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  1. Article ; Online: A Novel Strategy for Topical Administration by Combining Chitosan Hydrogel Beads with Nanostructured Lipid Carriers: Preparation, Characterization, and Evaluation.

    Sun, Rui / Xia, Qiang / Sun, Yufeng

    Gels (Basel, Switzerland)

    2024  Volume 10, Issue 3

    Abstract: The objective of the present study was to develop and evaluate NLC-chitosan hydrogel beads for topical administration. The feasibility of the preparation technology was verified by investigating various formulation factors and the impact of chitosan ... ...

    Abstract The objective of the present study was to develop and evaluate NLC-chitosan hydrogel beads for topical administration. The feasibility of the preparation technology was verified by investigating various formulation factors and the impact of chitosan hydrogel beads on the NLC. The encapsulation efficiency of NLC-chitosan hydrogel beads was above 95% in optimized process conditions. The physical characterization of the NLC-chitosan hydrogel beads showed that the NLC was distributed within the network of the chitosan hydrogel beads. Furthermore, the incorporation of NLC into the chitosan hydrogel beads was related to the electrostatic interaction between the surface of the NLC and chitosan, which influenced the lipid ordering degree of the NLC and contributed to the stability. The stability studies showed that the retention rate of quercetin in the NLC-chitosan hydrogel beads was 88.63 ± 2.57% after 10 months of storage under natural daylight. An in vitro permeation study showed that NLC-chitosan hydrogel beads exhibited superior ability in enhancing skin permeation by hydrophobic active ingredients compared to the NLC and significantly increased skin accumulation. These studies demonstrated that the use of NLC-chitosan hydrogel beads might be a promising strategy for the delivery of hydrophobic active ingredients in topical administration.
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels10030160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: "

    Wei, Lifang / Leung, Alex Ho-Cheong / Sun, Yufeng

    Frontiers in psychology

    2023  Volume 13, Page(s) 1070937

    Abstract: This study investigates the interpersonal meanings expressed by English tag questions in the context of British university seminars from two dimensions: evidential modification of tags and conduciveness of responses. The data for the study derive from ... ...

    Abstract This study investigates the interpersonal meanings expressed by English tag questions in the context of British university seminars from two dimensions: evidential modification of tags and conduciveness of responses. The data for the study derive from seminars in the British Academic Spoken English (BASE) Corpus, which is herein both quantitative and qualitative analyzed. The findings reveal that: (1) three-quarters of tag questions in the data are utilized by teachers, and the unmarked form of tag questions in university seminars are generally positive-negative forms, with a few examples of other varieties; (2) regarding evidential modification of tags, depending on the degree of epistemic certainty of the speakers on the proposition of the anchor, the default function of teachers' tag questions in the data is to convey emphasis, followed by confirmatory function, with only a few cases of informational function; and (3) regarding conduciveness of responses, over 70% of tag questions are followed by no verbal response, while less than 30% are followed by explicit responses. Accordingly, these findings raise the question of whether tag questions can really provide sufficient scope for interactions in classroom. It is hoped that this nuanced, corpus-based analysis of tag question utilization within the context of British university seminars would empirically reveal the interpersonal relations between teachers and students and thereby shed light on more efficient seminar discussions.
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.1070937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Multicolor colorimetric detection of dopamine based on iodide-responsive copper-gold nanoparticles.

    Sun, Yufeng / Peng, Minjie / Wu, Aiguo / Zhang, Yujie

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 81, Page(s) 12180–12183

    Abstract: Dopamine (DA) is one of the most essential catecholamine neurotransmitters in the human body. A rapid colorimetric detection method for DA in urine and serum was established in this work using unmodified iodide-responsive copper-gold nanoparticles (Cu-Au ...

    Abstract Dopamine (DA) is one of the most essential catecholamine neurotransmitters in the human body. A rapid colorimetric detection method for DA in urine and serum was established in this work using unmodified iodide-responsive copper-gold nanoparticles (Cu-Au NPs). The detection method provides a rapid response with color variability within 15 min at room temperature. In addition, the colorimetric probe has elevated stability, excellent selectivity and resistance to interference.
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc02873a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: What is the degree of social disability risk in China under the background of the aging population? Social disability risk measurement index system design and evaluation research based on China.

    Guo, Qianqian / Sun, Yufeng / Fan, Miao / Li, Zhichun

    Frontiers in public health

    2023  Volume 11, Page(s) 1087276

    Abstract: Objective: The impact of the aging population in China varies between regions. It is because regions with different resource endowments, such as those related to economy, population, and medical care, have different degrees of disability risk in the ... ...

