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  1. Article ; Online: Unveiling the panorama and emerging boundaries in the field of aging biomarkers.

    Sun, Zhou / Liu, Xingzi / Pan, Dikang / Wang, Jingyu

    Asian journal of surgery

    2024  Volume 47, Issue 4, Page(s) 2065–2066

    Language English
    Publishing date 2024-01-17
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.01.014
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    Zs.B 2831: Show issues Location:
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  2. Article ; Online: Isolation, Characterization, and Genomic Analysis of Multidrug-Resistant Rahnella aquatilis from Fruits in China.

    Wang, Bing / Jin, Hui / Xu, Yongjie / Sun, Zhou

    Current microbiology

    2023  Volume 80, Issue 10, Page(s) 321

    Abstract: Many fruits are consumed raw and act as vehicles for spreading antibiotic-resistant bacteria to consumers; hence, preventing foodborne diseases and ensuring food safety of fresh fruits are challenging. In this study, we aimed to analyze contamination in ... ...

    Abstract Many fruits are consumed raw and act as vehicles for spreading antibiotic-resistant bacteria to consumers; hence, preventing foodborne diseases and ensuring food safety of fresh fruits are challenging. In this study, we aimed to analyze contamination in fruits and characterize antibiotic resistance genes in pathogenic microorganisms isolated from fruits. Sixty fruit samples were collected and screened for pathogenic microorganisms. The strains were identified, and the minimum inhibitory concentration for various antibiotics was determined. Antibiotic-resistant strains were analyzed by whole-genome sequencing. We isolated strain L46 from lemon samples and identified it as Rahnella aquatilis using MALDI-TOF MS and 16S rRNA sequencing. The whole genome of R. aquatilis L46 was 4.94 Mb and contained 291 putative antibiotic resistance genes (6.53%), including the gene coding for β-lactamase RAHN-1 CTX-M-2 and conferring resistance to ampicillin, polymyxin B, nitrofurantoin, imipenem, aztreonam, and cefotaxime. Thus, fruits can pose a potential hazard to human health and require greater surveillance and attention, as they may contain pathogenic and multidrug-resistant bacteria.
    MeSH term(s) Humans ; Fruit ; Rahnella ; RNA, Ribosomal, 16S/genetics ; Genomics ; Anti-Bacterial Agents/pharmacology ; China
    Chemical Substances RNA, Ribosomal, 16S ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-023-03436-4
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  3. Article ; Online: Topological Equivalence of Stripy States and Skyrmion Crystals.

    Wang, X R / Hu, Xu-Chong / Sun, Zhou-Zhou

    Nano letters

    2023  Volume 23, Issue 9, Page(s) 3954–3962

    Abstract: Stripy states, consisting of a collection of stripy spin textures, are the precursors of skyrmion crystals (SkXs). The common belief is that stripy states and SkXs are topologically unconnected and that transitions between SkXs and stripy states are ... ...

    Abstract Stripy states, consisting of a collection of stripy spin textures, are the precursors of skyrmion crystals (SkXs). The common belief is that stripy states and SkXs are topologically unconnected and that transitions between SkXs and stripy states are phase transitions. Here, we show that both stripy states and SkXs are skyrmion condensates and they are topologically equivalent. By gradually tuning the stripe whose width goes from smaller than to larger than skyrmion-skyrmion separation, the structure of a skyrmion condensate transforms smoothly and continuously from various stripy phases, including helical states and mazes, to crystals, showing that stripy states are topologically connected to SkXs.
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c00718
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  4. Article ; Online: Association of Androgen-Receptor Gene Mutations with the Copy Number of Androgen-Receptor Silk Protein A Complex and Glutathione-S-Transferases T1 and M1 in Prostate Cancer Patients.

    Zhang, Yan / Meng, Xiangdi / Ma, Zhaosen / Sun, Zhou / Wang, Zhixin

    Genetics research

    2023  Volume 2023, Page(s) 5956951

    Abstract: Objective: The purpose of our work was to explore the association of mutations in the androgen receptor gene and copy numbers of the androgen-receptor silk protein A complex with glutathione-S-transferases T1 and M1 in prostate cancer patients.: ... ...

