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Article ; Online: Sodium Alginate/Modified Bentonite Composite Bead Adsorptive Removal of Norfloxacin: Static and Dynamic Adsorption.

Zhou, Jun / Sun, Qianyu

2022 Volume 14, Issue 19

Abstract: The low-cost calcium-based bentonite modified with anionic and cationic surfactants was granulated by cross-linking to sodium alginate (SA) to promote the adsorption efficiencies of norfloxacin (NOR). The characterization studies illustrated that the ... ...

Abstract	The low-cost calcium-based bentonite modified with anionic and cationic surfactants was granulated by cross-linking to sodium alginate (SA) to promote the adsorption efficiencies of norfloxacin (NOR). The characterization studies illustrated that the intercalation of cetyltrimethylammonium bromide (CTAB) and sodium dodecyl benzene sulfonate (SDBS) was successful. The modification improved the pore structure and the granular SA/organically modified bentonite composite (GOMBt) exhibited a lamellar structure with some roughness. The adsorption kinetics and isotherms indicated that adsorption of NOR on GOMBt was an endothermic process. The effects of various factors on the adsorption of NOR suggested that the maximum adsorption capacity was obtained under acidic conditions and cations improved the adsorption process. A fixed-bed column was employed to investigate the dynamic adsorption characteristics of NOR by GOMBt. The breakthrough time and bed height had a positive correlation; however, the relation of flow rate, pH, and breakthrough time had a negative correlation. The results showed that the dynamic adsorption data of NOR on GOMBt fitted Thomas and Yoon-Nelson models. The internal and external diffusion in GOMBt dynamic adsorption was not a rate-limiting step.
Language	English
Publishing date	2022-09-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym14193984
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Disulfidptosis features and prognosis in head and neck squamous cell carcinoma patients: unveiling and validating the prognostic signature across cohorts.

Xue, Hao / Sun, Qianyu / Zhang, Heqing / Huang, Hanxiao / Xue, Haowei

Journal of cancer research and clinical oncology

2024 Volume 150, Issue 3, Page(s) 156

Abstract: Background: Head and neck squamous cell carcinoma (HNSCC) is a significant health concern with a variable global incidence and is linked to regional lifestyle factors and HPV infections. Despite treatment advances, patient prognosis remains variable, ... ...

Abstract	Background: Head and neck squamous cell carcinoma (HNSCC) is a significant health concern with a variable global incidence and is linked to regional lifestyle factors and HPV infections. Despite treatment advances, patient prognosis remains variable, necessitating an understanding of its molecular mechanisms and the identification of reliable prognostic biomarkers. Methods: We analyzed 959 HNSCC samples and employed batch correction to obtain consistent transcriptomic data across cohorts. We examined 79 disulfidptosis-related genes to determine consensus clusters and utilized high-throughput sequencing to identify genetic heterogeneity within tumors. We established a disulfidptosis prognostic signature (DSPS) using least absolute shrinkage and selection operator (LASSO) regression and developed a prognostic nomogram integrating the DSPS with clinical factors. Personalized chemotherapy prediction was performed using the "pRRophetic" R package. Results: Batch corrections were used to harmonize gene expression data, revealing two distinct disulfidptosis subtypes, C1 and C2, with differential gene expression and survival outcomes. Subtype C1, characterized by increased expression of the MYH family genes ACTB, ACTN2, and FLNC, had a mortality rate of 48.4%, while subtype C2 had a mortality rate of 38.7% (HR = 0.77, 95% CI: 0.633-0.934, P = 0.008). LASSO regression identified 15 genes that composed the DSPS prognostic model, which independently predicted survival (HR = 2.055, 95% CI: 1.420-2.975, P < 0.001). The prognostic nomogram, which included the DSPS, age, and tumor stage, predicted survival with AUC values of 0.686, 0.704, and 0.789 at 3, 5, and 8 years, respectively, indicating strong predictive capability. In the external validation cohort (cohort B), the DSPS successfully identified patients at greater risk, with worse overall survival outcomes in the high-DSPS subgroup (HR = 1.54, 95% CI: 1.17-2.023, P = 0.002) and AUC values of 0.601, 0.644, 0.636, and 0.748 at 3, 5, 8, and 10 years, respectively, confirming the model's robustness. Conclusion: The DSPS provides a robust prognostic tool for HNSCC, underscoring the complexity of this disease and the potential for tailored treatment strategies. This study highlights the importance of molecular signatures in oncology, offering a step toward personalized medicine and improved patient outcomes in HNSCC management.
MeSH term(s)	Humans ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/genetics ; Nomograms ; Gene Expression Profiling ; Head and Neck Neoplasms/genetics
Language	English
Publishing date	2024-03-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-024-05691-9
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Article: Performance and microbial characterization of aerobic granular sludge in a sequencing batch reactor performing simultaneous nitrification, denitrification and phosphorus removal with varying C/N ratios

