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Article ; Online: Ginsenoside Rg1 Attenuates Chronic Sleep Deprivation-Induced Hippocampal Mitochondrial Dysfunction and Improves Memory by the AMPK-SIRT3 Pathway.

Jiang, Ning / Yao, Caihong / Zhang, Yiwen / Sun, Xinran / Choudhary, M Iqbal / Liu, Xinmin

Journal of agricultural and food chemistry

2024 Volume 72, Issue 4, Page(s) 2362–2373

Abstract: Ginsenoside Rg1 (Rg1) is the main bioactive ginseng component. This study investigates the effects of Rg1 on cognitive deficits triggered by chronic sleep deprivation stress (CSDS) and explores its underlying mechanisms. Rg1 effectively improved spatial ... ...

Abstract	Ginsenoside Rg1 (Rg1) is the main bioactive ginseng component. This study investigates the effects of Rg1 on cognitive deficits triggered by chronic sleep deprivation stress (CSDS) and explores its underlying mechanisms. Rg1 effectively improved spatial working and recognition memory, as evidenced by various behavioral tests. RNA-sequence analysis revealed differential gene expression in the metabolic pathway. Treatment with Rg1 abrogated reductions in SOD and CAT activity, lowered MDA content, and increased Nrf2 and HO-1 protein levels. Rg1 administration alleviated hippocampal mitochondrial dysfunction by restoring normal ultrastructure and enhancing ATP activities and Mfn2 expression while regulating Drp-1 expression. Rg1 mitigated neuronal apoptosis by reducing the Bax/Bcl-2 ratio and the levels of cleaved caspase-3. Additionally, Rg1 upregulated AMPK and SIRT3 protein expressions. These findings suggest that Rg1 has potential as a robust intervention for cognitive dysfunction associated with sleep deprivation, acting through the modulation of mitochondrial function, oxidative stress, apoptosis, and the AMPK-SIRT3 axis.
MeSH term(s)	Humans ; AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Sirtuin 3/genetics ; Sirtuin 3/metabolism ; Sirtuin 3/pharmacology ; Sleep Deprivation/complications ; Sleep Deprivation/drug therapy ; Sleep Deprivation/genetics ; Ginsenosides/chemistry ; Hippocampus/metabolism ; Mitochondrial Diseases ; Apoptosis
Chemical Substances	AMP-Activated Protein Kinases (EC 2.7.11.31) ; ginsenoside Rg1 (PJ788634QY) ; Sirtuin 3 (EC 3.5.1.-) ; Ginsenosides ; SIRT3 protein, human (EC 3.5.1.-)
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c04618
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Article ; Online: Global distribution and genomic characteristics of tet(X)-positive Escherichia coli among humans, animals, and the environment.

Li, Yan / Sun, Xinran / Xiao, Xia / Wang, Zhiqiang / Li, Ruichao

The Science of the total environment

2023 Volume 887, Page(s) 164148

Abstract: In recent years, the plasmid-mediated transmission of the tigecycline resistance gene tet(X) in Escherichia coli has received considerable attention. However, studies on the global distribution of tet(X)-positive E. coli remain scarce. Herein, we ... ...

