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Article ; Online: STAT3 regulates 5-Fu resistance in human colorectal cancer cells by promoting Mcl-1-dependent cytoprotective autophagy.

Yue, Yuanyi / Zhang, Qiang / Wang, Xueqing / Sun, Zhengrong

2023 Volume 114, Issue 6, Page(s) 2293–2305

Abstract: Chemoresistance to 5-fluorouracil (5-Fu)-based chemotherapy is one of the primary reasons for the failure of colorectal cancer (CRC) management. STAT3 can mediate tumor drug resistance through a variety of diverse mechanisms. Nonetheless, the underlying ... ...

Abstract	Chemoresistance to 5-fluorouracil (5-Fu)-based chemotherapy is one of the primary reasons for the failure of colorectal cancer (CRC) management. STAT3 can mediate tumor drug resistance through a variety of diverse mechanisms. Nonetheless, the underlying mechanisms of STAT3-induced 5-Fu resistance in CRC are still poorly understood. Here, we aimed to investigate the potential mechanism(s) of STAT3-induced 5-Fu resistance in CRC. Quantitative RT-PCR and Western blot were used to test the expression of STAT3 and Mcl-1 in chemosensitive and chemoresistant CRC tissues and cell lines. After overexpression or knockdown of STAT3 or Mcl-1, and/or treatment with or without 5-Fu or chloroquine (CQ), we tested cell viability, inhibitory concentration 50% (IC
MeSH term(s)	Humans ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Cell Line, Tumor ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Drug Resistance, Neoplasm ; Apoptosis ; Autophagy/genetics ; Cell Proliferation ; STAT3 Transcription Factor/metabolism
Chemical Substances	Fluorouracil (U3P01618RT) ; STAT3 protein, human ; STAT3 Transcription Factor
Language	English
Publishing date	2023-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.15761
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Photo-Thermal Superhydrophobic Sponge for Highly Efficient Anti-Icing and De-Icing.

Yu, Bo / Sun, Zhengrong / Liu, Yubo / Wu, Yang / Zhou, Feng

Langmuir : the ACS journal of surfaces and colloids

2023 Volume 39, Issue 4, Page(s) 1686–1693

Abstract: Ice accretion always brings much inconvenience in the field of production and life. How to anti-ice or de-ice easily on solid surfaces becomes research focus in the engineering material fields. In this work, a kind of photo-thermal superhydrophobic ... ...

Abstract	Ice accretion always brings much inconvenience in the field of production and life. How to anti-ice or de-ice easily on solid surfaces becomes research focus in the engineering material fields. In this work, a kind of photo-thermal superhydrophobic polyurethane sponge (PSP-SPONGE) was developed by depositing Fe
Language	English
Publishing date	2023-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.2c03384
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Article ; Online: CX3CR1 Acts as a Protective Biomarker in the Tumor Microenvironment of Colorectal Cancer.

Yue, Yuanyi / Zhang, Qiang / Sun, Zhengrong

Frontiers in immunology

2022 Volume 12, Page(s) 758040

Abstract: The tumor microenvironment (TME) plays an important role in the pathogenesis of many cancers. We aimed to screen the TME-related hub genes of colorectal adenoma (CRAD) and identify possible prognostic biomarkers. The gene expression profiles and clinical ...

Abstract	The tumor microenvironment (TME) plays an important role in the pathogenesis of many cancers. We aimed to screen the TME-related hub genes of colorectal adenoma (CRAD) and identify possible prognostic biomarkers. The gene expression profiles and clinical data of 464 CRAD patients in The Cancer Genome Atlas (TCGA) database were downloaded. The Estimation of STromal and Immune cells in MAlignant Tumours using Expression data (ESTIMATE) algorithm was performed to calculate the ImmuneScore, StromalScore, and EstimateScore. Thereafter, differentially expressed genes (DEGs) were screened. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and protein-protein interaction (PPI) analysis were performed to explore the roles of DEGs. Furthermore, univariate and multivariate Cox analyses were accomplished to identify independent prognostic factors of CRAD. CX3CR1 was selected as a hub gene, and the expression was confirmed in colorectal cancer (CRC) patients and cell lines. The correlations between CX3CR1 and tumor-infiltrating immune cells were estimated by Tumor IMmune Estimation Resource database (TIMER) and CIBERSORT analysis. Besides, we investigated the effects of coculture with THP-1-derived macrophages with HCT8 cells with low CX3CR1 expression on immune marker expression, cell viability, and migration. There were significant differences in the ImmuneScore and EstimateScore among different stages. Patients with low scores presented significantly lower lifetimes than those in the high-score group. Moreover, we recognized 1,578 intersection genes in ImmuneScore and StromalScore, and these genes were mainly enriched in numerous immune-related biological processes. CX3CR1 was found to be associated with immune cell infiltration levels, immune marker expression, and macrophage polarization. Simultaneous silencing of CX3CR1 and coculture with THP-1 cells further regulated macrophage polarization and promoted the cell proliferation and migration of CRC cells. CX3CR1 was decreased in CRAD tissues and cell lines and was related to T and N stages, tumor differentiation, and prognosis. Our results suggest that CX3CR1 contributes to the recruitment and regulation of immune-infiltrating cells and macrophage polarization in CRC and TAM-induced CRC progression. CX3CR1 may act as a prognostic biomarker in CRC.
MeSH term(s)	Algorithms ; Biomarkers, Tumor/genetics ; CX3C Chemokine Receptor 1/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Computational Biology/methods ; Databases, Genetic ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic/genetics ; Gene Ontology ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Prognosis ; Protein Interaction Maps/genetics ; Transcriptome/genetics ; Tumor Microenvironment/genetics
Chemical Substances	Biomarkers, Tumor ; CX3C Chemokine Receptor 1 ; CX3CR1 protein, human
Language	English
Publishing date	2022-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.758040
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Article: Polymorphism of E6 and E7 Genes in Human Papillomavirus Types 31 and 33 in Northeast China.

Yu, Miao / Wu, Si / Wang, Shuang / Cui, Changwan / Lu, Yiping / Sun, Zhengrong

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

2023 Volume 2023, Page(s) 9338294

Abstract: Persistent infection with human papillomavirus (HPV) types 31 and 33 is an important causative factor for cervical cancer. The E6/E7 genes are key oncogenes involved in the immortalization and transformation of human epithelial cells. Genetic ... ...

Abstract	Persistent infection with human papillomavirus (HPV) types 31 and 33 is an important causative factor for cervical cancer. The E6/E7 genes are key oncogenes involved in the immortalization and transformation of human epithelial cells. Genetic polymorphism may lead to differences in the virus' carcinogenic potential, the immune reaction of the host, and the potencies of vaccines. Few studies on HPV31/33 E6/E7 genetic polymorphism have been carried out. To study the genetic polymorphism of HPV31 and HPV33 E6/E7 genes in northeast China, these genes (HPV31 E6/E7,
Language	English
Publishing date	2023-03-13
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	1057056-1
ISSN	1712-9532 ; 1180-2332
ISSN	1712-9532 ; 1180-2332
DOI	10.1155/2023/9338294
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Article: Improving Anti-Icing and De-Icing Performances via Thermal-Regulation with Macroporous Xerogel

Yu, Bo / Sun, Zhengrong / Liu, Yubo / Zhang, Zhizhi / Wu, Yang / Zhou, Feng

ACS applied materials & interfaces. 2021 July 29, v. 13, no. 31

2021

Abstract: The accumulation of ice in winter has brought many problems in industrial production and everyday life, and how to prevent icing or remove ice rapidly has aroused great attention from researchers in recent years. In this work, we demonstrated a strategy ... ...

