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  1. Book ; Online ; E-Book: The Color of Precision Medicine

    Sun, Shirley / Ong, Zoe

    (Routledge Studies in Science, Technology and Society Series)

    2024  

    Abstract: This book proposes the concept of racialization of precision medicine, defined as the social processes by which racial/ethnic categories are incorporated (or not) into the development, interpretation and implementation of precision medicine research and ... ...

    Series title Routledge Studies in Science, Technology and Society Series
    Abstract This book proposes the concept of racialization of precision medicine, defined as the social processes by which racial/ethnic categories are incorporated (or not) into the development, interpretation and implementation of precision medicine research and practice. An important resource on how to deracialize precision medicine.
    Language English
    Size 1 online resource (160 pages)
    Edition 1st ed.
    Publisher Taylor & Francis Group
    Publishing place Oxford
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 9781040022894 ; 9781032565583 ; 1040022898 ; 1032565586
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Effect of yellowing time on bioactive compounds in yellow tea and their antiproliferative capacity in HepG2 cells

    Sun, Shili

    Food Science & Nutrition, 7(5):1838-1847

    2019  

    Abstract: Several studies have shown potent antineoplastic effects of tea, which can induce apoptosis and inhibit proliferation of cancer cells. Yellow tea is one of the six major types of tea, and yellowing time, a key factor in its processing, is known to ... ...

    Abstract Several studies have shown potent antineoplastic effects of tea, which can induce apoptosis and inhibit proliferation of cancer cells. Yellow tea is one of the six major types of tea, and yellowing time, a key factor in its processing, is known to improve its quality and bioactivity. However, the effects of yellowing on the composition of the bioactive substances of tea are poorly understood. We analyzed the biochemical composition and the antioxidant and anticancer activities of the extracts of yellow tea (EYTs) subjected to different yellowing durations. Prolonged yellowing increased the content of water extracts, amino acids, soluble sugars, theaflavins, and nonesterified catechins (p < 0.05, p < 0.01) and decreased that of polyphenols, flavonols, thearubigins, caffeine, GA, and esterified catechins (p < 0.05, p < 0.01). In addition, yellowing also slightly increased the antioxidant capacity of the EYTs, but did not significantly affect their ability to inhibit the proliferation of the hepatocarcinoma HepG2 cells. Mechanistically, the EYTs significantly downregulated the phosphorylation of PI3K and AKT and upregulated the Bax/Bcl‐2 ratio in the HepG2 cells. Taken together, the yellowing time influences the bioactive components of yellow tea, and the resulting yellow tea may have more potent antioxidant and anticancer effects.
    Keywords antioxidation ; anticancer ; bioactive component ; yellow tea ; yellowing time
    Language English
    Document type Article
    Database Repository for Life Sciences

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  3. Book ; Online: Machine Health Monitoring and Fault Diagnosis Techniques

    Sun, Shilong / Shen, Changqing / Wang, Dong

    2023  

    Keywords Technology: general issues ; History of engineering & technology ; Mechanical engineering & materials ; Machine health monitoring ; Fault diagnosis ; Intelligent diagnosis algorithm
    Language English
    Size 1 electronic resource (374 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English
    HBZ-ID HT030381400
    ISBN 9783036573335 ; 303657333X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Spectral Analysis of Bloch-Like Oscillations in Conjugated Polymers.

    Sun, Sutao

    ACS omega

    2023  Volume 8, Issue 43, Page(s) 40456–40462

    Abstract: We present a spectrum investigation of the behavior of dissociated polarons under high electric fields in conjugated polymers. The study employs the Su-Schrieffer-Heeger model along with nonadiabatic molecular dynamics and frequency-domain analysis ... ...

    Abstract We present a spectrum investigation of the behavior of dissociated polarons under high electric fields in conjugated polymers. The study employs the Su-Schrieffer-Heeger model along with nonadiabatic molecular dynamics and frequency-domain analysis methods to analyze the Bloch-like oscillations. It is found that the fundamental frequencies of the current density agree well with the theoretical Bloch frequencies of the perfect crystals. The electron-phonon coupling is a key factor in inducing the deviation between the Bloch-like oscillation behavior in conjugated polymers and that in perfect superlattices. Moreover, the increase in lattice thermal fluctuation is not conducive to the maintenance of Bloch-like oscillation behavior in conjugated polymers.
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c05078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Building Financial Capability and Assets to Reduce Poverty and Health Disparities: Race/Ethnicity Matters.

    Sun, Sicong

    Journal of racial and ethnic health disparities

    2023  

    Abstract: Background: Evidence has documented racial wealth inequity as one of the key pathways linking structural racism and racial health inequity. Most prior studies on the wealth-health relationship use net worth as the measure of wealth. This approach ... ...