    Abstract Objective: The impact of the aging population in China varies between regions. It is because regions with different resource endowments, such as those related to economy, population, and medical care, have different degrees of disability risk in the face of the increases in the disabled and semi-disabled older population caused by the overall aging of the population. This study aimed to construct an evaluation system to monitor and measure the degree of social disability risk in different regions in China and to evaluate and compare the degree of social disability risk in different regions using empirical data.
    Method: This study used the Delphi method to construct a social disability risk measurement index system with macro, meso, and micro dimensions. At the same time, based on the data of CHARLS2018, an AHP-entropy method was used to calculate the index's total weight, and the standard deviation classification method was used to classify the total and criterion-level measurement scores of 28 provinces.
    Results: The regional degree of social disability risk was analyzed in subdimensions. Our research indicates that China's social disability risk situation is not promising, with a general medium to high-risk level. The score of degree of social disability risk among provinces is consistent with the regional economic development level to a large extent. The risk of social disability varies significantly among the eastern and central, and western regions of China and the provinces within the three regions.
    Discussion: Currently, the situation facing the degree of social disability risk in China is that the overall risk level of the country is higher, and the difference between regions is significant. It is necessary to take measures to meet better the needs of the aging population and the disabled and semi-disabled older populations in a large-range, large-scale, multilevel way.
    MeSH term(s) China/epidemiology ; Economic Development
    Language English
    Publishing date 2023-03-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1087276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Enhancement of the Physical and Functional Properties of Chitosan Films by Incorporating

    Tao, Ran / Zheng, Xiuxia / Fan, Bei / He, Xuemei / Sun, Jian / Sun, Yufeng / Wang, Fengzhong

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 1

    Abstract: Composite films based on chitosan (CS) ... ...

    Abstract Composite films based on chitosan (CS) incorporating
    Language English
    Publishing date 2024-01-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13010069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Enhancing the Gelation Behavior of Transglutaminase-Induced Soy Protein Isolate(SPI) through Ultrasound-Assisted Extraction.

    Li, Gaolin / Tao, Ran / Sun, Yufeng / Wang, Lili / Li, Yurui / Fan, Bei / Wang, Fengzhong

    Foods (Basel, Switzerland)

    2024  Volume 13, Issue 5

    Abstract: Gelation, as an important functional property of soy protein isolate (SPI), can be improved by some green technologies in food manufacturing, including ultrasound, ultrahigh pressure and microwave treatments. This work investigated the effect of an ... ...

    Abstract Gelation, as an important functional property of soy protein isolate (SPI), can be improved by some green technologies in food manufacturing, including ultrasound, ultrahigh pressure and microwave treatments. This work investigated the effect of an alkaline solubilisation step in SPI extraction combined with sonication on protein properties. The TGase-induced gel of the modified SPI was prepared to explore the effect of ultrasound on gel properties, including structures, strength, water-holding capacity and rheological properties. Additionally, the differences between traditional ultrasound modification of SPI and current modification methods were analyzed. The results showed that the ultrasonication-assisted extraction method could result in a significant increase in extraction rate from 24.68% to 42.25%. Moreover, ultrasound-assisted modification of SPI gels induced with transglutaminase (TGase) exhibited significant improvement in mechanical properties, such as texture, water-holding capacity and rheological properties, In particular, SPI extracted at 400 W ultrasound intensity for 180 s showed the best overall performance in terms of gel properties. Our method efficiently uniformizes gel structure, enhancing mechanical properties compared to conventional ultrasound methods, which reduced energy consumption and costs. These findings provide insights into the production of high-gelation SPI in food manufacturing.
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13050738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Development of a Monoclonal Antibody-Based Indirect Competitive Enzyme-Linked Immunosorbent Assay for the Rapid Detection of Gallic Acid.

    Duan, Jiajing / Zheng, Xiuxia / Tao, Ran / Li, Long / Wang, Fengzhong / Sun, Yufeng / Fan, Bei

    Biosensors

    2024  Volume 14, Issue 4

    Abstract: Gallic acid (GA) is closely related to the quality of herbal medicines and other agricultural products. In order to facilitate the rapid detection of GA, we developed a monoclonal antibody-based ic-ELISA method. Antigens with and without connecting arms ... ...

