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  1. Article: [Development of Medical Needle-free Syringes and Direction of Standard Revision].

    Sun, Rui

    Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

    2023  Volume 47, Issue 2, Page(s) 204–206

    Abstract: This study briefly introduced the application and development trend of medical needle-free syringes. The applicability and contents to be revised of the current industry standards in China were discussed. At the same time, the revision direction of the ... ...

    Abstract This study briefly introduced the application and development trend of medical needle-free syringes. The applicability and contents to be revised of the current industry standards in China were discussed. At the same time, the revision direction of the corresponding international standards was introduced. On this basis, suggestions for the standardization of needle-free syringes were provided.
    MeSH term(s) Syringes ; China
    Language Chinese
    Publishing date 2023-04-25
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1671-7104
    ISSN 1671-7104
    DOI 10.3969/j.issn.1671-7104.2023.02.017
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  2. Article ; Online: Border-associated macrophages in the central nervous system.

    Sun, Rui / Jiang, Haowu

    Clinical immunology (Orlando, Fla.)

    2024  , Page(s) 109921

    Abstract: Tissue-resident macrophages play an important role in the local maintenance of homeostasis and immune surveillance. In the central nervous system (CNS), brain macrophages are anatomically divided into parenchymal microglia and non-parenchymal border- ... ...

    Abstract Tissue-resident macrophages play an important role in the local maintenance of homeostasis and immune surveillance. In the central nervous system (CNS), brain macrophages are anatomically divided into parenchymal microglia and non-parenchymal border-associated macrophages (BAMs). Among these immune cell populations, microglia have been well-studied for their roles in normal brain development, neurodegeneration, and brain cancers. BAMs, mostly located in the choroid plexus, meningeal and perivascular spaces, are now gaining increased attention due to advancements in multi-omics technologies and genetic methodologies. Research on BAMs over the past decade has focused on their ontogeny, immunophenotypes, involvement in various CNS diseases, and potential as therapeutic targets. Unlike microglia, BAMs display mixed origins and distinct self-renewal capacity. BAMs are believed to regulate neuroimmune responses associated with brain barriers and contribute to immune-mediated neuropathology. Notably, BAMs have been observed to function in diverse cerebral pathologies, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, ischemic stroke, and gliomas. The elucidation of the heterogeneity and diverse functions of BAMs during homeostasis and neuroinflammation is mesmerizing, since it may shed light on the precision medicine that emphasizes deep insights into programming cues in the unique brain immune microenvironment. In this review, we delve into the latest findings on BAMs, covering aspects like their origins, self-renewal capacity, adaptability, and implications in different brain disorders.
    Language English
    Publishing date 2024-02-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2024.109921
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  3. Article ; Online: Border-associated macrophages in the central nervous system.

    Sun, Rui / Jiang, Haowu

    Journal of neuroinflammation

    2024  Volume 21, Issue 1, Page(s) 67

    Abstract: Tissue-resident macrophages play an important role in the local maintenance of homeostasis and immune surveillance. In the central nervous system (CNS), brain macrophages are anatomically divided into parenchymal microglia and non-parenchymal border- ... ...

    Abstract Tissue-resident macrophages play an important role in the local maintenance of homeostasis and immune surveillance. In the central nervous system (CNS), brain macrophages are anatomically divided into parenchymal microglia and non-parenchymal border-associated macrophages (BAMs). Among these immune cell populations, microglia have been well-studied for their roles during development as well as in health and disease. BAMs, mostly located in the choroid plexus, meningeal and perivascular spaces, are now gaining increased attention due to advancements in multi-omics technologies and genetic methodologies. Research on BAMs over the past decade has focused on their ontogeny, immunophenotypes, involvement in various CNS diseases, and potential as therapeutic targets. Unlike microglia, BAMs display mixed origins and distinct self-renewal capacity. BAMs are believed to regulate neuroimmune responses associated with brain barriers and contribute to immune-mediated neuropathology. Notably, BAMs have been observed to function in diverse cerebral pathologies, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, ischemic stroke, and gliomas. The elucidation of the heterogeneity and diverse functions of BAMs during homeostasis and neuroinflammation is mesmerizing, since it may shed light on the precision medicine that emphasizes deep insights into programming cues in the unique brain immune microenvironment. In this review, we delve into the latest findings on BAMs, covering aspects like their origins, self-renewal capacity, adaptability, and implications in different brain disorders.
    MeSH term(s) Humans ; Central Nervous System/pathology ; Macrophages/pathology ; Microglia/pathology ; Brain/pathology ; Central Nervous System Diseases
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2156455-3
    ISSN 1742-2094 ; 1742-2094
    ISSN (online) 1742-2094
    ISSN 1742-2094
    DOI 10.1186/s12974-024-03059-x
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  4. Article ; Online: Author's Reply: Intracorporeal anastomosis versus extracorporeal anastomosis in laparoscopic right colectomy: An observational cohort study.

