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  1. AU="Sundar, Rajesh S"
  2. AU=Ahmed Marwan A.
  3. AU="Zevini, Alessandra"
  4. AU="Martin de Bustamante, Michelle"
  5. AU="Wurster, Claudia D"
  6. AU="Sillos, E M"
  7. AU="Vu An Do"
  8. AU=Rockstroh J K AU=Rockstroh J K
  9. AU="Ma, Di"
  10. AU="Chahine, A Alfred"
  11. AU=Pruimboom Leo
  12. AU="Naama, Moriyah"
  13. AU=Khan Israr
  14. AU="Ansary, Delwar"
  15. AU="Gamerra, Mario"
  16. AU="Eric M. Yoshida"
  17. AU="Raj, Rahul"
  18. AU="Semaan, Marie"
  19. AU="Trafton, Jodie"
  20. AU="Victoria Walker-Sperling"
  21. AU="Song, Wuqi"
  22. AU="Pham, K.‐C"
  23. AU="Boria Alegre, Felix"
  24. AU="Vecsey-Nagy, Milán"
  25. AU=Bazak Remon
  26. AU="Shaaban, Mahmoud"
  27. AU="Perminow, Gøri"
  28. AU="Akrim, Faraz"
  29. AU="Haider, Najm"
  30. AU="Jain, Divyanu"
  31. AU="Halpert, Richard"
  32. AU="Alkorta, Ibon"
  33. AU="Kwon, Kyungmi"
  34. AU="Bernardo Salasnich"
  35. AU="Hassan, Zurina"
  36. AU="Belarbi, M"
  37. AU="Rout, Ranjeet K"
  38. AU="Moreira, Catarina"
  39. AU=Warn-Cramer Bonnie J
  40. AU="Morral, Núria"
  41. AU="Silman, Miles R."
  42. AU="Palfi Salavat, Mădălina-Casiana"
  43. AU="Mohamed, Eid"
  44. AU="Hudson, Lance"
  45. AU="Imane Mihoub" AU="Imane Mihoub"
  46. AU="D. M. Wuchenich"

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  1. Artikel ; Online: Comparison of different QT correction methods for nonclinical safety assessment in ketamine-anesthetized Indian rhesus monkeys (

    Bhatt, Laxit K / Shah, Chitrang R / Patel, Rajesh J / Patel, Shital D / Patel, Sudhir R / Patel, Vipul A / Patel, Jitendra H / Dwivedi, Pankaj / Shah, Niraj A / Sundar, Rajesh S / Jain, Mukul R

    Toxicology mechanisms and methods

    2023  Band 33, Heft 6, Seite(n) 490–501

    Abstract: Rhesus monkeys are a non-rodent species employed in the preclinical safety evaluation of pharmaceuticals and biologics. These nonhuman primate species have been increasingly used in biomedical research because of the similarity in their ionic mechanisms ... ...

    Abstract Rhesus monkeys are a non-rodent species employed in the preclinical safety evaluation of pharmaceuticals and biologics. These nonhuman primate species have been increasingly used in biomedical research because of the similarity in their ionic mechanisms of repolarization with humans. Heart rate and QT interval are two primary endpoints in determining the pro-arrhythmic risk of drugs. As heart rate and QT interval have an inverse relationship, any change in heart rate causes a subsequent change in QT interval. This warrants for calculation of a corrected QT interval. This study aimed to identify an appropriate formula that best corrected QT for change in heart rate. We employed seven formulas based on source-species type, clinical relevance, and requirements of various international regulatory guidelines. Data showed that corrected QT interval values varied drastically for different correction formulas. Equations were compared on their slope values based on QTc versus RR plots. The rank order of the slope for different formulas was (closest to farthest from zero) QTcNAK, QTcHAS, QTcBZT, QTcFRD, QTcVDW, QTcHDG, and QTcFRM. QTcNAK emerged to be the best correcting formula in this study. It showed the least correlation with the RR interval (
    Mesh-Begriff(e) Animals ; Humans ; Electrocardiography ; Macaca mulatta ; Ketamine/toxicity ; Heart Rate ; Pharmaceutical Preparations ; Long QT Syndrome/chemically induced
    Chemische Substanzen Ketamine (690G0D6V8H) ; Pharmaceutical Preparations
    Sprache Englisch
    Erscheinungsdatum 2023-03-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2081252-8
    ISSN 1537-6524 ; 1537-6516 ; 1051-7235
    ISSN (online) 1537-6524
    ISSN 1537-6516 ; 1051-7235
    DOI 10.1080/15376516.2023.2187730
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Hematological and biochemical reference intervals of wild-caught and inhouse adult Indian rhesus macaques (Macaca mulatta).

