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Article: [Blood purification therapy in two cases of alcoholic liver disease combined with rhabdomyolysis and acute renal failure].

Li, T / Sun, S S / Bai, X / Zhou, J Y

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

2021 Volume 29, Issue 5, Page(s) 472–473

MeSH term(s)	Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Humans ; Liver Diseases, Alcoholic/complications ; Liver Diseases, Alcoholic/therapy ; Rhabdomyolysis/etiology ; Rhabdomyolysis/therapy
Language	Chinese
Publishing date	2021-06-09
Publishing country	China
Document type	Journal Article
ISSN	1007-3418
ISSN	1007-3418
DOI	10.3760/cma.j.cn501113-20200717-00395
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Article: [Role of NLRP3 inflammasome in the pathogenesis of alcoholic liver disease].

Bai, X / Sun, S S / Zhou, J Y

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

2019 Volume 27, Issue 7, Page(s) 567–571

Abstract: Chronic excess alcohol intake triggers the formation of enterogenic endotoxemia. TLR4 ligand localization activates nuclear transcription factor NF-κB by inducing the up-regulation of NLRP3 inflammasome and the biologically inactive IL-1β and IL-18 ... ...

Abstract	Chronic excess alcohol intake triggers the formation of enterogenic endotoxemia. TLR4 ligand localization activates nuclear transcription factor NF-κB by inducing the up-regulation of NLRP3 inflammasome and the biologically inactive IL-1β and IL-18 precursors to form initiation of pro-inflammatory signals. Under the influence of ethanol, the damaged hepatocyte release uric acid, and adenosine triphosphate and induces NLRP3 inflammasome assembly and functional activation in Kupffer cells to promote the release of inflammatory mediators, such as interleukin-1β and interleukin-18, that cascade mediates inflammation and drive alcoholic liver disease from steatosis to inflammation and fibrosis. The NLRP3 inflammasome acts as a ligand-sensing element and plays an important role in mediating the immune and inflammatory response in the course of alcoholic liver disease. Thus, exploring the activation mechanism of NLRP3 inflammasome and its pathogenic role may provide a new idea in the clinical treatment of alcoholic liver disease.
MeSH term(s)	Humans ; Inflammasomes/metabolism ; Interleukin-18/metabolism ; Interleukin-1beta/metabolism ; Kupffer Cells ; Liver Diseases, Alcoholic/pathology ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
Chemical Substances	IL1B protein, human ; Inflammasomes ; Interleukin-18 ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human
Language	Chinese
Publishing date	2019-09-18
Publishing country	China
Document type	Journal Article
ISSN	1007-3418
ISSN	1007-3418
DOI	10.3760/cma.j.issn.1007-3418.2019.07.019
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Article: [Research progress on urogenital function preservation in extralevator abdominoperineal resection].

Zhang, H H / Sun, C / Sun, S W / Sun, S S

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

2020 Volume 23, Issue 1, Page(s) 92–95

Abstract: Extralevator abdominoperineal excision (ELAPE) has been suggested to potentially improve oncological outcomes in advanced low rectal cancer patients. However, the urogenital function impairment as one of the main complications deteriorates the quality of ...

Abstract	Extralevator abdominoperineal excision (ELAPE) has been suggested to potentially improve oncological outcomes in advanced low rectal cancer patients. However, the urogenital function impairment as one of the main complications deteriorates the quality of life in these patients. The key point to prevent urogenital function impairment is to avoid autonomic nerve injury, including the superior and inferior hypogastric nerve plexus and neurovascular bundle. Three areas should be especially focused during surgery, including the posterolateral aspect of the prostate during the separation of the rectum from prostate, the lateral wall of ischioanal fossa and the area in front of anal canal. Previous presumption supposed that extended resection, though promoting oncologic outcomes, might lead to enlarged injury to surrounding vessels and nerves that deteriorated patients' urogenital function. But recent studies show that postoperative urogenital function outcomes of rectal cancer patients who underwent ELAPE are not inferior to conventional APE after the induction of minimal invasive approaches including laparoscopic and robotic surgery. Their quality of life can be comparable with patients who underwent conventional APE, and are even better in some particular area. Moreover, as further improvement of ELAPE procedure has been made, the concept of individualized ELAPE addressed the importance of personalized surgical procedure based on tumor stage and location, dedicating to avoid injury to vessels and nerves through preserving more surrounding tissues. Urogenital function outcomes, as part of postoperative outcomes, get more and more attention in recent years. We review current studies on urogenital function after ELAPE from anatomy to clinical research, in order to raise surgeons' attention of nerve preservation technique and to improve their understanding of ELAPE procedure.
MeSH term(s)	Autonomic Nervous System/injuries ; Autonomic Nervous System/surgery ; Humans ; Pelvic Floor/injuries ; Pelvic Floor/surgery ; Perineum ; Peripheral Nerve Injuries/etiology ; Peripheral Nerve Injuries/prevention & control ; Proctectomy/adverse effects ; Proctectomy/methods ; Proctectomy/standards ; Quality of Life ; Rectal Neoplasms/surgery ; Treatment Outcome ; Urogenital System/injuries ; Urogenital System/innervation ; Urogenital System/surgery
Language	Chinese
Publishing date	2020-01-20
Publishing country	China
Document type	Journal Article ; Review
ISSN	1671-0274
ISSN	1671-0274
DOI	10.3760/cma.j.issn.1671-0274.2020.01.017
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Article: Metabolism studies of paeoniflorin in rat liver microsomes by ultra-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS).

