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  1. Article ; Online: Training the gynecologic oncologists of the future - challenges and opportunities.

    Kemah, Ben-Lawrence / Bhagat, Nanak / Pandya, Aayushi / Sullivan, Richard / Sundar, Sudha S

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2024  Volume 34, Issue 4, Page(s) 619–626

    Abstract: Several recent advances in gynecologic cancer care have improved patient outcomes. These include national screening and vaccination programs for cervical cancer as well as neoadjuvant chemotherapy for ovarian cancer. Conversely, these advances have ... ...

    Abstract Several recent advances in gynecologic cancer care have improved patient outcomes. These include national screening and vaccination programs for cervical cancer as well as neoadjuvant chemotherapy for ovarian cancer. Conversely, these advances have cumulatively reduced surgical opportunities for training creating a need to supplement existing training strategies with evidence-based adjuncts. Technologies such as virtual reality and augmented reality, if properly evaluated and validated, have transformative potential to support training. Given the changing landscape of surgical training in gynecologic oncology, we were keen to summarize the evidence underpinning current training in gynecologic oncology.In this review, we undertook a literature search of Medline, Google, Google Scholar, Embase and Scopus to gather evidence on the current state of training in gynecologic oncology and to highlight existing evidence on the best methods to teach surgical skills. Drawing from the experiences of other surgical specialties we examined the use of training adjuncts such as cadaveric dissection, animation and 3D models as well as simulation training in surgical skills acquisition. Specifically, we looked at the use of training adjuncts in gynecologic oncology training as well as the evidence behind simulation training modalities such as low fidelity box trainers, virtual and augmented reality simulation in laparoscopic training. Finally, we provided context by looking at how training curriculums varied internationally.Whereas some evidence to the reliability and validity of simulation training exists in other surgical specialties, our literature review did not find such evidence in gynecologic oncology. It is important that well conducted trials are used to ascertain the utility of simulation training modalities before integrating them into training curricula.
    MeSH term(s) Female ; Humans ; Genital Neoplasms, Female/therapy ; Reproducibility of Results ; Computer Simulation ; Uterine Cervical Neoplasms ; Ovarian Neoplasms ; Clinical Competence
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-004557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: How do we deliver safe bowel resection in ovarian cancer cytoreductive surgery?

    Wood, Nicholas J / Dobbs, Stephen / Tierney, Gill / Maxwell-Armstrong, Charles / Sundar, Sudha S

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2022  

    Language English
    Publishing date 2022-06-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2022-003470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exploring international differences in ovarian cancer care: a survey report on global patterns of care, current practices, and barriers.

    Algera, Marc Daniël / Morton, Rhett / Sundar, Sudha S / Farrell, Rhonda / van Driel, Willemien J / Brennan, Donal / Rijken, Marcus J / Sfeir, Selina / Allen, Lucy / Eiken, Mary / Coleman, Robert L

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2023  Volume 33, Issue 10, Page(s) 1612–1620

    Abstract: Objective: Although global disparities in survival rates for patients with ovarian cancer have been described, variation in care has not been assessed globally. This study aimed to evaluate global ovarian cancer care and barriers to care.: Methods: A ...

