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Article ; Online: Design of integrated silicon waveguides for Raman-enhanced four-wave mixing in the telecom band.

Sun, Shiyu / Mashanovich, Goran Z / Peacock, Anna C

2024 Volume 32, Issue 6, Page(s) 8715–8722

Abstract: Silicon planar waveguides are designed to maximize the wavelength conversion efficiency via the use of Raman-enhanced four-wave mixing in the telecom band. By investigating the dispersion properties of various rib waveguide structures, the optimum etch ... ...

Abstract	Silicon planar waveguides are designed to maximize the wavelength conversion efficiency via the use of Raman-enhanced four-wave mixing in the telecom band. By investigating the dispersion properties of various rib waveguide structures, the optimum etch depth and width are selected to obtain efficient phase-matching for a continuous-wave pump at 1545 nm. The design benefits from good fabrication tolerance in the structural parameters, which are well within the precision of standard lithography and etching processes. Using the optimized waveguides, simulations show that it is possible to reach conversion efficiencies as high as ∼45 dB for waveguide lengths as short as 4.6 cm, with a pump power of only 130 mW. This enhancement in the conversion efficiency is about 50 dB higher than conventional values for FWM in integrated silicon photonic systems, highlighting the benefits of exploiting the coupling between the two nonlinear processes.
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.509992
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Article ; Online: Treatment of Circadian Rhythm Sleep-Wake Disorders.

Sun, Shi-Yu / Chen, Gui-Hai

Current neuropharmacology

2022 Volume 20, Issue 6, Page(s) 1022–1034

Abstract: Circadian rhythm sleep-wake disorders (CRSWDs) are a distinct class of sleep disorders caused by alterations to the circadian time-keeping system, its entrainment mechanisms, or a mismatch between the endogenous circadian rhythm and the external ... ...

Abstract	Circadian rhythm sleep-wake disorders (CRSWDs) are a distinct class of sleep disorders caused by alterations to the circadian time-keeping system, its entrainment mechanisms, or a mismatch between the endogenous circadian rhythm and the external environment. The main clinical manifestations are insomnia and excessive daytime sleepiness that often lead to clinically meaningful distress or cause mental, physical, social, occupational, educational, or other functional impairment. CRSWDs are easily mistaken for insomnia or early waking up, resulting in inappropriate treatment. CRSWDs can be roughly divided into two categories, namely, intrinsic CRSWDs, in which sleep disturbances are caused by alterations to the endogenous circadian rhythm system due to chronic changes in the regulation or capture mechanism of the biological clock, and extrinsic circadian rhythm sleep-wake disorders, in which sleep disorders, such as jet lag or shift-work disorder, result from environmental changes that cause a mismatch between sleep-wakefulness times and internal circadian rhythms. Sleep diaries, actigraphy, and determination of day and night phase markers (dim light melatonin onset and core body temperature minimum) have all become routine diagnostic methods for CRSWDs. Common treatments for CRSWD currently include sleep health education, time therapy, light therapy, melatonin, and hypnotic drug therapy. Here, we review the progress in the epidemiology, etiology, diagnostic evaluation, diagnostic criteria, and treatment of intrinsic CRSWD, with emphasis on the latter, in the hope of bolstering the clinical diagnosis and treatment of CRSWDs.
MeSH term(s)	Circadian Rhythm/physiology ; Humans ; Melatonin/therapeutic use ; Sleep/physiology ; Sleep Disorders, Circadian Rhythm/diagnosis ; Sleep Disorders, Circadian Rhythm/epidemiology ; Sleep Disorders, Circadian Rhythm/therapy ; Sleep Initiation and Maintenance Disorders/drug therapy ; Sleep Wake Disorders/drug therapy
Chemical Substances	Melatonin (JL5DK93RCL)
Language	English
Publishing date	2022-09-22
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2192352-8
ISSN	1875-6190 ; 1570-159X
ISSN (online)	1875-6190
ISSN	1570-159X
DOI	10.2174/1570159X19666210907122933
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Article ; Online: Modeling development using microfluidics: bridging gaps to foster fundamental and translational research.

