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Article ; Online: Emergence of Novel Norovirus GII.4 Variant

Preeti Chhabra / Damien C. Tully / Janet Mans / Sandra Niendorf / Leslie Barclay / Jennifer L. Cannon / Anna M. Montmayeur / Chao-Yang Pan / Nicola Page / Rachel Williams / Helena Tutill / Sunando Roy / Cristina Celma / Stuart Beard / Michael L. Mallory / Gédéon Prince Manouana / Thirumalaisamy P. Velavan / Ayola Akim Adegnika / Peter G. Kremsner /

Lisa C. Lindesmith / Stéphane Hué / Ralph S. Baric / Judith Breuer / Jan Vinjé

Emerging Infectious Diseases, Vol 30, Iss 1, Pp 163-

2024 Volume 167

Abstract: We detected a novel GII.4 variant with an amino acid insertion at the start of epitope A in viral protein 1 of noroviruses from the United States, Gabon, South Africa, and the United Kingdom collected during 2017–2022. Early identification of GII.4 ... ...

Abstract	We detected a novel GII.4 variant with an amino acid insertion at the start of epitope A in viral protein 1 of noroviruses from the United States, Gabon, South Africa, and the United Kingdom collected during 2017–2022. Early identification of GII.4 variants is crucial for assessing pandemic potential and informing vaccine development.
Keywords	norovirus ; viruses ; enteric infections ; acute gastroenteritis ; United States ; United Kingdom ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Centers for Disease Control and Prevention
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Molecular characterization of a human G20P[28] rotavirus a strain with multiple genes related to bat rotaviruses

Esona, Mathew D / Gloria Rey-Benito / Kunchala Rungsrisuriyachai / Michael D. Bowen / Rashi Gautam / Sandra Hermelijn / Sunando Roy

Infection, genetics, and evolution. 2018 Jan., v. 57

2018

Abstract: Group A rotaviruses are the major cause of severe gastroenteritis in the young of mammals and birds. This report describes characterization of an unusual G20P[28] rotavirus strain detected in a 24month old child from Suriname. Genomic sequence analyses ... ...

Abstract	Group A rotaviruses are the major cause of severe gastroenteritis in the young of mammals and birds. This report describes characterization of an unusual G20P[28] rotavirus strain detected in a 24month old child from Suriname. Genomic sequence analyses revealed that the genotype constellation of the Suriname strain RVA/Human-wt/SUR/2014735512/2013/G20P[28] was G20-P[28]-I13-R13-C13-M12-A23-N13-T15-E20-H15. Genes VP1, VP2, VP3, NSP1, NSP2, NSP3, NSP4 and NSP5 were recently assigned novel genotypes by the Rotavirus Classification Working Group (RCWG). Three of the 11 gene segments (VP7, VP4, VP6) were similar to cognate gene sequences of bat-like human rotavirus strain Ecu534 from Ecuador and the VP7, NSP3 and NSP5 gene segments of strain RVA/Human-wt/SUR/2014735512/2013/G20P[28] were found to be closely related to gene sequences of bat rotavirus strain 3081/BRA detected in Brazil. Although distantly related, the VP1 gene of the study strain and bat strain BatLi09 detected in Cameroon in 2014 are monophyletic. The NSP1 gene was found to be most closely related to human strain QUI-35-F5 from Brazil. These findings suggest that strain RVA/Human-wt/SUR/2014735512/2013/G20P[28] represents a zoonotic infection from a bat host.
Keywords	birds ; children ; Chiroptera ; gastroenteritis ; genes ; genotype ; humans ; monophyly ; nucleotide sequences ; Rotavirus A ; sequence analysis ; zoonoses ; Brazil ; Cameroon ; Ecuador ; Suriname
Language	English
Dates of publication	2018-01
Size	p. 166-170.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2037068-4
ISSN	1567-1348
ISSN	1567-1348
DOI	10.1016/j.meegid.2017.11.025
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Detection of Norovirus Variant GII.4 Hong Kong in Asia and Europe, 2017−2019

Martin Chi-Wai Chan / Sunando Roy / Joseph Bonifacio / Lin-Yao Zhang / Preeti Chhabra / Jenny C.M. Chan / Cristina Celma / Mary Ann Igoy / Sin-Leung Lau / Kirran N. Mohammad / Jan Vinjé / Harry Vennema / Judith Breuer / Marion Koopmans / Miranda de Graaf

Emerging Infectious Diseases, Vol 27, Iss 1, Pp 289-

2021 Volume 293

Abstract: We report a new norovirus GII.4 variant, GII.4 Hong Kong, with low-level circulation in 4 Eurasia countries since mid-2017. Amino acid substitutions in key residues on the virus capsid associated with the emergence of pandemic noroviruses suggest that ... ...

