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  1. Article: [Carbamazepine induced Stevens-Johnson syndrome in Han Chinese with positive

    Xu, Y Y / Sun, Z L / Zhang, X L / Liu, Z L / Liu, W / Guan, X

    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

    2023  Volume 55, Issue 4, Page(s) 755–757

    Abstract: Stevens-Johnson syndrome is a type of severe drug eruption, which is characterized by rapid onset and rapid progress. If not treated in time, it can develop into toxic epidermal necrolysis, even life-threatening. Common sensitizing drugs include sulfa, ... ...

    Abstract Stevens-Johnson syndrome is a type of severe drug eruption, which is characterized by rapid onset and rapid progress. If not treated in time, it can develop into toxic epidermal necrolysis, even life-threatening. Common sensitizing drugs include sulfa, carbamazepine, etc. In China, reports and studies of carbamazepine causing Stevens-Johnson syndrome mainly focus on the
    MeSH term(s) Female ; Humans ; Anticonvulsants/adverse effects ; Carbamazepine/adverse effects ; East Asian People ; HLA-A Antigens/genetics ; HLA-B Antigens/genetics ; Stevens-Johnson Syndrome/genetics
    Chemical Substances Anticonvulsants ; Carbamazepine (33CM23913M) ; HLA-A Antigens ; HLA-B Antigens
    Language Chinese
    Publishing date 2023-08-03
    Publishing country China
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 2452593-5
    ISSN 1671-167X
    ISSN 1671-167X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: LncRNA XIST is elevated in patients with chronic heart failure and has a regulatory role in cardiomyocyte function.

    Sun, Z L / Chen, M H / Guo, Y N / Liu, Z Q

    Journal of biological regulators and homeostatic agents

    2021  Volume 35, Issue 2, Page(s) 677–682

    MeSH term(s) Cell Proliferation ; Heart Failure/genetics ; Humans ; MicroRNAs ; Myocytes, Cardiac ; RNA, Long Noncoding/genetics
    Chemical Substances MicroRNAs ; RNA, Long Noncoding
    Language English
    Publishing date 2021-05-14
    Publishing country Italy
    Document type Letter
    ZDB-ID 639196-5
    ISSN 1724-6083 ; 0393-974X
    ISSN (online) 1724-6083
    ISSN 0393-974X
    DOI 10.23812/20-731-L
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2270: Show issues Location:
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  3. Article ; Online: Effects of miR-455 on PIK3R1 gene expression regulation and kidney cancer cell functions.

    Wang, Y-D / Sun, Z-L

    European review for medical and pharmacological sciences

    2017  Volume 21, Issue 15, Page(s) 3370–3376

    Abstract: Objective: Migration and proliferation of kidney cancer cells are critical factors affecting effective treatment. Abnormal gene expression exists during cancer pathogenesis. The study showed certain effects of PIK3R1 gene on migration and proliferation ... ...

    Abstract Objective: Migration and proliferation of kidney cancer cells are critical factors affecting effective treatment. Abnormal gene expression exists during cancer pathogenesis. The study showed certain effects of PIK3R1 gene on migration and proliferation of kidney cancer cells, although a few studies have been performed regulatory mechanism of microRNA on PIK3R1 gene. Previous sequencing of PIK3R1 gene found the existence of mir-455 binding site. This study confirmed the regulation of PIK3R1 gene expression in kidney cancer cells of mir-455 by in vitro assay, and analyzed its effects on migration or proliferation of kidney cancer cells.
    Materials and methods: mir-455 agonist and inhibitor sequences were designed and synthesized to transfect kidney cancer cell line CAKI-1, which were further divided into agonist, inhibitor, and control group. qRT-PCR was used to test expression of mir-455 and PIK3R1 at 12 h, 24 h and 48 h after transfection. PIK3R1 protein expression was measured by Western blot. MTT and cell scratch assay were employed to measure cell proliferation and migration potency.
    Results: 12 h after transfection with mir-455, no significant difference of the level of PIK3R1was found among the three groups (p>0.05). However, at 24 h and 48 h post-transfection, PIK3R1 expression in agonist group was significantly elevated, along with weakened cell proliferation or migration potency (p<0.05 with significant between-group comparison). By contrast, the level of PIK3R1 was statistically decreased in inhibitor group, in which cell proliferation and migration were enhanced (p<0.05).
    Conclusions: In kidney carcinoma cell CAKI-1, mir-455 expression regulation can positively alter PIK3R1 gene expression. Over-expression of PIK3Ra gene could reduce the proliferation or migration potency of CAKI-1 cells.
    MeSH term(s) Carcinoma, Renal Cell/genetics ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; MicroRNAs/pharmacology ; Phosphatidylinositol 3-Kinases/biosynthesis ; Phosphatidylinositol 3-Kinases/genetics ; Polymerase Chain Reaction ; Transfection
    Chemical Substances MIRN455 microRNA, human ; MicroRNAs ; PIK3R1 protein, human (EC 2.7.1.-) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
    Language English
    Publishing date 2017-08
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1887: Show issues Location:
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  4. Article ; Online: Up-regulation of serum miR-4262 predicts clinical outcome of patients with acute myeloid leukemia.

