen-Jie

Zhongguo gu shang = China journal of orthopaedics and traumatology

2023 Volume 36, Issue 4, Page(s) 329–335

Abstract: Objective: To explore correlation between femoral mechanical axis and Blumensaat line (FMBL) angle of knee joint (angle between Blumensaat line and femoral mechanical axis), α angle (angle between Blumensaat line and axis of distal femur in sagittal ... ...

Abstract	Objective: To explore correlation between femoral mechanical axis and Blumensaat line (FMBL) angle of knee joint (angle between Blumensaat line and femoral mechanical axis), α angle (angle between Blumensaat line and axis of distal femur in sagittal plane) on EOS biplane imaging and non-contact anterior cruciate ligament(ACL) injury, and evaluate angle for its accuracy in predicting the populations prone to non-contact ACL injury. Methods: From February 2018 to October 2020, EOS imaging and clinical data from 88 patients (176 knees) with unilateral non-contact ACL injury were retrospectively analyzed, including 53 males and 35 females, aged from 18 to 45 years old with an average of (30.3±6.2) years old, 48 patients on the left side and 40 patients on the right side. The patients were divided into ACL-affected group and ACL-health group according to side of ACL injuries, and 51 patients (51 knees) with non-ACL identified from EOS database were included in normal control group, including 28 males and 23 females, aged from 20 to 44 years old with an average of (31.6±5.5) years old, 26 patients on the left side and 25 patients on the right side. Full-length EOS imaging of skeleton extremitatis inferioris among three groups were reconstructed to 3D images of skeletal system with EOS software, and then FMBL angle and α angle were measured on the images. Univariate binary Logistic regression analysis was performed to determine the influence of the univariate(FMBL angle or α angle) on ACL status(normal or torn). And the angle cutoff value for univariate was selected based on receiver operating characteristics curve (ROC) to got the best accuracy. Results: There was no statistically significant difference in age, gender and side distribution between ACL-injured group and normal control group( Conclusion: FMBL angle formed by Blumensaat line and femoral mechanical axis is one of the risk factors for non-contact ACL injury and has good predictive accuracy. The general population with FMBL angle below 33.7° may be increased risk for ACL injury.
MeSH term(s)	Male ; Female ; Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Anterior Cruciate Ligament Injuries/diagnostic imaging ; Retrospective Studies ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging/methods ; Anterior Cruciate Ligament/diagnostic imaging ; Knee Joint/diagnostic imaging
Language	Chinese
Publishing date	2023-04-23
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1003-0034
ISSN	1003-0034
DOI	10.12200/j.issn.1003-0034.2023.04.007
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Article ; Online: Advances in Point-of-Care Testing of microRNAs Based on Portable Instruments and Visual Detection.

Wang, Zhong-Yu / Sun, Ming-Hui / Zhang, Qun / Li, Pei-Feng / Wang, Kun / Li, Xin-Min

Biosensors

2023 Volume 13, Issue 7

Abstract: MicroRNAs (miRNAs) are a class of small noncoding RNAs that are approximately 22 nt in length and regulate gene expression post-transcriptionally. miRNAs play a vital role in both physiological and pathological processes and are regarded as promising ... ...

Abstract	MicroRNAs (miRNAs) are a class of small noncoding RNAs that are approximately 22 nt in length and regulate gene expression post-transcriptionally. miRNAs play a vital role in both physiological and pathological processes and are regarded as promising biomarkers for cancer, cardiovascular diseases, neurodegenerative diseases, and so on. Accurate detection of miRNA expression level in clinical samples is important for miRNA-guided diagnostics. However, the common miRNA detection approaches like RNA sequencing, qRT-PCR, and miRNA microarray are performed in a professional laboratory with complex intermediate steps and are time-consuming and costly, challenging the miRNA-guided diagnostics. Hence, sensitive, highly specific, rapid, and easy-to-use detection of miRNAs is crucial for clinical diagnosis based on miRNAs. With the advantages of being specific, sensitive, efficient, cost-saving, and easy to operate, point-of-care testing (POCT) has been widely used in the detection of miRNAs. For the first time, we mainly focus on summarizing the research progress in POCT of miRNAs based on portable instruments and visual readout methods. As widely available pocket-size portable instruments and visual detection play important roles in POCT, we provide an all-sided discussion of the principles of these methods and their main limitations and challenges, in order to provide a guide for the development of more accurate, specific, and sensitive POCT methods for miRNA detection.
MeSH term(s)	Humans ; MicroRNAs/analysis ; Point-of-Care Testing ; Neoplasms ; Nucleic Acid Amplification Techniques ; Polymerase Chain Reaction
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-07-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios13070747
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Article ; Online: A disproportionality analysis of adverse events associated to pertuzumab in the FDA Adverse Event Reporting System (FAERS).