Zhou, Jun / Sun, Qianyu

Bioprocess and biosystems engineering. 2020 Apr., v. 43, no. 4

2020

Abstract: The mechanism and effect of C/N ratios on the aerobic granules simultaneous nitrification, denitrification and phosphorus removal (SNDPR) system are still unclear. The reactor performance and microbial community dynamics of the system were investigated ... ...

Abstract	The mechanism and effect of C/N ratios on the aerobic granules simultaneous nitrification, denitrification and phosphorus removal (SNDPR) system are still unclear. The reactor performance and microbial community dynamics of the system were investigated under variable C/N ratios (20, 10 and 5). The COD, TP and NH4+-N removal remained unaffected with variable C/N ratios. The decreased C/N ratio of five strongly influenced the nitrogen removal. Further investigations revealed that Candidatus_Accumulibacter, Acinetobacter, Candidatus_Competibacter were the predominant genera. Classification of key groups involved in nitrogen and phosphorus removal indicated the lowest C/N ratio resulting in a large microbial community shift. This study might contribute to the application of SNDPR system for the treatment of wastewater. Different C/N ratios led to shift on the microbial community and the dominant was phosphorus-accumulating bacteria. The nitrogen removal efficiency decreased while the removal of COD, TP and NH4+-N remained remarkable with the decreased C/N ratios.
Keywords	Acinetobacter ; ammonium nitrogen ; bacteria ; batch systems ; carbon nitrogen ratio ; chemical oxygen demand ; denitrification ; granules ; microbial communities ; nitrification ; nitrogen ; phosphorus ; sludge ; wastewater treatment
Language	English
Dates of publication	2020-04
Size	p. 663-672.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1476357-6
ISSN	1432-0797 ; 1615-7605 ; 1615-7591
ISSN (online)	1432-0797 ; 1615-7605
ISSN	1615-7591
DOI	10.1007/s00449-019-02264-w
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Article: Encapsulation of curcumin in CD-MOFs: promoting its incorporation into water-based products and consumption

Sun, Qianyu / Sheng, Jie / Yang, Rendang

Food & function. 2021 Nov. 1, v. 12, no. 21

2021

Abstract: Curcumin has received considerable interest in functional food areas due to its variety of biological effects. However, its utilization is often limited by its insolubility and instability in aqueous solutions. Herein, curcumin was encapsulated in γ- ... ...

Abstract	Curcumin has received considerable interest in functional food areas due to its variety of biological effects. However, its utilization is often limited by its insolubility and instability in aqueous solutions. Herein, curcumin was encapsulated in γ-cyclodextrin metal–organic frameworks (CD-MOFs) to achieve immediate release and rapid dissolution in water just by gentle stirring due to the dissociation of CD-MOFs. The released curcumin exhibited remarkably enhanced stability compared to its free form in aqueous solutions due to the inclusion effects of cyclodextrins. Besides, the impacts of temperature, light and gastrointestinal pH on the chemical stability of curcumin released from basic and neutral CD-MOFs were compared. The molar ratios of curcumin : γ-CD in basic CD-MOFs and neutral CD-MOFs were 1 : 1.7 and 1 : 9.8, respectively. Neutral CD-MOFs were more effective in retarding thermal and gastrointestinal degradation of curcumin because all curcumin molecules can form inclusion complexes with cyclodextrin. Basic CD-MOFs were more conducive to prolonging the half-life time of curcumin during photodegradation since its alkalinity darkened the color of curcumin solution causing lower light transmittance. Moreover, CD-MOFs exhibited higher loading and stability of curcumin due to their unique host–guest structure, than their pure cyclodextrin inclusion complex. Curcumin-loaded CD-MOFs having a fast-dissolving ability accompanied by the improved amorphous form stability of curcumin hold great potential as functional additives in instant food.
Keywords	alkalinity ; color ; curcumin ; dissociation ; encapsulation ; functional foods ; gastrointestinal system ; half life ; pH ; photolysis ; temperature ; transmittance
Language	English
Dates of publication	2021-1101
Size	p. 10795-10805.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d1fo02087k
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Article ; Online: Encapsulation of curcumin in CD-MOFs: promoting its incorporation into water-based products and consumption.

