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  1. Article ; Online: Erianin inhibits tumor growth by promoting ferroptosis and inhibiting invasion in hepatocellular carcinoma through the JAK2/STAT3/SLC7A11 pathway.

    Chen, Liyan / Sun, Rongrong / Fang, Kun

    Pathology international

    2024  Volume 74, Issue 3, Page(s) 119–128

    Abstract: Iron has been found to be involved in the tumor cell proliferation process, which can lead to the increased sensitivity of cancer cells to ferroptosis. Since erianin is associated with oxidative stress in hepatocellular carcinoma (HCC), we hypothesized ... ...

    Abstract Iron has been found to be involved in the tumor cell proliferation process, which can lead to the increased sensitivity of cancer cells to ferroptosis. Since erianin is associated with oxidative stress in hepatocellular carcinoma (HCC), we hypothesized that the therapeutic effect and mechanism of erianin on HCC is related to ferroptosis. HCC cells were stimulated with increase of erianin concentrations for 24 h, and the survival rates of Huh-7 and HepG2 cells gradually decreased. After intervention with different doses of erianin, cell proliferation, clone number, and invasion were prominently decreased, apoptosis ratio was increased. Moreover, Nec-1, CQ, and Z-VAD had no effect on the cell viability induced by erianin, while the combination of ferroptosis inhibitors (deferoxamine mesylate, ferrostatin-1, and liproxstatin-1) and erianin prominently increased cell survival rate. Erianin pretreatment induced ferroptosis by enhancing reactive oxygen species, MDA, and Fe
    MeSH term(s) Animals ; Mice ; Carcinoma, Hepatocellular/drug therapy ; Ferroptosis ; Liver Neoplasms/drug therapy ; Bibenzyls ; Phenol
    Chemical Substances Erianin ; Bibenzyls ; Phenol (339NCG44TV)
    Language English
    Publishing date 2024-01-19
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1194850-4
    ISSN 1440-1827 ; 1320-5463
    ISSN (online) 1440-1827
    ISSN 1320-5463
    DOI 10.1111/pin.13403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.200: Show issues Location:
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  2. Article: AKT/foxo3a signal pathway mediates the protective mechanism of resveratrol on renal interstitial fibrosis and oxidative stress in rats with unilateral ureteral obstruction.

    Sun, Rongrong / Zheng, Qu

    American journal of translational research

    2022  Volume 14, Issue 3, Page(s) 1788–1795

    Abstract: Objective: To explore whether protein kinase B (serine/threonrine kinase, AKT)/forkhead box protein O3a (foxo3a) pathway mediates the protective mechanism of resveratrol (RSV) on renal interstitial fibrosis (RIF) and oxidative stress.: Methods: ... ...

    Abstract Objective: To explore whether protein kinase B (serine/threonrine kinase, AKT)/forkhead box protein O3a (foxo3a) pathway mediates the protective mechanism of resveratrol (RSV) on renal interstitial fibrosis (RIF) and oxidative stress.
    Methods: Sprague-Dawley (SD) rats were grouped into Sham group, unilateral ureteral obstruction (UUO) group and UUO + RSV group. HE staining was used to test the pathological damage of RIF intervened by RSV, biochemical analyzer was used to measure serum renal injury indexes (creatinine, Cr, blood urea nitrogen, Bun), and enzyme-linked immunosorbent assay (ELISA) was used to detect oxidative stress indexes (malondialdehyde, MDA; glutathione, GSH; superoxide dismutase, SOD). AKT/FoxO3a signaling pathway markers and renal interstitial indexes were measured by western blot analysis.
    Results: Compared with Sham group, HE staining in UUO group showed significant RIF pathological damage; Cr and Bun indexes were increased, and AKT/FoxO3a signal pathway was activated, as indicated by increased p-AKT/AKT and p-FoxO3a/FoxO3a; TGF-β1 and α-SMA protein levels in fibrosis indexes were increased, while E-cadherin decreased; MDA was increased, GSH and SOD were decreased in oxidative stress indexes, while those in UUO + RSV group were improved.
    Conclusion: AKT/foxo3a signaling pathway mediates the protective mechanism of RSV on RIF and oxidative stress in UUO rats, and RSV can improve RIF and oxidative stress in UUO rats by inhibiting AKT/foxo3a signaling pathway.
    Language English
    Publishing date 2022-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The application effect of targeted nursing in the nursing of patients with chronic gastric ulcer.

    Yang, Mei / Wu, Xiaoyan / Sun, Rongrong

    Minerva gastroenterology

    2023  Volume 70, Issue 1, Page(s) 123–125

    MeSH term(s) Humans ; Stomach Ulcer ; Gastric Mucosa
    Language English
    Publishing date 2023-07-13
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062713-8
    ISSN 2724-5365
    ISSN (online) 2724-5365
    DOI 10.23736/S2724-5985.23.03503-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.51: Show issues Location:
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  4. Article ; Online: Soybean diacylglycerol regulates lipid metabolism in D-galactose-induced aging rats by altering gut microbiota and gene expression of colonic epithelial cells.

