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Buch ; Dissertation / Habilitation: Cloning and expression of calpain and phytase genes for the improvement of animal growth and nutrition

Sun, Weilin

1996

Verfasserangabe	by Weilin Sun
Umfang	X, 183 Bl. : Ill., graph. Darst.
Ausgabenhinweis	[Mikrofilm-Ausg.]
Erscheinungsland	Vereinigte Staaten
Dokumenttyp	Buch ; Dissertation / Habilitation
Dissertation / Habilitation	Lafayette, Ind., Purdue Univ., Diss., 1996
Anmerkung	Mikrofilm-Ausg.: Ann Arbor, MI : UMI, 1997. 1 Mikrofilm ; 35 mm. Best.-Nr. 97-25634
HBZ-ID	HT008490808
Datenquelle	Katalog ZB MED Ernährung, Umwelt, Agrar

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Artikel: A nomogram to predict the risk of colorectal anastomotic leakage combining inflammatory-nutritional and abdominal aorta calcium index.

Zhang, Zhaoxiong / Sun, Weilin / Wang, Jun / Deng, Yuanlin / Yan, Yongjia / Li, Dong / Fu, Weihua

Frontiers in surgery

2023 Band 9, Seite(n) 1008448

Abstract: Background: Anastomotic leakage is a serious complication after colorectal cancer surgery, which affects the quality of life and the prognosis. This study aims to create a novel nomogram to predict the risk of anastomotic leakage for patients with ... ...

Abstract	Background: Anastomotic leakage is a serious complication after colorectal cancer surgery, which affects the quality of life and the prognosis. This study aims to create a novel nomogram to predict the risk of anastomotic leakage for patients with colorectal cancer based on the preoperative inflammatory-nutritional index and abdominal aorta calcium index. Methods: 292 patients at Tianjin Medical University General Hospital (Tianjin, China) from January 2018 to October 2021 who underwent colorectal cancer surgery with a primary anastomosis were retrospectively reviewed. A nomogram was constructed based on the results of multivariate logistic regression model. The calibration curves and receiver operating characteristic curves were used to verify the efficacy of the nomogram. Results: Univariate and multivariate analyses showed that tumor location ( Conclusion: The nomogram, combining basic variables, inflammatory-nutritional index and abdominal aorta calcium index, could effectively predict the possibility of postoperative anastomotic leakage for patients with colorectal cancer, which could guide surgeons to carry out the appropriate treatment for the prevention of anastomotic leakage.
Sprache	Englisch
Erscheinungsdatum	2023-01-06
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.1008448
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Chemical and Geological Properties of Shale Gas: In Situ Desorption of Lower Cambrian Niutitang Shale in the Micangshan Tectonic Zone of South Shaanxi, China.

Zhang, Xiaotao / Shen, Bin / Tian, Tao / Li, Shizhen / Xu, Xuemin / Yang, Jiajia / Sun, Weilin / Qin, Jing

ACS omega

2024 Band 9, Heft 12, Seite(n) 13764–13781

Abstract: Shale gas was recently found in the Lower Cambrian Niutitang Formation (LCNF) of the Micangshan tectonic zone of south Shaanxi (MTZSS), but not in commercial quantities. To determine the laws governing the generation, enrichment, and desorption of shale ... ...

Abstract	Shale gas was recently found in the Lower Cambrian Niutitang Formation (LCNF) of the Micangshan tectonic zone of south Shaanxi (MTZSS), but not in commercial quantities. To determine the laws governing the generation, enrichment, and desorption of shale gases in overmatured shale strata in the LCNF of MTZSS, we carried out in situ desorption experiments on nine shale core samples and got 168 desorbed gas samples at different phases of desorption. Also measured were the chemical and carbon isotopic compositions of these desorbed gas samples and the geochemical parameters of the shale core samples. CH
Sprache	Englisch
Erscheinungsdatum	2024-03-12
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c08330
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Identification of differentially expressed miRNAs associated with diamide detoxification pathways in Spodoptera frugiperda.

Mahalle, Rashmi Manohar / Sun, Weilin / Posos-Parra, Omar A / Jung, Sunghoon / Mota-Sanchez, David / Pittendrigh, Barry R / Seong, Keon Mook

Scientific reports

2024 Band 14, Heft 1, Seite(n) 4308

Abstract: The fall armyworm (FAW) Spodoptera frugiperda is a severe economic pest of multiple crops globally. Control of this pest is often achieved using insecticides; however, over time, S. frugiperda has developed resistance to new mode of action compounds, ... ...