    Abstract Gallic acid (GA) is closely related to the quality of herbal medicines and other agricultural products. In order to facilitate the rapid detection of GA, we developed a monoclonal antibody-based ic-ELISA method. Antigens with and without connecting arms were prepared. It was found that the introduction of connecting arms (linear carbon chain) was beneficial for immune response. By utilizing hybridoma technology, a specific mAb (anti-GA-M702) was screened and identified, which exhibited a 1:40,500 antibody titer and IgG2b antibody subtype. The ic-ELISA assay was established based on anti-GA-M702. The optimal working concentrations of the encapsulated antigen and antibody were 0.5 µg/mL and 0.67 µg/mL, respectively. The ic-ELISA method showed a linear detection range of 297.17-2426.61 ng/mL for GA with a sensitivity of 849.18 ng/mL. It displayed a good applicability for the determination of GA in
    MeSH term(s) Enzyme-Linked Immunosorbent Assay/methods ; Antibodies, Monoclonal ; Gallic Acid ; Animals
    Chemical Substances Antibodies, Monoclonal ; Gallic Acid (632XD903SP)
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios14040182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Direct de/carboxylation of cannabidiolic acid (CBDA) and cannabidiol (CBD) from hemp plant material under supercritical CO

    Gao, Bao-Chang / Sun, Yu-Feng / Tian, Yuan / Shi, Yu / Zhang, Zhi-Guo / Mao, Guo-Liang

    Journal of Asian natural products research

    2024  , Page(s) 1–7

    Abstract: Many organic reactions rely on ... ...

    Abstract Many organic reactions rely on CO
    Language English
    Publishing date 2024-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2024.2345825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An alkaline protease from Bacillus cereus NJSZ-13 can act as a pathogenicity factor in infection of pinewood nematode.

    Li, Liangliang / Sun, Yufeng / Chen, Fengmao / Hao, Dejun / Tan, Jiajin

    BMC microbiology

    2023  Volume 23, Issue 1, Page(s) 10

    Abstract: Endophytic bacteria are an important biological control for nematodes. We isolated the nematicidal Bacillus cereus NJSZ-13 from healthy Pinus elliottii trunks. Bioassay experiments showed killing of all tested nematodes by proteins from the NJSZ-13 ... ...

    Abstract Endophytic bacteria are an important biological control for nematodes. We isolated the nematicidal Bacillus cereus NJSZ-13 from healthy Pinus elliottii trunks. Bioassay experiments showed killing of all tested nematodes by proteins from the NJSZ-13 culture filtrate within 72 h. Degradation of the nematode cuticles was observed, suggesting the action of extracellular bacterial enzymes. The responsible protease was purified by ammonium sulfate precipitation, hydrophobic interaction chromatography, ion-exchange chromatography, and SDS-PAGE. The protease had a molecular weight of 28 kDa and optimal activity at 55 °C and pH 9, indicating an alkaline protease. The study suggests the potential for using this B. cereus NJSZ-13 strain protease to prevent pinewood nematode infection.
    MeSH term(s) Animals ; Bacillus cereus/metabolism ; Virulence Factors ; Peptide Hydrolases/metabolism ; Nematoda/microbiology ; Pinus
    Chemical Substances alkaline protease (EC 3.4.99.-) ; Virulence Factors ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2023-01-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041505-9
    ISSN 1471-2180 ; 1471-2180
    ISSN (online) 1471-2180
    ISSN 1471-2180
    DOI 10.1186/s12866-022-02752-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Ligand relay catalysis for cobalt-catalyzed sequential hydrosilylation and hydrohydrazidation of terminal alkynes.

    Sun, Yufeng / Guo, Jun / Shen, Xuzhong / Lu, Zhan

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 650

    Abstract: Sequential double hydrofunctionalizationalization of alkynes is a powerful method to construct useful vicinal compounds. Herein, we report a cobalt-catalyzed sequential hydrosilylation/hydrohydrazidation of alkynes to afford 1,2-N,Si compounds via ligand ...

    Abstract Sequential double hydrofunctionalizationalization of alkynes is a powerful method to construct useful vicinal compounds. Herein, we report a cobalt-catalyzed sequential hydrosilylation/hydrohydrazidation of alkynes to afford 1,2-N,Si compounds via ligand relay catalysis. A phenomenon of ligand relay is found that the tridentate anionic N-ligand (OPAQ) could capture the cobalt ion from bidentate neutral P-ligand (Xantphos) cobalt complex. This protocol uses three abundant chemical feedstocks, alkynes, silanes, and diazo compounds, and also features operationally simple, mild conditions, low catalyst loading (1 mol%), and excellent functional group tolerance. The 1,2-N,Si compounds can be easily further derivatized to afford various substituted silane derivatives via Si-H functionalization, alcohols via Fleming-Tamao oxidation, free amines and amides via N-N bond cleavage and protection. The asymmetric reaction could also be carried out to afford chiral products with up to 86% ee. The ligand relay has been supported by control experiments and absorption spectra.
    Language English
    Publishing date 2022-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-28285-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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