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Article: [Correlation of prostate-specific antigen with the progression and metastasis of human prostate cancer].

Zhang, Shu-Jiang / Sun, Zu-Yue

Zhonghua nan ke xue = National journal of andrology

2018 Volume 24, Issue 5, Page(s) 457–461

Abstract: Prostate-specific antigen (PSA) is a biomarker for the diagnosis and management of prostate cancer and involved in the development of prostate cancer and/or its progression from the localized to the metastatic stage. This review presents an overview of ... ...

Abstract	Prostate-specific antigen (PSA) is a biomarker for the diagnosis and management of prostate cancer and involved in the development of prostate cancer and/or its progression from the localized to the metastatic stage. This review presents an overview of the roles of PSA in promoting the progression and metastasis of human prostate cancer and its underlying mechanisms, including its serine protease activity, interaction with the cellular membrane receptor, and suppression of specific immune responsiveness, and also points out some of the key problems to be solved.
MeSH term(s)	Disease Progression ; Humans ; Male ; Neoplasm Metastasis ; Prostate-Specific Antigen/physiology ; Prostatic Neoplasms/pathology
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	Chinese
Publishing date	2018-11-05
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Inhibitory Effect of Astaxanthin on Testosterone-Induced Benign Prostatic Hyperplasia in Rats

Wang, Liping / Hou, Yiwen / Wang, Rong / Pan, Qi / Li, Debao / Yan, Han / Sun, Zuyue

Marine drugs. 2021 Nov. 23, v. 19, no. 12

2021

Abstract: This study investigates the inhibitory effect of astaxanthin (AST) on testosterone-induced benign prostatic hyperplasia (BPH) in rats. Except for the sham operation, BPH model rats were randomly assigned to five groups: the BPH model control rats, AST- ... ...

Abstract	This study investigates the inhibitory effect of astaxanthin (AST) on testosterone-induced benign prostatic hyperplasia (BPH) in rats. Except for the sham operation, BPH model rats were randomly assigned to five groups: the BPH model control rats, AST-treated BPH model rats (20 mg/kg, 40 mg/kg, and 80 mg/kg), and epristeride (EPR)-treated BPH model rats. After treatment, as compared with the BPH model control rats, the prostate and ventral prostate weights of the AST-treated rats decreased, while there was a marked decline in the 80 mg/kg AST-treated rats. The same effect was also observed in the prostate index and ventral prostate index. The proliferation characteristics of epithelia observed in the BPH model control group were gradually alleviated in the AST-treated rats. As compared with the BPH model control rats, lower epithelial thicknesses of prostates and fewer secretory granules in epithelia were observed in the AST-treated rats. The superoxide dismutase (SOD) activity of prostates increased in all the AST-treated rats with a significant increase in the 40 mg/kg and 80 mg/kg AST-treated rats. The testosterone (T) and dihydrotestosterone (DHT) levels of prostates in the AST-treated groups were lower than those in the BPH model control group, and a significant decline was found in the T level of prostates in the 40 g/kg and 80 mg/kg AST-treated rats and the DHT level of prostates in the 40 mg/kg AST-treated rats. These results indicate that AST might have an inhibitory effect on T-induced BPH in rats, possibly due to SOD activity regulation and T and DHT levels.
Keywords	astaxanthin ; dihydrotestosterone ; epithelium ; hyperplasia ; superoxide dismutase ; testosterone
Language	English
Dates of publication	2021-1123
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2175190-0
ISSN	1660-3397
ISSN	1660-3397
DOI	10.3390/md19120652
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Inhibitory Effect of Astaxanthin on Testosterone-Induced Benign Prostatic Hyperplasia in Rats.

