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  1. AU="Sun, Yuan-Yuan"
  2. AU="Palazuelos Molinero, Jorge"
  3. AU="Papamikos, Vassilios"
  4. AU="Toledano-Osorio, Manuel"
  5. AU="Aston, Kenneth"
  6. AU="Crowe, Remle"
  7. AU="El-Yazbi, Amira F"
  8. AU=Wong Kai Yau AU=Wong Kai Yau
  9. AU="Wais, Verena"
  10. AU=Barbieri Lavinia AU=Barbieri Lavinia
  11. AU=McKay Jennifer S
  12. AU="Frohn, Marina"
  13. AU="Blaksley, C"
  14. AU="Heri Hermasyah"
  15. AU="Charlier, Filip"
  16. AU="Mihalopoulos, N"
  17. AU="Fernandez, S Gomez"

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  1. Artikel ; Online: METTL21C mediates autophagy and formation of slow-twitch muscle fibers in mice after exercise.

    Qu, Jing / Dang, Shuai / Sun, Yuan-Yuan / Zhang, Tao / Jiang, Hai / Lu, Hong-Zhao

    Genes & genetic systems

    2024  Band 99

    Abstract: Homeostasis is essential for muscle repair and regeneration after skeletal muscle exercise. This study investigated the role of methyltransferase-like 21C (METTL21C) in skeletal muscle of mice after exercise and the potential mechanism. First, muscle ... ...

    Abstract Homeostasis is essential for muscle repair and regeneration after skeletal muscle exercise. This study investigated the role of methyltransferase-like 21C (METTL21C) in skeletal muscle of mice after exercise and the potential mechanism. First, muscle samples were collected at 2, 4 and 6 weeks after exercise, and liver glycogen, muscle glycogen, blood lactic acid and triglyceride were assessed. Moreover, the expression levels of autophagy markers and METTL21C in skeletal muscle were analyzed. The results showed that the expression levels of METTL21C and MYH7 in the gastrocnemius muscle of mice in the exercise group were significantly higher after exercise than those in the control group, which suggested that long-term exercise promoted the formation of slow-twitch muscle fibers in mouse skeletal muscle. Likewise, the autophagy capacity was enhanced with the prolongation of exercise in muscles. The findings were confirmed in mouse C2C12 cells. We discovered that knockdown of Mettl21c reduced the expression of MYH7 and the autophagy level in mouse myoblasts. These findings indicate that METTL21C promotes skeletal muscle homeostasis after exercise by enhancing autophagy, and also contributes to myogenic differentiation and the formation of slow muscle fibers.
    Mesh-Begriff(e) Animals ; Autophagy ; Mice ; Physical Conditioning, Animal ; Methyltransferases/metabolism ; Methyltransferases/genetics ; Myosin Heavy Chains/metabolism ; Myosin Heavy Chains/genetics ; Muscle Fibers, Slow-Twitch/metabolism ; Male ; Muscle, Skeletal/metabolism ; Myoblasts/metabolism ; Cell Line ; Mice, Inbred C57BL ; Muscle Development
    Chemische Substanzen Methyltransferases (EC 2.1.1.-) ; Myosin Heavy Chains (EC 3.6.4.1) ; Myh7 protein, mouse
    Sprache Englisch
    Erscheinungsdatum 2024-04-18
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 1323536-9
    ISSN 1880-5779 ; 1341-7568
    ISSN (online) 1880-5779
    ISSN 1341-7568
    DOI 10.1266/ggs.23-00320
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Effects of different dehydration methods on the preservation of aortic and renal glycocalyx structures in mice.

    Li, Zhi / Zhang, Quanbin / Sun, Yuan-Yuan / Wu, Ning

    Heliyon

    2023  Band 9, Heft 4, Seite(n) e15197

    Abstract: Glycocalyx is located outside the vascular endothelial cells playing an important role in vascular homeostasis. However, lacking efficient detection methods is one of the biggest obstacles to study the glycocalyx. In this study, three dehydration methods ...