Abstract	In recent years, the plasmid-mediated transmission of the tigecycline resistance gene tet(X) in Escherichia coli has received considerable attention. However, studies on the global distribution of tet(X)-positive E. coli remain scarce. Herein, we performed a systematic genomic analysis of 864 tet(X)-positive E. coli isolates from humans, animals and the environment around the world. These isolates were reported in 25 countries and isolated from 13 different hosts. China reported the most tet(X)-positive isolates (71.76 %), followed by Thailand (8.45 %) and Pakistan (5.9 %). Pigs (53.93 %), humans (17.41 %), and chickens (17.41 %) were determined to be important reservoirs of these isolates. The sequence types (STs) of E. coli were highly diverse, with the ST10 clone complex (Cplx) being the most prevalent clone. Correlation analysis revealed a positive association between the antibiotic resistance genes (ARGs) in ST10 E. coli and the presence of insertion sequences and plasmid replicons; however, we found no significant correlation between ARGs and virulence genes. Furthermore, the ST10 tet(X)-positive isolates from multiple sources displayed a high degree of genetic similarity (<200 single-nucleotide polymorphisms [SNPs]) to the mcr-1-positive but tet(X)-negative human-derived isolates, suggesting clonal transmission. The most prevalent tet(X) variant in the E. coli isolates was tet(X4), followed by tet(X6)-v. Genome-wide association study (GWAS) indicated that compared to tet(X4), tet(X6)-v harbored more significantly different resistance genes. Notably, certain tet(X)-positive E. coli isolates from different geographical locations or hosts shared a few SNPs (<200 SNPs), indicating cross-contamination. Therefore, continuous global surveillance of tet(X)-positive E. coli is imperative in the future.
MeSH term(s)	Humans ; Animals ; Swine ; Escherichia coli/genetics ; Escherichia coli Infections/epidemiology ; Escherichia coli Proteins/genetics ; Genome-Wide Association Study ; Drug Resistance, Bacterial/genetics ; Chickens/genetics ; Anti-Bacterial Agents/pharmacology ; Genomics ; Plasmids ; Microbial Sensitivity Tests
Chemical Substances	Escherichia coli Proteins ; Anti-Bacterial Agents
Language	English
Publishing date	2023-05-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.164148
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Zs.A 949: Show issues

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Article ; Online: Global distribution and genomic characteristics of carbapenemase-producing Escherichia coli among humans, 2005-2023.

Li, Yan / Sun, Xinran / Dong, Ning / Wang, Zhiqiang / Li, Ruichao

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

2023 Volume 72, Page(s) 101031

Abstract: Carbapenem-resistant Escherichia coli (CREC) has become a major public health problem worldwide. To date, there is a limited understanding of the global distribution of CREC. In this study, we performed a comprehensive genomic analysis of 7, 731 CRECs of ...

Abstract	Carbapenem-resistant Escherichia coli (CREC) has become a major public health problem worldwide. To date, there is a limited understanding of the global distribution of CREC. In this study, we performed a comprehensive genomic analysis of 7, 731 CRECs of human origin collected from different countries worldwide between 2005 and 2023. Our results showed that these CRECs were distributed in 75 countries, mainly from the United States (17.49%), China (14.88%), and the United Kingdom (14.73%). Eight carbapenemases were identified among the CRECs analyzed, including KPC, IMP, NDM, VIM, OXA, FRI, GES, and IMI. NDM was the most predominant carbapenemase (52.15%), followed by OXA (30.09%) and KPC (14.72%). Notably, all CRECs carried multiple antibiotic resistance genes (ARGs), with 178 isolates carrying mcr-1 and 9 isolates carrying tet(X). The CREC isolates were classified into 465 known sequence types (STs), with ST167 being the most common (11.5%). Correlation analysis demonstrated the significant role of mobile genetic elements in facilitating the transfer of carbapenem resistance genes. Furthermore, some CRECs from different countries showed high genetic similarity, suggesting clonal transmission exists. According to the GWAS results, the genetic difference of bla
MeSH term(s)	Humans ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; beta-Lactamases/genetics ; beta-Lactamases/metabolism ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Escherichia coli/genetics ; Carbapenem-Resistant Enterobacteriaceae/genetics ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Genomics ; Microbial Sensitivity Tests
Chemical Substances	carbapenemase (EC 3.5.2.6) ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents ; Carbapenems
Language	English
Publishing date	2023-12-03
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	1474513-6
ISSN	1532-2084 ; 1368-7646
ISSN (online)	1532-2084
ISSN	1368-7646
DOI	10.1016/j.drup.2023.101031
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Zs.A 5099: Show issues

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Article ; Online: Does the central environmental inspection effectively improve air pollution?-An empirical study of 290 prefecture-level cities in China.

Wang, Wenwen / Sun, Xinran / Zhang, Ming

Journal of environmental management

2021 Volume 286, Page(s) 112274

Abstract: In order to control air pollution better, China has adopted the central environmental inspection mechanism. This paper adopts the data of 290 prefecture-level cities in China to evaluate the air improvement effect of the central environmental inspection ... ...