    Shah, Niraj A / Bhatt, Laxit K / Patel, Rajesh J / Patel, Tushar M / Patel, Nayankumar V / Trivedi, Harshida G / Patel, Nilam R / Patel, Jitendra H / Patel, Satish D / Sundar, Rajesh S / Jain, Mukul R

    Laboratory animal research

    2022  Band 38, Heft 1, Seite(n) 33

    Abstract: Background: Nonhuman primates are used for research purposes such as studying diseases and drug discovery and development programs. Various clinical pathology parameters are used as biomarkers of disease conditions in biomedical research. Detailed ... ...

    Abstract Background: Nonhuman primates are used for research purposes such as studying diseases and drug discovery and development programs. Various clinical pathology parameters are used as biomarkers of disease conditions in biomedical research. Detailed reports of these parameters are not available for Indian-origin rhesus macaques. To meet the increasing need for information, we conducted this study on 121 adult Indian rhesus macaques (57 wild-sourced and 64 inhouse animals, aged 3-7 years). A total of 18 hematology and 18 biochemistry parameters were evaluated and reported in this study. Data from these parameters were statistically evaluated for significance amongst inhouse and wild-born animals and for differences amongst sexes. The reference range was calculated according to C28-A3 guidelines for reporting reference intervals of clinical laboratory parameters.
    Results: Source of the animals and sex appeared to have statistically significant effects on reference values and range. Wild-born animals reported higher WBC, platelets, neutrophils, RBC, hemoglobin, HCT, MCV, and total protein values in comparison to inhouse monkeys. Sex-based differences were observed for parameters such as RBCs, hemoglobin, HCT, creatinine, calcium, phosphorus, albumin, and total protein amongst others.
    Conclusions: Through this study, we have established a comprehensive data set of reference values and intervals for certain hematological and biochemical parameters which will help researchers in planning, conducting, and interpreting various aspects of biomedical research employing Indian-origin rhesus monkeys.
    Sprache Englisch
    Erscheinungsdatum 2022-11-11
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2623220-0
    ISSN 2233-7660 ; 1738-6055
    ISSN (online) 2233-7660
    ISSN 1738-6055
    DOI 10.1186/s42826-022-00143-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Effect of repeated freezing and thawing on 18 clinical chemistry analytes in rat serum.

    Kale, Vijay P / Patel, Sweta G / Gunjal, Prashant S / Wakchaure, Santosh U / Sundar, Rajesh S / Ranvir, Ramchandra K / Jain, Mukul R

    Journal of the American Association for Laboratory Animal Science : JAALAS

    2012  Band 51, Heft 4, Seite(n) 475–478

    Abstract: In a preclinical research laboratory, using serum samples that have been frozen and thawed repeatedly is sometimes unavoidable when needing to confirm previous results or perform additional analysis. Here we determined the effects of multiple cycles of ... ...

    Abstract In a preclinical research laboratory, using serum samples that have been frozen and thawed repeatedly is sometimes unavoidable when needing to confirm previous results or perform additional analysis. Here we determined the effects of multiple cycles of refrigeration or freezing and thawing of rat serum at 3 temperature conditions for different storage times on clinical chemistry analytes. Serum samples obtained from adult Wistar rats were stored at 2 to 8 °C and -10 to -20 °C for as long as 72 h and at -70 °C for as long as 30 d. At different time points (24, 48, and 72 h for samples stored at 2 to 8 °C or -10 to -20 °C and 1, 7, and 30 d for samples stored at -70 °C), the samples were brought to room temperature, analyzed, and then stored again at the designated temperature. The results obtained after each storage cycle were compared with those obtained from the initial analysis of fresh samples. Of the 18 serum analytes evaluated, 14 were stable without significant changes, even after 3 freeze-thaw cycles at the tested temperature ranges. Results from this study will help researchers working with rat serum to interpret the biochemical data obtained from serum samples that have been frozen and thawed repeatedly.
    Mesh-Begriff(e) Animals ; Blood Chemical Analysis/veterinary ; Blood Preservation/methods ; Blood Preservation/veterinary ; Cryopreservation/methods ; Cryopreservation/veterinary ; Drug Stability ; Hot Temperature ; Male ; Rats ; Rats, Wistar/blood ; Refrigeration ; Temperature ; Time Factors
    Sprache Englisch
    Erscheinungsdatum 2012-10-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1559-6109
    ISSN 1559-6109
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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