Abstract	We report a new norovirus GII.4 variant, GII.4 Hong Kong, with low-level circulation in 4 Eurasia countries since mid-2017. Amino acid substitutions in key residues on the virus capsid associated with the emergence of pandemic noroviruses suggest that GII.4 Hong Kong has the potential to become the next pandemic variant.
Keywords	norovirus ; viruses ; norovirus GII.4 ; new variant ; surveillance ; gastroenteritis ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Centers for Disease Control and Prevention
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Protocol for the COG-UK hospital-onset COVID-19 infection (HOCI) multicentre interventional clinical study

BMJ Open, Vol 12, Iss

evaluating the efficacy of rapid genome sequencing of SARS-CoV-2 in limiting the spread of COVID-19 in UK NHS hospitals

2022 Volume 4

Keywords	Medicine ; R
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The emerging GII.P16-GII.4 Sydney 2012 norovirus lineage is circulating worldwide, arose by late-2014 and contains polymerase changes that may increase virus transmission.

Christopher Ruis / Sunando Roy / Julianne R Brown / David J Allen / Richard A Goldstein / Judith Breuer

PLoS ONE, Vol 12, Iss 6, p e

2017 Volume 0179572

Abstract: Noroviruses are a leading cause of human gastroenteritis worldwide. The norovirus genotype GII.4 is the most prevalent genotype in the human population and has caused six pandemics since 1995. A novel norovirus lineage containing the GII.P16 polymerase ... ...

Abstract	Noroviruses are a leading cause of human gastroenteritis worldwide. The norovirus genotype GII.4 is the most prevalent genotype in the human population and has caused six pandemics since 1995. A novel norovirus lineage containing the GII.P16 polymerase and pandemic GII.4 Sydney 2012 capsid was recently detected in Asia and Germany. We demonstrate that this lineage is also circulating within the UK and USA and has been circulating since October 2014 or earlier. While the lineage does not contain unique substitutions in the capsid, it does contain polymerase substitutions close to positions known to influence polymerase function and virus transmission. These polymerase substitutions are shared with a GII.P16-GII.2 virus that dominated outbreaks in Germany in Winter 2016. We suggest that the substitutions in the polymerase may have resulted in a more transmissible virus and the combination of this polymerase and the pandemic GII.4 capsid may result in a highly transmissible virus. Further surveillance efforts will be required to determine whether the GII.P16-GII.4 Sydney 2012 lineage increases in frequency over the coming months.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mixed cytomegalovirus genotypes in HIV-positive mothers show compartmentalization and distinct patterns of transmission to infants

Juanita Pang / Jennifer A Slyker / Sunando Roy / Josephine Bryant / Claire Atkinson / Juliana Cudini / Carey Farquhar / Paul Griffiths / James Kiarie / Sofia Morfopoulou / Alison C Roxby / Helena Tutil / Rachel Williams / Soren Gantt / Richard A Goldstein / Judith Breuer

eLife, Vol

2020 Volume 9

Abstract: Cytomegalovirus (CMV) is the commonest cause of congenital infection and particularly so among infants born to HIV-infected women. Studies of congenital CMV infection (cCMVi) pathogenesis are complicated by the presence of multiple infecting maternal CMV ...