Wang, Liping / Hou, Yiwen / Wang, Rong / Pan, Qi / Li, Debao / Yan, Han / Sun, Zuyue

Marine drugs

2021 Volume 19, Issue 12

Abstract	This study investigates the inhibitory effect of astaxanthin (AST) on testosterone-induced benign prostatic hyperplasia (BPH) in rats. Except for the sham operation, BPH model rats were randomly assigned to five groups: the BPH model control rats, AST-treated BPH model rats (20 mg/kg, 40 mg/kg, and 80 mg/kg), and epristeride (EPR)-treated BPH model rats. After treatment, as compared with the BPH model control rats, the prostate and ventral prostate weights of the AST-treated rats decreased, while there was a marked decline in the 80 mg/kg AST-treated rats. The same effect was also observed in the prostate index and ventral prostate index. The proliferation characteristics of epithelia observed in the BPH model control group were gradually alleviated in the AST-treated rats. As compared with the BPH model control rats, lower epithelial thicknesses of prostates and fewer secretory granules in epithelia were observed in the AST-treated rats. The superoxide dismutase (SOD) activity of prostates increased in all the AST-treated rats with a significant increase in the 40 mg/kg and 80 mg/kg AST-treated rats. The testosterone (T) and dihydrotestosterone (DHT) levels of prostates in the AST-treated groups were lower than those in the BPH model control group, and a significant decline was found in the T level of prostates in the 40 g/kg and 80 mg/kg AST-treated rats and the DHT level of prostates in the 40 mg/kg AST-treated rats. These results indicate that AST might have an inhibitory effect on T-induced BPH in rats, possibly due to SOD activity regulation and T and DHT levels.
MeSH term(s)	Animals ; Aquatic Organisms ; Disease Models, Animal ; Fishes ; Male ; Prostate/drug effects ; Prostatic Hyperplasia/chemically induced ; Prostatic Hyperplasia/prevention & control ; Rats ; Rats, Sprague-Dawley ; Specific Pathogen-Free Organisms ; Testosterone ; Xanthophylls/chemistry ; Xanthophylls/pharmacology
Chemical Substances	Xanthophylls ; Testosterone (3XMK78S47O) ; astaxanthine (8XPW32PR7I)
Language	English
Publishing date	2021-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md19120652
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Gene regulation of prostaglandin synthase and prostate diseases].

Wu, Shuang-Shuang / Wu, Jian-Hui / Sun, Zu-Yue

Zhonghua nan ke xue = National journal of andrology

2018 Volume 23, Issue 7, Page(s) 663–667

Abstract: Prostaglandin synthase (PGS) can catalyze the production of various types of prostaglandins and regulate the expression levels of related substances. The regulation mechanisms of the PGS gene are closely related with the occurrence and development of ... ...

Abstract	Prostaglandin synthase (PGS) can catalyze the production of various types of prostaglandins and regulate the expression levels of related substances. The regulation mechanisms of the PGS gene are closely related with the occurrence and development of prostate diseases. However, few studies are reported on the regulation mechanisms of PGS in prostatic diseases, such as benign prostatic hyperplasia (BPH) and prostate cancer (PCa), or on the relationship between PGS gene regulation and prostate diseases. This review aims to analyze their correlation and provide some ideas for the prevention and control of BPH and PCa by intervention of the prostaglandin synthase regulatory pathway.
MeSH term(s)	Gene Expression Regulation ; Humans ; Male ; Prostaglandin-Endoperoxide Synthases/genetics ; Prostaglandin-Endoperoxide Synthases/physiology ; Prostatic Hyperplasia/enzymology ; Prostatic Hyperplasia/genetics ; Prostatic Hyperplasia/prevention & control ; Prostatic Neoplasms/enzymology ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/prevention & control
Chemical Substances	Prostaglandin-Endoperoxide Synthases (EC 1.14.99.1)
Language	Chinese
Publishing date	2018-05-03
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Establishment of an in vitro screening model for steroid 5 alpha-reductase inhibitors with the microplate reader].