Sun, Shiyu / Xue, Xufeng / Fu, Jianping

Current opinion in genetics & development

2023 Volume 82, Page(s) 102097

Abstract: In vitro stem cell-derived embryo and organ models, termed embryoids and organoids, respectively, provide promising experimental tools to study physiological and pathological processes in mammalian development and organ formation. Most of current ... ...

Abstract	In vitro stem cell-derived embryo and organ models, termed embryoids and organoids, respectively, provide promising experimental tools to study physiological and pathological processes in mammalian development and organ formation. Most of current embryoid and organoid systems are developed using conventional three-dimensional cultures that lack controls of spatiotemporal extracellular signals. Microfluidics, an established technology for quantitative controls and quantifications of dynamic chemical and physical environments, has recently been utilized for developing next-generation embryoids and organoids in a controllable and reproducible manner. In this review, we summarize recent progress in constructing microfluidics-based embryoids and organoids. Development of these models demonstrates the successful applications of microfluidics in establishing morphogen gradients, accelerating medium transport, exerting mechanical forces, facilitating tissue coculture studies, and improving assay throughput, thus supporting using microfluidics for building next-generation embryoids and organoids for fundamental and translational research.
MeSH term(s)	Animals ; Translational Research, Biomedical ; Microfluidics ; Organoids ; Stem Cells ; Mammals
Language	English
Publishing date	2023-08-11
Publishing country	England
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1077312-5
ISSN	1879-0380 ; 0959-437X
ISSN (online)	1879-0380
ISSN	0959-437X
DOI	10.1016/j.gde.2023.102097
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Article: [Prenatal diagnosis of fetal microdeletion and microduplication syndromes among pregnant women with advanced maternal ages].

Duan, Fang / Wu, Qichang / Xu, Yasong / Sun, Shiyu / Ji, Yizhen / Sun, Li

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

2024 Volume 41, Issue 4, Page(s) 486–493

Abstract: Objective: To assess the value of combined chromosomal karyotyping and chromosomal microarray analysis (CMA) and/or copy number variation sequencing (CNV-seq) for the prenatal diagnosis for women with advanced maternal ages, and to explore the ... ...

Abstract	Objective: To assess the value of combined chromosomal karyotyping and chromosomal microarray analysis (CMA) and/or copy number variation sequencing (CNV-seq) for the prenatal diagnosis for women with advanced maternal ages, and to explore the challenges of prenatal genetic counseling brought by the types of fetal CNVs and uncertainty of related phenotypes. Methods: A retrospective analysis was carried out on 1 841 women with advanced maternal age who underwent interventional prenatal diagnosis at the Prenatal Diagnosis Center of Xiamen University Affiliated Women and Children's Hospital from January 2017 to December 2020. Routine chromosomal karyotyping analysis and CMA/CNV-seq detection were carried out. Results: CMA/CNV-seq had detected pathogenic variants in 2 cases which had failed karyotyping analysis. Two hundred and twenty one fetal chromosomal abnormalities were detected by karyotyping analysis, among which 187 were detected by CMA/CNV-seq. CMA/CNV-seq analysis of 23 cases with balanced chromosome structural aberrations and 10 cases with low proportion mosaicisms (including a marker chromosome) had yielded a negative result. In addition, 26 cases (26/1 841, 1.4%) with pathogenic CNVs were discovered among those with a normal karyotype, of which 13 (50.0%) were recurrent CNVs associated with neurocognitive impairment, with 22q11.21 microdeletions and microduplications being the most common types (26.92%). Conclusion: The combination of karyotyping analysis and CMA/CNV-seq not only increased the rate of prenatal diagnosis, but also complemented with each other, which has facilitated genetic counseling and formulation of prenatal diagnosis strategy for the affected families.
MeSH term(s)	Child ; Female ; Pregnancy ; Humans ; Maternal Age ; Pregnant Women ; DNA Copy Number Variations ; Retrospective Studies ; Prenatal Diagnosis ; Chromosome Aberrations ; Microarray Analysis ; Syndrome
Language	Chinese
Publishing date	2024-03-31
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1003-9406
ISSN	1003-9406
DOI	10.3760/cma.j.cn511374-20230412-00205
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Article ; Online: Machine learning vs. statistical model for prediction modeling and experimental validation: Application in groundwater permeable reactive barrier width design.