    Han, Lulu / Sun, Rongrong / Wang, Yong / Luo, Jianming / Peng, Xichun

    Food & function

    2022  Volume 13, Issue 3, Page(s) 1437–1446

    Abstract: Lipid metabolism is closely related to the health of aging bodies and its disorder often leads to cardiovascular diseases and chronic diseases. Dietary fat is one of the important sources of body fat, which affects the body's lipid metabolism. However, ... ...

    Abstract Lipid metabolism is closely related to the health of aging bodies and its disorder often leads to cardiovascular diseases and chronic diseases. Dietary fat is one of the important sources of body fat, which affects the body's lipid metabolism. However, how dietary fat affects lipid metabolism in aging bodies has not been reported. Thus, the effects of soybean diacylglycerol (DAG) on lipid metabolism in D-galactose-induced aging rats were investigated by detecting the serum biochemical indexes, hepatocyte morphology, gut microbiota changes, and gene expression of colonic epithelial cells. The results showed that DAG alleviated the lipid metabolism disorders, and the hepatocyte morphology of aging rats fed DAG was normal. 16S rDNA analysis showed that DAG restored Eisenbergiella and Veillonella that were missing in aging rats. The relative abundances of
    MeSH term(s) Aging ; Animals ; Colon/metabolism ; Diglycerides/pharmacology ; Disease Models, Animal ; Epithelial Cells/drug effects ; Galactose ; Gastrointestinal Microbiome/drug effects ; Gene Expression/drug effects ; Lipid Metabolism/drug effects ; Male ; Rats ; Rats, Sprague-Dawley ; Glycine max
    Chemical Substances Diglycerides ; Galactose (X2RN3Q8DNE)
    Language English
    Publishing date 2022-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d1fo04140a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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  5. Book ; Online: What measures Chinese monetary policy?

    Sun, Rongrong

    (HKIMR working paper ; 2015,07)

    2015  

    Author's details Rongrong Sun
    Series title HKIMR working paper ; 2015,07
    Keywords Geldpolitisches Ziel ; Dekompositionsverfahren ; VAR-Modell ; China
    Language English
    Size Online-Ressource (37 S.)
    Publisher Hong Kong Inst. for Monetary Research
    Publishing place Hong Kong
    Document type Book ; Online
    Database ECONomics Information System

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  6. Article: Soybean diacylglycerol regulates lipid metabolism in d-galactose-induced aging rats by altering gut microbiota and gene expression of colonic epithelial cells

    Han, Lulu / Sun, Rongrong / Wang, Yong / Luo, Jianming / Peng, Xichun

    Food & function. 2022 Feb. 7, v. 13, no. 3

    2022  

    Abstract: Lipid metabolism is closely related to the health of aging bodies and its disorder often leads to cardiovascular diseases and chronic diseases. Dietary fat is one of the important sources of body fat, which affects the body's lipid metabolism. However, ... ...

    Abstract Lipid metabolism is closely related to the health of aging bodies and its disorder often leads to cardiovascular diseases and chronic diseases. Dietary fat is one of the important sources of body fat, which affects the body's lipid metabolism. However, how dietary fat affects lipid metabolism in aging bodies has not been reported. Thus, the effects of soybean diacylglycerol (DAG) on lipid metabolism in d-galactose-induced aging rats were investigated by detecting the serum biochemical indexes, hepatocyte morphology, gut microbiota changes, and gene expression of colonic epithelial cells. The results showed that DAG alleviated the lipid metabolism disorders, and the hepatocyte morphology of aging rats fed DAG was normal. 16S rDNA analysis showed that DAG restored Eisenbergiella and Veillonella that were missing in aging rats. The relative abundances of Romboutsia and Ruminococcus_2 decreased and the relative abundance of Lachnospiraceae NK4A136 group increased significantly with the influence of DAG (P < 0.05). Gene expression profiles showed that the gene expression of colon epithelial cells was altered by DAG and DAG downregulated the genes Lipe and Fabp4 related to the lipolysis of adipocytes. In conclusion, DAG regulated the lipid metabolism of aging rats by regulating gut microbiota and gene expression of colonic epithelial cells.
    Keywords Lachnospiraceae ; Veillonella ; adipocytes ; blood serum ; body fat ; colon ; diacylglycerols ; dietary fat ; epithelium ; gene expression ; intestinal microorganisms ; lipolysis ; soybeans
    Language English
    Dates of publication 2022-0207
    Size p. 1437-1446.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d1fo04140a
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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  7. Article: What measures Chinese monetary policy?

    Sun, Rongrong

    Journal of international money and finance Vol. 59 , p. 263-286

    2015  Volume 59, Page(s) 263–286

    Author's details Rongrong Sun (School of Economics, University of Nottingham Ningbo, China)
    Keywords Monetary policy ; VAR ; Operating procedures ; Exogenous (endogenous) components
    Language English
    Publisher Elsevier$h1982-
    Publishing place Amsterdam [u.a.]
    Document type Article
    ZDB-ID 872014-9
    ISSN 0261-5606
    Database ECONomics Information System

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  8. Article: [A perspective of the development of medical metrology].