Abstract	The accumulation of ice in winter has brought many problems in industrial production and everyday life, and how to prevent icing or remove ice rapidly has aroused great attention from researchers in recent years. In this work, we demonstrated a strategy of using a superhydrophobic photothermal and thermal isolation macroporous xerogel (PMX) to delay icing and remove ice efficiently under faint sunlight irradiation. An oriented macroporous xerogel was prepared by an ice templating method, and multi-walled carbon nanotubes acting as the photothermal genesis component under sunlight irradiation were introduced into the xerogel. After fluorination, the PMX presented a robust water repellency and delayed icing. More importantly, numerous macropores in the PMX matrix acted as the thermal barrier that can restrict heat transmission to surroundings at maximum, which guarantees efficient anti-icing and de-icing in low temperature. Water on the PMX surface can never freeze at −30 °C under 0.25 kW/m² (“0.25 sun”) sunlight irradiation. The outdoor experiment also has confirmed the availability of PMX in a natural winter environment. The PMX integrated with thermogenesis and thermo-isolation functions provides a new route for highly efficient anti-icing and de-icing.
Keywords	carbon nanotubes ; heat production ; heat transfer ; hydrophobicity ; ice ; irradiation ; macropores ; porous media ; solar radiation ; temperature ; winter ; xerogels
Language	English
Dates of publication	2021-0729
Size	p. 37609-37616.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.1c08770
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Improving Anti-Icing and De-Icing Performances via Thermal-Regulation with Macroporous Xerogel.

Yu, Bo / Sun, Zhengrong / Liu, Yubo / Zhang, Zhizhi / Wu, Yang / Zhou, Feng

ACS applied materials & interfaces

2021 Volume 13, Issue 31, Page(s) 37609–37616

Abstract	The accumulation of ice in winter has brought many problems in industrial production and everyday life, and how to prevent icing or remove ice rapidly has aroused great attention from researchers in recent years. In this work, we demonstrated a strategy of using a superhydrophobic photothermal and thermal isolation macroporous xerogel (PMX) to delay icing and remove ice efficiently under faint sunlight irradiation. An oriented macroporous xerogel was prepared by an ice templating method, and multi-walled carbon nanotubes acting as the photothermal genesis component under sunlight irradiation were introduced into the xerogel. After fluorination, the PMX presented a robust water repellency and delayed icing. More importantly, numerous macropores in the PMX matrix acted as the thermal barrier that can restrict heat transmission to surroundings at maximum, which guarantees efficient anti-icing and de-icing in low temperature. Water on the PMX surface can never freeze at -30 °C under 0.25 kW/m
Language	English
Publishing date	2021-07-29
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c08770
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Neurotrophic factor levels in the serum and cerebrospinal fluid of neonates infected with human cytomegalovirus.

Wang, Shuang / Zou, Fei / Wu, Si / Wu, Yingying / Yue, Yuanyi / Sun, Zhengrong

Microbiology and immunology

2021 Volume 65, Issue 9, Page(s) 373–382

Abstract: Human cytomegalovirus (HCMV) is most likely to damage the central nervous system (CNS) during early embryonic development; however, the early neurodevelopmental abnormalities caused by HCMV infection and the regulation of cytokines remain unclear. ... ...

Abstract	Human cytomegalovirus (HCMV) is most likely to damage the central nervous system (CNS) during early embryonic development; however, the early neurodevelopmental abnormalities caused by HCMV infection and the regulation of cytokines remain unclear. Therefore, we investigated neuronal factors in the serum and cerebrospinal fluid (CSF) of newborns infected with HCMV using protein microarray technology with a view to elucidating the changes in specific neuronal factors for use in the development of a reliable index for predicting CNS injury caused by HCMV infection. Serum and CSF were collected from four newborns with HCMV infection and CNS injury (HCMV-infected group) and from four newborns without CNS infection (control group). A protein microarray containing 29 kinds of CNS-related cytokines was used to identify differentially expressed neuronal factors in the serum and CSF of the HCMV-infected and control groups. The levels of the differentially expressed proteins were verified further in 30 CSF samples from an HCMV-infected group using enzyme-linkedimmunosorbent assay (ELISA). Between newborns in the HCMV-infected and control groups, the protein microarray analysis identified three differentially expressed neurotrophic factors in the CSF samples: Acrp30, MMP-3, and interleukin-1 alpha (IL-1α). No differential cytokine expression was seen in the serum. ELISA showed significantly higher expression levels of Acrp30 and MMP-3 in the CSF of the 30 newborns with HCMV infection and CNS injury than in those in the control group, whereas the expression of IL-1α was significantly lower. Our results demonstrate that changes in the expression levels of Acrp30, MMP-3, and IL-1α in the CSF of newborns infected with HCMV may be related to the pathogenesis of CNS infection.
MeSH term(s)	Cytokines ; Cytomegalovirus/genetics ; Cytomegalovirus Infections ; Humans ; Infant, Newborn ; Nerve Growth Factors ; Polymerase Chain Reaction
Chemical Substances	Cytokines ; Nerve Growth Factors
Language	English
Publishing date	2021-07-16
Publishing country	Australia
Document type	Journal Article
ZDB-ID	224792-6
ISSN	1348-0421 ; 0385-5600
ISSN (online)	1348-0421
ISSN	0385-5600
DOI	10.1111/1348-0421.12918
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Article ; Online: Identification of key genes involved in JAK/STAT pathway in colorectal cancer.

