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  1. Book ; Online: Type 2 Diabetes Management: A Focus on Metabolic Defects

    Sun, Zilin / Carlsson, Per-Ola / Rayner, Chris / Wu, Tongzhi / Sun, Zheng

    2020  

    Keywords Science: general issues ; Physiology ; Diabetes ; metabolic defects ; β-cell function ; dietary intervention ; physical exercise
    Size 1 electronic resource (170 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230864
    ISBN 9782889660285 ; 2889660281
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Circadian clock and temporal meal pattern

    Li Xin / Sun Zheng

    Medical Review, Vol 3, Iss 1, Pp 85-

    2023  Volume 101

    Abstract: The central circadian clock in the brain controls the time-of-the-day variations in acute meal responses, with a low glycemic response but a high satiety/thermogenic response to meals consumed at waking compared to other time points. Consistently, ... ...

    Abstract The central circadian clock in the brain controls the time-of-the-day variations in acute meal responses, with a low glycemic response but a high satiety/thermogenic response to meals consumed at waking compared to other time points. Consistently, studies show that consuming a significant proportion of calories, particularly carbohydrates, in breakfast is beneficial for the chronic management of obesity and its associated metabolic syndrome, compared to consuming identical meals at dinner. Conversely, breakfast skipping or/and late dinner can have unfavorable metabolic outcomes. It remains controversial how meal frequency affects metabolic health. In contrast, irregular meals, especially irregular breakfasts, show consistent adverse metabolic consequences. Time-restricted feeding (TRF), with all calories consumed within less than 12-h per day, can improve metabolism and extend lifespan. A major component of TRF in humans is caloric restriction, which contributes significantly to the beneficial effects of TRF in humans. By comparison, TRF effects in rodents can be independent of caloric restriction and show day/night phase specificity. TRF could alleviate metabolic abnormalities due to circadian disruption, but its effects appear independent of the circadian clock in rodents. Understanding neuroendocrine mechanisms underlying clock-mediated metabolic regulation will shed light on the metabolic effects of temporal meal patterns.
    Keywords cardiometabolic ; circadian rhythm ; daily variation ; diabetes ; meal response ; suprachiasmatic nuclei ; Medicine ; R
    Subject code 571
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article ; Online: Gas-Liquid Flow Pattern and Hydrate Risk in Wellbore during the Deep-Water Gas-Well Cleanup Process.

    Chen, Dayong / Sun, Zheng

    ACS omega

    2023  Volume 8, Issue 14, Page(s) 12911–12921

    Abstract: The wellbore fluid flow characteristics and hydrate flow assurance problems during the deep-water gas well cleanup process seriously affect the safety of gas well testing. Aiming at the process of deep-water gas well cleanup where the liquid gas ratio ... ...

    Abstract The wellbore fluid flow characteristics and hydrate flow assurance problems during the deep-water gas well cleanup process seriously affect the safety of gas well testing. Aiming at the process of deep-water gas well cleanup where the liquid gas ratio changes dramatically, this study reveals the distribution law of gas-liquid flow patterns in the wellbore. Combined with the clean test conditions of deep-water gas wells, the transient numerical simulation and analysis are carried out. At the same time, a hydrate risk prediction model suitable for the well cleanup process is established to predict the hydrate risk under different cleaning conditions. The research results are as follows: (1) after flowback, the temperature at the wellhead and mud line presents different characteristics of temperature change, the wellhead temperature decreases first and then increases, while the flow temperature at the mud line rises first and then decreases; (2) slug flow and annular flow are more likely to occur in the wellbore under low wellhead pressure. Bubble flow often appears in the initial stage of flowback under high wellhead pressure and gradually changes into slug and annular flow patterns in the middle and late stages; (3) at the same flowback time, the wellbore will also present different flow patterns along the way. The lower part of the well bore mainly presents bubble flow and slug flow, and the upper and middle parts of the well bore mainly present annular flow patterns; (4) high liquid-gas ratio conditions, proper well cleaning speed, and the use of hydrate inhibitors can effectively reduce the hydrate risk during the cleaning process of deep-water gas wells.
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c00074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Research progress on image-based calculation of coronary artery fractional flow reserve].

    Sun, Zheng / Jiao, Wenbin

    Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi

    2023  Volume 40, Issue 1, Page(s) 171–179

    Abstract: Coronary artery fractional flow reserve (FFR) is a critical physiological indicator for assessment of impaired blood flow caused by coronary artery stenosis. The wire-based invasive measurement of blood flow pressure gradient across stenosis is the gold ... ...