    Abstract Objective: The purpose of our work was to explore the association of mutations in the androgen receptor gene and copy numbers of the androgen-receptor silk protein A complex with glutathione-S-transferases T1 and M1 in prostate cancer patients.
    Materials and methods: Eighty-five patients with PC and 85 healthy controls were included in the study. Fasting peripheral venous blood was collected, whole blood genomic DNA was extracted, and AR gene-receptor genotype was detected by a high-resolution melting curve analysis detection technology. Expression levels of androgen receptor (AR) and filamin protein A (FlnA) were detected by Western blotting. RT-PCR was used to detect the copy number of T1 and M1 glutathione-S-transferases.
    Results: The wild-type androgen receptor gene rs5918762 is of TT type. The frequencies of CC and TC genes in the prostate cancer group were significantly higher than those in the normal control group (
    Conclusion: Androgen-receptor gene polymorphisms were significantly associated with expression levels of androgen receptor complex
    MeSH term(s) Humans ; Male ; Case-Control Studies ; DNA Copy Number Variations ; Genetic Predisposition to Disease ; Genotype ; Glutathione Transferase/genetics ; Mutation ; Prostatic Neoplasms/genetics ; Receptors, Androgen/genetics ; Risk Factors ; Filamins/genetics
    Chemical Substances Glutathione Transferase (EC 2.5.1.18) ; Receptors, Androgen ; FLNA protein, human ; Filamins ; glutathione S-transferase T1 (EC 2.5.1.-) ; glutathione S-transferase M1 (EC 2.5.1.18) ; AR protein, human
    Language English
    Publishing date 2023-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2412681-0
    ISSN 1469-5073 ; 0016-6723
    ISSN (online) 1469-5073
    ISSN 0016-6723
    DOI 10.1155/2023/5956951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 730: Show issues Location:
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  5. Article: Effects of Probiotic Supplementation on Nutrient Intake, Ghrelin, and Adiponectin Concentrations in Diabetic Hemodialysis Patients.

    Zhang, Yan / Meng, Xiangdi / Ma, Zhaosen / Sun, Zhou / Wang, Zhixin

    Alternative therapies in health and medicine

    2023  Volume 29, Issue 4, Page(s) 36–42

    Abstract: Objective: The paper aimed to explore the effect of probiotic supplementation on nutrient intake, Ghrelin, and adiponectin concentrations in diabetic hemodialysis patients.: Methods: A total of 86 patients with diabetic nephropathy who received ... ...

    Abstract Objective: The paper aimed to explore the effect of probiotic supplementation on nutrient intake, Ghrelin, and adiponectin concentrations in diabetic hemodialysis patients.
    Methods: A total of 86 patients with diabetic nephropathy who received hemodialysis treatment in the Department of Nephrology of the First People's Hospital of Shanghai from May 2019 to March 2021 were selected as the research subjects, including 52 male patients and 34 female patients, with an average age of 56.57 ± 4.28. According to the research protocol, the patients were divided into the control group (n = 30) and the observation group (n = 56). In the control group, dietary soybean milk was used as a placebo. In the observation group, capsules containing probiotics Lactobacillus acidophilus, Lactobacillus casei, and Bifidobacterium were taken with soybean milk. All patients signed an informed consent form before being included in the study. The results of the experimental biochemical analysis and the archived data counted the general data of the patients. Plasma adiponectin concentrations were measured with a commercially available human enzyme immunoassay kit. Ghrelin concentrations were estimated by specific commercial methods. Correlation software was used to calculate patient nutritional intake data. Serum creatinine, insulin resistance, fasting blood glucose, and levels of oxidative stress and inflammatory factors were measured using appropriate biochemical assays.
    Results: There was no difference in baseline characteristics between the two groups (P > .05). Before treatment, there was no difference in serum adiponectin concentration between the two groups (P > .05). After treatment, the serum adiponectin concentration in the observation group was lower than in the control group (P < .05). Before treatment, there was no difference in serum ghrelin levels between the two groups (P > .05). After treatment, serum ghrelin levels in the observation group were higher than in the control group (P < .05). Before treatment, there was no difference in nutrient intake between the two groups (P > .05). After treatment, the nutrient intake in the observation group was higher than in the control group (P < .05). Serum creatinine, fasting blood glucose, urine protein/creatinine ratio, and HOMA-IR in the observation group were lower than in the control group (P < .05). The serum levels of malondialdehyde, C-reactive protein, and TNF-α in the observation group were lower than those in the control group (P < .05), and the levels of glutathione in the observation group were higher than those in the control group (P < .05).
    Conclusion: Supplementation of probiotics in DN dialysis patients can increase serum ghrelin concentration, increase nutrient intake through appetite regulation, and reduce adiponectin level, which is beneficial to blood sugar control, insulin resistance, and renal function.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Insulin Resistance ; Adiponectin ; Blood Glucose/metabolism ; Ghrelin ; Creatinine ; Biomarkers ; China ; Probiotics/therapeutic use ; Renal Dialysis ; Eating ; Diabetes Mellitus
    Chemical Substances Adiponectin ; Blood Glucose ; Ghrelin ; Creatinine (AYI8EX34EU) ; Biomarkers
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4504: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Preparation of nanocomposite aromatic polyamide reverse osmosis membranes by in-situ polymerization of bis(triethoxysilyl)ethane (BTESE)