Abstract	The fall armyworm (FAW) Spodoptera frugiperda is a severe economic pest of multiple crops globally. Control of this pest is often achieved using insecticides; however, over time, S. frugiperda has developed resistance to new mode of action compounds, including diamides. Previous studies have indicated diamide resistance is a complex developmental process involving multiple detoxification genes. Still, the mechanism underlying the possible involvement of microRNAs in post-transcriptional regulation of resistance has not yet been elucidated. In this study, a global screen of microRNAs (miRNAs) revealed 109 known and 63 novel miRNAs. Nine miRNAs (four known and five novel) were differentially expressed between insecticide-resistant and -susceptible strains. Gene Ontology analysis predicted putative target transcripts of the differentially expressed miRNAs encoding significant genes belonging to detoxification pathways. Additionally, miRNAs are involved in response to diamide exposure, indicating they are probably associated with the detoxification pathway. Thus, this study provides comprehensive evidence for the link between repressed miRNA expression and induced target transcripts that possibly mediate diamide resistance through post-transcriptional regulation. These findings highlight important clues for further research to unravel the roles and mechanisms of miRNAs in conferring diamide resistance.
Mesh-Begriff(e)	Animals ; Spodoptera/genetics ; MicroRNAs/genetics ; Diamide/pharmacology ; Insecticides/pharmacology ; Gene Expression Regulation ; Insecticide Resistance/genetics ; Larva
Chemische Substanzen	MicroRNAs ; Diamide (10465-78-8) ; Insecticides
Sprache	Englisch
Erscheinungsdatum	2024-02-21
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54771-w
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Comparative response of two seasonal spotted wing drosophila (Drosophila suzukii) morphs to different classes of insecticides

Seong, Keon Mook / Sun, Weilin / Huang, Juan / Gut, Larry / Kim, Young Ho / Pittendrigh, Barry R.

Entomological Research. 2022 Nov., v. 52, no. 11 p.504-512

2022

Abstract: Drosophila suzukii Matsumura (Drosophilidae) is a devasting invasive pest affecting berry crops and cherry production throughout North America, South America, and Europe. This species has two different morph phenotypes, winter and summer morphs, which ... ...

Abstract	Drosophila suzukii Matsumura (Drosophilidae) is a devasting invasive pest affecting berry crops and cherry production throughout North America, South America, and Europe. This species has two different morph phenotypes, winter and summer morphs, which are temperature dependent. Chemical control is the most widely used management approach for managing the spotted wing drosophila, D. suzukii. Little is known regarding the differential response of the two seasonal morphs to insecticides. In this study, we identified a high number of differentially expressed genes likely involved in phase I, II, and III of detoxification pathways and other cuticular proteins in winter morphs as compared to summer morphs. Specifically, several detoxification genes (phase I: Cyp4e3, Cyp4s3, Cyp6d5, Cyp49a1, Cyp318a1; phase II: GstD10, Ugt35Bb, Ugt37b1, Ugt58Fa; phase III: Mdr65) were overexpressed more than two‐fold in winter morph. Additionally, we determined the median lethal concentration, LC₅₀, values of Malathion, Cyantraniliprole, Imidan, Zeta‐cypermethrin, and Spinetoram insecticides to compare the insecticide susceptibility against two seasonal morphs of D. suzukii. For most of the pesticides tested, there were no differences between the LC₅₀ values, between summer and winter morphs, however, we found that winter morph exhibited an LC₅₀ value of Spinetoram 3.7‐fold, significantly higher than that of the summer morph. Overall, we demonstrated that seasonally induced different morphological phenotypes may result in different transcriptional response of phases I, II, and III of the detoxification pathways and other cuticular proteins. However, we found different responses to at least one insecticide, Spinetoram. It remains to be determined what are underlying physiological differences that lead to these changes in response to Spinetoram.
Schlagwörter	Drosophila suzukii ; chemical control ; cherries ; cyantraniliprole ; gene expression regulation ; insecticide resistance ; lethal concentration 50 ; malathion ; pests ; research ; summer ; temperature ; transcription (genetics) ; winter ; Europe ; North America ; South America
Sprache	Englisch
Erscheinungsverlauf	2022-11
Umfang	p. 504-512.
Erscheinungsort	John Wiley & Sons, Ltd
Dokumenttyp	Artikel ; Online
Anmerkung	JOURNAL ARTICLE
ZDB-ID	2227607-5
ISSN	1748-5967 ; 1738-2297
ISSN (online)	1748-5967
ISSN	1738-2297
DOI	10.1111/1748-5967.12624
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: The insulin signaling pathway in Drosophila melanogaster: A nexus revealing an “Achilles' heel” in DDT resistance

Zhang, Can / Seong, Keon Mook / Sun, Weilin / Mittapalli, Omprakash / Qiu, Baoli / Clark, John M / Pittendrigh, Barry R

Pesticide biochemistry and physiology. 2021 Jan., v. 171

2021

Abstract: Insecticide resistance is an ongoing challenge in agriculture and disease vector control. Here, we demonstrate a novel strategy to attenuate resistance. We used genomics tools to target fundamental energy-associated pathways and identified a potential “ ... ...

