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Article ; Online: Reevaluation of lock solutions for Central venous catheters in hemodialysis: a narrative review.

Wang, Yiqin / Sun, Xuefeng

2022 Volume 44, Issue 1, Page(s) 1501–1518

Abstract: Background: A significant proportion of incident and prevalent hemodialysis patients have central venous catheters for vascular access. No consensus is available on the prevention of catheter dysfunction or catheter-related bloodstream infections in ... ...

Abstract	Background: A significant proportion of incident and prevalent hemodialysis patients have central venous catheters for vascular access. No consensus is available on the prevention of catheter dysfunction or catheter-related bloodstream infections in patients undergoing hemodialysis by means of catheter lock solutions. Method: We reviewed the effects of single and combined anticoagulants with antibacterial catheter lock solutions or other antimicrobials for the prevention of thrombosis or infections in hemodialysis patients. Relative risks with 95% confidence intervals for trials of the same type of catheter locking solution were pooled. Sources of information: We included original research articles in English from PubMed, EMBASE, SpringerLink, Elsevier and Ovid using the search terms 'hemodialysis,' 'central venous catheter,' 'locking solution,' 'UFH,' 'low molecular weight heparin,' 'EDTA,' 'citrate,' 'rt-PA,' 'urokinase,' 'gentamicin,' 'vancomycin', 'taurolidine,' 'sodium bicarbonate,' 'hypertonic saline' and 'ethanol' and 'catheter'. Findings: Low-dose heparin lock solution (< 5000 U/ml) can efficiently achieve anticoagulation and will not increase the risk of bleeding. Low-concentration citrate (< 5%) combined with rt-PA can effectively prevent catheter infection and dysfunction. Catheter-related infections may be minimized by choosing the appropriate antibiotic and dose. Limitations: There is a lack of follow-up validation data for LMWH, EDTA, taurolidine, sodium bicarbonate, ethanol, and other lock solutions. Implications: Since catheterization is common in hemodialysis units, studies on long-term treatment and preventative strategies for catheter dysfunction and catheter-related infection are warranted.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Anticoagulants/therapeutic use ; Catheter-Related Infections/microbiology ; Catheterization, Central Venous ; Central Venous Catheters/adverse effects ; Citrates/adverse effects ; Citric Acid ; Edetic Acid ; Heparin/therapeutic use ; Heparin, Low-Molecular-Weight ; Humans ; Renal Dialysis/adverse effects ; Sodium Bicarbonate
Chemical Substances	Anti-Bacterial Agents ; Anticoagulants ; Citrates ; Heparin, Low-Molecular-Weight ; Citric Acid (2968PHW8QP) ; Sodium Bicarbonate (8MDF5V39QO) ; Heparin (9005-49-6) ; Edetic Acid (9G34HU7RV0)
Language	English
Publishing date	2022-09-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2022.2118068
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Article ; Online: Cardiac substructures dosimetric predicts cardiac toxicity and prognosis in esophageal squamous cell cancer treated by radiotherapy.

Jin, Zhicheng / Sun, Xuefeng / Zhou, Chao / Yang, Haihua / Zhou, Suna

Neoplasia (New York, N.Y.)

2024 Volume 48, Page(s) 100969

Abstract: Purpose: To look into the relationship between cardiac substructures (CS) dosimetric parameters and cardiac events (CE) or overall survival (OS) in patients undergoing radiation therapy (RT) for esophageal squamous cell carcinoma (ESCC).: Methods and ... ...

Abstract	Purpose: To look into the relationship between cardiac substructures (CS) dosimetric parameters and cardiac events (CE) or overall survival (OS) in patients undergoing radiation therapy (RT) for esophageal squamous cell carcinoma (ESCC). Methods and materials: A retrospective study included 350 patients with ESCC receiving definitive chemoradiotherapy or radiotherapy (d-CRT/d-RT) or neoadjuvant chemoradiotherapy (NCRT) from March 2013 to May 2022. Our study examined the adverse cardiac events of any grade or G3+, as defined by the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Competing risk analysis and Cox regression analysis were used to assess the relationship between CS doses and CEs or OS. Results: 201 (57.4 %) patients received any grade CEs over a median follow-up time of 22.50 months (IQR, 12.40-45.60), and 24 (6.86 %) patients suffered G3+ CEs. On landmark analysis, patients with any grade CEs had significantly lower OS (P = 0.003). Multivariable analysis revealed that any grade CEs were predicted by the dose of CSs in all populations. In addition, for G3+ cardiac events, arrhythmic and small probability of cardiac events, LAD V20 ((HR: 1.02, 95 % CI: 1.00-1.03, P = 0.012; HR: 1.01, 95 % CI: 1.00-1.02, P = 0.005; HR; 1.01, 95 % CI: 1.00-1.02, P = 0.012) was also an independent predictive factor. LAD V50 (HR: 1.07, 95 % CI: 1.03-1.10, P <0.001) predicted pericardium effusion events. Moreover, the multivariable analysis revealed that OS was predicted by LAD V30 (HR: 1.03; 95 % CI, 1.01-1.05, P = 0.015). Conclusions: In the population of ESCC patients receiving RT, we showed that the CS factors had a substantial predictive value for the various types and grades of CEs. The elevated radiation dose of LAD was a significant contributor to a higher rate of cardiac events and a worse prognosis.
MeSH term(s)	Humans ; Esophageal Squamous Cell Carcinoma/diagnosis ; Esophageal Squamous Cell Carcinoma/drug therapy ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/radiotherapy ; Carcinoma, Squamous Cell/drug therapy ; Cardiotoxicity/diagnosis ; Cardiotoxicity/etiology ; Cardiotoxicity/drug therapy ; Esophageal Neoplasms/diagnosis ; Esophageal Neoplasms/radiotherapy ; Esophageal Neoplasms/drug therapy ; Retrospective Studies ; Prognosis ; Chemoradiotherapy/adverse effects ; Epithelial Cells/pathology
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1483840-0
ISSN	1476-5586 ; 1522-8002
ISSN (online)	1476-5586
ISSN	1522-8002
DOI	10.1016/j.neo.2024.100969
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Zs.A 5203: Show issues

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Book ; Online: Low-temperature thermal Hall conductivity of Pr2Zr2O7 single crystal

Chu, Wenjun / Sun, Xuefeng

2023

Abstract: To probe the peculiar excitations spinons and magnetic monopoles in the quantum spin ice candidate Pr2Zr2O7, we studied the low-temperature thermal Hall conductivity (\k{appa}xy) and thermal conductivity (\k{appa}xx) of Pr2Zr2O7 single crystal with ... ...

Abstract	To probe the peculiar excitations spinons and magnetic monopoles in the quantum spin ice candidate Pr2Zr2O7, we studied the low-temperature thermal Hall conductivity (\k{appa}xy) and thermal conductivity (\k{appa}xx) of Pr2Zr2O7 single crystal with magnetic fields applied along the [111] axis. The magnetic field dependencies of \k{appa}xx suggest the roles of magnetic excitations in thermal conductivity, that is, the emergent magnetic monopoles can transport heat at T > 1.4 K and spinons mainly scatter phonons at lower temperatures. The finite \k{appa}xy was observed at low fields of several Tesla and was discussed to be related to the magnetic excitations, including magnetic monopoles as well as spinons.
Keywords	Condensed Matter - Strongly Correlated Electrons ; Condensed Matter - Materials Science
Publishing date	2023-02-26
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Deep learning-enhanced fluorescence microscopy via confocal physical imaging model.

Zhang, Baoyuan / Sun, Xuefeng / Mai, Jialuo / Wang, Weibo

Optics express

2023 Volume 31, Issue 12, Page(s) 19048–19064

Abstract: Confocal microscopy is one of the most widely used tools for high-resolution cellular, tissue imaging and industrial inspection. Micrograph reconstruction based on deep learning has become an effective tool for modern microscopy imaging techniques. While ...

Abstract	Confocal microscopy is one of the most widely used tools for high-resolution cellular, tissue imaging and industrial inspection. Micrograph reconstruction based on deep learning has become an effective tool for modern microscopy imaging techniques. While most deep learning methods neglect the imaging process mechanism, which requires a lot of work to solve the multi-scale image pairs aliasing problem. We show that these limitations can be mitigated via an image degradation model based on Richards-Wolf vectorial diffraction integral and confocal imaging theory. The low-resolution images required for network training are generated by model degradation from their high-resolution counterparts, thereby eliminating the need for accurate image alignment. The image degradation model ensures the generalization and fidelity of the confocal images. By combining the residual neural network with a lightweight feature attention module with degradation model of confocal microscopy ensures high fidelity and generalization. Experiments on different measured data report that compared with the two deconvolution algorithms, non-negative least squares algorithm and Richardson-Lucy algorithm, the structural similarity index between the network output image and the real image reaches a high level above 0.82, and the peak signal-to-noise ratio can be improved by more than 0.6 dB. It also shows good applicability in different deep learning networks.
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.490037
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Endostar acts as a pneumonitis protectant in patients with locally advanced non-small cell lung cancer receiving concurrent chemoradiotherapy.

Chen, Kuifei / Li, Shuling / Chen, Meng / Jin, Zhicheng / Sun, Xuefeng / Zhou, Suna / Yang, Haihua

BMC cancer

2024 Volume 24, Issue 1, Page(s) 257

Abstract: Background: CCRT is presently the standard treatment for LA-NSCLC. RP is one of the main obstacles to the completion of thoracic radiation therapy, resulting in limited survival benefits in NSCLC patients. This research aims to explore the role of ... ...

Abstract	Background: CCRT is presently the standard treatment for LA-NSCLC. RP is one of the main obstacles to the completion of thoracic radiation therapy, resulting in limited survival benefits in NSCLC patients. This research aims to explore the role of Endostar in the occurrence of grade≥2 RP and clinical curative effect in LA-NSCLC patients. Methods: This study retrospectively analyzed 122 patients with stage III NSCLC who received CCRT from December 2008 to December 2017, or Endostar intravenous drip concurrently with chemoradiotherapy (Endostar + CCRT group). Standard toxicity of the pneumonitis endpoint was also collected by CTCAE V5.0. We further summarized other available studies on the role of Endostar in the prognosis of NSCLC patients and the incidence of RP. Results: There were 76 cases in the CCRT group and 46 cases in the CCRT+ Endostar group. In the CCRT+ Endostar group, the occurrence of grade ≥2 RP in patients with V20Gy ≥25% was significantly higher than that in patients with V20Gy < 25% (p = 0.001). In the cohorts with V20Gy < 25%, 0 cases of 29 patients treated with Endostar developed grade ≥2 RP was lower than in the CCRT group (p = 0.026). The re-analysis of data from other available studies indicated that Endostar plus CCRT could be more efficient and safely in the occurrence of grade≥2 RP with LA-NSCLC. Conclusions: When receiving CCRT for LA-NSCLC patients, simultaneous combination of Endostar is recommended to enhance clinical benefit and reduce pulmonary toxicity.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/radiotherapy ; Lung Neoplasms/drug therapy ; Retrospective Studies ; Chemoradiotherapy/adverse effects ; Chemoradiotherapy/methods ; Pneumonia/chemically induced ; Pneumonia/epidemiology ; Radiation Pneumonitis/epidemiology ; Radiation Pneumonitis/etiology ; Recombinant Proteins ; Endostatins
Chemical Substances	endostar protein (GVG18ZDN65) ; Recombinant Proteins ; Endostatins
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-12001-6
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Article ; Online: Effects of traditional Chinese exercises in fibromyalgia syndrome: A meta-analysis of randomized controlled trials.

Zhang, Hongshi / Zhang, Xiaotu / Wang, Yidan / Sun, Xuefeng / Li, Sixuan / Zhang, Jindan / Jiao, Jundong

Complementary therapies in medicine

2024 Volume 80, Page(s) 103019

Abstract: Objectives: To explore the efficacy and safety of five traditional Chinese exercises (TCEs) in patients with fibromyalgia syndrome (FMS).: Methods: The PubMed, Embase, Scopus, ProQuest, Web of Science, Cochrane, CNKI, WanFang, and VIP databases were ... ...

Abstract	Objectives: To explore the efficacy and safety of five traditional Chinese exercises (TCEs) in patients with fibromyalgia syndrome (FMS). Methods: The PubMed, Embase, Scopus, ProQuest, Web of Science, Cochrane, CNKI, WanFang, and VIP databases were comprehensively searched for randomized controlled trials (RCTs) related to TCEs published from inception until February 2023. Standardized mean differences (SMD) and 95% confidence intervals (CI) were used to determine the combined effects of the intervention, and the Cochrane risk-of-bias assessment tool and Review 5.2 software were used to assess methodological quality. The data were extracted and analyzed by the Stata15.0 random effects model. Results: Nineteen RCTs including 1315 participants were included in the analysis. The studies were found to be heterogeneous (I Conclusions: TCEs can improve pain, sleep quality and depression in patients with FMS and are safe. However, they do not improve the quality of life significantly. Further large-scale, high-quality, and multi-center RCTs are required to verify the efficacy of TCEs.
MeSH term(s)	Humans ; Fibromyalgia/therapy ; Randomized Controlled Trials as Topic ; Exercise Therapy ; Pain ; China
Language	English
Publishing date	2024-01-09
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	1155895-7
ISSN	1873-6963 ; 0965-2299
ISSN (online)	1873-6963
ISSN	0965-2299
DOI	10.1016/j.ctim.2024.103019
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Zs.A 3726: Show issues

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Article: Application of exercise therapy in patients with chronic kidney disease-induced muscle atrophy: a scoping review.

Yin, Jiawei / Zhang, Xiaotu / Wang, Zilin / Qu, Zihan / Sun, Xuefeng / Song, Yuqing / Zhang, Hongshi

BMC sports science, medicine & rehabilitation

2024 Volume 16, Issue 1, Page(s) 100

Abstract: Background: The prevalence of muscle atrophy in patients suffering from chronic kidney disease (CKD) presents a significant challenge to healthcare providers, necessitating innovative approaches to management and care. Against this backdrop, this study ... ...

Abstract	Background: The prevalence of muscle atrophy in patients suffering from chronic kidney disease (CKD) presents a significant challenge to healthcare providers, necessitating innovative approaches to management and care. Against this backdrop, this study embarks on a comprehensive review of literature concerning the application of exercise interventions in the nursing care of these patients. Such interventions are critical in addressing the debilitating effects of the condition, which include progressive loss of muscle mass and strength, adversely affecting patient mobility, quality of life, and overall survival. This review aims to identify the specific exercise modalities, contents, outcome indicators, and application effects associated with this intervention, in the context of the complex interplay of metabolic, inflammatory, and hormonal factors contributing to muscle wasting in CKD patients. By examining the efficacy of various exercise interventions, this study seeks to elucidate optimal strategies for mitigating the impact of CKD-induced muscle atrophy, thereby informing clinical practices and improving patient outcomes. Methods: According to the method of a scoping review, nine databases (Cochrane, PubMed, EMBASE, Web of Science, ProQuest, Ovid, CNKI, Wanfang Data, and VIP) were searched until September 28, 2023. The included literature was screened, summarized, and analyzed. Results: A total of 20 pieces of literature were included. Some types include aerobic exercise, resistance exercise, and aerobic combined resistance exercise. The exercise intensity primarily falls within the mild to moderate range, with a recommended frequency of 2 - 3 times a week, lasting 30 - 60 min each time. The types of outcomes encompassed in this study include body composition, functional testing, strength measurements, laboratory examinations, cardiopulmonary function assessments, and patient-reported outcomes. To varying degrees, exercise intervention positively impacts the subjects' physical activity ability, body composition, and skeletal muscle status. Currently, resistance training is the primary type of intervention used for preventing and treating CKD patients induced by muscle atrophy. Conclusion: Exercise intervention can improve muscle strength, physical function, and quality of life in patients with CKD muscle atrophy. Therefore, patients should be fully informed of the effect of exercise intervention in the treatment of chronic kidney disease-induced muscle atrophy in future, so as to promote the standardized implementation of exercise intervention.
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2719537-5
ISSN	2052-1847
ISSN	2052-1847
DOI	10.1186/s13102-024-00876-8
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Article ; Online: Regulating the d-band electrons of the Fe-N-C single-atom catalyst for high-efficiency CO

Chen, Yiqun / Gong, Qinghua / Sun, Xuefeng / Li, Guochang / Zhou, Guowei

Dalton transactions (Cambridge, England : 2003)

2023 Volume 52, Issue 15, Page(s) 4819–4825

Abstract: Developing highly efficient electrocatalysts is crucially significant for the application of advanced energy conversion. The Fe-N-C single-atom catalyst is promising for ... ...

Abstract	Developing highly efficient electrocatalysts is crucially significant for the application of advanced energy conversion. The Fe-N-C single-atom catalyst is promising for CO
Language	English
Publishing date	2023-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt00394a
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Article ; Online: Disseminated nontuberculous mycobacterial infection with cryptic immunodeficiency mimicking malignancy: a case report.

Sun, Xiaochuan / Zhang, Ting / Sun, Hongli / Sun, Xuefeng

BMC pulmonary medicine

2022 Volume 22, Issue 1, Page(s) 452

Abstract: Background: Nontuberculous mycobacteria (NTM) usually invades vulnerable hosts. Disseminated NTM (dNTM) infection can affect nearly all organs and be easily misdiagnosed as metastatic carcinoma or other systemic diseases, especially in seemingly ... ...