Abstract	In order to control air pollution better, China has adopted the central environmental inspection mechanism. This paper adopts the data of 290 prefecture-level cities in China to evaluate the air improvement effect of the central environmental inspection mechanism. Firstly, based on the Mechanism Design Theory and Principal-agent Theory, this paper analyzes the government incentive measures and effort levels under the conditions of information as symmetry and asymmetry. Then, this paper introduces Regression Discontinuity Design (RDD) Model to evaluate the air improvement effect of the central environmental inspection mechanism. Lastly, this paper explores the sustainability of the environmental inspection mechanism through the regression analysis of environmental inspection revisit. The results show that: under the condition of information symmetry, the central government can make the local governments reach the Pareto optimal effort level through the design of incentive contract. In a short period of time, the first round of environmental inspection and environmental inspection revisit have significantly improved air quality, and significantly reduced PM2.5 and PM10 and other major single pollutants. In general, this system has had an immediate effect. The environmental inspection revisit has also significantly reduced the concentrations of AQI, PM2.5 and PM10. Compared with the first round of environmental inspection and environmental inspection revisit, the latter has a higher level of air pollution reduction and better effect. The sustainability of the improvement effect of environmental inspection mechanism is questioned. It is of great significance to evaluate the actual effect of the central environmental inspection system and tap the unique experience of "Chinese style" to explore how to control air pollution and promote green development.
MeSH term(s)	Air Pollutants/analysis ; Air Pollution/analysis ; Air Pollution/prevention & control ; China ; Cities ; Environmental Monitoring ; Particulate Matter/analysis
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2021-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2021.112274
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Article: Emergence of the fourth mobile sulfonamide resistance gene

Peng, Kai / Deng, Jianping / Zou, Nianli / Sun, Xinran / Huang, Weifeng / Li, Ruichao / Yang, Xiaorong

Frontiers in microbiology

2023 Volume 14, Page(s) 1242369

Abstract: The fourth mobile sulfonamide resistance ... ...

Abstract	The fourth mobile sulfonamide resistance gene
Language	English
Publishing date	2023-09-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1242369
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Article ; Online: Synthesis, Optical Properties and Cellular Toxicity of Water-Soluble near Infrared-II Fluorescent Assemblies Based on Pillar[5]arene.

Wu, Qiuxia / Sun, Xinran / Yang, Zhenming / Shi, Pengfei / Zhang, Huacheng / Han, Jie

Polymers

2023 Volume 15, Issue 18

Abstract: The main challenges in second near-infrared region molecular fluorophores are poor water solubility and unknown long-term toxicity at present. Herein, new NIR-II molecular fluorophores have been designed and employed to integrate biocompatible pillar[5] ... ...

Abstract	The main challenges in second near-infrared region molecular fluorophores are poor water solubility and unknown long-term toxicity at present. Herein, new NIR-II molecular fluorophores have been designed and employed to integrate biocompatible pillar[5]arene with 10 outer triethylene oxide groups for the synthesis of rotaxane IRCR. In addition, PEGylated pillar[5]arenes have been combined for the self-assembly of two supramolecular vesicular systems, i.e., PP5-IR1 and PP5-IR2, affording aqueous solubility and lowered cellular toxicity. In aqueous solution, all these fluorophores displayed room-temperature emission with λ
Language	English
Publishing date	2023-09-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15183853
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Article ; Online: Aurivillius-layered Bi

Tan, Lining / Sun, Xinran / Zhang, Jintao / Jin, Chengchao / Wang, Fei / Liu, Daiming

Dalton transactions (Cambridge, England : 2003)

2023 Volume 52, Issue 39, Page(s) 14210–14219

Abstract: Developing a high-performance piezocatalyst that directly transforms mechanical energy into hydrogen is highly desirable in the field of new energy. Herein, the Aurivillius-layered ... ...