Wu, Jian-Hui / Sun, Zu-Yue

Zhonghua nan ke xue = National journal of andrology

2013 Volume 19, Issue 6, Page(s) 483–486

Abstract: Objective: To establish an in vitro screening model for steroid 5 alpha-reductase inhibitors using the microplate reader.: Methods: Steroid 5 alpha-reductase was obtained from the liver of female rats, an in vitro screening model for steroid 5 alpha- ... ...

Abstract	Objective: To establish an in vitro screening model for steroid 5 alpha-reductase inhibitors using the microplate reader. Methods: Steroid 5 alpha-reductase was obtained from the liver of female rats, an in vitro screening model for steroid 5 alpha-reductase inhibitors established using the 96-well plate and microplate reader after determination of the enzymatic activity, and the reliability of the model verified with the known 5 alpha-reductase inhibitors epristeride and finasteride. Added to the 96-well plate were the final concentrations of testosterone (0-40 micromol/L), NADPH (22 micromol/L), epristeride (0-60 nmol/L) or finasteride (0-60 nmol/ L) and steroid 5 alpha-reductase (20 microl), the total volume of each well adjusted to 200 microl with Tris-Hcl buffer. The 96-well plate was placed in the microplate reader, mixed and incubated at 37 degrees C, followed by detection of the A340nm value at 0 and 10 min and analysis of the data. Results: The Km value of steroid 5 alpha-reductase was 3.794 micromol/L, with a Vmax of 0.271 micromol/(L. min). The Ki of epristeride was 148.2 nmol/L, with an IC50 of 31.5 nmol/L, and the enzymatic reaction kinetic curve suggested that epristeride was an uncompetitive enzyme inhibitor. The Ki of finasteride was 158. 8 nmol/L, with an IC50 of 13.6 nmol/L. The enzymatic reaction kinetic curve showed that both epristeride and finasteride were competitive enzyme inhibitors, similar to those reported in the published literature. Conclusion: A screening model was successfully established, which could rapidly and effectively screen steroid 5 alpha-reductase inhibitors in vitro.
MeSH term(s)	5-alpha Reductase Inhibitors/analysis ; Animals ; Drug Evaluation, Preclinical/methods ; Female ; High-Throughput Screening Assays/instrumentation ; High-Throughput Screening Assays/methods ; Immunoenzyme Techniques ; Rats ; Rats, Sprague-Dawley
Chemical Substances	5-alpha Reductase Inhibitors
Language	Chinese
Publishing date	2013-06
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Qilin Pill Exerts Therapeutic Effect on Resection-Induced Premature Ovarian Insufficiency Rats by Inhibiting the MAPK and PI3K-AKT Signaling Pathways.

Li, Debao / Jia, Yuling / Hou, Yiwen / Chen, Dingshi / Zheng, Chiyang / Chen, Lifen / Zhou, Li / Sun, Zuyue

Drug design, development and therapy

2021 Volume 15, Page(s) 3331–3345

Abstract: Background: The Qilin pill (QLP) is a traditional Chinese compound prescription comprising 15 herbs that has demonstrated significant therapeutic effects on premature ovarian insufficiency (POI) in recent years. However, a pharmacological evaluation of ... ...

