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Article: The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian randomization study.

Sun, Wanli / Yang, Fan / Yang, Yiyuan / Su, Xin / Xing, Yanwei

2023 Volume 14, Page(s) 1266869

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-10-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1266869
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: HPV prevalence and genotype distribution among 38 056 women in Weifang, China: a cross-sectional study.

Liu, Mengmeng / Zhang, Xuguang / Guo, Lulu / Sun, Wanli / Jiang, Xuanli

BMJ open

2023 Volume 13, Issue 9, Page(s) e073332

Abstract: Objectives: Human papillomavirus (HPV) infection is closely associated with cervical cancer, especially the persistent infection of high-risk HPV (HR-HPV) genotypes. Therefore, investigating the HPV prevalence, age-specific, genotype distribution and ... ...

Abstract	Objectives: Human papillomavirus (HPV) infection is closely associated with cervical cancer, especially the persistent infection of high-risk HPV (HR-HPV) genotypes. Therefore, investigating the HPV prevalence, age-specific, genotype distribution and the impact of the COVID-19 pandemic among large populations was essential for HPV screening and optimising vaccination. Design: This was a cross-sectional study. Methods: A total of 38 056 cervical epithelial cell specimens were collected in Weifang city from January 2018 to December 2022. The study was divided into seven age groups based on the age of the participants. HPV genotype testing was performed by using a commercial kit which is designed for the detection of 23 HPV genotypes. Result: A total of 8998 women were infected with HPV, with an overall positive rate of 23.64% (8998/38 056). Single infection of HPV was dominant among different age groups, which accounted for 71.33% of total infections. The most prevalent genotype was HR-HPV 16 (4.33%), followed by 52, 58, 53 and 68. Low-risk HPV (LR-HPV) 42 exhibited the highest prevalence (2.19%) among six LR-HPV genotypes, representing a novel finding. There was a significant difference in the prevalence across different age groups (p<0.01), with the highest prevalence in the group under 25 years old. During the 3 year COVID-19 breakout period, the number of HPV samples received in 2020, 2021 and 2022 was reduced by 24.03%, 14.79% and 24.76%, respectively. In 2018-2022, the annual prevalence varied between 21.09% and 25.30%, with a decreasing trend, while the prevalence of HR-HPV 39, 56, 31 and LR-HPV 42 increased. Conclusion: This study indicates a high-HPV infection rate and age-specific distribution characteristics of HPV genotype infections, as well as analyses of the impact of the COVID-19 outbreak on the HPV prevalence, which provides an epidemiological basis for the control and prevention of HPV infection in this region.
MeSH term(s)	Humans ; Female ; Adult ; Cross-Sectional Studies ; COVID-19 ; Pandemics ; Papillomavirus Infections ; Prevalence ; China ; Genotype ; Papillomaviridae
Language	English
Publishing date	2023-09-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-073332
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Book ; Online: Energy-Based Models For Speech Synthesis

Sun, Wanli / Tu, Zehai / Ragni, Anton

2023

Abstract: Recently there has been a lot of interest in non-autoregressive (non-AR) models for speech synthesis, such as FastSpeech 2 and diffusion models. Unlike AR models, these models do not have autoregressive dependencies among outputs which makes inference ... ...

Abstract	Recently there has been a lot of interest in non-autoregressive (non-AR) models for speech synthesis, such as FastSpeech 2 and diffusion models. Unlike AR models, these models do not have autoregressive dependencies among outputs which makes inference efficient. This paper expands the range of available non-AR models with another member called energy-based models (EBMs). The paper describes how noise contrastive estimation, which relies on the comparison between positive and negative samples, can be used to train EBMs. It proposes a number of strategies for generating effective negative samples, including using high-performing AR models. It also describes how sampling from EBMs can be performed using Langevin Markov Chain Monte-Carlo (MCMC). The use of Langevin MCMC enables to draw connections between EBMs and currently popular diffusion models. Experiments on LJSpeech dataset show that the proposed approach offers improvements over Tacotron 2.
Keywords	Computer Science - Sound ; Computer Science - Machine Learning ; Electrical Engineering and Systems Science - Audio and Speech Processing
Subject code	006
Publishing date	2023-10-19
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Combined inhibitory effect of interferon and antiserum on avian hepatitis E virus

Yan, Hongjian / Sun, Wanli / Wang, Jinjin / Gao, Qiming / Zhang, Yawen / Wang, Yixin / Chang, Shuang / Zhao, Peng

Poultry Science 2023 May, v. 102, no. 5, p. 102591

2023 , Page(s) 102591

Abstract: Epidemiologic investigations in recent years have shown that the detection rate of avian hepatitis E virus (HEV) in chicken flocks is increasing in China. Nevertheless, effective prevention and control measures are still lacking. In this study, specific ... ...

Abstract	Epidemiologic investigations in recent years have shown that the detection rate of avian hepatitis E virus (HEV) in chicken flocks is increasing in China. Nevertheless, effective prevention and control measures are still lacking. In this study, specific pathogen-free (SPF) chicken serum against HEV was prepared using recombinant HEV open reading frames (ORF2 and ORF3) proteins as immunogens. An SPF chicken infection model was established by intravenous inoculation of chick embryos. Swab samples were collected at 7, 14, 21, and 28 d of age and used to detect avian HEV load, along with other indicators, by fluorescence quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) assay. The therapeutic effects on blocking vertical HEV transmission were observed, by using the methods of antibody application alone, mixed, or combined application of each of the 2 antibodies with type I interferon. The results showed that type I interferon alone or in combination with antiserum reduced the positive rate of HEV from 100 to 62.5% and 25%, respectively. However, the avian HEV-positivity rate was reduced to 75, 50, and 37.5% after type I interferon was used alone or in combination with antisera against ORF2 and ORF3, respectively. The inhibitory effect of type I interferon alone or in combination with an antiserum, on HEV replication was more significant in cells than in vivo. In this study, the inhibitory effect of type I interferon alone or in combination with an antiserum on avian HEV replication was observed in vitro and in vivo, providing the necessary technical reserve for disease prevention and control.
Keywords	Orthohepevirus B ; antibodies ; antigens ; antiserum ; blood serum ; chickens ; chicks ; disease prevention ; fluorescence ; interferons ; intravenous injection ; models ; reverse transcriptase polymerase chain reaction ; specific pathogen-free animals ; China ; antiviral therapy ; avian hepatitis E virus ; interferon ; ORF2 ; ORF3
Language	English
Dates of publication	2023-05
Size	p. 102591
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102591
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A novel electrocoagulation process with centrifugal electrodes for wastewater treatment: Electrochemical behavior of anode and kinetics of heavy metal removal.

Yu, Yu / Zhong, Yiwei / Sun, Wanli / Xie, Jiajun / Wang, Mingyong / Guo, Zhancheng

Chemosphere

2022 Volume 310, Page(s) 136862

Abstract: Anodic passivation is a key problem to impair the efficiency of in the electrocoagulation (EC) process. Process intensification of EC has attracted increasingly greater attention. In this work, a novel centrifugal electrode reactor was designed and ... ...

Abstract	Anodic passivation is a key problem to impair the efficiency of in the electrocoagulation (EC) process. Process intensification of EC has attracted increasingly greater attention. In this work, a novel centrifugal electrode reactor was designed and applied in EC process to enhance the treatment of simulated heavy metal wastewater using aluminum anode. Results showed that the removal efficiency of heavy metals was significantly improved by the centrifugal electrodes, compared with the stationary electrodes. Electrochemical behavior of centrifugal electrodes was analyzed by an improved rotating disk electrode system. Anodic polarization behavior of aluminium showed a typical characteristic of dissolution in centrifugal electrodes, rather than passivation in static condition. Anode dissolution was controlled by the diffusion of Cl
MeSH term(s)	Waste Water/analysis ; Kinetics ; Electrodes ; Metals, Heavy/analysis ; Electrocoagulation/methods ; Aluminum/analysis ; Water Purification/methods ; Water Pollutants, Chemical/analysis ; Waste Disposal, Fluid/methods
Chemical Substances	Waste Water ; Metals, Heavy ; Aluminum (CPD4NFA903) ; Water Pollutants, Chemical
Language	English
Publishing date	2022-10-12
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.136862
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Article: Efficacy and safety of prophylactic intraoperative sac embolization in EVAR for abdominal aortic aneurysm: A meta-analysis.

Chen, Quan / Zhang, Yuan / Lei, Kangqing / Fu, Liangyin / Zhang, Dengxiao / Sun, Wanli / Shi, Chaohai / Niu, Qibing

Frontiers in surgery

2023 Volume 9, Page(s) 1027231

Abstract: Objective: We aimed to investigate the effectiveness and safety of prophylactic sac embolization during endovascular aneurysm repair (EVAR) in patients suffering from abdominal aortic aneurysms.: Methods: We performed a systematic literature search ... ...