    Abstract Objective: Although global disparities in survival rates for patients with ovarian cancer have been described, variation in care has not been assessed globally. This study aimed to evaluate global ovarian cancer care and barriers to care.
    Methods: A survey was developed by international ovarian cancer specialists and was distributed through networks and organizational partners of the International Gynecologic Cancer Society, the Society of Gynecologic Oncology, and the European Society of Gynecological Oncology. Respondents received questions about care organization. Outcomes were stratified by World Bank Income category and analyzed using descriptive statistics and logistic regressions.
    Results: A total of 1059 responses were received from 115 countries. Respondents were gynecological cancer surgeons (83%, n=887), obstetricians/gynecologists (8%, n=80), and other specialists (9%, n=92). Income category breakdown was as follows: high-income countries (46%), upper-middle-income countries (29%), and lower-middle/low-income countries (25%). Variation in care organization was observed across income categories. Respondents from lower-middle/low-income countries reported significantly less frequently that extensive resections were routinely performed during cytoreductive surgery. Furthermore, these countries had significantly fewer regional networks, cancer registries, quality registries, and patient advocacy groups. However, there is also scope for improvement in these components in upper-middle/high-income countries. The main barriers to optimal care for the entire group were patient co-morbidities, advanced presentation, and social factors (travel distance, support systems). High-income respondents stated that the main barriers were lack of surgical time/staff and patient preferences. Middle/low-income respondents additionally experienced treatment costs and lack of access to radiology/pathology/genetic services as main barriers. Lack of access to systemic agents was reported by one-third of lower-middle/low-income respondents.
    Conclusions: The current survey report highlights global disparities in the organization of ovarian cancer care. The main barriers to optimal care are experienced across all income categories, while additional barriers are specific to income levels. Taking action is crucial to improve global care and strive towards diminishing survival disparities and closing the care gap.
    MeSH term(s) Humans ; Female ; Ovarian Neoplasms/surgery ; Surveys and Questionnaires ; Genital Neoplasms, Female ; Gynecology ; Surgeons
    Language English
    Publishing date 2023-10-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-004563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Methods Used in Economic Evaluations of Testing and Diagnosis for Ovarian Cancer: A Systematic Review.

    Sharma, Vishal / Sundar, Sudha S / Breheny, Katie / Monahan, Mark / Sutton, Andrew John

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2016  Volume 26, Issue 5, Page(s) 865–872

    Abstract: Objective: There are multiple tests available that can help diagnose ovarian cancer, and the cost-effective analysis of these diagnostic interventions is essential for making well-informed decisions regarding resource allocation. There are multiple ... ...

    Abstract Objective: There are multiple tests available that can help diagnose ovarian cancer, and the cost-effective analysis of these diagnostic interventions is essential for making well-informed decisions regarding resource allocation. There are multiple factors that can impact on the conclusions drawn from economic evaluations including test accuracy, the impact of the testing pathway on patient costs and outcomes, and delays along the ovarian cancer test-treat pathway. The objective of this study was to evaluate how test accuracy, the choice of perspective, and delays along the testing and diagnostic pathway have been incorporated in economic evaluations of testing for ovarian cancer.
    Methods: A systematic review of published literature was undertaken to identify economic evaluations (eg, cost-effectiveness, cost-utility analysis) focused on testing and diagnosis for ovarian cancer.
    Results: Seven studies met the inclusion criteria. Six studies incorporated test accuracy and its impact on patients to some extent. Four studies adopted a societal perspective, but only one considered the costs incurred by patients on the testing and diagnosis pathway. Where delays on the testing pathway were incorporated into the analysis, these were frequently due to false-negative test results leading to delays in patients accessing treatment. Any anxiety that patients might experience as a result of a positive test was not considered in these studies.
    Conclusions: The impact on patients of receiving a positive test in terms of anxiety and the costs incurred by patients having to attend for testing and diagnosis are rarely considered. Delays along the testing and diagnosis pathway can have a major effect on patient outcomes, and it is important that these are acknowledged in economic evaluations focused on testing. Future economic analysis should incorporate these key determinants in order that diagnostic tests for ovarian cancer can be robustly evaluated.
    MeSH term(s) Cost-Benefit Analysis ; Early Detection of Cancer/economics ; Early Detection of Cancer/methods ; Female ; Humans ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/economics
    Language English
    Publishing date 2016-03-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1097/IGC.0000000000000699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Role of lymphangiogenesis in cancer.

    Sundar, Sudha S / Ganesan, Trivadi S

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2007  Volume 25, Issue 27, Page(s) 4298–4307

    Abstract: Regional lymph node metastasis is a common event in solid tumors and is considered a marker for dissemination, increased stage, and worse prognosis. Despite rapid advances in tumor biology, the molecular processes that underpin lymphatic invasion and ... ...