Zhu, L J / Sun, S S / Hu, Y X / Liu, Y F

Royal Society open science

2018 Volume 5, Issue 10, Page(s) 180759

Abstract: To explore metabolism mechanism of paeoniflorin in the liver and further understand intact metabolism process of paeoniflorin, a rapid, convenient and effective assay is described using ultra-performance liquid chromatography coupled with hybrid ... ...

Abstract	To explore metabolism mechanism of paeoniflorin in the liver and further understand intact metabolism process of paeoniflorin, a rapid, convenient and effective assay is described using ultra-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS). The strategy was confirmed in the following primary processes: firstly, different concentration of paeoniflorin, rat liver microsomes, coenzymes and different incubated conditions were optimized to build a biotransformation model of rat liver microsomes
Language	English
Publishing date	2018-10-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.180759
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Article: [Diagnosis and treatment of a case of infection caused by shark fin stabbing right hand for more than two years].

Xue, Z X / Wang, L K / Sun, S S / Zhou, F F / Guo, H W / Ma, X J

Zhonghua nei ke za zhi

2021 Volume 61, Issue 6, Page(s) 691–693

MeSH term(s)	Animals ; Humans ; Seafood/analysis ; Sharks
Language	Chinese
Publishing date	2021-11-03
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	754223-9
ISSN	0578-1426
ISSN	0578-1426
DOI	10.3760/cma.j.cn112138-20210602-00392
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Article ; Online: Biofortification of rice with lysine using endogenous histones.

Wong, H W / Liu, Q / Sun, S S M

Plant molecular biology

2015 Volume 87, Issue 3, Page(s) 235–248

Abstract: Rice is the most consumed cereal grain in the world, but deficient in the essential amino acid lysine. Therefore, people in developing countries with limited food diversity who rely on rice as their major food source may suffer from malnutrition. ... ...

Abstract	Rice is the most consumed cereal grain in the world, but deficient in the essential amino acid lysine. Therefore, people in developing countries with limited food diversity who rely on rice as their major food source may suffer from malnutrition. Biofortification of stable crops by genetic engineering provides a fast and sustainable method to solve this problem. In this study, two endogenous rice lysine-rich histone proteins, RLRH1 and RLRH2, were over-expressed in rice seeds to achieve lysine biofortification. Their protein sequences passed an allergic sequence-based homology test. Their accumulations in rice seeds were raised to a moderate level by the use of a modified rice glutelin 1 promoter with lowered expression strength to avoid the occurrence of physiological abnormalities like unfolded protein response. The expressed proteins were further targeted to protein storage vacuoles for stable storage using a glutelin 1 signal peptide. The lysine content in the transgenic rice seeds was enhanced by up to 35 %, while other essential amino acids remained balanced, meeting the nutritional standards of the World Health Organization. No obvious unfolded protein response was detected. Different degrees of chalkiness, however, were detected in the transgenic seeds, and were positively correlated with both the levels of accumulated protein and lysine enhancement. This study offered a solution to the lysine deficiency in rice, while at the same time addressing concerns about food safety and physiological abnormalities in biofortified crops.
MeSH term(s)	Allergens/genetics ; Amino Acids/analysis ; Biotechnology ; Food Hypersensitivity/prevention & control ; Food Safety ; Food, Fortified/analysis ; Food, Genetically Modified ; Gene Expression ; Genes, Plant ; Histones/genetics ; Histones/immunology ; Histones/metabolism ; Humans ; Lysine/deficiency ; Lysine/metabolism ; Malnutrition/prevention & control ; Microscopy, Electron, Transmission ; Oryza/genetics ; Oryza/immunology ; Oryza/metabolism ; Plant Proteins/genetics ; Plant Proteins/immunology ; Plant Proteins/metabolism ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/metabolism ; Promoter Regions, Genetic ; Seeds/genetics ; Seeds/metabolism ; Seeds/ultrastructure ; Unfolded Protein Response
Chemical Substances	Allergens ; Amino Acids ; Histones ; Plant Proteins ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2015-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	778032-1
ISSN	1573-5028 ; 0167-4412
ISSN (online)	1573-5028
ISSN	0167-4412
DOI	10.1007/s11103-014-0272-z
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Article: [Validation and optimization of the indicator system of risk assessment for mechanical cuts].

Fu, C D / Lin, D Y / Liang, C K / Qiu, X L / Sun, S S / Feng, Q / Liu, H X

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

2019 Volume 37, Issue 6, Page(s) 449–452

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Delivery of Health Care ; Risk Assessment
Language	Chinese
Publishing date	2019-06-15
Publishing country	China
Document type	Journal Article
ISSN	1001-9391
ISSN	1001-9391
DOI	10.3760/cma.j.issn.1001-9391.2019.06.011
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Article ; Online: Relationships between childhood growth parameters and adult blood pressure: the Fels Longitudinal Study.