    Abstract Background: Evidence has documented racial wealth inequity as one of the key pathways linking structural racism and racial health inequity. Most prior studies on the wealth-health relationship use net worth as the measure of wealth. This approach provides little evidence on the most effective interventions as various types of assets and debt affect health differently. This paper examines how U.S. young adults' wealth components (e.g., financial assets, nonfinancial assets, secured debt, and unsecured debt) are associated with physical and mental health, and if the associations differ by race/ethnicity.
    Methods: Data were drawn from the National Longitudinal Survey of Youth 1997. Health outcomes were measured by mental health inventory and self-rated health. Logistic regressions and ordinary least square regressions were used to assess the association between wealth components and physical and mental health.
    Results: I found that financial assets and secured debt were positively associated with self-rated health and mental health. Unsecured debt was negatively associated with mental health only. The positive associations between financial assets and health outcomes were significantly weaker for non-Hispanic Black respondents. Unsecured debt was protective of self-rated health for non-Hispanic Whites only. For Black young adults, unsecured debt had more severe negative health consequences compared to other racial/ethnic groups.
    Conclusion: This study provides a nuanced understanding of the complex relationship among race/ethnicity, wealth components, and health. Findings could inform asset building and financial capability policies and programs to effectively reduce racialized poverty and health disparities.
    Language English
    Publishing date 2023-06-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2760524-3
    ISSN 2196-8837 ; 2197-3792
    ISSN (online) 2196-8837
    ISSN 2197-3792
    DOI 10.1007/s40615-023-01648-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Racial/Ethnic Heterogeneity in Parental Wealth and Substance Use from Adolescence to Young Adulthood.

    Sun, Sicong

    Journal of racial and ethnic health disparities

    2023  

    Abstract: Background: Substance use has a negative impact on health outcomes, at the individual and population levels. Little consensus exists regarding the relationship between socioeconomic position and substance use across race/ethnicity. This study examines ... ...

    Abstract Background: Substance use has a negative impact on health outcomes, at the individual and population levels. Little consensus exists regarding the relationship between socioeconomic position and substance use across race/ethnicity. This study examines how race/ethnicity and socioeconomic factors, especially parental wealth, are associated with substance use across an 18-year span from adolescence to young adulthood.
    Method: Data were drawn from the National Longitudinal Survey of Youth 1997. Substance use behaviors were measured by self-reported heavy episodic drinking, daily cigarette smoking, and use of cannabis. Parental wealth and parental education were measured at baseline. Other socioeconomic factors included education, employment status, and household income. Two-level logistic regression was performed.
    Results: White respondents were more likely to drink, smoke cigarettes, and use cannabis compared to other racial/ethnic groups. More parental wealth was associated with greater odds of heavy episodic drinking, but lower odds of cigarette and cannabis usage. Race/ethnicity modifies the relationships between parental wealth and substance use. Whereas Black respondents from wealthier families had lower odds of heavy episodic drinking, the direction was opposite among white respondents. Wealth functioned as a protective factor against smoking for all groups, although to a lesser extent among respondents of color than for white respondents. Finally, wealthier Hispanics were more likely to smoke daily and use cannabis compared to other racial/ethnic groups.
    Conclusion: These findings highlight a nuanced patterning of racial/ethnic heterogeneity in the relationship between parental wealth and substance use behaviors. Implications for policy and programming are discussed.
    Language English
    Publishing date 2023-12-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2760524-3
    ISSN 2196-8837 ; 2197-3792
    ISSN (online) 2196-8837
    ISSN 2197-3792
    DOI 10.1007/s40615-023-01893-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Effect of Saccharomyces uvarum on lipid oxidation and carbonyl compounds in silver carp mince during cold storage

    Fu, Xiangjin / Sun, Shuguo

    Food Science & Nutrition, 7(7):2404-2411

    2019  

    Abstract: Fish lipid is highly susceptible to oxidation, resulting in accumulation of toxic substances reactive carbonyl compounds (RCCs), the reduction of nutritional value, and the production of odorous substances. In this study, the effect of yeast ( ... ...

    Abstract Fish lipid is highly susceptible to oxidation, resulting in accumulation of toxic substances reactive carbonyl compounds (RCCs), the reduction of nutritional value, and the production of odorous substances. In this study, the effect of yeast (Saccharomyces uvarum) on RCCs, fat acid composition, volatiles, and sensory traits in silver carp mince stored at 4°C was evaluated. Yeast eliminated malondialdehyde, 4‐hydroxyl‐2‐hexenal, and 4‐hydroxyl‐2‐nonenal by about 80%, 68%, and 60%, which increased by about 170%, 340%, and 300% in the control, respectively. Yeast helped retain about 80% of the polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), respectively; only about 53% and 46% of EPA and DHA, respectively, were maintained in the control. Yeast removed off‐odors hexanal, nonanal, and decenal, resulting in enhanced sensory traits. These findings were economically important for improving the quality of fish products. It might present an approach to improve the flavor of fish products.
    Keywords Saccharomyces uvarum ; carbonyl compounds ; docosahexaenoic acid (DHA) ; eicosapentaenoic acid (EPA) ; flavor ; lipid oxidation ; silver carp
    Language English
    Document type Article
    Database Repository for Life Sciences

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  8. Article ; Online: The demand for a COVID-19 vaccine.

