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Article ; Online: Prognostic and clinicopathological significance of prognostic nutritional index (PNI) in patients with oral cancer: a meta-analysis.

Dai, Menglu / Sun, Qijun

Aging

2023 Volume 15, Issue 5, Page(s) 1615–1627

Abstract: Accumulating literature has explored how prognostically significant the prognostic nutritional index (PNI) was for the oral carcinoma population, but with inconsistent findings. Therefore, we retrieved the most recent data and carried out this meta- ... ...

Abstract	Accumulating literature has explored how prognostically significant the prognostic nutritional index (PNI) was for the oral carcinoma population, but with inconsistent findings. Therefore, we retrieved the most recent data and carried out this meta-analysis to comprehensively analyze the prognostic performance of pretreatment PNI in oral cancer. The electronic databases of PubMed, Embase, China National Knowledge Infrastructure (CNKI), Cochrane Library and Web of Science were fully retrieved. PNI's prognostic value for survival outcomes in oral carcinoma was assessed by estimating pooled hazard ratios (HRs) plus 95% confidence intervals (CIs). We examined the correlation of PNI with clinicopathological traits of oral carcinoma by utilizing the pooled odds ratios (ORs) plus 95% CIs. According to the pooled results of the present meta-analysis, which enrolled 10 studies involving 3,130 patients, for oral carcinoma suffers whose PNI was low, their disease-free survival (DFS) (HR=1.92, 95%CI=1.53-2.42, p<0.001) and overall survival (OS) (HR=2.44, 95%CI=1.45-4.12, p=0.001) would be inferior. Nonetheless, cancer-specific survival (CSS) was not linked significantly to PNI for the oral carcinoma population (HR=1.89, 95%CI=0.61-5.84, p=0.267). Significant associations of low PNI with TNM stages III-IV (OR=2.16, 95%CI=1.60-2.91, p<0.001) and age ≥ 65 years (OR=2.29, 95%CI=1.76-2.98, p<0.001) were found. As suggested by the present meta-analysis, a low PNI was linked to inferior DFS and OS among oral carcinoma patients. Oral cancer patients with low PNI may have high-risk of tumor progression. PNI could be served as a promising and effective index to predict prognosis in patients with oral cancer.
MeSH term(s)	Humans ; Aged ; Prognosis ; Nutrition Assessment ; Proportional Hazards Models ; Mouth Neoplasms ; Carcinoma
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204576
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sustainable paper electronics and neuromorphic paper chip.

Xu, Nuo / Lin, Xiangde / Han, Jing / Sun, Qijun

Nanotechnology

2024 Volume 35, Issue 22

Abstract: Paper electronics have received a lot of attention due to their special properties of mechanical flexibility/foldability, sustainability, biodegradability, light weight, and low cost. It provides a superb on-chip prototype with simple modular design and ... ...

Abstract	Paper electronics have received a lot of attention due to their special properties of mechanical flexibility/foldability, sustainability, biodegradability, light weight, and low cost. It provides a superb on-chip prototype with simple modular design and feasible energy-autonomous features, which can surpass the problems of inconvenience and possible pollution caused by conventional power sources by integrating different functional modules. Commonly, the sustainable operation of integrated paper electronics can be guaranteed by the basic components, including energy-harvesting devices, energy-storage devices, and low-power-consuming functional circuits/devices. Furthermore, sustainable paper electronics are possible to be further extended to develop energy-efficient neuromorphic paper chip by utilizing cutting-edge neuromorphic components based on traditional paper-based transistors, memories, and logic gates toward potential in-memory computing applications. The working process of the sustainable paper electronics implies an energy cycling of surrounding energy conversion, electrochemical energy storage, and energy utilization in functional circuits (in the form of photonic, thermal, electromagnetic, or mechanical energy). Sustainable paper electronics provide a promising path for achieving efficient, cost-effective, and customizable integrated electronics and self-powered systems with complementary features.
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Letter
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/ad2c57
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Article: LRRC59 promotes the progression of oral squamous cell carcinoma by interacting with SRP pathway components and enhancing the secretion of CKAP4-containing exosomes.

Sun, Qijun / Jin, Lili / Dong, Shunli / Zhang, Ling

Heliyon

2024 Volume 10, Issue 6, Page(s) e28083

Abstract: Background: As a ribosome receptor, LRRC59 was thought to regulate mRNA translation on the ER membrane. Evidence suggests that LRRC59 is overexpressed in a number of human malignancies and is associated with poor prognoses, but its primary biological ... ...