    Abstract Regional lymph node metastasis is a common event in solid tumors and is considered a marker for dissemination, increased stage, and worse prognosis. Despite rapid advances in tumor biology, the molecular processes that underpin lymphatic invasion and lymph node metastasis remain poorly understood. However, exciting discoveries have been made in the field of lymphangiogenesis in recent years. The identification of vascular endothelial growth factor ligands and cognate receptors involved in lymphangiogenesis, an understanding of the embryology of the mammalian lymphatic system, the recent isolation of pure populations of lymphatic endothelial cells, the investigation of lymphatic metastases in animal models, and the identification of markers that discriminate lymphatics from blood vessels at immunohistochemistry are current advances in the field of lymphangiogenesis, and as such are the main focus of this article. This review also evaluates evidence for lymphangiogenesis (ie, new lymphatic vessel formation in cancer) and critically reviews current data on the prognostic significance of lymphatic vascular density in tumors. A targeted approach to block pathways of lymphangiogenesis seems to be an attractive anticancer treatment strategy. Conversely, promotion of lymphangiogenesis may be a promising approach to the management of treatment-induced lymphedema in cancer survivors. Finally, the implications of these developments in cancer therapeutics and directions for future research are discussed.
    MeSH term(s) Animals ; Humans ; Lymph Nodes/embryology ; Lymph Nodes/pathology ; Lymphangiogenesis ; Lymphatic Metastasis ; Lymphedema/metabolism ; Models, Biological ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasms/complications ; Neoplasms/pathology ; Prognosis
    Language English
    Publishing date 2007-09-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2006.07.1092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Homologous recombination deficiency in newly diagnosed FIGO stage III/IV high-grade epithelial ovarian cancer: a multi-national observational study.

    Morgan, Robert D / Clamp, Andrew R / Barnes, Bethany M / Timms, Kirsten / Schlecht, Helene / Yarram-Smith, Laura / Wallis, Yvonne / Valganon-Petrizan, Mikel / MacMahon, Suzanne / White, Rhian / Morgan, Sian / McKenna, Sarah / Hudson, Emma / Tookman, Laura / George, Angela / Manchanda, Ranjit / Sundar, Sudha S / Nicum, Shibani / Brenton, James D /
    Kristeleit, Rebecca S / Banerjee, Susana / McNeish, Iain A / Ledermann, Jonathan A / Taylor, Stephen S / Evans, D Gareth R / Jayson, Gordon C

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2023  Volume 33, Issue 8, Page(s) 1253–1259

    Abstract: Objective: Olaparib plus bevacizumab maintenance therapy improves survival outcomes in women with newly diagnosed, advanced, high-grade ovarian cancer with a deficiency in homologous recombination. We report data from the first year of routine ... ...

    Abstract Objective: Olaparib plus bevacizumab maintenance therapy improves survival outcomes in women with newly diagnosed, advanced, high-grade ovarian cancer with a deficiency in homologous recombination. We report data from the first year of routine homologous recombination deficiency testing in the National Health Service (NHS) in England, Wales, and Northern Ireland between April 2021 and April 2022.
    Methods: The Myriad myChoice companion diagnostic was used to test DNA extracted from formalin-fixed, paraffin-embedded tumor tissue in women with newly diagnosed International Federation of Gynecology and Obstetrics (FIGO) stage III/IV high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer. Tumors with homologous recombination deficiency were those with a
    Results: The myChoice assay was performed on 2829 tumors. Of these, 2474 (87%) and 2178 (77%) successfully underwent
    Conclusion: This is the largest real-world evaluation of homologous recombination deficiency testing in newly diagnosed FIGO stage III/IV high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer. It is important to select tumor tissue with adequate tumor content and quality to reduce the risk of assay failure. The rapid uptake of testing across England, Wales, and Northern Ireland demonstrates the power of centralized NHS funding, center specialization, and the NHS Genomic Laboratory Hub network.
    MeSH term(s) Female ; Humans ; Carcinoma, Ovarian Epithelial/genetics ; BRCA1 Protein/genetics ; Ovarian Neoplasms/pathology ; State Medicine ; BRCA2 Protein/genetics ; Genomic Instability ; Homologous Recombination ; Mutation
    Chemical Substances BRCA1 protein, human ; BRCA1 Protein ; BRCA2 protein, human ; BRCA2 Protein
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2022-004211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: British Gynaecological Cancer Society recommendations for women with gynecological cancer who received non-standard care during the COVID-19 pandemic.

    Taylor, Alexandra / Sundar, Sudha S / Bowen, Rebecca / Clayton, Rick / Coleridge, Sarah / Fotopoulou, Christina / Ghaem-Maghami, Sadaf / Ledermann, