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Article: [Study on the Mechanism of Multi-Drug Resistance of Agaricus Blazei Extract FA-2-b-β Mediated Wnt Signaling Pathway to Reverse Acute T Lymphoblastic Leukemia].

Feng, Wen-Wen / Bai, Yu / Wang, Dong-Ping / Fan, Fu-Yan / Sun, Yan-Qing

2023 Volume 31, Issue 3, Page(s) 621–627

Abstract: Objective: To investigate the mechanism of drug reversing resistance of Agaricus blazei extract FA-2-b-β on T cell acute lymphoblastic leukemia (T-ALL) cell lines.: Methods: Cell proliferation was detected by CCK-8 assay; the apoptosis, cell cycle ... ...

Abstract	Objective: To investigate the mechanism of drug reversing resistance of Agaricus blazei extract FA-2-b-β on T cell acute lymphoblastic leukemia (T-ALL) cell lines. Methods: Cell proliferation was detected by CCK-8 assay; the apoptosis, cell cycle mitochondrial membrane potential, and intracellular rhodamine accumulation were detected by flow cytometry, and apoptosis-related gene and protein expression were detected by qPCR and Western blot; the membrane surface protein MDR1 was observed by immunofluorescence microscopy. Results: Different concentrations of FA-2-b-β significantly inhibited proliferation and induced apoptosis of CCRF-CEM and CEM/C1 ( Conclusion: Agaricus Blazei Extract FA-2-b-β inhibits cell proliferation, promotes apoptosis, regulates the cell cycle, reduces mitochondrial energy supply, and down-regulate MDR1 expression to reverse the resistance of CEM/C1, which all suggest it is through regulating the Wnt signaling pathway in T-ALL.
MeSH term(s)	Humans ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma ; Wnt Signaling Pathway ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Apoptosis ; Drug Resistance, Multiple ; Membrane Proteins ; Cell Line, Tumor ; Cell Proliferation
Chemical Substances	Membrane Proteins
Language	Chinese
Publishing date	2023-04-14
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2023.03.001
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Article: [Value of Neutrophil/Lymphocyte Ratio and Monocyte/Lymphocyte Ratio in the Prognosis of Patients with Multiple Myeloma].

Yang, Wen-Hui / Sun, Yan-Qing / Zhang, Qi-Ke / Wei, Xiao-Fang / Li, Gao

Zhongguo shi yan xue ye xue za zhi

2020 Volume 29, Issue 1, Page(s) 122–130

Abstract: Objective: To investigate the effect of neutrophil/lymphocyte ratio (NLR) and monocyte/lymphocyte ratio (MLR) in the valuation prognosis of patients with multiple myeloma (MM).: Methods: The clinical data of 82 patients with initially diagnosed MM ... ...

Abstract	Objective: To investigate the effect of neutrophil/lymphocyte ratio (NLR) and monocyte/lymphocyte ratio (MLR) in the valuation prognosis of patients with multiple myeloma (MM). Methods: The clinical data of 82 patients with initially diagnosed MM admitted to Gansu Provincial People's Hospital was analyzed retrospectively. NLR and MLR were calculated based on blood routine results respectively. The optimal cut-off point of NLR and MLR was determined according to the ROC curve, and the patients were divided into the high NLR/MLR group and the low NLR/MLR group. The general data, biochemical indicators and prognosis of the patients in each groups were compared respectively. The prognostic significance of the high NLR/MLR group and the low NLR/MLR group in patients between different treatment regimens and different clinical characteristics were analyzed. Risk stratification was designed based on NLR and high MLR as two risk factors, and the effect of risk factors, on the prognosis of MM patients were compared. Results: ROC curve analysis determined that the optimal cut-off point of NLR was 3.1 (sensitivity 75%, specificity 70.7%) and the optimal cut-off point of MLR was 0.34 (sensitivity 83.3%, specificity 53.4%). The lactate dehydrogenase (LDH) and mean platelet volume (MPV) were correlated to NLR and MLR (P<0.05). There were no significant difference in age, sex, serum calcium (Ca), β Conclusion: Elevated NLR and MLR are associated with poor prognosis in MM patients and may serve as the cost-effective and readily available prognostic biomarkers.
MeSH term(s)	Blood Platelets ; Humans ; Lymphocytes ; Monocytes ; Multiple Myeloma ; Neutrophils ; Prognosis ; Retrospective Studies
Language	Chinese
Publishing date	2020-10-14
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2021.01.020
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Article: [Expression of CD56 in Multiple Myeloma Cells and Its Relationship with Extramedullary Disease and Extramedullary Relapse].

Li, Gao / Huang, Xiu-Juan / Niu, Tong / Wei, Chi / Cheng, Ming-Xia / Han, Cai-Juan / Sun, Yan-Qing

Zhongguo shi yan xue ye xue za zhi

2021 Volume 29, Issue 2, Page(s) 553–556

Abstract: Objective: To investigate the expression of CD56 in multiple myeloma (MM) cells and its relationship between extramedullary disease and extramedullary relapse.: Methods: Clinical data of 99 patients with MM treated in our hospital from January 2015 ... ...

Abstract	Objective: To investigate the expression of CD56 in multiple myeloma (MM) cells and its relationship between extramedullary disease and extramedullary relapse. Methods: Clinical data of 99 patients with MM treated in our hospital from January 2015 to December 2019 was retrospectively analyzed. The patients were divided into positive group and negative group according to the expression of CD56. The relationship between CD56 and multiple myeloma extramedullary disease, extramedullary relapse was analyzed. Results: Among 99 newly diagnosed patients with MM, the positive rate of CD56 was 65%, and the incidence of extramedullary disease of patients in the CD56 positive group was lower than that in the CD56 negative group (17.19% vs 48.57%) (P<0.01). Meanwhile, the incidence of extramedullary relapse of patients in the CD56 positive group was lower than that in the CD56 negative group (1.56% vs 34.29%) (P<0.01). Conclusion: CD56 is highly expressed in MM, and its low expression is associated with the occurrence of extramedullary disease and extramedullary relapse, which suggests that CD56 may be an important indicator for predicting the occurrence of extramedullary disease and extramedullary relapse.
MeSH term(s)	CD56 Antigen ; Humans ; Multiple Myeloma ; Neoplasm Recurrence, Local ; Retrospective Studies
Chemical Substances	CD56 Antigen
Language	Chinese
Publishing date	2021-04-03
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2021.02.039
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Article: [Significance of Neutrophil/Lymphocyte Ratio in the Prognosis of Patients with Multiple Myeloma].

Sun, Yan-Qing / Li, Qing-Fen / Zhang, Qi-Ke / Wei, Xiao-Fang / Feng, You-Fan

Zhongguo shi yan xue ye xue za zhi

2019 Volume 27, Issue 2, Page(s) 489–493

Abstract: Objective: To study the value of neutrophil/lymphocyte ratio (NLR) in the evaluation of prognosis of patients with multiple myeloma (MM).: Methods: NLR was calculated on the basis of the blood routine examination results of 65 patients with primary ... ...

Abstract	Objective: To study the value of neutrophil/lymphocyte ratio (NLR) in the evaluation of prognosis of patients with multiple myeloma (MM). Methods: NLR was calculated on the basis of the blood routine examination results of 65 patients with primary MM (MM group) and 83 persons receiving physical examination as control group, and the difference in 2 group was compared; moreover according to the median as threshold, the patients were divided into low NLR group (NLR＜2.34) and high NLR group (NLR≥2.34); the differences of age, sex, serum calcium β Results: the NLR of MM patients was statistically significantly higher than that of the control group (z=-2.415, P＜0.05). Compared with the low NLR group, the β Conclusion: NLR elevation in patients with primary diagnosis of MM indicates a poor prognosis, which is an independent risk factor affecting the prognosis.
MeSH term(s)	Humans ; Leukocyte Count ; Lymphocytes ; Multiple Myeloma ; Neutrophils ; Prognosis ; Retrospective Studies
Language	Chinese
Publishing date	2019-04-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2019.02.029
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Article: [Transformation Regularity of Nitrogen in Aqueous Product Derived from Hydrothermal Liquefaction of Sewage Sludge in Subcritical Water].

Sun, Yan-qing / Sun, Zhen / Zhang, Jing-lai

Huan jing ke xue= Huanjing kexue

2015 Volume 36, Issue 6, Page(s) 2210–2215

Abstract: Hydrothermal liquefaction in subcritical water is a potential way to treat sewage sludge as a resource rather than a waste. This study focused on the transformation regularity of nitrogen in aqueous product which was derived from hydrothermal ... ...

Abstract	Hydrothermal liquefaction in subcritical water is a potential way to treat sewage sludge as a resource rather than a waste. This study focused on the transformation regularity of nitrogen in aqueous product which was derived from hydrothermal liquefaction of sewage sludge under different operating conditions. Results showed, within the studied temperature scope and time span, the concentration of total nitrogen (TN) fluctuated in the range of 2867.62 mg x L(-1) to 4171.30 mg x L(-1). The two major exiting formation of nitrogen in aqueous product was ammonia nitrogen (NH4+ -N) and organic nitrogen (Org-N). NH4+ -N possessed 54.6%-90.7% of TN, while Org-N possessed 7.4%-44.5%. The concentration of nitrate nitrogen (NO- -N) was far more less than NH4+ -N and Org-N. Temperature had a great influence on the transformation regularity of nitrogen. Both the concentration of TN and Org-N increased accordingly to the increase of reaction temperature. With the reaction time prolonging, the concentration of TN and Org-N increased, while the concentration of NH4+ -N increased first, then became stationary, and then decreased slightly.
MeSH term(s)	Nitrogen/chemistry ; Sewage/chemistry ; Temperature ; Waste Disposal, Fluid/methods ; Water/chemistry
Chemical Substances	Sewage ; Water (059QF0KO0R) ; Nitrogen (N762921K75)
Language	Chinese
Publishing date	2015-06
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
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Article: [Analysis on Related Factors of Pulmonary Infection in Patients with Multiple Myeloma Treated with Bortezomib].

Li, Gao / Zhang, Qi-Ke / Wei, Xiao-Fang / Feng, You-Fan / Yang, Wen-Hui / Sun, Yan-Qing

Zhongguo shi yan xue ye xue za zhi

2020 Volume 29, Issue 1, Page(s) 152–157

Abstract: Objective: To analyze the risk factors, distribution of pathogenic strains and tolerance of pulmonary infection in patients with multiple myeloma(MM) during bortezomib chemotherapy.: Methods: The clinical data of 85 patients with multiple myeloma ... ...

Abstract	Objective: To analyze the risk factors, distribution of pathogenic strains and tolerance of pulmonary infection in patients with multiple myeloma(MM) during bortezomib chemotherapy. Methods: The clinical data of 85 patients with multiple myeloma treated by bortezomib in our hospital from January 2015 to January 2019 was analyzed. The patients were divided into infection group and control group according to whether they were infected. The tolerance, pathogen distribution, and related risk factors were retrospectively analyzed. Results: Pulmonary infection rate was 55.29% in 85 MM patients. The proportions of the patients with anemia, neutropenia, and ECOG score ≥2 points in the infection group were significantly higher than those in the control group (P<0.05). In this study, 30 strains of pathogenic bacteria were detected, with gram-negative bacteria accounting for 60%, gram-positive bacteria for 33.33%, fungi for 3.3% and tuberculosis bacteria for 3.3%. Pseudomonas aeruginosa, klebsiella pneumoniae, streptococcus pneumoniae, staphylococcus aureus accounted showed the highest proportion. Most of MM patients with pulmonary infection showed a heterprognosis after two weeks antibiotic treatment, while 3 patients died. About 30 percent of early deaths were due to pulmonary infections. Conclusion: Anemia, neutropenia, ECOG score ≥2 points are the major clinical characteristics of the multiple myeloma patients with pulmonary infections. Pulmonary infection is an important cause of early death in patients with multiple myeloma. Pathogenic bacteria are mainly composed of gram-negative bacteria. Beta-lacta/ beta-lactamase inhibitor combinations or Carbapenems are effective empiric treatment for controlling the progression of pulmonary infection.
MeSH term(s)	Bortezomib ; Drug Resistance, Bacterial ; Humans ; Microbial Sensitivity Tests ; Multiple Myeloma/drug therapy ; Retrospective Studies
Chemical Substances	Bortezomib (69G8BD63PP)
Language	Chinese
Publishing date	2020-10-14
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2021.01.024
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Article: [Analysis of Risk Factors of Herpes Zoster in Patients with Multiple Myeloma Treated with Bortezomib].

Li, Gao / Zhang, Qi-Ke / Wei, Xiao-Fang / Feng, You-Fan / Yang, Wen-Hui / Sun, Yan-Qing

Zhongguo shi yan xue ye xue za zhi

2020 Volume 28, Issue 6, Page(s) 1972–1976

Abstract: Objective: To explore and analyze the risk factors of herpes zoster in patients with multiple myeloma (MM) during the chemotherapy with bortezomib.: Methods: Clinical data of 85 MM patients treated with bontizomib from January 2015 to January 2019 ... ...

Abstract	Objective: To explore and analyze the risk factors of herpes zoster in patients with multiple myeloma (MM) during the chemotherapy with bortezomib. Methods: Clinical data of 85 MM patients treated with bontizomib from January 2015 to January 2019 were selected and divided into case group and control group accroding to the occurred of herpes zoster. The clinical characteristic, treatment outcome and related factor of herpes zoster were retrospective analyzed. Results: Twenty of the 85 patients with MM treated with bortezomib developed herpes zoster occurred (23.5%). Single-factor analysis showed that age≥65 years, lymphocytopenia occurred before treatment, neutropenia occurred before treatment, ECOG score≥2, application of cyclophosphamide, absence of preventive antiviral therapy were associated with the genesis of herpes zoster (P＜0.05). Multivariate logistic regression analysis showed that lymphocytopenia occurred before treatment, the application of cyclophosphamide and the absence of preventive antiviral therapy were the independent risk factors for herpes zoster (P＜0.05). Conclusion: The incidence of herpes zoster is high in the multiple myeloma patients treated with bortezomib. Lymphocytopenia occurred before treatment, the application of cyclophosphamide, and the absence of prophylactic antiviral therapy are the important risk factors for herpes zoster, for which the clinicians should attach great importance.
MeSH term(s)	Boronic Acids ; Bortezomib ; Herpes Zoster/epidemiology ; Humans ; Multiple Myeloma/drug therapy ; Pyrazines ; Retrospective Studies ; Risk Factors
Chemical Substances	Boronic Acids ; Pyrazines ; Bortezomib (69G8BD63PP)
Language	Chinese
Publishing date	2020-12-06
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2020.06.029
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Article: [Primary Mechanisms of CD34

Wang, Dong-Ping / Shi, Wei / Ge, Wan-Wen / Zhang, Ju-Xia / Zhao, Lian-Ping / Chen, Xue / Dong, Li / Sun, Yan-Qing

Zhongguo shi yan xue ye xue za zhi

2019 Volume 27, Issue 6, Page(s) 1761–1766

Abstract: Objective: To investigate the apoptosis of CD34: Methods: CD34: Results: The proportion of CD34: Conclusion: FA-2-b-β can regulate proliferation and apoptosis KG1a stem cells, the involved mechanism may be related with the activation of ... ...

Abstract	Objective: To investigate the apoptosis of CD34 Methods: CD34 Results: The proportion of CD34 Conclusion: FA-2-b-β can regulate proliferation and apoptosis KG1a stem cells, the involved mechanism may be related with the activation of mitochondrial-mediated apoptotic pathway.
MeSH term(s)	ADP-ribosyl Cyclase 1 ; Antigens, CD34 ; Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Membrane Glycoproteins ; Neoplastic Stem Cells ; Selenium
Chemical Substances	Antigens, CD34 ; Membrane Glycoproteins ; CD38 protein, human (EC 3.2.2.5) ; ADP-ribosyl Cyclase 1 (EC 3.2.2.6) ; Selenium (H6241UJ22B)
Language	Chinese
Publishing date	2019-12-14
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2019.06.009
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Article: [Primary Study on Chronic Myeloid Leukemia in NCG Mice from Qinba Mushroom].