Abstract	Cytomegalovirus (CMV) is the commonest cause of congenital infection and particularly so among infants born to HIV-infected women. Studies of congenital CMV infection (cCMVi) pathogenesis are complicated by the presence of multiple infecting maternal CMV strains, especially in HIV-positive women, and the large, recombinant CMV genome. Using newly developed tools to reconstruct CMV haplotypes, we demonstrate anatomic CMV compartmentalization in five HIV-infected mothers and identify the possibility of congenitally transmitted genotypes in three of their infants. A single CMV strain was transmitted in each congenitally infected case, and all were closely related to those that predominate in the cognate maternal cervix. Compared to non-transmitted strains, these congenitally transmitted CMV strains showed statistically significant similarities in 19 genes associated with tissue tropism and immunomodulation. In all infants, incident superinfections with distinct strains from breast milk were captured during follow-up. The results represent potentially important new insights into the virologic determinants of early CMV infection.
Keywords	cytomegalovirus ; congenital ; transmission ; genome ; sequencing ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Study of P. falciparum-infected erythrocytes and induced anisotropies under optical and fluid forces

Sunando Roy / Jayashree Dharmadhikari / Aditya Dharmadhikari / Deepak Mathur / Shobhona Sharma

Journal of Vector Borne Diseases, Vol 44, Iss 1, Pp 23-

2007 Volume 32

Abstract: Background & objectives: The effect of P. falciparum on erythrocytes has been studied for a longtime at the population level but actual studies at the single cell level remain largely unexplored. Theaim of this study was to address the host-parasite ... ...

Abstract	Background & objectives: The effect of P. falciparum on erythrocytes has been studied for a longtime at the population level but actual studies at the single cell level remain largely unexplored. Theaim of this study was to address the host-parasite relationship at the single cell level under twodifferent kinds of forces, an optical force and a fluid force. The questions addressed were about thebasic host-parasite interactions, but our findings have larger implications in diverse fields of parasitebiology.Methods: Erythrocytes were monitored under optical forces (using optical tweezers) and fluid forces(using microfluidic chambers) and dynamical images were captured in real-time video clips. Thesevideos were then split into their respective frames so as to yield temporal information and variousparameters pertaining to membrane structure, ionic imbalance and interaction with different forceswere studied.Results: The results of this study mainly bring to fore the inherent differences between infected andnormal cell populations at the single cell level under various external forces. We probed three differentcriteria folding times, rotation speeds and rolling frequency to show inherent difference in variouscell populations and also the dependence of the above to the cycle of the parasite.Interpretation & conclusion: This study portrays the importance of single cell observations pertainingto the host-parasite relationship. It shows the effect the malarial parasite has on erythrocytes and howthe intrinsic property of the infected and its neighbouring uninfected cells change as compared tonormal erythrocytes. There are thus implications in the fields of cytoadherence, parasite invasionsand host immune evasion.
Keywords	Cytoadherence ; flow cell ; malaria-infected red blood cells ; optical laser tweezer ; red blood cells (RBC) ; rolling ; Public aspects of medicine ; RA1-1270 ; Medicine ; R ; DOAJ:Public Health ; DOAJ:Health Sciences
Language	English
Publishing date	2007-03-01T00:00:00Z
Publisher	National Institute of Malaria Research
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Full genomic characterization and phylogenetic analysis of a zoonotic human G8P[14] rotavirus strain detected in a sample from Guatemala

Gautam, Rashi / Slavica Mijatovic-Rustempasic / Sunando Roy / Mathew D. Esona / Beatriz Lopez / Yolanda Mencos / Gloria Rey-Benito / Michael D. Bowen

Infection, Genetics and Evolution. 2015 July, v. 33

2015

Abstract: We report the genomic characterization of a rare human G8P[14] rotavirus strain, identified in a stool sample from Guatemala (GTM) during routine rotavirus surveillance. This strain was designated as RVA/Human-wt/GTM/2009726790/2009/G8P[14], with a ... ...

Abstract	We report the genomic characterization of a rare human G8P[14] rotavirus strain, identified in a stool sample from Guatemala (GTM) during routine rotavirus surveillance. This strain was designated as RVA/Human-wt/GTM/2009726790/2009/G8P[14], with a genomic constellation of G8-P[14]-I2-R2-C2-M2-A13-N2-T6-E2-H3. The VP4 gene occupied lineage VII within the P[14] genotype. Phylogenetic analysis of each genome segment revealed close relatedness to several zoonotic simian, guanaco and bovine strains. Our findings suggest that strain RVA/Human-wt/GTM/2009726790/2009/G8P[14] is an example of a direct zoonotic transmission event. The results of this study reinforce the potential role of interspecies transmission and reassortment in generating novel and rare rotavirus strains which infect humans.
Keywords	Lama guanicoe ; cattle ; disease transmission ; feces ; genes ; genotype ; humans ; monitoring ; phylogeny ; Guatemala
Language	English
Dates of publication	2015-07
Size	p. 206-211.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2037068-4
ISSN	1567-1348
ISSN	1567-1348
DOI	10.1016/j.meegid.2015.05.004
Database	NAL-Catalogue (AGRICOLA)