Abstract	Developing a high-performance piezocatalyst that directly transforms mechanical energy into hydrogen is highly desirable in the field of new energy. Herein, the Aurivillius-layered Bi
Language	English
Publishing date	2023-10-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt02077k
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Article ; Online: Nanoscale Metal-Organic Frameworks Combined with Metal Nanoparticles and Metal Oxide/Peroxide to Relieve Tumor Hypoxia for Enhanced Photodynamic Therapy.

Shi, Pengfei / Sun, Xinran / Yuan, Haoming / Chen, Kaixiu / Bi, Sai / Zhang, Shusheng

ACS biomaterials science & engineering

2023 Volume 9, Issue 10, Page(s) 5441–5456

Abstract: Photodynamic therapy (PDT) is a clinically approved noninvasive tumor therapy that can selectively kill malignant tumor cells, with promising use in the treatment of various cancers. PDT is typically composed of three important parts: the specific ... ...

Abstract	Photodynamic therapy (PDT) is a clinically approved noninvasive tumor therapy that can selectively kill malignant tumor cells, with promising use in the treatment of various cancers. PDT is typically composed of three important parts: the specific wavelength of light, photosensitizer (PS), and oxygen. With the progressing investigation on PDT treatment, the most recent attention has focused on improving photodynamic efficiency. Tumor hypoxia has always been a critical factor hindering the efficacy of PDT. Nanoscale metal-organic frameworks (nMOF), the fourth generation of PS, present great potential in photodynamic therapy. In particular, nMOF combined with metal nanoparticles and metal oxide/peroxide has demonstrated unique properties for enhanced PDT. The metal and metal oxide nanoparticles can catalyze H
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.3c00509
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Article: A critical review on granulation of pharmaceuticals and excipients: Principle, analysis and typical applications

Wang, Bo / Sun, Xinran / Xiang, Jia / Guo, Xu / Cheng, Zeneng / Liu, Wenjie / Tan, Songwen

Powder technology. 2022 Mar., v. 401

2022

Abstract: Solid dosage forms require the addition of different types of excipients such as flowability, compressibility, disintegration, solubility, stability and other physical and chemical properties to the active pharmaceutical ingredient (API) in order to ... ...

Abstract	Solid dosage forms require the addition of different types of excipients such as flowability, compressibility, disintegration, solubility, stability and other physical and chemical properties to the active pharmaceutical ingredient (API) in order to achieve the physical and chemical properties required by the pharmaceutical industry. In the pharmaceutical industry, the most common way to achieve these properties is by mixing the drug substance with a variety of excipients and granulating them using different techniques to ensure uniform mixing, such as direct mixing, roll granulation, spray drying or freeze drying. This paper introduces in detail the mixing granulation process, equipment, technical principles, key parameters, detection methods and typical applications which are most commonly used in the pharmaceutical industry. It is hoped that this review will provide some insight for all researchers engaged in the granulation method of formulating solid dosage forms.
Keywords	active pharmaceutical ingredients ; compressibility ; drugs ; equipment ; pharmaceutical industry ; solubility
Language	English
Dates of publication	2022-03
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0032-5910
DOI	10.1016/j.powtec.2022.117329
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Porphyrin-Based Metal-Organic Framework Probe: Highly Selective and Sensitive Fluorescent Turn-On Sensor for M

Fu, Chenchen / Sun, Xinran / Zhang, Guoda / Shi, Pengfei / Cui, Ping

Inorganic chemistry

2021 Volume 60, Issue 2, Page(s) 1116–1123

Abstract: The development of porphyrin-based metal-organic frameworks (MOFs) has attracted significant interest in the scientific community in recent years because of their versatile applications particularly in optical and electronic fields. In this study, a ... ...

Abstract	The development of porphyrin-based metal-organic frameworks (MOFs) has attracted significant interest in the scientific community in recent years because of their versatile applications particularly in optical and electronic fields. In this study, a highly selective and sensitive fluorescent turn-on sensor using a porphyrinic MOF, Tb-TCPP, is presented, which displays a 10-fold fluorescence enhancement in the presence of Al
Language	English
Publishing date	2021-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.0c03268
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