Abstract	Objective: We aimed to investigate the effectiveness and safety of prophylactic sac embolization during endovascular aneurysm repair (EVAR) in patients suffering from abdominal aortic aneurysms. Methods: We performed a systematic literature search of PubMed, Web of Science, EMbase, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, Wanfang and China Biomedical Literature Database (CBM) to identify studies evaluating the outcomes of sac embolization vs. no embolization among patients who had received EVAR. The time limit of the search was from the establishing database to July 22, 2022. Outcome measures involved the type II endoleak rate, the other endoleak rate, the reintervention rate, mortality, and operation time. Fixed (no heterogeneity) or random effects models were constructed for each outcome. The outcomes are represented as the odds ratio (OR) with a 95% confidence interval (CI). Results: Among the 2,622 studies screened, 13 studies involving 747 participants were included in the review. The incidence of early-term type II endoleak (OR = 0.2, 95% CI (0.13,0.31), Conclusions: EVAR combined with sac embolization effectively reduces the incidence of type II endoleak and the reintervention rate without enhancing the operation time. Therefore, more high-quality studies are still needed for validation due to the limited amount and quality of included literature. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022365648.
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.1027231
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Article ; Online: Combined inhibitory effect of interferon and antiserum on avian hepatitis E virus.

Yan, Hongjian / Sun, Wanli / Wang, Jinjin / Gao, Qiming / Zhang, Yawen / Wang, Yixin / Chang, Shuang / Zhao, Peng

Poultry science

2023 Volume 102, Issue 5, Page(s) 102591

Abstract	Epidemiologic investigations in recent years have shown that the detection rate of avian hepatitis E virus (HEV) in chicken flocks is increasing in China. Nevertheless, effective prevention and control measures are still lacking. In this study, specific pathogen-free (SPF) chicken serum against HEV was prepared using recombinant HEV open reading frames (ORF2 and ORF3) proteins as immunogens. An SPF chicken infection model was established by intravenous inoculation of chick embryos. Swab samples were collected at 7, 14, 21, and 28 d of age and used to detect avian HEV load, along with other indicators, by fluorescence quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) assay. The therapeutic effects on blocking vertical HEV transmission were observed, by using the methods of antibody application alone, mixed, or combined application of each of the 2 antibodies with type I interferon. The results showed that type I interferon alone or in combination with antiserum reduced the positive rate of HEV from 100 to 62.5% and 25%, respectively. However, the avian HEV-positivity rate was reduced to 75, 50, and 37.5% after type I interferon was used alone or in combination with antisera against ORF2 and ORF3, respectively. The inhibitory effect of type I interferon alone or in combination with an antiserum, on HEV replication was more significant in cells than in vivo. In this study, the inhibitory effect of type I interferon alone or in combination with an antiserum on avian HEV replication was observed in vitro and in vivo, providing the necessary technical reserve for disease prevention and control.
MeSH term(s)	Chick Embryo ; Animals ; Hepevirus ; Chickens ; Immunoglobulins ; Immune Sera ; Interferon Type I
Chemical Substances	Immunoglobulins ; Immune Sera ; Interferon Type I
Language	English
Publishing date	2023-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102591
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Article: Enhanced Antiviral Ability by a Combination of Zidovudine and Short Hairpin RNA Targeting Avian Leukosis Virus.

Wang, Qun / Su, Qi / Liu, Bowen / Li, Yan / Sun, Wanli / Liu, Yanxue / Xue, Ruyu / Chang, Shuang / Wang, Yixin / Zhao, Peng

Frontiers in microbiology

2022 Volume 12, Page(s) 808982

Abstract: Avian leukosis virus (ALV) causes tumor diseases in poultry and is circulating all over the world, leading to significant economic losses. In addition, mixed infection of ALV with other viruses is very common and is often reported to contaminate live ... ...

Abstract	Avian leukosis virus (ALV) causes tumor diseases in poultry and is circulating all over the world, leading to significant economic losses. In addition, mixed infection of ALV with other viruses is very common and is often reported to contaminate live vaccines. At present, there is no effective method to suppress the replication of ALV
Language	English
Publishing date	2022-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.808982
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Article: Non-coding RNAs in cancer therapy-induced cardiotoxicity: Mechanisms, biomarkers, and treatments.