    Abstract Coronary artery fractional flow reserve (FFR) is a critical physiological indicator for assessment of impaired blood flow caused by coronary artery stenosis. The wire-based invasive measurement of blood flow pressure gradient across stenosis is the gold standard for clinical measurement of FFR. However, it has the risk of vascular injury and requires the use of vasodilators, increasing the time and overall cost of interventional examination. Coronary imaging is playing an important role in clinical diagnosis of stenotic lesions, evaluation of severity of lesions, and planning of therapies. In recent years, the computation of FFR based on the physiological information of blood flow obtained from routinely collected coronary image data has become a research focus in this field. This technique reduces the cost of physiological assessment of coronary lesions and the use of pressure wires. It is beneficial to strengthen the physiological guidance in interventional therapy. In order to better understand this emerging technique, this paper highlights its implementation principle and diagnostic performance, analyzes practical problems and current challenges in clinical applications, and discusses possible future development.
    MeSH term(s) Humans ; Coronary Vessels/diagnostic imaging ; Fractional Flow Reserve, Myocardial ; Heart ; Constriction, Pathologic ; Coronary Stenosis/diagnostic imaging
    Language Chinese
    Publishing date 2023-03-02
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2576847-5
    ISSN 1001-5515
    ISSN 1001-5515
    DOI 10.7507/1001-5515.202206044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6887: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: A High-Performance Strain Sensor for the Detection of Human Motion and Subtle Strain Based on Liquid Metal Microwire.

    Zhu, He / Sun, Zheng / Wang, Xin / Xia, Hong

    Nanomaterials (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: Flexible strain sensors have a wide range of applications, such as human motion monitoring, wearable electronic devices, and human-computer interactions, due to their good conformability and sensitive deformation detection. To overcome the internal ... ...

    Abstract Flexible strain sensors have a wide range of applications, such as human motion monitoring, wearable electronic devices, and human-computer interactions, due to their good conformability and sensitive deformation detection. To overcome the internal stress problem of solid sensing materials during deformation and prepare small-sized flexible strain sensors, it is necessary to choose a more suitable sensing material and preparation technology. We report a simple and high-performance flexible strain sensor based on liquid metal nanoparticles (LMNPs) on a polyimide substrate. The LMNPs were assembled using the femtosecond laser direct writing technology to form liquid metal microwires. A wearable strain sensor from the liquid metal microwire was fabricated with an excellent gauge factor of up to 76.18, a good linearity in a wide sensing range, and a fast response/recovery time of 159 ms/120 ms. Due to these extraordinary strain sensing performances, the strain sensor can monitor facial expressions in real time and detect vocal cord vibrations for speech recognition.
    Language English
    Publishing date 2024-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14020231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: CO

    Yang, Jixin / Yu, Pengliang / Wang, Suran / Sun, Zheng

    Nanomaterials (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: In the field of ... ...

    Abstract In the field of CO
    Language English
    Publishing date 2024-01-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14020138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Suppression of acoustic reflection artifact in endoscopic photoacoustic tomographic images based on approximation of ideal signals.

    Sun, Zheng / Zhang, Xiaoxue

    Technology and health care : official journal of the European Society for Engineering and Medicine

    2022  Volume 30, Issue S1, Page(s) 201–214

    Abstract: Background: In endoscopic photoacoustic tomography (EPAT), the photoacoustically induced ultrasonic wave reflects at tissue boundaries due to the acoustic inhomogeneity of the imaged tissue, resulting in reflection artifacts (RAs) in the reconstructed ... ...

    Abstract Background: In endoscopic photoacoustic tomography (EPAT), the photoacoustically induced ultrasonic wave reflects at tissue boundaries due to the acoustic inhomogeneity of the imaged tissue, resulting in reflection artifacts (RAs) in the reconstructed images.
    Objective: To suppress RAs in EPAT image reconstruction for improving the image quality.
    Methods: A method was presented to render the cross-sectional images of the optical absorption with reduced RAs from acoustic measurements. The ideal photoacoustic signal was recovered from acoustic signals collected by the detector through solving a least square problem. Then, high-quality images of the optical absorption distribution were reconstructed from the ideal signal.
    Results: The results demonstrated the improvement in the quality of the images rendered by this method in comparison with the conventional back-projection (BP) reconstructions. Compared with the short lag spatial coherence (SLSC) method, the peak signal-to-noise ratio (PSNR), normalized mean square absolute distance (NMSAD), and structural similarity (SSIM) were improved by up to 8%, 20%, and 5%, respectively.
    Conclusions: This method was capable of rendering images displaying the complex tissue types with reduced RAs and lower computational burden in comparison with previously developed methods.
    MeSH term(s) Acoustics ; Algorithms ; Artifacts ; Humans ; Image Processing, Computer-Assisted/methods ; Phantoms, Imaging ; Photoacoustic Techniques
    Language English
    Publishing date 2022-04-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1159961-3
    ISSN 1878-7401 ; 0928-7329
    ISSN (online) 1878-7401
    ISSN 0928-7329
    DOI 10.3233/THC-228019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3846: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Image reconstruction for endoscopic photoacoustic tomography including effects of detector responses.

    Sun, Zheng / Sun, Huifeng

    Experimental biology and medicine (Maywood, N.J.)

    2022  Volume 247, Issue 11, Page(s) 881–897

    Abstract: In photoacoustic tomography (PAT), conventional image reconstruction methods are generally based on the assumption of an ideal point-like ultrasonic detector. This assumption is appropriate when the receiving surface of the detector is sufficiently small ...