Abstract	Background: As a ribosome receptor, LRRC59 was thought to regulate mRNA translation on the ER membrane. Evidence suggests that LRRC59 is overexpressed in a number of human malignancies and is associated with poor prognoses, but its primary biological function in the development of oral squamous cell carcinoma (OSCC) remains obscure. Objective: The purpose of this study is to investigate at the expression changes and functional role of LRRC59 in OSCC. Methods: LRRC59 gene expression and correlation with prognosis of OSCC patients were first examined using the data from The Cancer Genome Atlas (TCGA) databases. Following that, a series of functional experiments, including cell counting kit-8, cell cycle analysis, wound healing assays, and transwell assays, were carried out to analyze the biological roles of LRRC59 in tumor cells. Mechanistically, we employed Tandem Affinity Purification-Mass Spectrometry (TAP-MS) approach to isolate and identify protein complexes of LRRC59. Downstream regulatory proteins of LRRC59 were verified through immunoprecipitation and immunofluorescence experiments. Furthermore, we isolated exosomes from OSCC cell supernatant and conducted co-culture experiments to examine the effect of LRRC59 knockdown on OSCC cells. Results: In samples from OSCC patients, LRRC59 was highly expressed and correlated with poor prognoses. Moreover, the gene sets analysis based on TCGA RNA-seq data indicated that LRRC59 seemed to be strongly related with protein secretory and OSCC migration. Upregulated levels of LRRC59 are more prone to lymph node metastasis in OSCC patients. LRRC59 knockdown impaired the ability of OSCC cell proliferation, migration, and invasion invitro. Mechanistically, our TAP-MS data situate LRRC59 in a functional nexus for mRNA translation regulation via interactions with SRP pathway components, translational initiation factors, CRD-mediated mRNA stabilization factors. More importantly, we found that LRRC59 interacted with cytoskeleton-associated protein 4 (CKAP4) and promoted the formation of CKAP4-containing exosomes. We also revealed that the LRRC59-CKAP4 axis was a crucial regulator of CKAP4-containing exosome secretion in OSCC cells for migration and invasion. Conclusions: Therefore, based on our findings, LRRC59 may serve as a potential biomarker for OSCC patients, and LRRC59-induced exosome secretion via the CKAP4 axis may serve as a potential therapeutic target for OSCC.
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28083
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Article ; Online: The Stabilizing Effect of Carboxymethyl Cellulose on Foamed Concrete.

Ji, Yongcheng / Sun, Qijun

International journal of molecular sciences

2022 Volume 23, Issue 24

Abstract: Foam concrete is widely used for its excellent properties, such as light weight, heat insulation, fire resistance, and sound insulation. The stability of foam is the main factor that affects the mechanical performance of foam concrete. The experiments ... ...

Abstract	Foam concrete is widely used for its excellent properties, such as light weight, heat insulation, fire resistance, and sound insulation. The stability of foam is the main factor that affects the mechanical performance of foam concrete. The experiments are designed from two perspectives: the foam's stability performance and the foam concrete's modification effect. The effects on foam volume, foam half-life, foam bleeding rate, and foam pore size were investigated based on different concentrations of foam stabilizer CMC (0%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%). A combination of macroscopic testing and microscopic analysis, a comparative study of dry density, water absorption test, mechanical property test, and pore structure analysis were conducted after using the modified foam for foam concrete. It is shown that the addition of CMC has an enhanced effect on foam stability. Foaming volume, water secretion rate, and average pore size showed a decreasing trend with the increase of CMC admixture, while the foam half-life displayed an increasing trend. In addition, adding CMC reduces the dry density and improves water absorption and compressive strength. The pore structure development of foam concrete has a noticeable improvement effect, and the optimal amount of admixture is 0.4%. Research results provide a reference for applying thickening foam stabilizer CMC in foam concrete.
Language	English
Publishing date	2022-12-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232415473
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Article ; Online: Rational Biomimetic Construction of Lignin-based Carbon Nanozyme for Identification of Uric Acid in Human Urine.

Sun, Qijun / Xu, Xiaoyu / Wu, Meng / Niu, Na / Chen, Ligang

Talanta

2024 Volume 271, Page(s) 125657

Abstract: Nanozymes have made remarkable progress in the field of sensing assays by replacing native enzyme functions. However, it is still a challenge to rationally design active centers from molecular structure to enhance the catalytic performance and develop ... ...

