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  1. Article ; Online: Evaluating the Field Emission Properties of N-Type Black Silicon Cold Cathodes Based on a Three-Dimensional Model.

    Zhang, Yuanpeng / Cheng, Pengfei / Wang, Dong / Wang, Hui / Tang, Yongliang / Wang, Wei / Li, Yuhang / Sun, Zeqi / Lv, Wenmei / Liu, Qingxiang

    ACS applied materials & interfaces

    2024  Volume 16, Issue 2, Page(s) 2932–2939

    Abstract: Black silicon (BS), a nanostructured silicon surface containing highly roughened surface morphology, has recently emerged as a promising candidate for field emission (FE) cathodes in novel electron sources due to its huge number of sharp tips with ease ... ...

    Abstract Black silicon (BS), a nanostructured silicon surface containing highly roughened surface morphology, has recently emerged as a promising candidate for field emission (FE) cathodes in novel electron sources due to its huge number of sharp tips with ease of large-scale fabrication and controllable geometrical shapes. However, evaluating the FE performance of BS-based nanostructures with high accuracy is still a challenge due to the increasing complexity in the surface morphology. Here, we demonstrate a 3D modeling methodology to fully characterize highly disordered BS-based field emitters randomly distributed on a roughened nonflat surface. We fabricated BS cathode samples with different morphological features to demonstrate the validity of this method. We utilize parametrized scanning electron microscopy images that provide high-precision morphology details, successfully describing the electric field distribution in field emitters and linking the theoretical analysis with the measured FE property of the complex nanostructures with high precision. The 3D model developed here reveals a relationship between the field emission performance and the density of the cones, successfully reproducing the classical relationship between current density
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c15402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A Study on the Field Emission Characteristics of High-Quality Wrinkled Multilayer Graphene Cathodes.

    Lv, Wenmei / Wang, Lian / Lu, Yiwei / Wang, Dong / Wang, Hui / Hao, Yuxin / Zhang, Yuanpeng / Sun, Zeqi / Tang, Yongliang

    Nanomaterials (Basel, Switzerland)

    2024  Volume 14, Issue 7

    Abstract: Field emission (FE) necessitates cathode materials with low work function and high thermal and electrical conductivity and stability. To meet these requirements, we developed FE cathodes based on high-quality wrinkled multilayer graphene (MLG) prepared ... ...

    Abstract Field emission (FE) necessitates cathode materials with low work function and high thermal and electrical conductivity and stability. To meet these requirements, we developed FE cathodes based on high-quality wrinkled multilayer graphene (MLG) prepared using the bubble-assisted chemical vapor deposition (B-CVD) method and investigated their emission characteristics. The result showed that MLG cathodes prepared using the spin-coating method exhibited a high field emission current density (~7.9 mA/cm
    Language English
    Publishing date 2024-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14070613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Yang-Xin-Shu-Mai granule alleviates atherosclerosis by regulating macrophage polarization via the TLR9/MyD88/NF-κB signaling pathway.

    Huang, Hong / Sun, Zeqi / Xu, Junyao / Wang, Linjie / Zhao, Jing / Li, Jie / Zhang, Siqi / Yuan, Fang / Liu, Ming / Fang, Zhuyuan

    Journal of ethnopharmacology

    2023  Volume 318, Issue Pt A, Page(s) 116868

    Abstract: Ethnopharmacological relevance: Previous studies have found that Yang-Xin-Shu-Mai granule (YXSMG) has certain advantages in the treatment of stable coronary heart disease. However, YXSMG can inhibit the progression of atherosclerotic plaque and ... ...