Zou, Shu-Peng / Yang, Hai-Yun / Ouyang, Meng-Ling / Cheng, Qian / Shi, Xuan / Sun, Ming-Hui

BMC pharmacology & toxicology

2023 Volume 24, Issue 1, Page(s) 62

Abstract: Background: Pertuzumab is widely used for the treatment of HER2 + breast cancer. But its safety in the real world should be continuously monitored. So, we evaluated the safety of pertuzumab by pharmacovigilance analyze based on related adverse events ( ... ...

Abstract	Background: Pertuzumab is widely used for the treatment of HER2 + breast cancer. But its safety in the real world should be continuously monitored. So, we evaluated the safety of pertuzumab by pharmacovigilance analyze based on related adverse events (AEs) from the FDA Adverse Event Reporting System (FAERS) and find whether potential or uncertain adverse events were present. Methods: In disproportionality analysis, four algorithms were employed to detect the signals of pertuzumab from the FAERS between 2012 and 2022. In addition, we also used MYSQL 8.0, Navicat Premium 15, and Microsoft EXCEL 2019 to analyze the potential and high-ROR (reporting odds ratio) signals of pertuzumab. We also collected the onset times of pertuzumab-associated AEs. Results: From January 2012 to December 2022, there are 39,190,598 AEs reported from the FAERS database, of which 14,707 AEs listed pertuzumab as the 'primary suspected (PS)' drug. A total of 115 (46 potential) significant disproportionality preferred terms (PTs) conforming to the four algorithms were retained. Finally, we detected that the pertuzumab-induced AEs occurred in 12 organ systems. For pertuzumab, unexpected and significant PTs of AEs were found, including but not limited to below PTs: haematotoxicity, cardiotoxicity, cardiomyopathy, mitral valve incompetence, tachycardia, intestinal perforation, hemorrhoids, erysipelas, dehydration, pneumonitis, skin toxicity, onychomadesis, cyanosis, and circulatory collapse. We found there were 9 strong signals (5 potential safety signals) and 68 medium intensity signals (21 potential safety signals) according to IC Conclusion: Analysis of FAERS data identified pertuzumab-associated AEs, and our findings supported continuous clinical monitoring, pharmacovigilance, and further studies of pertuzumab. A significant association was detected between pertuzumab and some potential adverse events which should be regarded with some care. We have to pay attention to the first month after pertuzumab therapy and prepare emergency measures, especially for the elderly and patients with cardiovascular diseases.
MeSH term(s)	Humans ; Aged ; Female ; Cardiotoxicity ; Adverse Drug Reaction Reporting Systems ; Antibodies, Monoclonal, Humanized/adverse effects ; Pharmacovigilance ; Breast Neoplasms/drug therapy
Chemical Substances	pertuzumab (K16AIQ8CTM) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-11-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2680259-4
ISSN	2050-6511 ; 2050-6511
ISSN (online)	2050-6511
ISSN	2050-6511
DOI	10.1186/s40360-023-00702-w
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Article ; Online: Short peptides derived from pigment epithelium-derived factor attenuate retinal ischemia reperfusion injury through inhibition of apoptosis and inflammatory response in rats.

Sun, Ming-Hui / Ho, Tsung-Chuan / Yeh, Shu-I / Chen, Show-Li / Tsao, Yeou-Ping

Experimental eye research

2023 Volume 238, Page(s) 109743

Abstract: Pigment epithelium-derived factor (PEDF) is widely recognized as a neuroprotective factor expressed in the retina and has shown therapeutic potential in several retinal diseases. Our study aimed to identify the neuroprotective fragment in PEDF and ... ...

Abstract	Pigment epithelium-derived factor (PEDF) is widely recognized as a neuroprotective factor expressed in the retina and has shown therapeutic potential in several retinal diseases. Our study aimed to identify the neuroprotective fragment in PEDF and investigate its protective activity in retinas under ischemia-reperfusion (IR) condition. We synthesized a series of shorter synthetic peptides, 6-mer (Ser93-Gln98) and its d-form variant (6 dS) derived from the 44-mer (Val78-Thr121; a PEDF neurotrophic fragment), to determine their cytoprotective activity in IR injury, which was induced in rat retinas by injection of saline into the anterior chamber to increase the intraocular pressure (IOP) followed by reperfusion. We found the cytoprotective effect of 6-mer on glutamate-treated Neuro-2a cells and tert-butyl hydroperoxide (tBHP)-treated 661W cells were 2.6-fold and 1.5-fold higher than the 44-mer, respectively. The cytoprotective effect was blocked by a chemical inhibitor atglistatin and blocking antibody targeting PEDF receptor (PEDF-R). IR induced several impairments in retina, including cell apoptosis, activation of microglia/macroglia, degeneration of retinal capillaries, reduction in electroretinography (ERG) amplitudes, and retinal atrophy. Such IR injuries were ameliorated by treatment with 6-mer and 6 dS eye drops. Also, the neuroprotective activity of 6-mer and 6 dS in ischemic retinas were dramatically reversed by atglistatin preconditioning. Taken together, our data demonstrate smallest neuroprotective fragment of PEDF has potential to treat retinal degeneration-related diseases.
MeSH term(s)	Animals ; Rats ; Rabbits ; Nerve Growth Factors/administration & dosage ; Nerve Growth Factors/chemistry ; Nerve Growth Factors/metabolism ; Eye Proteins/administration & dosage ; Eye Proteins/chemistry ; Eye Proteins/metabolism ; Serpins/administration & dosage ; Serpins/chemistry ; Serpins/metabolism ; Retina/metabolism ; Retina/pathology ; Reperfusion Injury/metabolism ; Cytoprotection ; Apoptosis ; Neurons/metabolism ; Retinitis/drug therapy ; Retinitis/metabolism ; Administration, Topical ; Peptides/administration & dosage ; Peptides/metabolism
Chemical Substances	pigment epithelium-derived factor ; Nerve Growth Factors ; Eye Proteins ; Serpins ; Peptides
Language	English
Publishing date	2023-12-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2023.109743
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Article ; Online: Post-marketing safety of anti-IL-5 monoclonal antibodies (mAbs): an analysis of the FDA Adverse Event Reporting System (FAERS).