Abstract	Insecticide resistance is an ongoing challenge in agriculture and disease vector control. Here, we demonstrate a novel strategy to attenuate resistance. We used genomics tools to target fundamental energy-associated pathways and identified a potential “Achilles' heel” for resistance, a resistance-associated protein that, upon inhibition, results in a substantial loss in the resistance phenotype. Specifically, we compared the gene expression profiles and structural variations of the insulin/insulin-like growth factor signaling (IIS) pathway genes in DDT-susceptible (91-C) and -resistant (91-R) Drosophila melanogaster (Drosophila) strains. A total of eight and seven IIS transcripts were up- and down-regulated, respectively, in 91-R compared to 91-C. A total of 114 nonsynonymous mutations were observed between 91-C and 91-R, of which 51.8% were fixed. Among the differentially expressed transcripts, phosphoenolpyruvate carboxykinase (PEPCK), down-regulated in 91-R, encoded the greatest number of amino acid changes, prompting us to perform PEPCK inhibitor–pesticide exposure bioassays. The inhibitor of PEPCK, hydrazine sulfate, resulted in a 161- to 218-fold decrease in the DDT resistance phenotype (91-R) and more than a 4- to 5-fold increase in susceptibility in 91-C. A second target protein, Glycogen synthase kinase 3β (GSK3β-PO), had one amino acid difference between 91-C and 91-R, and the corresponding transcript was also down-regulated in 91-R. A GSK3β-PO inhibitor, lithium chloride, likewise reduced the resistance but to a lesser extent than did hydrazine sulfate for PEPCK. We demonstrate the potential role of IIS genes in DDT resistance and the potential discovery of an “Achilles' heel” against pesticide resistance in this pathway.
Schlagwörter	Drosophila melanogaster ; amino acids ; carboxy-lyases ; disease vectors ; gene expression ; gene expression regulation ; genomics ; glycogen synthase kinases ; hydrazine ; insecticide resistance ; insulin ; lithium chloride ; phenotype ; physiology ; sulfates ; vector control
Sprache	Englisch
Erscheinungsverlauf	2021-01
Erscheinungsort	Elsevier Inc.
Dokumenttyp	Artikel
Anmerkung	NAL-AP-2-clean
ZDB-ID	184819-7
ISSN	1095-9939 ; 0048-3583 ; 0048-3575
ISSN (online)	1095-9939
ISSN	0048-3583 ; 0048-3575
DOI	10.1016/j.pestbp.2020.104727
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: CD40×HER2 bispecific antibody overcomes the CCL2-induced trastuzumab resistance in HER2-positive gastric cancer.

Sun, Weilin / Wang, Xi / Wang, Daohan / Lu, Li / Lin, Hai / Zhang, Zhaoxiong / Jia, Yangpu / Nie, Xinyang / Liu, Tong / Fu, Weihua

Journal for immunotherapy of cancer

2022 Band 10, Heft 7

Abstract: Background: There was much hard work to study the trastuzumab resistance in HER2-positive gastric cancer (GC), but the information which would reveal this abstruse mechanism is little. In this study, we aimed to investigate the roles of tumor cell- ... ...