Sun, Qianyu / Sheng, Jie / Yang, Rendang

Food & function

2021 Volume 12, Issue 21, Page(s) 10795–10805

Abstract	Curcumin has received considerable interest in functional food areas due to its variety of biological effects. However, its utilization is often limited by its insolubility and instability in aqueous solutions. Herein, curcumin was encapsulated in γ-cyclodextrin metal-organic frameworks (CD-MOFs) to achieve immediate release and rapid dissolution in water just by gentle stirring due to the dissociation of CD-MOFs. The released curcumin exhibited remarkably enhanced stability compared to its free form in aqueous solutions due to the inclusion effects of cyclodextrins. Besides, the impacts of temperature, light and gastrointestinal pH on the chemical stability of curcumin released from basic and neutral CD-MOFs were compared. The molar ratios of curcumin : γ-CD in basic CD-MOFs and neutral CD-MOFs were 1 : 1.7 and 1 : 9.8, respectively. Neutral CD-MOFs were more effective in retarding thermal and gastrointestinal degradation of curcumin because all curcumin molecules can form inclusion complexes with cyclodextrin. Basic CD-MOFs were more conducive to prolonging the half-life time of curcumin during photodegradation since its alkalinity darkened the color of curcumin solution causing lower light transmittance. Moreover, CD-MOFs exhibited higher loading and stability of curcumin due to their unique host-guest structure, than their pure cyclodextrin inclusion complex. Curcumin-loaded CD-MOFs having a fast-dissolving ability accompanied by the improved amorphous form stability of curcumin hold great potential as functional additives in instant food.
MeSH term(s)	Curcumin/chemistry ; Cyclodextrins/chemistry ; Humans ; Hydrogen-Ion Concentration ; Organometallic Compounds/chemistry ; Temperature ; Water ; X-Ray Diffraction
Chemical Substances	Cyclodextrins ; Organometallic Compounds ; Water (059QF0KO0R) ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2021-11-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d1fo02087k
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Article: A novel, effective machine learning-based RNA editing profile for predicting the prognosis of lower-grade gliomas.

Wang, Boshen / Tian, Peijie / Sun, Qianyu / Zhang, Hengdong / Han, Lei / Zhu, Baoli

Heliyon

2023 Volume 9, Issue 7, Page(s) e18075

Abstract: Patients with low-grade glioma (LGG) may survive for long time periods, but their tumors often progress to higher-grade lesions. Currently, no cure for LGG is available. A-to-I RNA editing accounts for nearly 90% of all RNA editing events in humans and ... ...

Abstract	Patients with low-grade glioma (LGG) may survive for long time periods, but their tumors often progress to higher-grade lesions. Currently, no cure for LGG is available. A-to-I RNA editing accounts for nearly 90% of all RNA editing events in humans and plays a role in tumorigenesis in various cancers. However, little is known regarding its prognostic role in LGG. On the basis of The Cancer Genome Atlas (TCGA) data, we used LASSO and univariate Cox regression to construct an RNA editing site signature. The results derived from the TCGA dataset were further validated with Gene Expression Omnibus (GEO) and Chinese Glioma Genome Atlas (CGGA) datasets. Five machine learning algorithms (Decision Trees C5.0, XGboost, GBDT, Lightgbm, and Catboost) were used to confirm the prognosis associated with the RNA editing site signature. Finally, we explored immune function, immunotherapy, and potential therapeutic agents in the high- and low-risk groups by using multiple biological prediction websites. A total of 22,739 RNA editing sites were identified, and a signature model consisting of four RNA editing sites (PRKCSH\|chr19:11561032, DSEL\|chr18:65174489, UGGT1\|chr2:128952084, and SOD2\|chr6:160101723) was established. Cox regression analysis indicated that the RNA editing signature was an independent prognostic factor, according to the ROC curve (AUC = 0.823), and the nomogram model had good predictive power (C-index = 0.824). In addition, the predictive ability of the RNA editing signature was confirmed with the machine learning model. The sensitivity of PCI-34051 and Elephantin was significantly higher in the high-risk group than the low-risk group, thus potentially providing a marker to predict the effects of lung cancer drug treatment. RNA editing may serve as a novel survival prediction tool, thus offering hope for developing editing-based therapeutic strategies to combat LGG progression. In addition, this tool may help optimize survival risk assessment and individualized care for patients with low-grade gliomas.
Language	English
Publishing date	2023-07-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e18075
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Article ; Online: Chitosan-graft-poly(lactic acid)/CD-MOFs degradable composite microspheres for sustained release of curcumin.

