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  1. Book ; Thesis: Mesenchymal stem cell-conditioned medium improves endothelial dysfunction of vascular grafts submitted to ischemia, reperfusion injury in 15-month-old rats

    Sun, XiaoXin / Szabó, Gábor

    2019  

    Institution Universität Heidelberg
    Author's details vorgelegt von XiaoXin SUN ; Doktorvater: Prof. Dr. med. Gábor Szabó, PhD
    Language English
    Size 90 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2020
    HBZ-ID HT020623225
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 E 1402 order for loan Magazin

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  2. Article: Impacts of reclamation marsh restoration on greenhouse gas emission in the Sanjiang Plain, China.

    Zhao, Yue-Qin / Ma, Xiu-Jing / Zhao, Wan-Jing / Zhang, Zhi-Jun / Sun, Xiao-Xin

    Ying yong sheng tai xue bao = The journal of applied ecology

    2023  Volume 34, Issue 8, Page(s) 2142–2152

    Abstract: To understand the variations in greenhouse gas fluxes during the process of returning cropland to wetland in the Sanjiang Plain, we selected naturally restored wetlands of 4, 7, 11, 16 and 20 years as research objects to compare with a cultivated site ( ... ...

    Title translation 三江平原垦殖湿地恢复对温室气体排放的影响.
    Abstract To understand the variations in greenhouse gas fluxes during the process of returning cropland to wetland in the Sanjiang Plain, we selected naturally restored wetlands of 4, 7, 11, 16 and 20 years as research objects to compare with a cultivated site (soybean plantation for 13 years) and an uncultivated marsh dominated by
    MeSH term(s) Greenhouse Gases ; Wetlands ; Carbon Dioxide ; China ; Soil ; Glycine max ; Water
    Chemical Substances Greenhouse Gases ; Carbon Dioxide (142M471B3J) ; Soil ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-09-08
    Publishing country China
    Document type Journal Article
    ZDB-ID 2881809-X
    ISSN 1001-9332
    ISSN 1001-9332
    DOI 10.13287/j.1001-9332.202308.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Targeting the MYC Ubiquitination-Proteasome Degradation Pathway for Cancer Therapy.

    Sun, Xiao-Xin / Li, Yanping / Sears, Rosalie C / Dai, Mu-Shui

    Frontiers in oncology

    2021  Volume 11, Page(s) 679445

    Abstract: Deregulated MYC overexpression and activation contributes to tumor growth and progression. Given the short half-life and unstable nature of the MYC protein, it is not surprising that the oncoprotein is highly ... ...

    Abstract Deregulated MYC overexpression and activation contributes to tumor growth and progression. Given the short half-life and unstable nature of the MYC protein, it is not surprising that the oncoprotein is highly regulated
    Language English
    Publishing date 2021-06-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.679445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: p73 to the rescue: Role of RPL26.

    Sun, Xiao-Xin / Dai, Mu-Shui

    Oncotarget

    2017  Volume 8, Issue 4, Page(s) 5641–5642

    Language English
    Publishing date 2017-03-16
    Publishing country United States
    Document type News
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.14383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8.

    Li, Yanping / Carey, Timothy S / Feng, Catherine H / Zhu, Hong-Ming / Sun, Xiao-Xin / Dai, Mu-Shui

    Cancer research communications

    2023  Volume 3, Issue 3, Page(s) 459–470

    Abstract: miRNA biogenesis is a cellular process that produces mature miRNAs from their primary transcripts, pri-miRNAs, via two RNAse III enzyme complexes: the Drosha-DGCR8 microprocessor complex in the nucleus and the Dicer-TRBP complex in the cytoplasm. ... ...

    Abstract miRNA biogenesis is a cellular process that produces mature miRNAs from their primary transcripts, pri-miRNAs, via two RNAse III enzyme complexes: the Drosha-DGCR8 microprocessor complex in the nucleus and the Dicer-TRBP complex in the cytoplasm. Emerging evidence suggests that miRNA biogenesis is tightly regulated by posttranscriptional and posttranslational modifications and aberrant miRNA biogenesis is associated with various human diseases including cancer. DGCR8 has been shown to be modified by SUMOylation. Yet, the SUMO ligase mediating DGCR8 SUMOylation is currently unknown. Here, we report that USP36, a nucleolar ubiquitin-specific protease essential for ribosome biogenesis, is a novel regulator of DGCR8. USP36 interacts with the microprocessor complex and promotes DGCR8 SUMOylation, specifically modified by SUMO2. USP36-mediated SUMOylation does not affect the levels of DGCR8 and the formation of the Drosha-DGCR8 complex, but promotes the binding of DGCR8 to pri-miRNAs. Consistently, abolishing DGCR8 SUMOylation significantly attenuates its binding to pri-miRNAs and knockdown of USP36 attenuates pri-miRNA processing, resulting in marked reduction of tested mature miRNAs. Induced expression of a SUMOylation-defective mutant of DGCR8 inhibits cell proliferation. Together, these results suggest that USP36 plays an important role in regulating miRNA biogenesis by SUMOylating DGCR8.
    Significance: This study identifies that USP36 mediates DGCR8 SUMOylation by SUMO2 and is critical for miRNA biogenesis. As USP36 is frequently overexpressed in various human cancers, our study suggests that deregulated USP36-miRNA biogenesis pathway may contribute to tumorigenesis.
    MeSH term(s) Humans ; MicroRNAs/genetics ; RNA-Binding Proteins/genetics ; RNA Processing, Post-Transcriptional ; Carcinogenesis/genetics ; Neoplasms/genetics ; Microcomputers ; Ubiquitin Thiolesterase/genetics
    Chemical Substances MicroRNAs ; RNA-Binding Proteins ; DGCR8 protein, human ; USP36 protein, human ; Ubiquitin Thiolesterase (EC 3.4.19.12)
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2767-9764
    ISSN (online) 2767-9764
    DOI 10.1158/2767-9764.CRC-22-0344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Seasonal variation characteristics and influencing factors of dissolved organic carbon of soil water in permafrost peatlands of the Great Hing'an Mountains in summer and autumn.

    Jiang, Jing-Yi / Sun, Xiao-Xin / Wang, Xian-Wei / Wang, Shu-Jie / Ma, Guo-Bao / Chen, Ning / DU, Yu

    Ying yong sheng tai xue bao = The journal of applied ecology

    2023  Volume 34, Issue 9, Page(s) 2413–2420

    Abstract: Dissolved organic carbon (DOC) plays a crucial role in the assessment of greenhouse gas emission and carbon balance in peatlands. However, limited research has been conducted on the seasonal variations and properties of soil water DOC content at ... ...

    Title translation 大兴安岭多年冻土泥炭地土壤水可溶性有机碳夏秋季节变化特征及其影响因素.
    Abstract Dissolved organic carbon (DOC) plays a crucial role in the assessment of greenhouse gas emission and carbon balance in peatlands. However, limited research has been conducted on the seasonal variations and properties of soil water DOC content at different depths in the permafrost peatlands of the Great Hing'an Mountains. In this study, we analyzed the seasonal patterns of soil water DOC contents (surface, 10 cm, 20 cm, 30 cm, 40 cm, and permafrost layer) the permafrost peatlands of the Great Hing'an Mountains (Tuqiang Forestry Bureau), and investigated the influencing factors, such as electrical conductivity, dissolved oxygen, HCO
    MeSH term(s) Soil/chemistry ; Seasons ; Permafrost/chemistry ; Dissolved Organic Matter ; Water/analysis ; Carbon Dioxide/analysis ; Carbon/analysis ; Oxygen
    Chemical Substances Soil ; Dissolved Organic Matter ; Water (059QF0KO0R) ; Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-10-29
    Publishing country China
    Document type Journal Article
    ZDB-ID 2881809-X
    ISSN 1001-9332
    ISSN 1001-9332
    DOI 10.13287/j.1001-9332.202309.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Artificial cells delivering itaconic acid induce anti-inflammatory memory-like macrophages to reverse acute liver failure and prevent reinjury.

    Yin, Na / Zhang, Wenjun / Sun, Xiao-Xin / Wei, Runxiu / Yang, Qiang / He, Fengming / Li, Changrui / Guo, Ling / Feng, Min

    Cell reports. Medicine

    2023  Volume 4, Issue 8, Page(s) 101132

    Abstract: Hepatic macrophages represent a key cellular component of the liver and are essential for the progression of acute liver failure (ALF). We construct artificial apoptotic cells loaded with itaconic acid (AI-Cells), wherein the compositions of the ... ...

    Abstract Hepatic macrophages represent a key cellular component of the liver and are essential for the progression of acute liver failure (ALF). We construct artificial apoptotic cells loaded with itaconic acid (AI-Cells), wherein the compositions of the synthetic plasma membrane and surface topology are rationally engineered. AI-Cells are predominantly localized to the liver and further transport to hepatic macrophages. Intravenous administration of AI-Cells modulates macrophage inflammation to protect the liver from acetaminophen-induced ALF. Mechanistically, AI-Cells act on caspase-1 to suppress NLRP3 inflammasome-mediated cleavage of pro-IL-1β into its active form in macrophages. Notably, AI-Cells specifically induce anti-inflammatory memory-like hepatic macrophages in ALF mice, which prevent constitutive overproduction of IL-1β when liver reinjury occurs. In light of AI-Cells' precise delivery and training of memory-like hepatic macrophages, they offer promising therapeutic potential in reversing ALF by finely controlling inflammatory responses and orchestrating liver homeostasis, which potentially affect the treatment of various types of liver failure.
    MeSH term(s) Animals ; Mice ; Artificial Cells ; Reinjuries/metabolism ; Macrophages/metabolism ; Liver Failure, Acute/chemically induced ; Liver Failure, Acute/drug therapy ; Liver Failure, Acute/prevention & control ; Anti-Inflammatory Agents/adverse effects
    Chemical Substances itaconic acid (Q4516562YH) ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2023.101132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Molecular Crosstalk Between MYC and HIF in Cancer.

    Li, Yanping / Sun, Xiao-Xin / Qian, David Z / Dai, Mu-Shui

    Frontiers in cell and developmental biology

    2020  Volume 8, Page(s) 590576

    Abstract: The transcription factor c-MYC (MYC thereafter) is a global regulator of gene expression. It is overexpressed or deregulated in human cancers of diverse origins and plays a key role in the development of cancers. Hypoxia-inducible factors (HIFs), a ... ...

    Abstract The transcription factor c-MYC (MYC thereafter) is a global regulator of gene expression. It is overexpressed or deregulated in human cancers of diverse origins and plays a key role in the development of cancers. Hypoxia-inducible factors (HIFs), a central regulator for cells to adapt to low cellular oxygen levels, is also often overexpressed and activated in many human cancers. HIF mediates the primary transcriptional response of a wide range of genes in response to hypoxia. Earlier studies focused on the inhibition of MYC by HIF during hypoxia, when MYC is expressed at physiological level, to help cells survive under low oxygen conditions. Emerging evidence suggests that MYC and HIF also cooperate to promote cancer cell growth and progression. This review will summarize the current understanding of the complex molecular interplay between MYC and HIF.
    Language English
    Publishing date 2020-11-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2020.590576
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  9. Article ; Online: Rescue Protocol to Improve the Image Quality of 18F-FDG PET/CT Myocardial Metabolic Imaging.