Abstract	Nanozymes have made remarkable progress in the field of sensing assays by replacing native enzyme functions. However, it is still a challenge to rationally design active centers from molecular structure to enhance the catalytic performance and develop low-cost nanozymes. In this work, guided by the catalytic site of horseradish peroxidase (HRP), iron source and histidine were coupled to the main chain of aminated sodium lignosulfonate (SL) through the self-assembly biomimetic strategy to construct His-SL-Fe with peroxidase activity. The inherent functional groups and basic framework of aminated SL provide a robust environment and promote the formation of active sites. His-SL-Fe shows excellent robustness over multiple test cycles and has a strong affinity for the substrate compared to HRP. His-SL-Fe had been effectively integrated in the sensing system for catalytic detection of uric acid (UA) to achieve accurate recognition of UA in the range of 0.5-100 μM with the limit of detection as low as 0.18 μM. The recovery of human urine samples is in the range of 96.8%-106.1 % and the error is within 4 %. This work not only provides a new approach for the directed design of high-performance nanozymes, but also demonstrates promising ideas for the refined application of biomass resources.
MeSH term(s)	Humans ; Carbon/chemistry ; Uric Acid ; Lignin ; Biomimetics ; Horseradish Peroxidase ; Colorimetry ; Peroxidase/chemistry ; Hydrogen Peroxide
Chemical Substances	Carbon (7440-44-0) ; Uric Acid (268B43MJ25) ; Lignin (9005-53-2) ; Horseradish Peroxidase (EC 1.11.1.-) ; Peroxidase (EC 1.11.1.7) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2024-01-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2024.125657
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Article: Emerging Functional Polymer Composites for Tactile Sensing.

Lian, Jia-Jin / Guo, Wen-Tao / Sun, Qi-Jun

Materials (Basel, Switzerland)

2023 Volume 16, Issue 12

Abstract: In recent years, extensive research has been conducted on the development of high-performance flexible tactile sensors, pursuing the next generation of highly intelligent electronics with diverse potential applications in self-powered wearable sensors, ... ...

Abstract	In recent years, extensive research has been conducted on the development of high-performance flexible tactile sensors, pursuing the next generation of highly intelligent electronics with diverse potential applications in self-powered wearable sensors, human-machine interactions, electronic skin, and soft robotics. Among the most promising materials that have emerged in this context are functional polymer composites (FPCs), which exhibit exceptional mechanical and electrical properties, enabling them to be excellent candidates for tactile sensors. Herein, this review provides a comprehensive overview of recent advances in FPCs-based tactile sensors, including the fundamental principle, the necessary property parameter, the unique device structure, and the fabrication process of different types of tactile sensors. Examples of FPCs are elaborated with a focus on miniaturization, self-healing, self-cleaning, integration, biodegradation, and neural control. Furthermore, the applications of FPC-based tactile sensors in tactile perception, human-machine interaction, and healthcare are further described. Finally, the existing limitations and technical challenges for FPCs-based tactile sensors are briefly discussed, offering potential avenues for the development of electronic products.
Language	English
Publishing date	2023-06-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16124310
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Article ; Online: Self-Powered Sensing in Wearable Electronics─A Paradigm Shift Technology.

Tang, Wei / Sun, Qijun / Wang, Zhong Lin

Chemical reviews

2023 Volume 123, Issue 21, Page(s) 12105–12134

Abstract: With the advancements in materials science and micro/nanoengineering, the field of wearable electronics has experienced a rapid growth and significantly impacted and transformed various aspects of daily human life. These devices enable individuals to ... ...

Abstract	With the advancements in materials science and micro/nanoengineering, the field of wearable electronics has experienced a rapid growth and significantly impacted and transformed various aspects of daily human life. These devices enable individuals to conveniently access health assessments without visiting hospitals and provide continuous, detailed monitoring to create comprehensive health data sets for physicians to analyze and diagnose. Nonetheless, several challenges continue to hinder the practical application of wearable electronics, such as skin compliance, biocompatibility, stability, and power supply. In this review, we address the power supply issue and examine recent innovative self-powered technologies for wearable electronics. Specifically, we explore self-powered sensors and self-powered systems, the two primary strategies employed in this field. The former emphasizes the integration of nanogenerator devices as sensing units, thereby reducing overall system power consumption, while the latter focuses on utilizing nanogenerator devices as power sources to drive the entire sensing system. Finally, we present the future challenges and perspectives for self-powered wearable electronics.
MeSH term(s)	Humans ; Wearable Electronic Devices ; Electric Power Supplies ; Electronics ; Technology
Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	207949-5
ISSN	1520-6890 ; 0009-2665
ISSN (online)	1520-6890
ISSN	0009-2665
DOI	10.1021/acs.chemrev.3c00305
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Article ; Online: Recent Advances in Polymer Composites for Flexible Pressure Sensors.