Sun, Wanli / Xu, Juping / Wang, Li / Jiang, Yuchen / Cui, Jingrun / Su, Xin / Yang, Fan / Tian, Li / Si, Zeyu / Xing, Yanwei

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 946137

Abstract: As a result of ongoing breakthroughs in cancer therapy, cancer patients' survival rates have grown considerably. However, cardiotoxicity has emerged as the most dangerous toxic side effect of cancer treatment, negatively impacting cancer patients' ... ...

Abstract	As a result of ongoing breakthroughs in cancer therapy, cancer patients' survival rates have grown considerably. However, cardiotoxicity has emerged as the most dangerous toxic side effect of cancer treatment, negatively impacting cancer patients' prognosis. In recent years, the link between non-coding RNAs (ncRNAs) and cancer therapy-induced cardiotoxicity has received much attention and investigation. NcRNAs are non-protein-coding RNAs that impact gene expression post-transcriptionally. They include microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). In several cancer treatments, such as chemotherapy, radiotherapy, and targeted therapy-induced cardiotoxicity, ncRNAs play a significant role in the onset and progression of cardiotoxicity. This review focuses on the mechanisms of ncRNAs in cancer therapy-induced cardiotoxicity, including apoptosis, mitochondrial damage, oxidative stress, DNA damage, inflammation, autophagy, aging, calcium homeostasis, vascular homeostasis, and fibrosis. In addition, this review explores potential ncRNAs-based biomarkers and therapeutic strategies, which may help to convert ncRNAs research into clinical practice in the future for early detection and improvement of cancer therapy-induced cardiotoxicity.
Language	English
Publishing date	2022-08-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.946137
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Article ; Online: Efficacy of endostatin combined with continuous transcatheter arterial infusion and chemoembolization on gastric cancer with liver metastasis and analysis of prognosis.

Chen, Long / Shi, Hao / Che, Yang / Sun, Wanli / Niu, Xiangdong / Lu, Weilong

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

2020 Volume 25, Issue 3, Page(s) 1469–1475

Abstract: Purpose: To explore the efficacy and safety of Endostatin combined with continuous transcatheter arterial infusion (TAI) and transcatheter arterial chemoembolization (TACE) in the treatment of gastric cancer with liver metastasis, and analyze the ... ...

Abstract	Purpose: To explore the efficacy and safety of Endostatin combined with continuous transcatheter arterial infusion (TAI) and transcatheter arterial chemoembolization (TACE) in the treatment of gastric cancer with liver metastasis, and analyze the prognosis. Methods: 96 gastric cancer patients with liver metastasis treated in our hospital from September 2013 to September 2016 were collected and randomly divided into TAI+TACE group (n=48) and Endostatin+TAI+TACE group (n=48). The clinical efficacy, changes in the level of vascular endothelial growth factor (VEGF) before and after treatment, adverse reactions, postoperative tumor recurrence and patient survival were observed and recorded, and the possible influencing factors for prognosis were analyzed. Results: In the Endostatin+TAI+TACE group and TAI+TACE group, the objective response rate (ORR) was 70.8% (34/48) and 47.9% (23/48), and the disease control rate (DCR) was 91.7% (44/48) and 83.3% (40/48), respectively. After treatment, the concentration of VEGF declined significantly in both groups compared with that before treatment, more obviously in the Endostatin+TAI+TACE group than in the TAI+TACE group. According to the follow-up results, both overall survival (OS) and progression-free survival (PFS) in the Endostatin+TAI+TACE group were evidently higher than those in the TAI+TACE group. The Cox regression analysis revealed that the grade of tumor differentiation and Endostatin combination therapy were independent factors influencing the prognosis of patients. Conclusion: Endostatin combined with TAI and TACE can obtain good short-term clinical efficacy in the treatment of gastric cancer with liver metastasis. Compared with those treated with chemotherapy alone, patients receiving Endostatin+TAI+TACE have significantly improved OS and PFS, a reduced level of VEGF and a lower incidence rate of adverse reactions, so Endostatin+TAI+TACE is worthy of clinical popularization and application.
MeSH term(s)	Adult ; Aged ; Chemoembolization, Therapeutic/methods ; Combined Modality Therapy/methods ; Endostatins/therapeutic use ; Female ; Humans ; Infusions, Intra-Arterial/methods ; Liver Neoplasms/drug therapy ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Prognosis ; Progression-Free Survival ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Treatment Outcome ; Vascular Endothelial Growth Factor A/metabolism ; Young Adult
Chemical Substances	Endostatins ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2020-08-30
Publishing country	Greece
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2040386-0
ISSN	2241-6293 ; 1107-0625
ISSN (online)	2241-6293
ISSN	1107-0625
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