    Sun, Xiao-Xin / Li, Shuheng / Wang, Yawen / Li, Wei / Wei, Hongxing / He, Zuo-Xiang

    Clinical nuclear medicine

    2021  Volume 46, Issue 5, Page(s) 369–374

    Abstract: Purpose: 18F-FDG PET myocardial metabolic imaging is used to estimate myocardial viability. However, poor image quality can affect the accurate quantification of viable myocardium. We assessed the feasibility of a rescue protocol that reinjected low- ... ...

    Abstract Purpose: 18F-FDG PET myocardial metabolic imaging is used to estimate myocardial viability. However, poor image quality can affect the accurate quantification of viable myocardium. We assessed the feasibility of a rescue protocol that reinjected low-dose 18F-FDG with simultaneous 1 to 2 U of insulin injection and oral administration of 10 g of glucose to improve the image quality of 18F-FDG PET myocardial metabolic imaging.
    Patients and methods: Fifty-one consecutive patients with poor quality to uninterpretable 18F-FDG PET/CT myocardial metabolic images received the rescue protocol immediately after the initial image acquisition. The postrescue image acquisition was performed 1 hour later. The rescue image quality was compared with the initial image. The qualitative visual estimation of the images was graded as follows: grade 0, homogeneous, minimal uptake; grade 1, predominantly minimal or mild uptake; grade 2, moderate uptake; and grade 3, good uptake. The myocardium-to-blood pool activity ratio (M/B) was measured to assess the image quality quantitatively.
    Results: The grades of 0 to 3 were observed in 24 (47%), 27 (53%), 0 (0%), and 0 (0%) patients, respectively, for the initial imaging, and in 0 (0%), 3 (5.9%), 4 (7.8%), and 44 (86.3%) patients for the rescue imaging (P < 0.001). The rescue M/B was significantly higher than the initial M/B (3.4 ± 1.4 vs 1.6 ± 0.6, respectively; P < 0.001).
    Conclusions: The rescue protocol successfully and rapidly improved the quality of myocardial 18F-FDG metabolic imaging.
    MeSH term(s) Female ; Fluorodeoxyglucose F18/metabolism ; Heart/diagnostic imaging ; Humans ; Male ; Middle Aged ; Myocardium/metabolism ; Positron Emission Tomography Computed Tomography/methods ; Quality Control
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000003572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1276: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Detection of Post-translational Modifications on MYC.

    Daniel, Colin J / Sun, Xiao-Xin / Chen, Yingxiao / Zhang, Xiaoli / Dai, Mu-Shui / Sears, Rosalie C

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2318, Page(s) 69–85

    Abstract: Detection of post-translational modifications in c-Myc is an invaluable tool in assessing Myc status, particularly in cancer. However, it can be challenging to detect these modifications. The evaluation of phosphorylation status of c-Myc can also be ... ...

    Abstract Detection of post-translational modifications in c-Myc is an invaluable tool in assessing Myc status, particularly in cancer. However, it can be challenging to detect these modifications. The evaluation of phosphorylation status of c-Myc can also be challenging with the current commercially available phosphorylation sensitive antibodies. Here, we describe protocols for the immunoprecipitation of endogenous c-Myc to probe for phosphorylation status, as well as the detection of ubiquitination and SUMOylation on c-Myc. We will also discuss the challenges of detecting phosphorylated c-Myc in formalin-fixed paraffin-embedded tissues by immunofluorescence and describe a protocol using a new rat monoclonal antibody we have generated suitable for this purpose.
    MeSH term(s) Fluorescent Antibody Technique ; Genes, myc/genetics ; Genes, myc/physiology ; Humans ; Immunoprecipitation/methods ; Phosphorylation ; Protein Processing, Post-Translational/genetics ; Protein Processing, Post-Translational/physiology ; Proteins/genetics ; Proteins/metabolism ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Sumoylation ; Ubiquitination
    Chemical Substances Proteins ; Proto-Oncogene Proteins c-myc
    Language English
    Publishing date 2021-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1476-1_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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