Guo, Wen-Tao / Tang, Xin-Gui / Tang, Zhenhua / Sun, Qi-Jun

Polymers

2023 Volume 15, Issue 9

Abstract: Pressure sensors show significant potential applications in health monitoring, bio-sensing, electronic skin, and tactile perception. Consequently, tremendous research interest has been devoted to the development of high-performance pressure sensors. In ... ...

Abstract	Pressure sensors show significant potential applications in health monitoring, bio-sensing, electronic skin, and tactile perception. Consequently, tremendous research interest has been devoted to the development of high-performance pressure sensors. In this paper, recent progress on the polymer composite-based flexible pressure sensor is reviewed. The parameters of pressure sensors, including sensitivity, linear response range, detection limit, response speed, and reliability, are first introduced. Secondly, representative types of pressure sensors and relevant working principles are introduced and discussed. After that, the applications in human physiology monitoring, health monitoring, artificial skin, and self-powered smart system are listed and discussed in detail. Finally, the remaining challenges and outlook of polymer composite-based flexible sensors are summarized at the end of this review paper. This work should have some impact on the development of high-performance flexible pressure sensors.
Language	English
Publishing date	2023-05-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15092176
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Article ; Online: Emerging ferroelectric materials ScAlN: applications and prospects in memristors.

Yang, Dong-Ping / Tang, Xin-Gui / Sun, Qi-Jun / Chen, Jia-Ying / Jiang, Yan-Ping / Zhang, Dan / Dong, Hua-Feng

Materials horizons

2024

Abstract: The research found that after doping with rare earth elements, a large number of electrons and holes will be produced on the surface of AlN, which makes the material have the characteristics of spontaneous polarization. A new type of ferroelectric ... ...

Abstract	The research found that after doping with rare earth elements, a large number of electrons and holes will be produced on the surface of AlN, which makes the material have the characteristics of spontaneous polarization. A new type of ferroelectric material has made a new breakthrough in the application of nitride-materials in the field of integrated devices. In this paper, the application prospects and development trends of ferroelectric material ScAlN in memristors are reviewed. Firstly, various fabrication processes and structures of the current ScAlN thin films are described in detail to explore the implementation of their applications in synaptic devices. Secondly, a series of electrical properties of ScAlN films, such as the current switching ratio and long-term cycle durability, were tested to explore whether their electrical properties could meet the basic needs of memristor device materials. Finally, a series of summaries on the current research studies of ScAlN thin films in the synaptic simulation are made, and the working state of ScAlN thin films as a synaptic device is observed. The results show that the ScAlN ferroelectric material has high residual polarization, no wake-up function, excellent stability and obvious STDP behavior, which indicates that the modified material has wide application prospects in the research and development of memristors.
Language	English
Publishing date	2024-03-25
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2744250-0
ISSN	2051-6355 ; 2051-6347
ISSN (online)	2051-6355
ISSN	2051-6347
DOI	10.1039/d3mh01942j
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Article ; Online: A sensitive coumarin fluorescence sensor designed for isoprene detection and imaging research in plants.

Liu, Zhixin / Wang, Mengyuan / Wu, Meng / Yu, Xueling / Sun, Qijun / Su, Chenglin / Sun, Yining / Cao, Shuang / Niu, Na / Chen, Ligang

Biosensors & bioelectronics

2024 Volume 248, Page(s) 115998

Abstract: The release of isoprene by plants is considered to be an adaptation to the environment. Herein, a highly selective coumarin fluorescent probe (DMIC) was designed for detecting isoprene. When isoprene came into contact with the maleimide of DMIC, an ... ...

Abstract	The release of isoprene by plants is considered to be an adaptation to the environment. Herein, a highly selective coumarin fluorescent probe (DMIC) was designed for detecting isoprene. When isoprene came into contact with the maleimide of DMIC, an electrophilic addition process took place. The powerful push-pull effect of DMIC was disrupted. Simultaneously, intramolecular charge transfer was initiated. This enabled DMIC to achieve rapid detection of isoprene within 5 min. Furthermore, excellent linearity was observed in the concentration range of 1-560 ppm (R
MeSH term(s)	Biosensing Techniques ; Plants ; Hemiterpenes ; Coumarins ; Butadienes
Chemical Substances	isoprene (0A62964IBU) ; Hemiterpenes ; Coumarins ; Butadienes
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2024.115998
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