Sun, Qianyu / Yuan, Tianzhong / Yang, Gang / Guo, Daliang / Sha, Lizheng / Yang, Rendang

International journal of biological macromolecules

2023 Volume 253, Issue Pt 8, Page(s) 127519

Abstract: The solubility of cyclodextrin metal-organic frameworks (CD-MOFs) in aqueous media making it not suitable as sustained-release drug carrier. Here, curcumin-loaded CD-MOFs (CD-MOFs-Cur) was embedded in chitosan-graft-poly(lactic acid) (CS-LA) via a solid- ... ...

Abstract	The solubility of cyclodextrin metal-organic frameworks (CD-MOFs) in aqueous media making it not suitable as sustained-release drug carrier. Here, curcumin-loaded CD-MOFs (CD-MOFs-Cur) was embedded in chitosan-graft-poly(lactic acid) (CS-LA) via a solid-in-oil-in-oil (s/o/o) emulsifying solvent evaporation method forming the sustained-release composite microspheres. At CS-LA concentration of 20 mg/mL, the composite microspheres showed good sphericity. The average particle size of CS-LA/CD-MOFs-Cur (2:1), CS-LA/CD-MOFs-Cur (4:1) and CS-LA/CD-MOFs-Cur (6:1) composite microspheres was about 9.3, 12.3 and 13.5 μm, respectively. The above composite microspheres exhibited various degradation rates and curcumin release rates. Treating in HCl solution (pH 1.2) for 120 min, the average particle size of above microspheres reduced 28.19 %, 24.34 % and 6.19 %, and curcumin released 86.23 %, 78.37 % and 52.57 %, respectively. Treating in PBS (pH 7.4) for 12 h, the average particle size of above microspheres reduced 30.56 %, 26.56 % and 10.66 %, and curcumin released 68.54 %, 54.32 % and 31.25 %, respectively. Moreover, the composite microspheres had a favorable cytocompatibility, with cell viability of higher than 90 %. These composite microspheres open novel opportunity for sustained drug release of CD-MOFs.
MeSH term(s)	Curcumin/pharmacology ; Delayed-Action Preparations ; Metal-Organic Frameworks ; Chitosan ; Cyclodextrins ; Microspheres ; Drug Carriers ; Particle Size
Chemical Substances	Curcumin (IT942ZTH98) ; Delayed-Action Preparations ; Metal-Organic Frameworks ; poly(lactide) (459TN2L5F5) ; Chitosan (9012-76-4) ; Cyclodextrins ; Drug Carriers
Language	English
Publishing date	2023-10-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.127519
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Article ; Online: Performance and microbial characterization of aerobic granular sludge in a sequencing batch reactor performing simultaneous nitrification, denitrification and phosphorus removal with varying C/N ratios.

Zhou, Jun / Sun, Qianyu

Bioprocess and biosystems engineering

2019 Volume 43, Issue 4, Page(s) 663–672

Abstract	The mechanism and effect of C/N ratios on the aerobic granules simultaneous nitrification, denitrification and phosphorus removal (SNDPR) system are still unclear. The reactor performance and microbial community dynamics of the system were investigated under variable C/N ratios (20, 10 and 5). The COD, TP and NH
MeSH term(s)	Bacteria/metabolism ; Batch Cell Culture Techniques ; Bioreactors/microbiology ; Denitrification ; Microbiota ; Sewage/microbiology
Chemical Substances	Sewage
Language	English
Publishing date	2019-12-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1476357-6
ISSN	1615-7605 ; 1432-0797 ; 1615-7591
ISSN (online)	1615-7605 ; 1432-0797
ISSN	1615-7591
DOI	10.1007/s00449-019-02264-w
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Article ; Online: Cervical Cancer Cell-derived Tie1 Expression Via PI3K/AKT Signaling Pathway Promotes Tumour Progression.