    Abstract Glycocalyx is located outside the vascular endothelial cells playing an important role in vascular homeostasis. However, lacking efficient detection methods is one of the biggest obstacles to study the glycocalyx. In this study, three dehydration methods were used to compare the preservation of HUVEC, aorta and kidney glycocalyx by transmission electron microscope. The chemical pre-fixation was performed by lanthanum nitrate staining, and the mice aorta and renal glycocalyx were prepared by different dehydration methods such as ethanol gradient, acetone gradient and low temperature dehydration. HUVEC glycocalyx was prepared by acetone gradient and low temperature dehydration. Low temperature dehydration method preserves HUVEC and mice aortic glycocalyx completely, which had a certain thickness and presented a needle-like structure. But for mice kidney, the acetone gradient dehydration preparation method could better preserve the glycocalyx integrity than other two methods. In conclusion, low temperature dehydration method is suitable for HUVEC and aortic glycocalyx preservation, acetone gradient dehydration method is more suitable for kidney glycocalyx preservation.
    Sprache Englisch
    Erscheinungsdatum 2023-04-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15197
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: A step-by-step strategy to design active and stable quaternary intermetallic compounds for the hydrogen evolution reaction.

    Hao, Tong-Tong / Yang, Yu-Qing / Sun, Yuan-Yuan / Suen, Nian-Tzu

    Chemical communications (Cambridge, England)

    2023  Band 59, Heft 72, Seite(n) 10781–10784

    Abstract: Multinary intermetallic compounds with rich chemical compositions enable one to achieve a logical design for desired materials based on the required function. In this work, we have demonstrated a step-by-step strategy to design a quaternary intermetallic ...

    Abstract Multinary intermetallic compounds with rich chemical compositions enable one to achieve a logical design for desired materials based on the required function. In this work, we have demonstrated a step-by-step strategy to design a quaternary intermetallic compound that exhibits highly active and stable performance for the hydrogen evolution reaction (HER). With binary intermetallic TaCo
    Sprache Englisch
    Erscheinungsdatum 2023-09-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc02606j
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: A new species of Sedum (Crassulaceae) from Mount Danxia in Guangdong, China

    Huang, Yan-Shuang / Meng, Kai-Kai / Sun, Yuan-Yuan / Chen, Zai-Xiong / Fan, Qiang

    PhytoKeys. 2023 Mar. 10, v. 221 p.117-129

    2023  

    Abstract: AbstractSedum jinglanii, a new species of Crassulaceae from Mount Danxia in Guangdong, China, is described and illustrated. Phylogenetic analysis based on the internal transcribed spacer (ITS) region of nrDNA suggests that the new species belongs to S ... ...

    Abstract AbstractSedum jinglanii, a new species of Crassulaceae from Mount Danxia in Guangdong, China, is described and illustrated. Phylogenetic analysis based on the internal transcribed spacer (ITS) region of nrDNA suggests that the new species belongs to S.sect.Sedum sensu Fu and Ohba (2001) in the “Flora of China”, and is sister to a clade comprising S. alfredi and S. emarginatum with high support values (SH-aLRT = 84, UFBS = 95) but is distantly related to S. baileyi. The new species is morphologically similar to S. alfredi but it can be distinguished from the latter in its opposite leaves (vs. alternate leaves), its usually wider leaves (0.4–1.2 cm vs. 0.2–0.6 cm), its usually shorter petals (3.4–4.5 mm vs. 4–6 mm), its shorter nectar scales (0.4–0.5 mm vs. 0.5–1 mm), its shorter carpels (1.5–2.6 mm vs. 4–5 mm), and its shorter styles (0.6–0.9 mm vs. 1–2 mm). The new species can be easily distinguished from S. emarginatum which both have opposite leaves by its short, erect or ascending rhizome (vs. long and prostrate rhizome in the latter), shorter petals (3.4–4.5 mm vs. 6–8 mm) and shorter carpels (1.5–2.6 mm vs. 4–5 mm). It can also be easily distinguished from S. baileyi by its short, erect or ascending rhizome (vs. long and prostrate rhizome) and its shorter style (0.6–0.9 mm vs. 1–1.5 mm).
    Schlagwörter Sedum ; flora ; internal transcribed spacers ; nectar ; new species ; phylogeny ; rhizomes ; China ; Danxia landscape ; morphology ; nrITS ; Sedum sect. Sedum
    Sprache Englisch
    Erscheinungsverlauf 2023-0310
    Umfang p. 117-129.
    Erscheinungsort Pensoft Publishers
    Dokumenttyp Artikel ; Online
    ZDB-ID 2579891-1
    ISSN 1314-2003 ; 1314-2011
    ISSN (online) 1314-2003
    ISSN 1314-2011
    DOI 10.3897/phytokeys.221.97495
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: Effects of different dehydration methods on the preservation of aortic and renal glycocalyx structures in mice

    Li, Zhi / Zhang, Quanbin / Sun, Yuan-yuan / Wu, Ning

    Heliyon. 20232023 Apr. 05, Apr. 05, v. 9, no. 4 p.e15197-

    2023  

    Abstract: Glycocalyx is located outside the vascular endothelial cells playing an important role in vascular homeostasis. However, lacking efficient detection methods is one of the biggest obstacles to study the glycocalyx. In this study, three dehydration methods ...