Yue, Yuanyi / Zhang, Qiang / Wu, Si / Wang, Shuang / Cui, Changwan / Yu, Miao / Sun, Zhengrong

Molecular immunology

2020 Volume 128, Page(s) 287–297

Abstract: JAK/STAT pathway has been well confirmed in the development of colorectal cancer (CRC), however, the exact mechanism is unclear. Therefore, we aimed to identify key genes involved in JAK/STAT pathway in CRC, as well as the potential mechanism. RT² ... ...

Abstract	JAK/STAT pathway has been well confirmed in the development of colorectal cancer (CRC), however, the exact mechanism is unclear. Therefore, we aimed to identify key genes involved in JAK/STAT pathway in CRC, as well as the potential mechanism. RT² profiler PCR arrays were performed to identify key genes of the JAK/STAT pathway. GO, KEGG pathway and PPI analyses were performed to screen the main functions of differentially expressed genes (DEGs). Moreover, the expression of DEGs was detected by GEPIA based on TCGA database and verified by qPCR and/or Western blot. Subsequently, the association between the two DEGs (CXCL9 and IL6ST) and clinicopathological features were determined by immunohistochemistry, and survival analysis was also conducted. Finally, the effects of IL6ST overexpression on STAT3 activation and HT29 cell functions were analyzed. A total of 14 DEGs were identified. Among the DEGs, GHR, NR3C1, IL6ST and A2M were confirmed to be statistically decreased, while CXCL9 was significantly increased in the CRC tissues. Furthermore, CXCL9 was significantly associated with differentiation, lymph node metastasis, distant metastasis and invasion, while IL6ST was related with tumor size, differentiation, stage and invasion. Patients with high expression of IL6ST presented significantly lower lifetime, however, CXCL9 showed the opposite results without significance. Additionally, we found that overexpression of IL6ST statistically elevated p-STAT3 level, cell viability, adhesion rate and migration, and decreased apoptosis, but had no effects on cell cycle. Our results suggest that IL6ST is a critical key gene involved in JAK/STAT signaling pathway in CRC.
MeSH term(s)	Apoptosis/genetics ; Cell Adhesion/genetics ; Cell Cycle/genetics ; Cell Differentiation/genetics ; Cell Line, Tumor ; Cell Survival/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Cytokine Receptor gp130/metabolism ; HCT116 Cells ; HT29 Cells ; Humans ; Janus Kinases/genetics ; Lymphatic Metastasis/genetics ; Lymphatic Metastasis/pathology ; STAT Transcription Factors/genetics ; Signal Transduction/genetics
Chemical Substances	STAT Transcription Factors ; Cytokine Receptor gp130 (133483-10-0) ; Janus Kinases (EC 2.7.10.2)
Language	English
Publishing date	2020-11-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/j.molimm.2020.10.007
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Zs.A 166: Show issues

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Article: STAT1 expression and HPV16 viral load predict cervical lesion progression.

Wu, Si / Wu, Yingying / Lu, Yiping / Yue, Yuanyi / Cui, Changwan / Yu, Miao / Wang, Shuang / Liu, Miao / Zhao, Ying / Sun, Zhengrong

Oncology letters

2020 Volume 20, Issue 4, Page(s) 28

Abstract: Cervical cancer is the fourth leading cause of cancer-associated mortality worldwide. However, its underlying molecular mechanisms are unclear. It is important to explore these mechanisms in order to identify novel diagnostic and prognostic biomarkers. ... ...