Abstract	Background: There was much hard work to study the trastuzumab resistance in HER2-positive gastric cancer (GC), but the information which would reveal this abstruse mechanism is little. In this study, we aimed to investigate the roles of tumor cell-derived CCL2 on trastuzumab resistance and overcome the resistance by treatment with the anti-CD40-scFv-linked anti-HER2 (CD40 ×HER2) bispecific antibody (bsAb). Methods: We measured the levels of CCL2 expression in HER2-positive GC tissues, and revealed biological functions of tumor cell-derived CCL2 on tumor-associated macrophages (TAMs) and the trastuzumab resistance. Then, we developed CD40 ×HER2 bsAb, and examined the targeting roles on HER2 and CD40, to overcome the trastuzumab resistance without systemic toxicity. Results: We found the level of CCL2 expression in HER2-postive GC was correlated with infiltration of TAMs, polarization status of infiltrated TAMs, trastuzumab resistance and survival outcomes of GC patients. On exposure to CCL2, TAMs decreased the M1-like phenotype, thereby eliciting the trastuzumab resistance. CCL2 activated the transcription of ZC3H12A, which increased K63-linked deubiquitination and K48-linked auto-ubiquitination of TRAF6/3 to inactivate NF-κB signaling in TAMs. CD40 ×HER2 bsAb, which targeted the CD40 to restore the ubiquitination level of TRAF6/3, increased the M1-like phenotypic transformation of TAMs, and overcame trastuzumab resistance without immune-related adversary effects (irAEs). Conclusions: We revealed a novel mechanism of trastuzumab resistance in HER2-positive GC via the CCL2-ZC3H12A-TRAF6/3 signaling axis, and presented a CD40 ×HER2 bsAb which showed great antitumor efficacy with few irAEs.
Mesh-Begriff(e)	CD40 Antigens/metabolism ; Chemokine CCL2/metabolism ; Chemokine CCL2/pharmacology ; Humans ; Receptor, ErbB-2/metabolism ; Signal Transduction ; Stomach Neoplasms/pathology ; TNF Receptor-Associated Factor 6/metabolism ; TNF Receptor-Associated Factor 6/pharmacology ; Trastuzumab/pharmacology ; Trastuzumab/therapeutic use
Chemische Substanzen	CCL2 protein, human ; CD40 Antigens ; Chemokine CCL2 ; TNF Receptor-Associated Factor 6 ; Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
Sprache	Englisch
Erscheinungsdatum	2022-07-16
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2022-005063
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Fabrication of homogeneously Cu2+/La3+-doped CeO2 nanosheets and their application in CO oxidation

Zhou, Xia / Ling, Jun / Sun, Weilin / Shen, Zhiquan

Journal of materials chemistry A. 2017 May 23, v. 5, no. 20

2017

Abstract: Nanosheets of coordination polymers (CPs) were synthesized via a facile and one-step complexing-coprecipitation (CC) method. Upon calcination, pure CeO2 and homogeneously La3+- or Cu2+-doped CeO2 products were fabricated by using CPs as precursors. The ... ...

Abstract	Nanosheets of coordination polymers (CPs) were synthesized via a facile and one-step complexing-coprecipitation (CC) method. Upon calcination, pure CeO2 and homogeneously La3+- or Cu2+-doped CeO2 products were fabricated by using CPs as precursors. The final products not only retained a stable nano-scale sheet-shaped morphology of their CP precursors, but also possessed high catalytic activity towards CO oxidation. Superior to commercial ceria with negligible catalytic activity, the synthesized CeO2 nanosheets exhibited high activity achieving a CO conversion of 60% at a temperature of 360 °C. When doped with Cu2+, remarkable improvement of catalysis is observed owing to the homogeneous incorporation of Cu2+ into the CeO2 lattice. As a catalytically active center, uniformly dispersed CuO also produces more oxygen vacancies and improves oxygen mobility, which results in an enhancement in catalytic activity. The detected temperatures with 50% CO conversion (T50) for Cu0.1Ce0.9O2−δ and Cu0.04Ce0.96O2−δ are 83 and 95 °C, respectively. In contrast, the catalytic test for La3+ doped ceria reveals a decreased activity compared with un-doped ceria. We believe that the Cu2+-doped CeO2 with superior catalytic performance can also be applied to other catalytic systems.
Schlagwörter	carbon monoxide ; catalytic activity ; ceric oxide ; coordination polymers ; copper ; cupric oxide ; lanthanum ; nanosheets ; oxidation ; oxygen ; temperature
Sprache	Englisch
Erscheinungsverlauf	2017-0523
Umfang	p. 9717-9722.
Erscheinungsort	The Royal Society of Chemistry
Dokumenttyp	Artikel
ZDB-ID	2702232-8
ISSN	2050-7496 ; 2050-7488
ISSN (online)	2050-7496
ISSN	2050-7488
DOI	10.1039/c7ta00924k
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Construction and Validation of a Nomogram for the Preoperative Prediction of Lymph Node Metastasis in Gastric Cancer.

Li, Shilong / Zhao, Zongxian / Yang, Huaxiang / Wang, Daohan / Sun, Weilin / Li, Shuliang / Zhang, Zhaoxiong / Fu, Weihua

Cancer control : journal of the Moffitt Cancer Center

2021 Band 28, Seite(n) 10732748211027160

Abstract: Background: Increasing evidence indicated that the tumor microenvironment (TME) plays a critical role in tumor progression. This study aimed to identify and evaluate mRNA signature involved in lymph node metastasis (LNM) in TME for gastric cancer (GC).!# ...