    Abstract Glycocalyx is located outside the vascular endothelial cells playing an important role in vascular homeostasis. However, lacking efficient detection methods is one of the biggest obstacles to study the glycocalyx. In this study, three dehydration methods were used to compare the preservation of HUVEC, aorta and kidney glycocalyx by transmission electron microscope. The chemical pre-fixation was performed by lanthanum nitrate staining, and the mice aorta and renal glycocalyx were prepared by different dehydration methods such as ethanol gradient, acetone gradient and low temperature dehydration. HUVEC glycocalyx was prepared by acetone gradient and low temperature dehydration. Low temperature dehydration method preserves HUVEC and mice aortic glycocalyx completely, which had a certain thickness and presented a needle-like structure. But for mice kidney, the acetone gradient dehydration preparation method could better preserve the glycocalyx integrity than other two methods. In conclusion, low temperature dehydration method is suitable for HUVEC and aortic glycocalyx preservation, acetone gradient dehydration method is more suitable for kidney glycocalyx preservation.
    Schlagwörter acetone ; aorta ; ethanol ; homeostasis ; kidneys ; lanthanum ; nitrates ; temperature ; transmission electron microscopes ; Glycocalyx ; Dehydration ; Transmission electron microscopy
    Sprache Englisch
    Erscheinungsverlauf 2023-0405
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel ; Online
    Anmerkung Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15197
    Datenquelle NAL Katalog (AGRICOLA)

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  6. Artikel ; Online: MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription.

    Liang, Ying / Wei, Xin / Yue, Peng-Jie / Zhang, He-Cheng / Li, Zhen-Ning / Wang, Xiao-Xue / Sun, Yuan-Yuan / Fu, Wei-Neng

    Cellular & molecular biology letters

    2024  Band 29, Heft 1, Seite(n) 5

    Abstract: Background: The abnormality of chromosomal karyotype is one factor causing poor prognosis of lymphoma. In the analysis of abnormal karyotype of lymphoma patients, three smallest overlap regions were found, in which MYCT1 was located. MYCT1 is the first ... ...

    Abstract Background: The abnormality of chromosomal karyotype is one factor causing poor prognosis of lymphoma. In the analysis of abnormal karyotype of lymphoma patients, three smallest overlap regions were found, in which MYCT1 was located. MYCT1 is the first tumor suppressor gene cloned by our research team, but its studies relating to the occurrence and development of lymphoma have not been reported.
    Methods: R banding analyses were employed to screen the abnormality of chromosomal karyotype in clinical specimen and MYCT1 over-expression cell lines. FISH was to monitor MYCT1 copy number aberration. RT-PCR and Western blot were to detect the mRNA and protein levels of the MYCT1 and RUNX1 genes, respectively. The MYCT1 and RUNX1 protein levels in clinical specimen were evaluated by immunohistochemical DAB staining. The interaction between MYCT1 and MAX proteins was identified via Co-IP and IF. The binding of MAX on the promoter of the RUNX1 gene was detected by ChIP and Dual-luciferase reporter assay, respectively. Flow cytometry and CCK-8 assay were to explore the effects of MYCT1 and RUNX1 on the cell cycle and proliferation, respectively.
    Results: MYCT1 was located in one of three smallest overlap regions of diffuse large B-cell lymphoma, it altered chromosomal instability of diffuse large B-cell lymphoma cells. MYCT1 negatively correlated with RUNX1 in lymphoma tissues of the patients. MAX directly promoted the RUNX1 gene transcription by binding to its promoter region. MYCT1 may represses RUNX1 transcription by binding MAX in diffuse large B-cell lymphoma cells. MYCT1 binding to MAX probably suppressed RUNX1 transcription, leading to the inhibition of proliferation and cell cycle of the diffuse large B-cell lymphoma cells.
    Conclusion: This study finds that there is a MYCT1-MAX-RUNX1 signaling pathway in diffuse large B-cell lymphoma. And the study provides clues and basis for the in-depth studies of MYCT1 in the diagnosis, treatment and prognosis of lymphoma.
    Mesh-Begriff(e) Humans ; Core Binding Factor Alpha 2 Subunit/genetics ; Core Binding Factor Alpha 2 Subunit/metabolism ; Promoter Regions, Genetic ; Lymphoma, Large B-Cell, Diffuse/genetics ; Hematopoiesis ; Cell Line, Tumor ; Nuclear Proteins/metabolism
    Chemische Substanzen Core Binding Factor Alpha 2 Subunit ; MYCT1 protein, human ; Nuclear Proteins ; RUNX1 protein, human
    Sprache Englisch
    Erscheinungsdatum 2024-01-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2108724-6
    ISSN 1689-1392 ; 1689-1392
    ISSN (online) 1689-1392
    ISSN 1689-1392
    DOI 10.1186/s11658-023-00522-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Bacillus fonticola sp. nov., isolated from deep sea cold seep sediment.