    Zheng, Feng-Tao / Qu, Jianbo / Sun, Zhou

    Journal of membrane science. 2022 Nov. 05, v. 661

    2022  

    Abstract: Bis(triethoxysilyl)ethane (BTESE) nanoparticles were incorporated into aromatic polyamide (PA) membranes via in-situ polymerization to prepare BTESE nanocomposite PA (BTESE-TFN) membranes for reverse osmosis. In-situ polymerization was utilized to ... ...

    Abstract Bis(triethoxysilyl)ethane (BTESE) nanoparticles were incorporated into aromatic polyamide (PA) membranes via in-situ polymerization to prepare BTESE nanocomposite PA (BTESE-TFN) membranes for reverse osmosis. In-situ polymerization was utilized to produce BTESE nanoparticles with high dispersion in PA membranes by adding BTESE as precursors into PA membranes for in-situ polymerization. Organic bridged -C-C- in BTESE provided enhanced compatibility between BTESE nanoparticles and PA membranes. The BTESE-TFN membranes showed durability with stable RO performance for more than 96 h because of the high dispersion of BTESE nanoparticles and enhanced compatibility between BTESE nanoparticles and PA membranes. The BTESE nanoparticles increased surface roughness, thickness, hydrophilicity of PA membranes. The BTESE nanoparticles changed surfaces of PA membranes to looser structure with more pores and gaps. However, low loadings of BTESE nanoparticles in the BTESE-TFN membranes were observed due to low reactivity of Si-OC₂H₅ groups in BTESE. Even so, salt rejection of prepared TFN-0.12 membrane was slightly improved to 96.81%, compared with that of prepared pristine PA membrane. The TFN-0.12 membrane showed water flux of 1.6 L/(m²•h•bar), 25% higher than the water flux of pristine PA membrane because of enlargement of pore sizes in BTESE nanoparticles, formation of a loose and rough membrane surface and enhancement of hydrophilicity of the membrane surface. Furthermore, modification of organic bridged groups in the BTESE exhibited great potential to further optimize the water flux and durability of BTESE-TFN membranes.
    Keywords durability ; ethane ; hydrophilicity ; nanocomposites ; nanoparticles ; polyamides ; polymerization ; reverse osmosis ; surface roughness
    Language English
    Dates of publication 2022-1105
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 194516-6
    ISSN 0376-7388
    ISSN 0376-7388
    DOI 10.1016/j.memsci.2022.120914
    Database NAL-Catalogue (AGRICOLA)

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    Z 78/706: Show issues

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  7. Article ; Online: Nucleosides rich extract from Cordyceps cicadae alleviated cisplatin-induced neurotoxicity in rats

    Naihe Liu / Sun Zhou / Opeyemi Joshua Olatunji / Yong Wu

    Arabian Journal of Chemistry, Vol 15, Iss 1, Pp 103476- (2022)

    A behavioral, biochemical and histopathological study

    2022  

    Abstract: This work explored the protective effects of nucleosides rich extract from C. cicadae (CCNE) against cisplatin-induced neurotoxicity. The rats were divided into four groups: normal control (NCA), cisplatin control (CCA), CCNE-L + cisplatin (CCNE-L) and ... ...