    Sun, Sizhong

    Economics and human biology

    2022  Volume 46, Page(s) 101135

    Abstract: Taking willingness to pay as primitive, this paper establishes an analytical framework for demand estimation, where the estimator is robust to endogeneity of price. Applying the framework, this paper then estimates demand functions for a COVID-19 vaccine ...

    Abstract Taking willingness to pay as primitive, this paper establishes an analytical framework for demand estimation, where the estimator is robust to endogeneity of price. Applying the framework, this paper then estimates demand functions for a COVID-19 vaccine and compute the consumer surplus in both China and the UAE. We find that the price elasticities of demand are mostly greater than one in both countries. An elastic demand suggests subsidy is likely to be successful in promoting vaccination. The consumer surplus is sizeable, around 58 billion US$ in China and 646 million US$ in the UAE. The figures can inform policymakers in assessing their vaccine programs.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; China/epidemiology ; Humans ; Immunization Programs ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-03-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2099749-8
    ISSN 1873-6130 ; 1570-677X
    ISSN (online) 1873-6130
    ISSN 1570-677X
    DOI 10.1016/j.ehb.2022.101135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [

    Ruan, H / She, D / Sun, S

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

    2024  Volume 43, Issue 12, Page(s) 1998–2005

    Abstract: Objective: To explore the role of epigenetic signal molecule bromodomain protein 4 (BRD4) in mediating the therapeutic effect of : Methods: Thirty rat models of PMOP induced by bilateral ovariectomy were randomized equally into two groups for ... ...

    Abstract Objective: To explore the role of epigenetic signal molecule bromodomain protein 4 (BRD4) in mediating the therapeutic effect of
    Methods: Thirty rat models of PMOP induced by bilateral ovariectomy were randomized equally into two groups for treatment with normal saline (model group) or LWDH Pills (385.7 mg/kg), with another 15 sham-operated rats as the sham operation group. After 12 weeks of treatment, femoral samples were taken to determine the bone density and BRD4 protein expression. The weight-bearing exhaustive swimming time of the rat models was recorded, and serum levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) were measured using enzyme-linked immunosorbent assay. In cultured primary osteoblasts the changes in the expressions of BRD4, MAPK and NF-κB proteins were detected by immunofluorescence staining following treatment with LWDH Pills.
    Results: The rat models of PMOP showed significantly up-regulated expression of BRD4 protein in the femoral tissue (
    Conclusion: LWDH can alleviate PMOP and fatigue by decreasing BRD4 signaling pathway, suggesting that potential of BRD4 as a promising therapeutic target for PMOP.
    MeSH term(s) Humans ; Female ; Animals ; Rats ; NF-kappa B ; Nuclear Proteins ; Osteoporosis, Postmenopausal/drug therapy ; Transcription Factors ; Fatigue/drug therapy ; Epigenesis, Genetic ; Bromodomain Containing Proteins ; Cell Cycle Proteins
    Chemical Substances NF-kappa B ; Nuclear Proteins ; Transcription Factors ; BRD4 protein, human ; Bromodomain Containing Proteins ; Cell Cycle Proteins
    Language Chinese
    Publishing date 2024-01-08
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2250951-3
    ISSN 1673-4254
    ISSN 1673-4254
    DOI 10.12122/j.issn.1673-4254.2023.12.02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Water use efficiency evolution in the Yellow River Basin: an integrated analysis of spatial-temporal decomposition

    Sun, Siao

    Hydrological Sciences Journal. 2023 Jan. 02, v. 68, no. 1 p.119-130

    2023  

    Abstract: Understanding water use efficiency evolution and its driving factors should underpin water use efficiency improvement and water demand management. Here I present an integrated analysis framework combining spatial and temporal decomposition analyses to ... ...

    Abstract Understanding water use efficiency evolution and its driving factors should underpin water use efficiency improvement and water demand management. Here I present an integrated analysis framework combining spatial and temporal decomposition analyses to assess sub-basin water use efficiency performances in the Yellow River Basin. Two well-established decomposition approaches, i.e. logarithmic mean Divisia index decomposition and structure decomposition analysis, are used to break down spatial and temporal changes of water use efficiency variables into different contributing factors, and the sensitivity of the result to decomposition methods is examined. The results indicate that sub-basin water use efficiencies overall tend to improve, but show large variability in the magnitude of improvement. The graph of pathways provides a clear virtual presentation to understand the evolution of contributions from different socio-economic factors to water use efficiency changes. The results help in understanding water use changes and have important implications for sustainable water use and management.
    Keywords evolution ; hydrology ; socioeconomics ; water use efficiency ; watersheds ; Yellow River ; arid and semi-arid region ; decomposition ; evolution path ; water use management ; water conservation
    Language English
    Dates of publication 2023-0102
    Size p. 119-130.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ISSN 2150-3435
    DOI 10.1080/02626667.2022.2150552
    Database NAL-Catalogue (AGRICOLA)

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