Abstract	Background: The Qilin pill (QLP) is a traditional Chinese compound prescription comprising 15 herbs that has demonstrated significant therapeutic effects on premature ovarian insufficiency (POI) in recent years. However, a pharmacological evaluation of QLP on ovarian function remains to be conducted, and the key mechanism of QLP treatment on POI is unclear. Methods: Premature ovarian insufficiency rats were established by bilateral partial ovariectomy. The model rats were administrated with low (QLP-L), medium (QLP-M) and high (QLP-H) doses of QLP for 4 weeks to evaluate the ovarian function in terms of estrous cycle, hormone level, and follicle count. The mechanism of QLP in the treatment of POI was systematically explored by network pharmacology, and expression levels of the MAPK and PI3K-AKT signaling pathways were verified by Western blotting and molecular docking. Results: The rat model of resection-induced POI was successfully established, and QLP could significantly recover the estrous cycle, decrease serum FSH levels, and decelerate follicle depletion after 4 weeks of administration. The optimal dose of QLP in the experiment was preliminarily determined to be 0.9 g/kg. Based on the network pharmacology methods, we constructed the compound-target network and protein protein interaction (PPI) network of QLP for the treatment of POI. The experimental verification of the enrichment analysis showed that QLP inhibited the MAPK and PI3K-AKT signaling pathways, and the key compounds and key targets involved were verified by molecular docking. Conclusion: QLP exerted significant therapeutic effects on resection-induced POI rats, and this was achieved by the inhibition of the MAPK and PI3K-AKT signaling pathways. This study is the first to systematically investigate the effects and mechanism of QLP on POI rats, which will provide valuable guidance in clinic.
MeSH term(s)	Animals ; Drugs, Chinese Herbal/pharmacology ; Female ; MAP Kinase Signaling System/drug effects ; Molecular Docking Simulation ; Network Pharmacology ; Ovariectomy ; Phosphatidylinositol 3-Kinase/metabolism ; Primary Ovarian Insufficiency/drug therapy ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects
Chemical Substances	Drugs, Chinese Herbal ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2021-07-30
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S321010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Establishment of an in vitro method of rabbit embryo toxicity with toxicokinetics study.

Zhu, Qiuyang / Jia, Yuling / Guo, Jun / Meng, Xiang / Chong, Liming / Xu, Li / Zhou, Li / Sun, Zuyue

Journal of applied toxicology : JAT

2021 Volume 42, Issue 3, Page(s) 380–391

Abstract: This report introduces a novel method, rabbit whole embryo culture (WEC) combined with toxicokinetics (TK), for toxicity testing. Rodent WEC has been extensively used for in vitro screening of developmental toxicity. To improve the reliability of in ... ...

Abstract	This report introduces a novel method, rabbit whole embryo culture (WEC) combined with toxicokinetics (TK), for toxicity testing. Rodent WEC has been extensively used for in vitro screening of developmental toxicity. To improve the reliability of in vitro data, it is important to consider TK and species specificity. To test the utility and effectiveness of this method, we investigated the toxic effect of thalidomide on rabbit embryos and its behavior in test systems both in vitro and in vivo under the same experimental condition. The data showed that thalidomide induced embryo malformations such as embryonic brain hypoplasia, short limb buds, and declined embryonic growth both in vitro and in vivo. The toxic effect increased with the increasing exposure of the embryo to thalidomide. In addition, we observed similar toxic effects and exposure-effect relationships in vivo and in vitro. Therefore, we preliminarily conclude that this new method can effectively predict and explain thalidomide toxicity. Furthermore, we investigated the behavior of test compounds in the WEC system for the first time, and this method is expected to be an important technique for in vitro toxicity study after extensive verification.
MeSH term(s)	Animals ; Embryo, Mammalian/drug effects ; In Vitro Techniques/methods ; Rabbits ; Reproducibility of Results ; Teratogens/toxicity ; Toxicity Tests/instrumentation ; Toxicity Tests/methods ; Toxicokinetics
Chemical Substances	Teratogens
Language	English
Publishing date	2021-07-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604625-3
ISSN	1099-1263 ; 0260-437X
ISSN (online)	1099-1263
ISSN	0260-437X
DOI	10.1002/jat.4223
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Research progress in mechanism of traditional Chinese medicine treatment of polycystic ovary syndrome].

Zhou, Xian-Ying / Zhou, Li / Sun, Zu-Yue

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2016 Volume 41, Issue 20, Page(s) 3715–3720

Abstract: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder, which is characterized by hyperandrogenism, insulin resistance and chronic anovulation, and has become a serious threat to the health of adolescents and women of childbearing age.At ... ...