    Sun, Rui / Xiao, Yi

    World journal of surgery

    2024  Volume 48, Issue 4, Page(s) 990

    MeSH term(s) Humans ; Colectomy ; Anastomosis, Surgical ; Laparoscopy ; Cohort Studies ; Colonic Neoplasms/surgery ; Treatment Outcome ; Retrospective Studies
    Language English
    Publishing date 2024-02-25
    Publishing country United States
    Document type Observational Study ; Letter
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1002/wjs.12070
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  5. Book ; Thesis: Physikalische und biologische Charakterisierung SPIO- und USPIO-markierter Zellen

    Sun, Rui

    2007  

    Author's details vorgelegt von Rui Sun
    Subject code 616.075
    Language German
    Size 69 S., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2008
    HBZ-ID HT016239349
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 E 1301 order for loan Magazin

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  6. Article: Intervention uncertainty, household health, and pandemic.

    Sun, Rui / Zhao, Yikai

    Journal of mathematical economics

    2023  Volume 105, Page(s) 102819

    Abstract: This study builds a policy choice model wherein household health status responds to the lockdown during the COVID-19 pandemic. Considering an exogenous policy-decision date, the model implies that the government should maintain the current policy if the ... ...

    Abstract This study builds a policy choice model wherein household health status responds to the lockdown during the COVID-19 pandemic. Considering an exogenous policy-decision date, the model implies that the government should maintain the current policy if the perceived effects on infection are below a certain threshold. Specifically, the threshold is determined by policy uncertainty and household concerns regarding health service provision, which further controls the announcement effects of the lockdown. Higher policy uncertainty and concerns regarding health services will diminish the positive impact of the lockdown on household health status.
    Language English
    Publishing date 2023-02-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 0304-4068
    ISSN 0304-4068
    DOI 10.1016/j.jmateco.2023.102819
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  7. Article ; Online: Peripheral ApoE4 Leads to Cerebrovascular Dysfunction and Aβ Deposition in Alzheimer's Disease.

    Sun, Rui / Xie, Chunming

    Neuroscience bulletin

    2023  Volume 39, Issue 8, Page(s) 1330–1332

    MeSH term(s) Humans ; Alzheimer Disease/genetics ; Apolipoprotein E4/genetics ; Amyloid beta-Peptides
    Chemical Substances Apolipoprotein E4 ; Amyloid beta-Peptides
    Language English
    Publishing date 2023-04-24
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2419741-5
    ISSN 1995-8218 ; 1673-7067
    ISSN (online) 1995-8218
    ISSN 1673-7067
    DOI 10.1007/s12264-023-01058-1
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  8. Article: Effects of

    Sun, Rui / Cheng, Zedong / Li, Di / Yin, Jingyao

    Zhongguo zhen jiu = Chinese acupuncture & moxibustion

    2024  Volume 44, Issue 2, Page(s) 169–174

    Abstract: Objectives: To observe the effects of : Methods: A total of 31 male SPF-grade C57BL/6J ApoE-/- mice were fed with high-fat diet for 8 weeks to establish AS model. After successful modeling, the remaining 30 mice were randomly divided into a model ... ...

    Title translation “理中通脉”法针刺对动脉粥样硬化小鼠TMAO、CD36表达及胆固醇沉积的影响.
    Abstract Objectives: To observe the effects of
    Methods: A total of 31 male SPF-grade C57BL/6J ApoE-/- mice were fed with high-fat diet for 8 weeks to establish AS model. After successful modeling, the remaining 30 mice were randomly divided into a model group, a medication group, and an EA group, with 10 mice in each group. An additional 10 normal mice of the same strain were selected as a blank group. The mice in the blank group and the model group received no intervention. The mice in the medication group were treated with intragastric administration of atorvastatin calcium. The mice in the EA group were treated with EA at "Neiguan" (PC 6), "Tianshu" (ST 25) and "Zusanli" (ST 36). The same-side "Neiguan" (PC 6) and "Zusanli" (ST 36), "Tianshu" (ST 25) and the tail of the mice were connected to the EA apparatus, with disperse-dense wave, a frequency of 2 Hz/15 Hz, and a current intensity of 0.3 mA for 10 min per session. Acupuncture was performed unilaterally per session, alternating between the left and right sides, with a frequency of once every other day. After intervention, HE staining was used to observe the pathological morphology of the aorta. Microplate assays were conducted to measure triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels in serum. Ultra high performance liquid chromatography-mass spectrometry technique (UPLC-MS) was employed to detect TMAO level in plasma. Western blot was performed to assess CD36 protein expression level in the aorta. Microanalysis was used to measure cholesterol ester (CE) level in the aorta and the CE/TC ratio was calculated.
    Results: Compared with the blank group, the mice in the model group exhibited significant pathological changes of atherosclerosis, serum TG, TC, LDL-C levels were increased (
    Conclusions: The
    MeSH term(s) Male ; Mice ; Animals ; CD36 Antigens/genetics ; Cholesterol, LDL/metabolism ; Chromatography, Liquid ; Mice, Inbred C57BL ; Acupuncture Points ; Mice, Knockout, ApoE ; Tandem Mass Spectrometry ; Atherosclerosis/genetics ; Atherosclerosis/therapy ; Atherosclerosis/metabolism ; Electroacupuncture ; Methylamines
    Chemical Substances trimethyloxamine (FLD0K1SJ1A) ; CD36 Antigens ; Cholesterol, LDL ; Methylamines
    Language Chinese
    Publishing date 2024-02-12
    Publishing country China
    Document type Journal Article
    ISSN 0255-2930
    ISSN 0255-2930
    DOI 10.13703/j.0255-2930.20230606-0001
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  9. Article ; Online: Impact of the Unstirred Water Layer on the Permeation of Small-Molecule Drugs.