Abstract	Background: Nontuberculous mycobacteria (NTM) usually invades vulnerable hosts. Disseminated NTM (dNTM) infection can affect nearly all organs and be easily misdiagnosed as metastatic carcinoma or other systemic diseases, especially in seemingly immunocompetent hosts. Identification of underlying immunodeficiency is critical for the diagnosis and treatment of dNTM. Adult-onset immunodeficiency (AOID) with anti-IFN-γ autoantibodies has recently been recognized as a crucial but frequently neglected risk factor for dNTM infection. Frequent relapses of infection are common in AOID patients despite appropriate anti-infective treatment and B-cell-depleting therapy has shown some promising results. Herein, we report a case of dNTM infection mimicking malignancy in an AOID patient who was successfully treated with rituximab. Case presentation: A middle-aged male presented with fever, productive cough, multifocal skin abscesses and multiple osteolytic lesions with pathological fractures. Chest CT revealed consolidation of the lingula while bronchoscopy showed a mass completely blocking the airway opening of the inferior lingual segment. Metagenomic next-generation sequencing and mycobacterial culture of skin pus and bronchoalveolar lavage fluid reported Mycobacterium Colombiense, confirming the diagnosis of dNTM infection. However, anti-NTM antibiotics alone failed to prevent disease relapse and progression. Further evaluation indicated undetectable serum IFN-γ concentration and high-titer autoantibodies against IFN-γ, suggesting that AOID was the underlying reason for dNTM. Rituximab was added to treatment and successfully controlled the infection without relapse at one-year follow-up. Conclusion: We reported a rare case of disseminated Mycobacterium Colombiense infection manifested with pulmonary mass, pathological fracture and dermapostasis in a host with AOID. Our case demonstrated that AOID should be screened when patients get the episode of disseminated NTM infection particularly when other risk factors are excluded. Besides prolonged anti-NTM therapy, AOID-associated NTM infection should be treated with B-cell-depleting therapy to prevent recurrence.
MeSH term(s)	Humans ; Male ; Middle Aged ; Autoantibodies ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/drug therapy ; Neoplasm Recurrence, Local ; Nontuberculous Mycobacteria ; Opportunistic Infections ; Rituximab/therapeutic use
Chemical Substances	Autoantibodies ; Rituximab (4F4X42SYQ6)
Language	English
Publishing date	2022-11-29
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-022-02227-0
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Article ; Online: Efficacy and safety of acupuncture combined Chinese herbal medicine for diabetic peripheral neuropathy: A protocol for systematic review and meta-analysis.

Shi, Yong / Liu, Le / Sun, Xuefeng / Jiao, Jundong

Medicine

2022 Volume 100, Issue 50, Page(s) e28086

Abstract: Background: Acupuncture combined with Chinese herbal medicine has been widely utilized for pain management in patients with diabetic peripheral neuropathy (DPN). However, its results are still inconsistent, and no systematic review has specifically ... ...

Abstract	Background: Acupuncture combined with Chinese herbal medicine has been widely utilized for pain management in patients with diabetic peripheral neuropathy (DPN). However, its results are still inconsistent, and no systematic review has specifically addressed this issue. Thus, this systematic review will comprehensively and systematically investigate the effectiveness and safety of acupuncture combined with Chinese herbal medicine for pain relief in DPN. Methods: Randomized controlled trials on acupuncture combined with Chinese herbal medicine treatment of DPN published before September of 2021 will be searched in 9 databases including Medline, Web of Science, PubMed, Cochrane Library, Excerpta Medica Database, Sinomed, China National Knowledge Infrastructure, WanFang, and China Science and Technology Journal Database. The methodological assessment performed using the risk of bias assessment tool of Cochrane, and the level of evidence quality for the main results will be evaluated by a recommended grading, evaluation, formulation, and evaluation system approach. Bayesian network meta-analysis will be conducted using STATA V.14.0 and WinBUGS V.1.4.3. Results: This study will provide a high-quality comprehensive evaluation of the safety of acupuncture combined with Chinese herbal medicine for treating DPN. Conclusion: This systematic review will evaluate the efficacy and safety of Chinese herbal medicine combined with acupuncture in the treatment of DPN, and provide the latest evidence for clinical application. Ethics and dissemination: The protocol of the systematic review does not require ethical approval because it does not involve humans. This article will be published in peer-reviewed journals and presented at relevant conferences.Registration number: INPLASY2021100004.
MeSH term(s)	Acupuncture Therapy ; Bayes Theorem ; Diabetes Mellitus/therapy ; Diabetic Neuropathies/therapy ; Drugs, Chinese Herbal/adverse effects ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Meta-Analysis as Topic ; Research Design ; Systematic Reviews as Topic ; Treatment Outcome
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2022-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000028086
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