    Sun, Yuan-Yuan / Zhou, Hai-Zhen / Sun, Qing-Lei

    Archives of microbiology

    2021  Band 203, Heft 7, Seite(n) 4127–4132

    Abstract: In this study, we report a novel Gram-positive bacterium, designated as strain ... ...

    Abstract In this study, we report a novel Gram-positive bacterium, designated as strain CS13
    Mesh-Begriff(e) Bacillus/classification ; Bacillus/genetics ; Fatty Acids/analysis ; Geologic Sediments/microbiology ; Phospholipids/analysis ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Species Specificity
    Chemische Substanzen Fatty Acids ; Phospholipids ; RNA, Ribosomal, 16S
    Sprache Englisch
    Erscheinungsdatum 2021-05-31
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 124824-8
    ISSN 1432-072X ; 0302-8933
    ISSN (online) 1432-072X
    ISSN 0302-8933
    DOI 10.1007/s00203-021-02401-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

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  8. Artikel ; Online: Balance between Activity and Stability of Single Metal and Intermetallic Compounds for Electrocatalytic Hydrogen Evolution Reaction.

    Li, Hao-Nan / Li, Dan / Hao, Tong-Tong / Sun, Yuan Yuan / Suen, Nian-Tzu

    Inorganic chemistry

    2023  Band 62, Heft 31, Seite(n) 12175–12180

    Abstract: The higher population of the antibonding state around the Fermi level will result in better activity yet lower stability of HER (Re vs Ru metal). There seems to be a limitation or balance for using a single metal since the bonding scheme of a single ... ...

    Abstract The higher population of the antibonding state around the Fermi level will result in better activity yet lower stability of HER (Re vs Ru metal). There seems to be a limitation or balance for using a single metal since the bonding scheme of a single metal is relatively simple. Combining Re (strong bonding), Ru (HER active), and Zr metal (corrosion-resistant) grants ternary intermetallic compound ZrRe
    Sprache Englisch
    Erscheinungsdatum 2023-07-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c01572
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: A new species of

    Huang, Yan-Shuang / Meng, Kai-Kai / Sun, Yuan-Yuan / Chen, Zai-Xiong / Fan, Qiang

    PhytoKeys

    2023  Band 221, Seite(n) 117–129

    Abstract: ... ...

    Abstract Sedumjinglanii
    Sprache Englisch
    Erscheinungsdatum 2023-03-10
    Erscheinungsland Bulgaria
    Dokumenttyp Journal Article
    ZDB-ID 2579891-1
    ISSN 1314-2003 ; 1314-2011
    ISSN (online) 1314-2003
    ISSN 1314-2011
    DOI 10.3897/phytokeys.221.97495
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: The Impact of Spring Festival Travel on Epidemic Spreading in China.

    Sun, Hao-Chen / Pei, Sen / Wang, Lin / Sun, Yuan-Yuan / Xu, Xiao-Ke

    Viruses

    2023  Band 15, Heft 7

    Abstract: The large population movement during the Spring Festival travel in China can considerably accelerate the spread of epidemics, especially after the relaxation of strict control measures against COVID-19. This study aims to assess the impact of population ... ...

    Abstract The large population movement during the Spring Festival travel in China can considerably accelerate the spread of epidemics, especially after the relaxation of strict control measures against COVID-19. This study aims to assess the impact of population migration in Spring Festival holiday on epidemic spread under different scenarios. Using inter-city population movement data, we construct the population flow network during the non-holiday time as well as the Spring Festival holiday. We build a large-scale metapopulation model to simulate the epidemic spread among 371 Chinese cities. We analyze the impact of Spring Festival travel on the peak timing and peak magnitude nationally and in each city. Assuming an
    Mesh-Begriff(e) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Holidays ; China/epidemiology ; Epidemics/prevention & control ; Travel
    Sprache Englisch
    Erscheinungsdatum 2023-07-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15071527
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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