    Sun, Rongrong

    Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

    2011  Volume 35, Issue 6, Page(s) 459–461

    Abstract: This paper summarized the internal and external development of medical metrology, posed its main problem and studied its development trend. ...

    Abstract This paper summarized the internal and external development of medical metrology, posed its main problem and studied its development trend.
    MeSH term(s) Biometry ; Epidemiologic Measurements
    Language Chinese
    Publishing date 2011-11
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1671-7104
    ISSN 1671-7104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Prognostic Nomogram Based on Circular RNA-Associated Competing Endogenous RNA Network for Patients with Lung Adenocarcinoma.

    Li, Yang / Sun, Rongrong / Li, Rui / Chen, Yonggang / Du, He

    Oxidative medicine and cellular longevity

    2021  Volume 2021, Page(s) 9978206

    Abstract: Evidence is increasingly indicating that circular RNAs (circRNAs) are closely involved in tumorigenesis and cancer progression. However, the function and application of circRNAs in lung adenocarcinoma (LUAD) are still unknown. In this study, we ... ...

    Abstract Evidence is increasingly indicating that circular RNAs (circRNAs) are closely involved in tumorigenesis and cancer progression. However, the function and application of circRNAs in lung adenocarcinoma (LUAD) are still unknown. In this study, we constructed a circRNA-associated competitive endogenous RNA (ceRNA) network to investigate the regulatory mechanism of LUAD procession and further constructed a prognostic signature to predict overall survival for LUAD patients. Differentially expressed circRNAs (DEcircRNAs), differentially expressed miRNAs (DEmiRNAs), and differentially expressed mRNAs (DEmRNAs) were selected to construct the ceRNA network. Based on the TargetScan prediction tool and Pearson correlation coefficient, we constructed a circRNA-associated ceRNA network including 11 DEcircRNAs, 8 DEmiRNAs, and 49 DEmRNAs. GO and KEGG enrichment indicated that the ceRNA network might be involved in the regulation of GTPase activity and endothelial cell differentiation. After removing the discrete points, a PPI network containing 12 DEmRNAs was constructed. Univariate Cox regression analysis showed that three DEmRNAs were significantly associated with overall survival. Therefore, we constructed a three-gene prognostic signature for LUAD patients using the LASSO method in the TCGA-LUAD training cohort. By applying the signature, patients could be categorized into the high-risk or low-risk subgroups with significant survival differences (HR: 1.62, 95% CI: 1.12-2.35, log-rank
    MeSH term(s) Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/pathology ; Adult ; Aged ; Aged, 80 and over ; Gene Regulatory Networks/genetics ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Middle Aged ; Nomograms ; Prognosis ; RNA, Circular/genetics
    Chemical Substances RNA, Circular
    Language English
    Publishing date 2021-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2021/9978206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Dynamic monitoring and a clinical correlation analysis of the serum vitamin A, D, and E levels in children with recurrent respiratory tract infections.

    Sun, Mei / Yan, Zhixin / Sun, Rongrong / Tian, Wenqiu / Yi, Wenxia / Zhang, Jing

    American journal of translational research

    2022  Volume 14, Issue 5, Page(s) 3533–3538

    Abstract: Objective: To investigate the correlation of the serum vitamin A, D, and E (VA, VD, and VE) levels with the occurrence and development of recurrent respiratory tract infections (RRTIs).: Methods: A total of 129 children with respiratory tract ... ...

    Abstract Objective: To investigate the correlation of the serum vitamin A, D, and E (VA, VD, and VE) levels with the occurrence and development of recurrent respiratory tract infections (RRTIs).
    Methods: A total of 129 children with respiratory tract infections (RTIs) treated in our hospital from January 2018 to February 2020 (the RTIs group) and 50 healthy children undergoing physical examinations (the control group) in our hospital were recruited as the study cohort. The serum VA, VD, and VE levels were measured upon admission (the active phase) and at two weeks after discharge (the stable phase). The serum VA, VD, and VE levels in the children with RRTIs were compared with the levels in the control group, and the correlation between these three vitamins and the occurrence and development of RRTIs was analyzed.
    Results: The RRTIs group and the RTIs group witnessed markedly lower serum VA, VD, VE, and humoral immunity index levels, including IgG, IgA, and IgM, compared to the control group, with an apparent lower outcome in the RRTIs group than in the RTIs group. The serum levels of the above indexes in the RRTIs children were reduced in the active phase compared with the stable phase. A Pearson correlation analysis showed a positive correlation between VA and IgA. A multivariate logistic regression analysis revealed that a low BMI (Body mass index), prematurity, VA deficiency, VD deficiency, and VE deficiency were the risk factors for RRTIs in children, and outdoor activity was the protective factor.
    Conclusion: The VA, VD, and VE levels are closely related to RRTIs in children. It is important to determine and supplement the VA, VD, and VE levels to prevent RTIs in children.
    Language English
    Publishing date 2022-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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