Abstract	Background: Increasing evidence indicated that the tumor microenvironment (TME) plays a critical role in tumor progression. This study aimed to identify and evaluate mRNA signature involved in lymph node metastasis (LNM) in TME for gastric cancer (GC). Methods: Gene expression and clinical data were downloaded from The Cancer Genome Atlas (TCGA). The ESTIMATE algorithm was used to evaluate the TME of GC. The heatmap and Venn plots were applied for visualizing and screening out intersect differentially expressed genes (DEGs) involved in LNM in TME. Functional enrichment analysis, gene set enrichment analysis (GSEA) and protein-protein interaction (PPI) network were also conducted. Furthermore, binary logistic regression analysis were employed to develop a 4-mRNAs signature for the LNM prediction. ROC curves were applied to validate the LNM predictive ability of the riskscore. Nomogram was constructed and calibration curve was plotted to verify the predictive power of nomogram. Results: A total of 88 LNM related DEGs were identified. Functional enrichment analysis and GSEA implied that those genes were associated with some biological processes, such as ion transportation, lipid metabolism and thiolester hydrolase activity. After univariate and multivariate logistic regression analysis, 4 mRNAs (RASSF2, MS4A2, ANKRD33B and ADH1B) were eventually screened out to develop a predictive model. ROC curves manifested the good performance of the 4-mRNAs signature. The proportion of patients with LNM in high-risk group was significantly higher than that in low-risk group. The C-index of nomogram from training and test cohorts were 0.865 and 0.765, and the nomogram was well calibrated. Conclusions: In general, we identified a 4-mRNAs signature that effectively predicted LNM in GC patients. Moreover, the 4-mRNAs signature and nomogram provide a guidance for the preoperative evaluation and postoperative treatment of GC patients.
Mesh-Begriff(e)	Age Factors ; Aged ; Biomarkers, Tumor ; Female ; Humans ; Logistic Models ; Lymphatic Metastasis/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Nomograms ; Protein Interaction Maps ; RNA, Messenger ; ROC Curve ; Reproducibility of Results ; Risk Assessment ; Risk Factors ; Sex Factors ; Stomach Neoplasms/pathology ; Tumor Microenvironment
Chemische Substanzen	Biomarkers, Tumor ; RNA, Messenger
Sprache	Englisch
Erscheinungsdatum	2021-06-22
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	1328503-8
ISSN	1526-2359 ; 1073-2748
ISSN (online)	1526-2359
ISSN	1073-2748
DOI	10.1177/10732748211027160
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Effects of a high body mass index on the short-term outcomes and prognosis after radical gastrectomy.

Zhao, Wei / Wang, Pengliang / Sun, Weilin / Gu, Pengfei / Wang, Xinyu / Wu, Zizhen / Liang, Han / Deng, Jingyu

Surgery today

2021 Band 51, Heft 7, Seite(n) 1169–1178

Abstract: Purpose: This study aimed to investigate the effects of a high body mass index (BMI) on the outcomes of radical gastrectomy for gastric cancer.: Methods: We conducted a retrospective cohort study of 1729 patients with stage I to III gastric cancer ... ...

Abstract	Purpose: This study aimed to investigate the effects of a high body mass index (BMI) on the outcomes of radical gastrectomy for gastric cancer. Methods: We conducted a retrospective cohort study of 1729 patients with stage I to III gastric cancer who received open radical gastrectomy from February 2003 to August 2011. The patients were divided into 3 groups according to their BMI: a low BMI group (BMI < 18.5 kg/m Results: A total of 871 patients were included in the final analysis, of which the median BMI was 22.7 kg/m Conclusions: A high BMI increased the operative morbidity after radical gastrectomy for gastric cancer. However, a high BMI did not negatively affect the quality of lymphadenectomy or the OS of gastric cancer patients in experienced high-volume centers. A careful approach during operation and meticulous perioperative management are required for gastric cancer patients with a high BMI.
Mesh-Begriff(e)	Adult ; Aged ; Body Mass Index ; Female ; Gastrectomy/methods ; Humans ; Intestinal Fistula/epidemiology ; Intestinal Fistula/etiology ; Lymph Node Excision ; Male ; Middle Aged ; Neoplasm Staging ; Obesity/complications ; Overweight/complications ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Prognosis ; Retrospective Studies ; Risk ; Stomach Neoplasms/complications ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Survival Rate ; Treatment Outcome
Sprache	Englisch
Erscheinungsdatum	2021-03-10
Erscheinungsland	Japan
Dokumenttyp	Journal Article
ZDB-ID	1115435-4
ISSN	1436-2813 ; 0941-1291
ISSN (online)	1436-2813
ISSN	0941-1291
DOI	10.1007/s00595-021-02259-9
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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