Abstract	Cervical cancer is the fourth leading cause of cancer-associated mortality worldwide. However, its underlying molecular mechanisms are unclear. It is important to explore these mechanisms in order to identify novel diagnostic and prognostic biomarkers. The present study determined the association between STAT1 and human papillomavirus (HPV)16 in cervical lesions. STAT1 expression was detected by immunohistochemistry. Quantitative PCR was used to detect HPV16 viral load and STAT1 expression in cervical lesions. The potential associations among STAT1 expression, HPV16 viral load and the severity of cervical lesions in patients were analyzed using receiver operating characteristic (ROC) curves. The Cancer Genome Atlas database was used to analyze STAT1 expression and survival. High STAT1 expression was observed in 10.71 (3/28), 41.18 (14/34), 53.06 (26/49) and 90.00% (27/30) of normal tissue, low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL) and cervical squamous cell carcinoma samples, respectively. The HPV16 copy number gradually increased with the progression of cervical lesions, with the highest copy number observed in cervical cancer samples. In addition, STAT1 expression was positively correlated with HPV16 viral load. Furthermore, ROC curve analysis demonstrated that the combination of STAT1 expression and HPV16 viral load was able to differentiate between LSIL/HSIL and cervical cancer samples. Bioinformatics analysis revealed that STAT1 expression was associated with improved survival in cervical cancer. Additionally, STAT1 expression was positively associated with the progression of cervical lesions, and HPV16 viral load may affect STAT1 expression. Overall, these findings indicate that STAT1 may be an indicator of the status of cervical lesions.
Language	English
Publishing date	2020-07-17
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2020.11889
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Gene Expression Along with Genomic Copy Number Variation and Mutational Analysis Were Used to Develop a 9-Gene Signature for Estimating Prognosis of COAD.

Lu, Yiping / Wu, Si / Cui, Changwan / Yu, Miao / Wang, Shuang / Yue, Yuanyi / Liu, Miao / Sun, Zhengrong

OncoTargets and therapy

2020 Volume 13, Page(s) 10393–10408

Abstract: Purpose: This study aims to systematically analyze multi-omics data to explore new prognosis biomarkers in colon adenocarcinoma (COAD).: Materials and methods: Multi-omics data of COAD and clinical information were obtained from The Cancer Genome ... ...

Abstract	Purpose: This study aims to systematically analyze multi-omics data to explore new prognosis biomarkers in colon adenocarcinoma (COAD). Materials and methods: Multi-omics data of COAD and clinical information were obtained from The Cancer Genome Atlas (TCGA). Univariate Cox analysis was used to select genes which significantly related to the overall survival. GISTIC 2.0 software was used to identify significant amplification or deletion. Mutsig 2.0 software was used to identify significant mutation genes. The 9-gene signature was screened by random forest algorithm and Cox regression analysis. GSE17538 dataset was used as an external dataset to verify the predictive ability of 9-gene signature. qPCR was used to detect the expression of 9 genes in clinical specimens. Results: A total of 71 candidate genes are obtained by integrating genomic variation, mutation and prognostic data. Then, 9-gene signature was established, which includes HOXD12, RNF25, CBLN3, DOCK3, DNAJB13, PYGO2, CTNNA1, PTPRK, and NAT1. The 9-gene signature is an independent prognostic risk factor for COAD patients. In addition, the signature shows good predicting performance and clinical practicality in training set, testing set and external verification set. The results of qPCR based on clinical samples showed that the expression of HOXD12, RNF25, CBLN3, DOCK3, DNAJB13, and PYGO2 was increased in colon cancer tissues and the expression of CTNNA1, PTPRK, NAT1 was decreased in colon cancer tissues. Conclusion: In this study, 9-gene signature is constructed as a new prognostic marker to predict the survival of COAD patients.
Language	English
Publishing date	2020-10-14
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495130-4
ISSN	1178-6930
ISSN	1178-6930
DOI	10.2147/OTT.S255590
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