    Han, G-T / Sun, Z-L

    European review for medical and pharmacological sciences

    2017  Volume 21, Issue 9, Page(s) 2172–2176

    Abstract: Objective: The aim of this study was to investigate whether miR-4262 was associated with the prognosis of acute myeloid leukemia (AML) patients.: Patients and methods: Serum and bone marrow miR-4262 expression were investigated in 186 AML patients ... ...

    Abstract Objective: The aim of this study was to investigate whether miR-4262 was associated with the prognosis of acute myeloid leukemia (AML) patients.
    Patients and methods: Serum and bone marrow miR-4262 expression were investigated in 186 AML patients and 115 healthy normal controls by using Real-time PCR. Associations between miR-4262 expressions and various clinicopathological characteristics were analyzed. Overall survival and relapse-free survival were evaluated using the Kaplan-Meier method. Univariate and multivariate analysis were performed using the Cox proportional hazard analysis.
    Results: Expression levels of miR-4262 in the bone marrow and serum of AML patients were both significantly higher than those in healthy controls (both p<0.01). Moreover, increased miR-4262 expression was significantly associated with FAB classification (p=0.001) and cytogenetics (p=0.001). Patients with high miR-4262 expression had poorer overall survival time and relapse-free survival time than those with low miR-4262 expression. Finally, multivariate analysis identified high miR-4262 expression as an independent prognostic factor for AML (p<0.001).
    Conclusions: Our data revealed that the evaluation of miR-4262 expression in the bone marrow and serum was an ideal tool for predicting the progression of AML and prognosis.
    MeSH term(s) Adult ; Female ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/mortality ; Male ; MicroRNAs/blood ; Middle Aged ; Prognosis ; Up-Regulation
    Chemical Substances MicroRNAs ; microRNA-4262 microRNA, human
    Language English
    Publishing date 2017-05-23
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1887: Show issues Location:
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  5. Article: [Effect of total prostate volume and transitional zone volume on the curative effect of transurethral resection of prostate in benign prostatic hyperplasia].

    Liu, H M / Tian, Y / Su, Z Y / Sun, Z L / Luo, G H

    Zhonghua yi xue za zhi

    2021  Volume 101, Issue 2, Page(s) 137–141

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Male ; Prostatic Hyperplasia/surgery ; Quality of Life ; Retrospective Studies ; Transurethral Resection of Prostate ; Treatment Outcome
    Language Chinese
    Publishing date 2021-01-17
    Publishing country China
    Document type Journal Article
    ZDB-ID 132513-9
    ISSN 0376-2491
    ISSN 0376-2491
    DOI 10.3760/cma.j.cn112137-20200526-01664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Diagnostic value of the combinations of bronchoalveolar lavage fluid pathogen detection and cryptococcal antigen test in pulmonary cryptococcosis].

    Yan, Q F / Sun, Z L / Gao, Y / Xiao, T / Lin, H / Ji, M

    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

    2021  Volume 44, Issue 8, Page(s) 711–716

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; Aged ; Antigens, Fungal ; Bronchoalveolar Lavage Fluid ; Cryptococcosis/diagnosis ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Sensitivity and Specificity
    Chemical Substances Antigens, Fungal
    Language Chinese
    Publishing date 2021-10-11
    Publishing country China
    Document type Journal Article
    ZDB-ID 1027965-9
    ISSN 1001-0939
    ISSN 1001-0939
    DOI 10.3760/cma.j.cn112147-20201123-01113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2465: Show issues Location:
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  7. Article: [Associations of metabolic score for insulin resistance with chronic kidney disease and albuminuria in the Chinese population].