    Abstract In photoacoustic tomography (PAT), conventional image reconstruction methods are generally based on the assumption of an ideal point-like ultrasonic detector. This assumption is appropriate when the receiving surface of the detector is sufficiently small and/or the distance between the imaged object and the detector is large enough. However, it does not hold in endoscopic applications of PAT. In this study, we propose a model-based image reconstruction method for endoscopic photoacoustic tomography (EPAT), considering the effect of detector responses on image quality. We construct a forward model to physically describe the imaging process of EPAT, including the generation of the initial pressure due to optical absorption and thermoelastic expansion, the propagation of photoacoustic waves in tissues, and the acoustic measurement. The model outputs the theoretical sampling voltage signal, which is the response of the ultrasonic detector to the acoustic pressure reaching its receiving surface. The images representing the distribution map of the optical absorption energy density on cross-sections of the imaged luminal structures are reconstructed from the sampling voltage signals output by the detector through iterative inversion of the forward model. Compared with the conventional approaches based on back-projection and other imaging models, our method improved the quality and spatial resolution of the resulting images.
    MeSH term(s) Acoustics ; Algorithms ; Image Processing, Computer-Assisted/methods ; Phantoms, Imaging ; Photoacoustic Techniques/methods ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-03-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.1177/15353702221079570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.111: Show issues Location:
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  9. Article ; Online: Circadian clock and temporal meal pattern.

    Li, Xin / Sun, Zheng

    Medical review (2021)

    2022  Volume 3, Issue 1, Page(s) 85–101

    Abstract: The central circadian clock in the brain controls the time-of-the-day variations in acute meal responses, with a low glycemic response but a high satiety/thermogenic response to meals consumed at waking compared to other time points. Consistently, ... ...

    Abstract The central circadian clock in the brain controls the time-of-the-day variations in acute meal responses, with a low glycemic response but a high satiety/thermogenic response to meals consumed at waking compared to other time points. Consistently, studies show that consuming a significant proportion of calories, particularly carbohydrates, in breakfast is beneficial for the chronic management of obesity and its associated metabolic syndrome, compared to consuming identical meals at dinner. Conversely, breakfast skipping or/and late dinner can have unfavorable metabolic outcomes. It remains controversial how meal frequency affects metabolic health. In contrast, irregular meals, especially irregular breakfasts, show consistent adverse metabolic consequences. Time-restricted feeding (TRF), with all calories consumed within less than 12-h per day, can improve metabolism and extend lifespan. A major component of TRF in humans is caloric restriction, which contributes significantly to the beneficial effects of TRF in humans. By comparison, TRF effects in rodents can be independent of caloric restriction and show day/night phase specificity. TRF could alleviate metabolic abnormalities due to circadian disruption, but its effects appear independent of the circadian clock in rodents. Understanding neuroendocrine mechanisms underlying clock-mediated metabolic regulation will shed light on the metabolic effects of temporal meal patterns.
    Language English
    Publishing date 2022-09-05
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2749-9642
    ISSN (online) 2749-9642
    DOI 10.1515/mr-2022-0021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A Motion-Aware DNN Model with Edge Focus Loss and Quality Control for Short-Axis Left Ventricle Segmentation of Cine MR Sequences.

    Wang, Yu / Sun, Zheng / Liu, Zhi / Lu, Jie / Zhang, Nan

    Journal of imaging informatics in medicine

    2024  

    Abstract: Accurate segmentation of the left ventricle myocardium is the key step of automatic assessment of cardiac function. However, the current methods mainly focus on the end-diastolic and the end-systolic frames in cine MR sequences and lack the attention to ... ...

    Abstract Accurate segmentation of the left ventricle myocardium is the key step of automatic assessment of cardiac function. However, the current methods mainly focus on the end-diastolic and the end-systolic frames in cine MR sequences and lack the attention to myocardial motion in the cardiac cycle. Additionally, due to the lack of fine segmentation tools, the simplified approach, excluding papillary muscles and trabeculae from myocardium, is applied in clinical practice. To solve these problems, we propose a motion-aware DNN model with edge focus loss and quality control in this paper. Specifically, the bidirectional ConvLSTM layer and a new motion attention layer are proposed to encode motion-aware feature maps, and an edge focus loss function is proposed to train the model to generate the fine segmentation results. Additionally, a quality control method is proposed to filter out the abnormal segmentations before subsequent analyses. Compared with state-of-the-art segmentation models on the public dataset and the in-house dataset, the proposed method has obtained high segmentation accuracy. On the 17-segment model, the proposed method has obtained the highest Pearson correlation coefficient at 14 of 17 segments, and the mean PCC of 85%. The experimental results highlight the segmentation accuracy of the proposed method as well as its availability to substitute for the manually annotated boundaries for the automatic assessment of cardiac function.
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2948-2933
    ISSN (online) 2948-2933
    DOI 10.1007/s10278-023-00942-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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