Wei, Yan / Yu, Panpan / Zouyu Zhao / Sun, Chongfeng / Sun, Qianyu / Bai, Rui / Gao, Weirui / Yang, Ping

Experimental cell research

2024 , Page(s) 114060

Abstract: Background: Tie1 orphan receptor has become a focus of research, Tie1 can form a polymer with Tie2, regulate the Ang/Tie2 pathway and play a vital role in pathological angiogenesis and tumor progression, the function of Tie1 has remained uncertain in ... ...

Abstract	Background: Tie1 orphan receptor has become a focus of research, Tie1 can form a polymer with Tie2, regulate the Ang/Tie2 pathway and play a vital role in pathological angiogenesis and tumor progression, the function of Tie1 has remained uncertain in the progression of cervical cancer (CC). Here, we investigated the functional influences of Tie1 overexpress on CC in vitro and in vivo. Methods: We used Immunohistochemistry (IHC) analysis to detect the relative expression of Tie1 in CC, and we analyzed its connection with the overall survival (OS) and progression free survival (PFS)of CC patients. To prove the role of Tie1 in cell proliferation and metastatic, Tie1 expression in CC cell lines was upregulated by lentivirus. Results: The high expression of Tie1 in tumor cells of cervical cancer tissues is significantly correlated with FIGO stage, differentiated tumors, tumors with diameters, deep stromal invasion. We found that cell progression was promoted in Tie1-overexpress CC cell lines in vivo and in vitro. Tie1 potentially exerts a commanding influence on the expression of markers associated with epithelial-mesenchymal transition (EMT) and the PI3K/AKT signaling pathway. Conclusions: Our research indicates that Tie1 is highly connected to CC progression as it may play a role in the EMT process through the PI3K/AKT signaling pathway.
Language	English
Publishing date	2024-05-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1493-x
ISSN	1090-2422 ; 0014-4827
ISSN (online)	1090-2422
ISSN	0014-4827
DOI	10.1016/j.yexcr.2024.114060
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Article ; Online: Research development and trends of benzene-induced leukemia from 1990 to 2019-A bibliometric analysis

Sun, Qianyu / Wang, Boshen / Xu, Shouxiang / Cong, Xiaowei / Pu, Yuepu / Zhang, Juan

Environ Sci Pollut Res. 2022 Feb., v. 29, no. 7 p.9626-9639

2022

Abstract: Benzene is an occupational and environmental toxicant, causing hematopoietic damage. Our study is aimed to extract the trend of benzene-induced leukemia (BIL) and qualitatively and quantitatively estimate research on it. Publications on BIL were ... ...

Abstract	Benzene is an occupational and environmental toxicant, causing hematopoietic damage. Our study is aimed to extract the trend of benzene-induced leukemia (BIL) and qualitatively and quantitatively estimate research on it. Publications on BIL were identified from the Web of Science Core Collection (WoSCC). Microsoft Excel 2019 (Redmond, WA) and The CiteSpace 5.6.R5 software (Drexel University, Philadelphia, PA) were used to analyze the publication outcomes, countries, institutions, authors, keywords, and research frontiers. The overall 1152 publications were collected from 1990 to 2019 until November 6, 2020. Environ Health Persp had the highest number of articles published. The USA were the top country in terms of BIL. The Smith MT, Yin SN, Lan Q, and Hayes RB are both listed in the top 10 of co-cited authors, high contribution authors, and the authors of co-cited references. High IF articles account for a considerable proportion, among all the publications. Chinese institutions engaged in BIL and contributed a large part of articles. Exposure population, exposure dose, and exposure risk are the research hotspots in this field. The risk of benzene exposure on childhood leukemia is at issue, and the studies on attributable risk of benzene-induced leukemia are few. More early, sensitive, and specific epigenetic biomarkers of benzolism may be the leading research fields of benzene-induced leukemia in the next few years.
Keywords	at-risk population ; benzene ; bibliometric analysis ; biomarkers ; childhood ; computer software ; epigenetics ; leukemia ; risk
Language	English
Dates of publication	2022-02
Size	p. 9626-9639.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
Note	Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-17432-3
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