    Abstract This work explored the protective effects of nucleosides rich extract from C. cicadae (CCNE) against cisplatin-induced neurotoxicity. The rats were divided into four groups: normal control (NCA), cisplatin control (CCA), CCNE-L + cisplatin (CCNE-L) and CCNE-H + cisplatin (CCNE-H). The rats in CCNE-L and CCNE-H were orally administered with 100 and 400 mg/kg of CCNE, respectively for five weeks, while the rats in CCA, CCNE-L and CCNE-H groups received intraperitoneal injection of 2.5 mg/kg cisplatin once a week for four weeks starting from the second week of CCNE treatment. After the final treatment, the rats were subjected to behavioural task including Morris water maze test (MWMT), Y maze test, forced swimming (FST), open field test (OFT), rotarod test as well as heat and mechanical hyperalgesia test. Thereafter, the animals were sacrificed and oxidative stress biomarkers, inflammatory mediators and acetylcholinesterase activities were measured in the brain. The histopathological assessment of the brain issues was also performed using H&E staining. The results indicated that CCNE significantly ameliorative cisplatin induced learning and memory impairment (MWMT and Y maze test), depressive behaviours (FST and OFT), motor coordination as well as thermal (hot plate and tail withdrawal test) and mechanical hyperalgesia (von Frey filament test). Furthermore, CCNE decreased acetylcholinesterase level, proinflammatory cytokines levels and lipid peroxidation, with concomitant increase in antioxidant enzymes profiles in the brain tissues of cisplatin treated rats. Additionally, CCNE treatment alleviated histopathological alterations in the brain tissues caused by cisplatin treatment. These results suggested that CCNE ameliorated memory impairment deficits, neuropathy, increased oxidative stress, inflammation in cisplatin treated rats through the inhibition of oxidative stress and inflammation.
    Keywords Cordyceps cicadae ; Nucleosides ; Cisplatin ; Neurotoxicity ; Cognitive impairment ; Oxidative stress ; Chemistry ; QD1-999
    Subject code 150
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Analysis of epidemic characteristics of forty-two COVID-19 cluster outbreaks in Hangzhou

    SUN Zhou / CHEN Junfang / LIU Muwen / KAO Qingjun / KONG Qingxin

    Shanghai yufang yixue, Vol 34, Iss 3, Pp 265-

    2022  Volume 267

    Abstract: ObjectiveTo determine the epidemic characteristics of forty-two coronavirus disease 2019 （COVID-19） cluster outbreaks in Hangzhou city and provide scientific evidence for further prevention and control measures.MethodsData of the COVID-19 cluster ... ...

    Abstract ObjectiveTo determine the epidemic characteristics of forty-two coronavirus disease 2019 （COVID-19） cluster outbreaks in Hangzhou city and provide scientific evidence for further prevention and control measures.MethodsData of the COVID-19 cluster outbreaks in Hangzhou were obtained from the National Public Health Emergency Management Information System. Epidemic characteristics were summarized by reviewing the epidemiological investigation reports.ResultsA total of forty-two COVID-19 cluster outbreaks were documented in Hangzhou in 2020， including 130 confirmed cases and 7 cases with asymptomatic infection. The majority occurred from January to February， 2020. Moreover， 92.86% （39/42） of the cluster outbreaks were familial transmission. The proportion of the cluster outbreaks involving 2 cases accounted for 54.7% （23/42）. In the secondary cases， family members accounted for 84.15% （69/82）.ConclusionThe COVID-19 cluster outbreaks in Hangzhou mainly occur in families， and the majority of the secondary cases is family members.
    Keywords covid-19 ; cluster outbreak ; epidemiology ; investigation ; Medicine ; R
    Language Chinese
    Publishing date 2022-03-01T00:00:00Z
    Publisher Shanghai Preventive Medicine Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Unveiling Anoikis-related genes: A breakthrough in the prognosis of bladder cancer.

    Jiang, Shen / Yang, Xiping / Lin, Yang / Liu, Yunfei / Tran, Lisa Jia / Zhang, Jing / Qiu, Chengjun / Ye, Fangdie / Sun, Zhou

    The journal of gene medicine

    2024  Volume 26, Issue 1, Page(s) e3651

    Abstract: Background: Bladder cancer (BLCA) is a prevalent malignancy worldwide. Anoikis remains a new form of cell death. It is necessary to explore Anoikis-related genes in the prognosis of BLCA.: Methods: We obtained RNA expression profiles from the The ... ...