Guo, Fengshi / Ren, Yangmin / Zhou, Yongyue / Sun, Shiyu / Cui, Mingcan / Khim, Jeehyeong

Journal of hazardous materials

2024 Volume 469, Page(s) 133825

Abstract: Permeable reactive barrier (PRB) is an effective in-situ technology for groundwater remediation. The important factors in PRB design are the width and reactive material. In this study, the beaded coal mine drainage sludge (BCMDS) was employed as the ... ...

Abstract	Permeable reactive barrier (PRB) is an effective in-situ technology for groundwater remediation. The important factors in PRB design are the width and reactive material. In this study, the beaded coal mine drainage sludge (BCMDS) was employed as the filling material to adsorb arsenic pollutants in groundwater, aiming to design the width of PRB. The design methods involving traditional continue column experiments and empirical formulas, as well as machine learning (ML) predictions and statistical methods, which are compared with each other. Traditional methods are determined based on breakthrough curves under several conditions. ML method has advantages in predicting the width of mass transfer zone (W
Language	English
Publishing date	2024-02-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2024.133825
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Article: Serum Cystatin C is Associated with Depression After Intracerebral Hemorrhage.

Zhu, Lei / Yu, Chuanqing / Chang, Yueyue / Sun, Shiyu / Sun, Zhongwu

Neuropsychiatric disease and treatment

2023 Volume 19, Page(s) 1117–1126

Abstract: Purpose: Cystatins are associated with neuronal degeneration and nervous system healing. Cystatin C (Cys C) has recently been linked to brain injury and immunological inflammation. This study aimed to determine the relationship between serum Cys C ... ...

Abstract	Purpose: Cystatins are associated with neuronal degeneration and nervous system healing. Cystatin C (Cys C) has recently been linked to brain injury and immunological inflammation. This study aimed to determine the relationship between serum Cys C levels and depression following intracranial hemorrhage (ICH). Patients and methods: Between September 2020 and December 2022, 337 patients with ICH were sequentially recruited and followed up for three months. The post-stroke depression (PSD) and non-PSD groups were separated based on the 17-item Hamilton Depression Rating Scale (HAMD). The PSD diagnosis was established based on the DSM-IV criteria. Cys-C levels were documented within twenty-four hours of admission. Results: Three months after ICH, 93 (27.6%) of 337 enrolled patients were diagnosed with depression. The Cys C levels were significantly higher in depressed patients than in nondepressed patients after ICH (1.32 vs 1.01; p<0.001). After adjusting for potential confounding variables, depression after ICH was associated with the highest quartile of Cys C levels (odds ratio (OR) = 3.195, 95% CI: 1.562-6.536; p=0.001). The receiver operating characteristic curve (ROC) curve predicted that the ideal cut-off for CysC levels as a predictor of depression after ICH would be 0.730, resulting in 84.5% sensitivity and 88.4% specificity, with an area under curve (AUC) of 0.880 (95% CI: 0.843-0.917; p< 0.0001). Conclusion: Increased CysC concentrations were independently related to depression three months after ICH, highlighting that CysC levels at admission may be a potential biomarker for predicting the onset of depression following ICH.
Language	English
Publishing date	2023-05-08
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186503-6
ISSN	1178-2021 ; 1176-6328
ISSN (online)	1178-2021
ISSN	1176-6328
DOI	10.2147/NDT.S409421
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Article: Extended application of BACs-on-Beads technique in prenatal diagnosis.

Sun, Shiyu / Zhang, Zhonghua / Zhao, Jing / Lan, Xinqiang

Archives of medical science : AMS

2022 Volume 19, Issue 1, Page(s) 250–257

Abstract: Introduction: This study explored the application of bacterial artificial chromosomes (BACs)-on-Beads (BoBs) technique, especially its ability to detect microdeletion/microduplication regions with a single probe.: Methods: Both chromosome karyotyping ...

Abstract	Introduction: This study explored the application of bacterial artificial chromosomes (BACs)-on-Beads (BoBs) technique, especially its ability to detect microdeletion/microduplication regions with a single probe. Methods: Both chromosome karyotyping and BoBs technique were applied on a total of 2218 pregnant women. Chromosome microarray analysis (CMA) was performed on patients whose cells were reported as being abnormal by BoBs technique with a single probe. Results: Twenty-two cases were detected as microdeletion/microduplication with a single probe, which was consistent with the CMA results. Conclusions: We believe that the microdeletion/microduplication results detected by BoBs technique with a single probe provide comprehensive guidance for prenatal diagnosis.
Language	English
Publishing date	2022-12-09
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2203781-0
ISSN	1734-1922
ISSN	1734-1922
DOI	10.5114/aoms/155981
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Article ; Online: Crystallization Selectivity of Ribavirin Solution and Amorphous Phase.