Zou, Shu-Peng / Yang, Hai-Yun / Ouyang, Mengling / Cheng, Qian / Shi, Xuan / Sun, Ming-Hui

Expert opinion on drug safety

2023 Volume 23, Issue 3, Page(s) 353–362

Abstract: Background: Anti-IL-5 monoclonal antibodies (mAbs) targeting IL-5 or IL-5 R α (including mepolizumab, benralizumab, and reslizumab) are widely used for inflammatory diseases such as asthma, eosinophilia, and polyangiitis. However, real-world data ... ...

Abstract	Background: Anti-IL-5 monoclonal antibodies (mAbs) targeting IL-5 or IL-5 R α (including mepolizumab, benralizumab, and reslizumab) are widely used for inflammatory diseases such as asthma, eosinophilia, and polyangiitis. However, real-world data regarding its safety in a large sample population are incomplete. So, we evaluated the safety of anti-IL-5 mAbs by pharmacovigilance analyzes based on related adverse events (AEs) from the FDA Adverse Event Reporting System (FAERS). Methods: In disproportionality analysis, four algorithms were employed to detect the signals of anti-IL-5 mAbs from the FAERS between 2016 and 2022. In addition, we also used MYSQL 8.0, Navicat Premium 15, and Microsoft EXCEL 2019 to analyze the signals of anti-IL-5 mAbs systematically. Results: There are 9,476,351 reports collected from the FAERS database, of which 22,174 reports listed anti-IL-5 mAbs as the 'primary suspected (PS)' drug. A total of 59 (20 new signals, mepolizumab) and 62 (19 new signals, benralizumab) significant disproportionality preferred terms (PTs) conforming to the four algorithms were retained synchronously. Finally, we detected that the anti-IL-5 mAbs-induced AEs occurred in 31 organ systems (mepolizumab) and 30 organ systems (benralizumab). For mepolizumab and reslizumab, unexpected and new significant PTs of AEs were found, such as asthmatic crisis, chronic obstructive pulmonary disease (COPD), pneumonia, COVID-19, pneumothorax, adrenal insufficiency and so on. Notably, the risk signal of asthmatic crisis for mepolizumab was stronger than benralizumab (ROR 108.04 [95%CI, 96.09-121.47] vs 26.83 [95%CI, 18.91-38.06]). Comparing with mepolizumab and benralizumab, we found the proportion of serious adverse events in mepolizumab was both greater than benralizumab in each age group (≤20, 20-65, and ≥ 65). The median onset time of mepolizumab was 280 days (interquartile range [IQR] 1-367 days). Conclusion: Analysis of FAERS data identified anti-IL-5 mAbs-associated AEs, and our findings supported continuous clinical monitoring, pharmacovigilance, and further studies of anti-IL-5 mAbs. In addition, clinicians may be more aware of the limitations of use in package inserts of anti-IL-5 mAbs: Not for relief of acute bronchospasm or status asthmaticus. Because of some limitations in the FAERS such as self-reports from patients and other confounding factors, the safety of anti-IL-5 mAbs needed more studies in different dimensions, especially the risk of cancer.
MeSH term(s)	Humans ; United States ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Drug-Related Side Effects and Adverse Reactions/etiology ; Interleukin-5 ; Status Asthmaticus ; Antibodies, Monoclonal/adverse effects ; Asthma/drug therapy ; Pharmacovigilance ; United States Food and Drug Administration ; Adverse Drug Reaction Reporting Systems
Chemical Substances	Interleukin-5 ; Antibodies, Monoclonal
Language	English
Publishing date	2023-08-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2088728-0
ISSN	1744-764X ; 1474-0338
ISSN (online)	1744-764X
ISSN	1474-0338
DOI	10.1080/14740338.2023.2251382
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