    Abstract Background: Bladder cancer (BLCA) is a prevalent malignancy worldwide. Anoikis remains a new form of cell death. It is necessary to explore Anoikis-related genes in the prognosis of BLCA.
    Methods: We obtained RNA expression profiles from the The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases for dimensionality reduction analysis and isolated epithelial cells, T cells and fibroblasts for copy number variation analysis, pseudotime analysis and transcription factor analysis based on R package. We integrated machine-learning algorithms to develop the artificial intelligence-derived prognostic signature (AIDPS).
    Results: The performance of AIDPS with clinical indicators was stable and robust in predicting BLCA and showed better performance in every validation dataset compared to other models. Mendelian randomization analysis was conducted. Single nucleotide polymorphism (SNP) sites of rs3100578 (HK2) and rs66467677 (HSP90B1) exhibited significant correlation of bladder problem (not cancer) and bladder cancer, whereasSNP sites of rs3100578 (HK2) and rs947939 (BAD) had correlation between bladder stone and bladder cancer. The immune infiltration analysis of the TCGA-BLCA cohort was calculated via the ESTIMATE (i.e. Estimation of STromal and Immune cells in MAlignantTumours using Expression data) algorithm which contains stromal, immune and estimate scores. We also found significant differences in the IC
    Conclusions: In conclusion, these findings indicated Anoikis-related prognostic genes in BLCA and constructed an innovative machine-learning model of AIDPS with high prognostic value for BLCA.
    MeSH term(s) Humans ; Anoikis/genetics ; Artificial Intelligence ; DNA Copy Number Variations ; Urinary Bladder Neoplasms/genetics ; Algorithms
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1458024-x
    ISSN 1521-2254 ; 1099-498X
    ISSN (online) 1521-2254
    ISSN 1099-498X
    DOI 10.1002/jgm.3651
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    Zs.A 5423: Show issues Location:
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  10. Article ; Online: Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.

    Sun, Zhou / Zhu, Kejing / Liang, Guofu / Yan, Fu / Chao, Sheng / Jia, Lei / Niu, Yulin

    Experimental and therapeutic medicine

    2023  Volume 27, Issue 1, Page(s) 30

    Abstract: The effect of vitamin K on clinical outcomes in patients receiving kidney transplantation is contested according to previous studies. This meta-analysis aimed to summarize the impact of vitamin K on all-cause mortality, renal function, inflammation, and ... ...

    Abstract The effect of vitamin K on clinical outcomes in patients receiving kidney transplantation is contested according to previous studies. This meta-analysis aimed to summarize the impact of vitamin K on all-cause mortality, renal function, inflammation, and vascular/bone health in patients receiving kidney transplantation. EMBASE, PubMed, and Cochrane were searched for literature concerning the effect of vitamin K on clinical outcomes of patients receiving kidney transplantation until December 2022. Normal vitamin K status/vitamin K supplementation was considered as the experimental group; while vitamin K deficiency/no vitamin K supplementation was considered as the control group. All-cause mortality, renal function indexes, C-reactive protein (CRP), and vascular/bone health indexes were extracted and analyzed. A total of seven studies with 1,101 patients in the experimental group and 651 patients in the control group were included. All-cause mortality was decreased in the experimental group vs. the control group [relative risk (95% confidence interval (CI)]: 0.72 (0.60-0.86), P<0.001]. Regarding renal function indexes, the estimated glomerular filtration rate was increased in the experimental group vs. the control group [mean difference (95% CI): 9.87 (1.48-18.26), P=0.021]; while creatinine and albumin remained unchanged between the two groups (both P>0.05). Moreover, CRP, systolic blood pressure, diastolic blood pressure, triglycerides, hemoglobin, calcium, and 25-hydroxyvitamin D were unchanged between the two groups (all P>0.05). Publication bias was low, and the robustness assessed by sensitivity analysis was generally acceptable. Thus vitamin K exerted a potential implication in reducing all-cause mortality and improving renal function in patients receiving kidney transplantation.
    Language English
    Publishing date 2023-11-23
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2023.12318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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