Li, Fuying / Chen, Shiying / Hu, Haoxin / Liang, Chengfeng / Sun, Shiyu / Jin, Can / Chen, Fenghua

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 17

Abstract: Crystallization selectivity is an important principle in polymorph control. Ribavirin Form I, Form II, DMSO solvate, and amorphous ribavirin are prepared, and the short-range order similarities between these solid forms and ribavirin aqueous solution and ...

Abstract	Crystallization selectivity is an important principle in polymorph control. Ribavirin Form I, Form II, DMSO solvate, and amorphous ribavirin are prepared, and the short-range order similarities between these solid forms and ribavirin aqueous solution and DMSO solution are compared via mid-frequency Raman difference spectra (MFRDS). The crystallization process from amorphous ribavirin to Form I and from solution to amorphous phase is explained. Reasons for the difficulty in preparing the DMSO solvate are proposed. The rationale provided for the crystallization selectivity provides a foundation for the synthesis of metastable phases with a robust and convenient method.
Language	English
Publishing date	2023-08-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28176320
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Article ; Online: Utilizing machine learning for reactive material selection and width design in permeable reactive barrier (PRB).

Ren, Yangmin / Cui, Mingcan / Zhou, Yongyue / Sun, Shiyu / Guo, Fengshi / Ma, Junjun / Han, Zhengchang / Park, Jooyoung / Son, Younggyu / Khim, Jeehyeong

Water research

2024 Volume 251, Page(s) 121097

Abstract: Permeable reactive barrier (PRB) is an important groundwater treatment technology. However, selecting the optimal reactive material and estimating the width remain critical and challenging problems in PRB design. Machine learning (ML) has advantages in ... ...

Abstract	Permeable reactive barrier (PRB) is an important groundwater treatment technology. However, selecting the optimal reactive material and estimating the width remain critical and challenging problems in PRB design. Machine learning (ML) has advantages in predicting evolution and tracing contaminants in temporal and spatial distribution. In this study, ML was developed to design PRB, and its feasibility was validated through experiments and a case study. ML algorithm showed a good prediction about the Freundlich equilibrium parameter (R
MeSH term(s)	Water Pollutants, Chemical/analysis ; Environmental Restoration and Remediation ; Groundwater/analysis ; Adsorption
Chemical Substances	Water Pollutants, Chemical
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2023.121097
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Article ; Online: Stem cell-based models of early mammalian development.

Terhune, Aidan H / Bok, Jeyoon / Sun, Shiyu / Fu, Jianping

Development (Cambridge, England)

2022 Volume 149, Issue 20

Abstract: The complex process by which a single-celled zygote develops into a viable embryo is nothing short of a miraculous wonder of the natural world. Elucidating how this process is orchestrated in humans has long eluded the grasp of scientists due to ethical ... ...

Abstract	The complex process by which a single-celled zygote develops into a viable embryo is nothing short of a miraculous wonder of the natural world. Elucidating how this process is orchestrated in humans has long eluded the grasp of scientists due to ethical and practical limitations. Thankfully, pluripotent stem cells that resemble early developmental cell types possess the ability to mimic specific embryonic events. As such, murine and human stem cells have been leveraged by scientists to create in vitro models that aim to recapitulate different stages of early mammalian development. Here, we examine the wide variety of stem cell-based embryo models that have been developed to recapitulate and study embryonic events, from pre-implantation development through to early organogenesis. We discuss the applications of these models, key considerations regarding their importance within the field, and how such models are expected to grow and evolve to achieve exciting new milestones in the future.
MeSH term(s)	Humans ; Mice ; Animals ; Embryo, Mammalian/metabolism ; Embryonic Development ; Pluripotent Stem Cells ; Organogenesis ; Zygote ; Mammals
Language	English
Publishing date	2022-10-18
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.201015
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