Abstract	Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder, which is characterized by hyperandrogenism, insulin resistance and chronic anovulation, and has become a serious threat to the health of adolescents and women of childbearing age.At present,lowering androgen, improving insulin resistance and inducing ovulation are the main methods adopted by doctors to treat the disease, but the adverse reactions of the western medicine and the long-term treatment are hard to be accepted by the patients. PCOS treated by traditional Chinese medicine has achieved a certain effect in recent years.Traditional Chinese medicine is relatively safe and has more effect in many links and targets in improving the symptom of endocrine and metabolic disorder in patients with PCOS. This paper expounds the traditional Chinese medicine pathogenesis of PCOS through clinical and experimental aspects of the literature research：correcting endocrine hormone disorder,the effects of the expression of gene and regulatory factors,improving insulin resistance,correcting lipid metabolic disorder,improving the pregnancy outcome and improving ovarian morphology to summarize the treatment of traditional Chinese medicine in PCOS research results in recent years.
Language	Chinese
Publishing date	2016-10
Publishing country	China
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.4268/cjcmm20162003
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Zs.A 3056: Show issues

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Article ; Online: Oral exposure to low-dose bisphenol A induces hyperplasia of dorsolateral prostate and upregulates EGFR expression in adult

Wu, Shuangshuang / Huang, Dongyan / Su, Xin / Yan, Han / Wu, Jianhui / Sun, Zuyue

Toxicology and industrial health

2019 Volume 35, Issue 10, Page(s) 647–659

Abstract: Prostate is sensitive to endocrine hormone level, and the synergetic effect of estrogen and androgen is critical in prostate growth. The change of signal pathways caused by the imbalance of estrogen and androgen might function in the occurrence of ... ...

Abstract	Prostate is sensitive to endocrine hormone level, and the synergetic effect of estrogen and androgen is critical in prostate growth. The change of signal pathways caused by the imbalance of estrogen and androgen might function in the occurrence of prostate diseases. As a well-known endocrine disruptor compound, bisphenol A (BPA) can disturb the normal function of endocrine hormone and affect prostate development. This study aims to investigate effects of BPA on the dorsolateral prostate (DLP) and the related gene expression of the tissue in adult
MeSH term(s)	Animals ; Benzhydryl Compounds/pharmacology ; Dose-Response Relationship, Drug ; Endocrine Disruptors/pharmacology ; ErbB Receptors/biosynthesis ; Hyperplasia ; Male ; Phenols/pharmacology ; Prostate/drug effects ; Rats ; Rats, Sprague-Dawley ; Testosterone/metabolism ; Up-Regulation
Chemical Substances	Benzhydryl Compounds ; Endocrine Disruptors ; Phenols ; Testosterone (3XMK78S47O) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2019-11-27
Publishing country	England
Document type	Journal Article
ZDB-ID	56831-4
ISSN	1477-0393 ; 0748-2337
ISSN (online)	1477-0393
ISSN	0748-2337
DOI	10.1177/0748233719885565
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Article: Effects of low dose of bisphenol A on the proliferation and mechanism of primary cultured prostate epithelial cells in rodents.

Huang, Dongyan / Wu, Jianhui / Su, Xin / Yan, Han / Sun, Zuyue

Oncology letters

2017 Volume 14, Issue 3, Page(s) 2635–2642

Abstract: Bisphenol A (BPA) is a well-known endocrine disruptor compound (EDC) that aggravates testosterone-induced benign prostate hyperplasia by increasing the relative weight of the ventral and dorsolateral prostate in rats. This phenomenon is primarily ... ...

Abstract	Bisphenol A (BPA) is a well-known endocrine disruptor compound (EDC) that aggravates testosterone-induced benign prostate hyperplasia by increasing the relative weight of the ventral and dorsolateral prostate in rats. This phenomenon is primarily attributed to the exogenous estrogen effect of BPA. However, the direct effect of BPA on prostate cells has not been characterized. The present study investigated the proliferative effect and possible mechanisms of action of BPA on the prostatic epithelium of rats. The ventral prostate epithelial cells were cultured
Language	English
Publishing date	2017-06-23
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2017.6469
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