    Abstract Ethnopharmacological relevance: Previous studies have found that Yang-Xin-Shu-Mai granule (YXSMG) has certain advantages in the treatment of stable coronary heart disease. However, YXSMG can inhibit the progression of atherosclerotic plaque and stabilize vulnerable plaque needs to be further explored and studied. This research, mass spectrometry analysis, network pharmacology, in vivo and in vitro experimental studies were conducted to explore the mechanism of YXSMG on atherosclerosis.
    Aim of the study: To decipher the mechanism of atherosclerotic plaque, stabilization for YXSMG by analysis of its active ingredients and biological network and activity in whole animal and at cellular and molecular levels.
    Methods: The active components of YXSMG were determined using high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) analysis. The 'Disease-Compound-Target-Pathway' network diagram was constructed using network pharmacology, and the stability of binding between core targets and core compounds was analyzed with molecular docking. After intervention with YXSMG, the pathology of aortic plaque, inflammation in the surrounding tissue, expression of TLR9/MyD88/NF-κB pathway protein in plaque and M1/M2 polarization of plaque macrophages were evaluated in vivo in apolipoprotein E-deficient (ApoE
    Results: Five active compounds were identified in YXSMG: catechin, formononetin, tanshinone IIA, cryptotanshinone and glycitein. Network pharmacology studies revealed TLR9 as one of the core targets of YXSMG intervention in atherosclerosis. Computer simulation of molecular docking showed that TLR9 could interact with the core compound to form a stable complex. In vivo experiments confirmed that YXSMG could significantly inhibit atherosclerotic plaque, reduce levels of blood lipids and inflammatory factors, downregulate TLR9/MyD88/NF-κB pathway protein and inhibit aortic sinus macrophages polarization to M1, but promote their polarization to M2 to inhibit inflammation. In vitro experiments revealed that YXSMG could downregulate expression of TLR9 gene and protein in ODN1826-activated RAW264.7 macrophages. ODN2088 had a synergistic effect with YXSMG on the TLR9/MyD88/NF-κB signaling pathway, and reprogrammed macrophages polarization from M1 to M2 by inhibiting TLR9, thus reducing immuno-inflammatory response.
    Conclusion: YXSMG can reduce the level of blood lipid and improve the size of atherosclerotic plaque and inflammatory infiltration in ApoE
    MeSH term(s) Mice ; Animals ; Plaque, Atherosclerotic/pathology ; NF-kappa B/metabolism ; Myeloid Differentiation Factor 88/metabolism ; Toll-Like Receptor 9/metabolism ; Computer Simulation ; Molecular Docking Simulation ; Tandem Mass Spectrometry ; Atherosclerosis/genetics ; Signal Transduction ; Macrophages ; Adaptor Proteins, Signal Transducing/metabolism ; Inflammation/pathology ; Lipids/pharmacology ; Apolipoproteins E/genetics ; Mice, Inbred C57BL
    Chemical Substances NF-kappa B ; Myeloid Differentiation Factor 88 ; Toll-Like Receptor 9 ; Adaptor Proteins, Signal Transducing ; Lipids ; Apolipoproteins E
    Language English
    Publishing date 2023-07-16
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: MiR-203 improves cardiac dysfunction by targeting PARP1-NAD

    Zhao, Limin / Tang, Pingping / Lin, Yuan / Du, Menghan / Li, Huimin / Jiang, Lintong / Xu, Henghui / Sun, Heyang / Han, Jingjing / Sun, Zeqi / Xu, Run / Lou, Han / Chen, Zhouxiu / Kopylov, Philipp / Liu, Xin / Zhang, Yong

    Aging cell

    2023  Volume 23, Issue 3, Page(s) e14063

    Abstract: Heart aging is a prevalent cause of cardiovascular diseases among the elderly. ... ...

    Abstract Heart aging is a prevalent cause of cardiovascular diseases among the elderly. NAD
    MeSH term(s) Mice ; Humans ; Animals ; Aged ; NAD/metabolism ; Aging/genetics ; Aging/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Myocytes, Cardiac/metabolism ; Cellular Senescence/genetics ; Mice, Transgenic ; Heart Diseases ; Poly (ADP-Ribose) Polymerase-1/genetics
    Chemical Substances NAD (0U46U6E8UK) ; MicroRNAs ; PARP1 protein, human (EC 2.4.2.30) ; Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30) ; MIRN203 microRNA, human ; MIRN203 microRNA, mouse
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.14063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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