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Article: Full genomic characterization of a novel genotype combination, G4P[14], of a human rotavirus strain from Barbados

Tam, Ka Ian / Sunando Roy / Mathew D. Esona / Starlene Jones / Stephanie Sobers / Victoria Morris-Glasgow / Gloria Rey-Benito / Jon R. Gentsch / Michael D. Bowen

Infection, Genetics and Evolution. 2014 Dec., v. 28

2014

Abstract: Since 2004, the Pan American Health Organization (PAHO) has carried out rotavirus surveillance in Latin America and the Caribbean. Here we report the characterization of human rotavirus with the novel GâP combination of G4P[14], detected through PAHO ... ...

Abstract	Since 2004, the Pan American Health Organization (PAHO) has carried out rotavirus surveillance in Latin America and the Caribbean. Here we report the characterization of human rotavirus with the novel GâP combination of G4P[14], detected through PAHO surveillance in Barbados. Full genome sequencing of strain RVA/Human-wt/BRB/CDC1133/2012/G4P[14] revealed that its genotype is G4-P[14]-I1-R1-C1-M1-A8-N1-T1-E1-H1. The possession of a Genogroup 1 (Wa-like) backbone distinguishes this strain from other P[14] rotavirus strains. Phylogenetic analyses suggested that this strain was likely generated by genetic reassortment between human, porcine and possibly other animal rotavirus strains and identified 7 lineages within the P[14] genotype. The results of this study reinforce the potential role of interspecies transmission in generating human rotavirus diversity through reassortment. Continued surveillance is important to determine if rotavirus vaccines will protect against strains that express the P[14] rotavirus genotype.
Keywords	Rotavirus ; disease transmission ; genotype ; humans ; monitoring ; phylogeny ; sequence analysis ; swine ; vaccines ; Barbados ; Caribbean ; Latin America
Language	English
Dates of publication	2014-12
Size	p. 524-529.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2037068-4
ISSN	1567-1348
ISSN	1567-1348
DOI	10.1016/j.meegid.2014.09.020
Database	NAL-Catalogue (AGRICOLA)

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Article: Molecular characterization of the first G24P[14] rotavirus strain detected in humans

Ward, M. Leanne / Carol J. Baker / Daniel C. Payne / Julie A. Boom / Kunchala Rungsrisuriyachai / Leila C. Sahni / Marcia A. Rench / Mary E. Wikswo / Michael D. Bowen / Slavica Mijatovic-Rustempasic / Sunando Roy / Umesh D. Parashar

Infection, genetics, and evolution. 2016 Sept., v. 43

2016

Abstract: Here we report the genome of a novel rotavirus A (RVA) strain detected in a stool sample collected during routine surveillance by the Centers for Disease Control and Prevention's New Vaccine Surveillance Network. The strain, RVA/human-wt/USA/2012741499/ ... ...

Abstract	Here we report the genome of a novel rotavirus A (RVA) strain detected in a stool sample collected during routine surveillance by the Centers for Disease Control and Prevention's New Vaccine Surveillance Network. The strain, RVA/human-wt/USA/2012741499/2012/G24P[14], has a genomic constellation of G24-P[14]-I2-R2-C2-M2-A3-N2-T9-E2-H3. The VP2, VP3, VP7 and NSP3 genes cluster phylogenetically with bovine strains. The other genes occupy mixed clades containing animal and human strains. Strain RVA/human-wt/USA/2012741499/2012/G24P[14] most likely is the product of interspecies transmission and reassortment events. This is the second report of the G24 genotype and the first report of the G24P[14] genotype combination in humans.
Keywords	cattle ; Centers for Disease Control and Prevention ; disease transmission ; feces ; genes ; genotype ; humans ; monitoring ; phylogeny ; Rotavirus A ; vaccines
Language	English
Dates of publication	2016-09
Size	p. 338-342.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2037068-4
ISSN	1567-1348
ISSN	1567-1348
DOI	10.1016/j.meegid.2016.05.033
Database	NAL-Catalogue (AGRICOLA)

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