    Kang, Christopher / Shoji, Alyson / Chipot, Christophe / Sun, Rui

    Journal of chemical information and modeling

    2024  Volume 64, Issue 3, Page(s) 933–943

    Abstract: Over the last two decades, numerous molecular dynamics (MD) simulation-based investigations have attempted to predict the membrane permeability to small-molecule drugs as indicators of their bioavailability, a majority of which utilize the inhomogeneous ... ...

    Abstract Over the last two decades, numerous molecular dynamics (MD) simulation-based investigations have attempted to predict the membrane permeability to small-molecule drugs as indicators of their bioavailability, a majority of which utilize the inhomogeneous solubility diffusion (ISD) model. However, MD-based membrane permeability is routinely 3-4 orders of magnitude larger than the values measured with the intestinal perfusion technique. There have been contentious discussions on the sources of the large discrepancies, and the two indisputable, potentially dominant ones are the fixed protonation state of the permeant and the neglect of the unstirred water layer (UWL). Employing six small-molecule drugs of different biopharmaceutical classification system classes, the current MD study relies on the ISD model but introduces the (de)protonation of the permeant by characterizing the permeation free energy of both neutral and charged states. In addition, the role of the UWL as a potential resistance against permeation is explored. The new MD protocol closely mimics the nature of small-molecule permeation and yields estimates that agree well with in vivo intestinal permeability.
    MeSH term(s) Water ; Intestinal Absorption ; Permeability ; Diffusion ; Cell Membrane Permeability
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.3c01629
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  10. Article ; Online: The influence of recommendation algorithm's information flow on targeted advertising audience's coping behavior.

    Chen, Lijun / Sun, Rui / Yuan, Yuan / Zhan, Xuemei

    Acta psychologica

    2024  Volume 243, Page(s) 104168

    Abstract: Targeted advertising equipped with a recommendation algorithm can achieve accurate matching between users and recommended content, but overly precise recommendations may exacerbate negative audience reactions or behaviors. Improving the transparency of ... ...

    Abstract Targeted advertising equipped with a recommendation algorithm can achieve accurate matching between users and recommended content, but overly precise recommendations may exacerbate negative audience reactions or behaviors. Improving the transparency of algorithm recommendation is one of the ways to address audience concerns or skepticism, and transparency guarantees the audience's right to know and thus brings more trust, which will reduce the audience's negative behavior. But increased transparency may also make the audience feel pressured or threatened, and requiring more cognitive and behavioral effort, which was called coping behavior. In order to clarify the relationship between the transparency of the algorithm recommendation and the audience's coping behavior, based on the persuasion theory, this study discusses the mechanism of the influence of the characteristics of the algorithm recommendation information flow on the audience's coping behavior of targeted advertising from the perspective of the flow mode and transmission principle of information. Based on the data of 120 online pretests and 297 formal tests, the results show that the perceived trust and perceived threat caused by the information flow characteristics of the algorithm recommendation jointly determine the possible coping behaviors of targeted advertising audiences. Additionally, users' self-efficacy regulates the relationship between mental process and coping behavior. Different from previous studies on audience coping behaviors of targeted ads, which mainly start from the perspective of participants and advertising content, this research tries to start from the perspective of information flow. The research results demystify the relationship between recommendation algorithm information flow and the audience's coping behavior, and enrich the algorithmic persuasion framework. The research results have reference value for the improvement of personalized recommendation effect, and provide a new way to further study the transparency of algorithm recommendation in the field of consumer behavior. Meanwhile, it also provides suggestions for the practices of platforms and advertisers in practice.
    MeSH term(s) Humans ; Advertising/methods ; Coping Skills ; Emotions ; Algorithms
    Language English
    Publishing date 2024-02-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1480049-4
    ISSN 1873-6297 ; 0001-6918
    ISSN (online) 1873-6297
    ISSN 0001-6918
    DOI 10.1016/j.actpsy.2024.104168
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