    Lin, H L / Qiu, S H / Hu, H / Liu, Y / Chen, J / Li, T T / Liu, J N / Yuan, Y / Sun, Z L

    Zhonghua nei ke za zhi

    2023  Volume 62, Issue 3, Page(s) 281–289

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Male ; Humans ; Female ; Insulin Resistance ; Albuminuria ; Blood Glucose ; Cross-Sectional Studies ; Uric Acid ; East Asian People ; Renal Insufficiency, Chronic ; Glomerular Filtration Rate
    Chemical Substances Blood Glucose ; Uric Acid (268B43MJ25)
    Language Chinese
    Publishing date 2023-02-23
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 754223-9
    ISSN 0578-1426
    ISSN 0578-1426
    DOI 10.3760/cma.j.cn112138-20220420-00288
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    Zs.A 1620: Show issues Location:
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  8. Article: [Expression of Tim-3 on natural killer cells in patients with acute myeloid leukemia and its clinical significance].

    Ma, J F / Li, C X / Wu, D P / Sun, Z L / Yan, C L

    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

    2019  Volume 40, Issue 9, Page(s) 755–758

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Flow Cytometry ; Hepatitis A Virus Cellular Receptor 2/metabolism ; Humans ; Killer Cells, Natural ; Leukemia, Myeloid, Acute ; Prognosis
    Chemical Substances HAVCR2 protein, human ; Hepatitis A Virus Cellular Receptor 2
    Language Chinese
    Publishing date 2019-11-11
    Publishing country China
    Document type Journal Article
    ISSN 0253-2727
    ISSN 0253-2727
    DOI 10.3760/cma.j.issn.0253-2727.2019.09.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Increased urinary glucose excretion is associated with a reduced risk of hyperuricaemia.

    Chen, J / Qiu, S-H / Guo, H-J / Li, W / Sun, Z-L

    Diabetic medicine : a journal of the British Diabetic Association

    2019  Volume 36, Issue 7, Page(s) 902–907

    Abstract: Aim: To investigate the association of urinary glucose excretion with levels of serum uric acid in adults with newly diagnosed diabetes.: Methods: A total of 597 people with newly diagnosed diabetes, confirmed in an oral glucose tolerance test, were ... ...

    Abstract Aim: To investigate the association of urinary glucose excretion with levels of serum uric acid in adults with newly diagnosed diabetes.
    Methods: A total of 597 people with newly diagnosed diabetes, confirmed in an oral glucose tolerance test, were included in the present study. The participants were divided into two groups: 142 participants with low urinary glucose excretion and 455 with high urinary glucose excretion. Demographic characteristics and clinical variables were evaluated. The association of urinary glucose excretion with uric acid was analysed using multivariable regression analysis.
    Results: The low urinary glucose excretion group had a significantly higher prevalence of hyperuricaemia than the high urinary glucose excretion group. Moreover, urinary glucose excretion was negatively associated with uric acid level. The correlation remained significant after adjusting for potential confounders, including gender, age, fasting plasma glucose, 2-h plasma glucose and BMI. The results also showed that participants with high urinary glucose excretion were at decreased risk of hyperuricaemia (odds ratio 0.47, 95% CI 0.27-0.80; P = 0.006).
    Conclusion: Urinary glucose excretion was independently associated with uric acid level in participants with newly diagnosed diabetes. In addition to lowering blood glucose, promoting urinary glucose excretion may also be an effective approach to reducing serum uric acid levels, especially for people with diabetes complicated with hyperuricaemia.
    MeSH term(s) Adult ; Blood Glucose/metabolism ; China ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/physiopathology ; Diabetes Mellitus, Type 2/urine ; Female ; Glucose Tolerance Test ; Humans ; Hyperuricemia/urine ; Male ; Middle Aged ; Uric Acid/metabolism
    Chemical Substances Blood Glucose ; Uric Acid (268B43MJ25)
    Language English
    Publishing date 2019-04-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605769-x
    ISSN 1464-5491 ; 0742-3071 ; 1466-5468
    ISSN (online) 1464-5491
    ISSN 0742-3071 ; 1466-5468
    DOI 10.1111/dme.13956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1954: Show issues Location:
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  10. Article: [Comparative observation of thulium laser resection of the prostate-tangerine technique and transurethral resection of the prostate for the treatment of benign prostatic hyperplasia of various sizes].

    Tian, Y / Luo, G H / Yang, X S / Xia, S J / Sun, Z L

    Zhonghua yi xue za zhi

    2019  Volume 99, Issue 6, Page(s) 423–427

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Laser Therapy ; Male ; Prostatic Hyperplasia ; Quality of Life ; Retrospective Studies ; Thulium ; Transurethral Resection of Prostate ; Treatment Outcome
    Chemical Substances Thulium (8RKC5ATI4P)
    Language Chinese
    Publishing date 2019-02-17
    Publishing country China
    Document type Comparative Study ; Journal Article
    ZDB-ID 132513-9
    ISSN 0376-2491
    ISSN 0376-2491
    DOI 10.3760/cma.j.issn.0376-2491.2019.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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