Sabo, R T / Wang, A / Deng, Y / Sabo, C S / Sun, S S

Journal of developmental origins of health and disease

2017 Volume 8, Issue 1, Page(s) 113–122

Abstract: Previous research has shown that childhood body size is associated with blood pressure in adulthood, and that early and rapid growth rates are correlated with adverse cardiovascular outcomes. Our objectives are to estimate associations between childhood ... ...

Abstract	Previous research has shown that childhood body size is associated with blood pressure in adulthood, and that early and rapid growth rates are correlated with adverse cardiovascular outcomes. Our objectives are to estimate associations between childhood body size growth parameters and adult blood pressure, and to examine the effect of early attainment of critical growth milestones on adult blood pressure, relative to normal or late attainment. Lifetime height and body mass index (BMI) measurements in childhood, and systolic blood pressure (SBP) and diastolic blood pressure (DBP) measurements in adulthood are taken from participants in the Fels Longitudinal Study. Childhood growth curves are estimated separately for stature and BMI using the Preece-Baines and third-degree polynomial models, respectively. Associations between the resulting parameter estimates and adult blood pressure are then examined using linear mixed models. Our findings show that the ages of achievement of the stature-based growth onset and peak velocity, as well as the age of achievement of the BMI-based adiposity rebound, are negatively associated with adult blood pressure, implying that early height or BMI growth can lead to increased blood pressure in adulthood. There were subtle differences in these relationships based on age and gender, and also between SBP and DBP. These results expand on the existing literature, showing that not only childhood body size, but also the timing of childhood growth can have a deleterious effect on adult cardiovascular health.
Language	English
Publishing date	2017-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2554780-X
ISSN	2040-1752 ; 2040-1744
ISSN (online)	2040-1752
ISSN	2040-1744
DOI	10.1017/S2040174416000520
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Article: Molecular properties of phosphoenolpyruvate carboxylase from C3, C 3-C 4 intermediate, and C 4 Flaveria species.

Adams, C A / Leung, F / Sun, S S

Planta

2013 Volume 167, Issue 2, Page(s) 218–225

Abstract: Phosphoenolpyruvate carboxylase (PEPCase; EC 4.1.1.31) from Flaveria trinervia Mohr (C4), F. floridana Johnston (C3-C4), and F. cronquistii Powell (C3) leaves were compared by electrotransfer blotting/enzyme-linked immunoassay (Western-blot analysis), ... ...

Abstract	Phosphoenolpyruvate carboxylase (PEPCase; EC 4.1.1.31) from Flaveria trinervia Mohr (C4), F. floridana Johnston (C3-C4), and F. cronquistii Powell (C3) leaves were compared by electrotransfer blotting/enzyme-linked immunoassay (Western-blot analysis), mobility of the native enzyme in polyacrylamide gels and in isoelectric focusing (IEF) gels, peptide mapping, and in-vitro translation of RNA isolated from each plant. The PEPCases from the C3 and C3-C4 plants were very similar to each other in terms of electrophoretic mobilities on gels and isoenzyme patterns on IEF gels, and identical in peptide mapping. Quantitative differences were noted, however, in that the C3-C4 intermediate plant contained more PEPCase overall and that the relative activity of individual isoenzymes shifted between the C3 and C3-C4 intermediate PEPCases. The PEPCase from the C4 plant had a different isoenzyme pattern, a different peptide map, and was far more abundant than the other two enzymes. Western blot analysis demonstrated the cross-reactivity of PEPCases from all three Flaveria species with antibody raised against maize PEPCase. The results provide evidence, at the molecular level, that supports the view of C3-C4 intermediate species as C3-like plants with some C4-like photosynthetic characteristics, but there are differences from the C3 plant in the quantity and properties of the PEPCase from the C3-C4 intermediate plant.
Language	English
Publishing date	2013-11-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	208909-9
ISSN	1432-2048 ; 0032-0935 ; 1866-2749
ISSN (online)	1432-2048
ISSN	0032-0935 ; 1866-2749
DOI	10.1007/BF00391418
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Article ; Online: Note: A novel normalization scheme for laser-based plasma x-ray sources.

Zhang, B B / Sun, S S / Sun, D R / Tao, Y

The Review of scientific instruments

2014 Volume 85, Issue 9, Page(s) 96110

Abstract: A kHz repetition rate laser pump-X-ray probe system for ultrafast X-ray diffraction is set up based on a laser-driven plasma X-ray source. A simple and reliable normalization approach has been developed to minimize the impact of large X-ray pulse ... ...

Abstract	A kHz repetition rate laser pump-X-ray probe system for ultrafast X-ray diffraction is set up based on a laser-driven plasma X-ray source. A simple and reliable normalization approach has been developed to minimize the impact of large X-ray pulse intensity fluctuation on data quality. It utilizes one single X-ray area detector to record both sample and reference signals simultaneously. Performance of this novel normalization method is demonstrated in reflectivity oscillation measurement of a superlattice sample at sub-ps resolution.
Language	English
Publishing date	2014-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/1.4896252
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