Cheng, Ming-Xia / Qi, Jing / Zhao, Lian-Ping / Lyu, Li / Chen, Xue / Li, Gao / Bai, Kun-Tian / Han, Cai-Juan / Sun, Yan-Qing

Zhongguo shi yan xue ye xue za zhi

2021 Volume 29, Issue 2, Page(s) 381–388

Abstract: Objective: The present study was to evaluate the anti-tumor effects of acidic RNA protein complex (FA-2-b-β) extracted from the wild edible Qinba mushroom in inducing of apoptosis and immunoregulation of tumor cell.: Methods: Cell proliferation ... ...

Abstract	Objective: The present study was to evaluate the anti-tumor effects of acidic RNA protein complex (FA-2-b-β) extracted from the wild edible Qinba mushroom in inducing of apoptosis and immunoregulation of tumor cell. Methods: Cell proliferation inducing rate of FA-2-b-β to K562 cell was measured using CCK-8. Apoptosis rate was detected by using flow cytometry. Chronic myeloid leukemia model was developed by tail vein injection/subcutaneous inoculation of K562 cells in NCG mice. The tumor burden of mice was observed. The general condition of the mice was monitored twice daily. The peripherivcal full blood counts of mice was tested daily. RT-qPCR and Western blot was FA-2-b-β performed to determine involvement of apoptotic-related gene and protenin, Immunofluorescence and immunohistochemistry was used to detected the expression of CD3, CD4 and CD8. Results: The proliferation and apoptosis of K562 cell could be inhibitied and induced by FA-2-b-β, there was 100% successful in the tumor formation in vivo, after treated by drug for 21 days there were significantly increased peripheral leucocytes, but decreased hemoglobin of mice treated by FA-2-b-β as compared with those in control group. The CD3, CD4 and CD8 showed positive in mice, and the propotation was imbalance, but it showed reserved after treated by FA-2-b-β. Conclusion: FA-2-b-β is strong anti-leukemia effect in vitro and in vivo, suggesting the traditional Chinese medicine maybe contribute to the anti-cancer and immunoregulation research.
MeSH term(s)	Agaricales ; Animals ; Apoptosis ; Cell Proliferation ; Humans ; K562 Cells ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; Mice
Language	Chinese
Publishing date	2021-04-03
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2021.02.012
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Article: [Inhibitory Effects of Agaricus Blazei Murrill (FA-2-b-β) on Proliferation of Chronic Myeloid Leukemia Cells in vivo and Its Mechanism].

Cheng, Ming-Xia / Yu, Shang-Rui / Wang, Zhan-Dong / Bai, Kun-Tian / Wang, Dong-Ping / Li, Juan / Liu, Shi-Dong / Sun, Yan-Qing / Dong, Li

Zhongguo shi yan xue ye xue za zhi

2020 Volume 28, Issue 6, Page(s) 1885–1891

Abstract: Objective: To investigated the anti-tumor in vivo effect and mechanism of the acid RNA protein complex (FA-2-b-β) of Agaricus blazei Murrill extract.: Methods: CCK-8 method was used to detected the inhibitory effect of FA-2-b-β on proliferation of ... ...

Abstract	Objective: To investigated the anti-tumor in vivo effect and mechanism of the acid RNA protein complex (FA-2-b-β) of Agaricus blazei Murrill extract. Methods: CCK-8 method was used to detected the inhibitory effect of FA-2-b-β on proliferation of primary CML cells from newly diagnosed CML patients, the CML mouse model was established by trail-venous injection of primary CML cells, and the survival time, blood cell count and body weight were observed, the immunoflouresence and immunehistochemistry analysis, RT-qPCR, Western bolt were used to detemine the expression of caspase-3 signal pathway-related apoptosis genes and proteins. Results: The experiments in vitro showed that the proliferative inhibitory rate in drug-treated group increased with concentration- and time-dependent manner (r Conclusion: The FA-2-b-β can induce apoptosis of primary CML cells and prolong the survival time of CML model mouse, which may be related with the caspase-3 signal pathway related genes and proteins.
MeSH term(s)	Agaricus ; Animals ; Apoptosis ; Cell Proliferation ; Humans ; Imatinib Mesylate ; K562 Cells ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; Mice
Chemical Substances	Imatinib Mesylate (8A1O1M485B)
Language	Chinese
Publishing date	2020-12-14
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2020.06.016
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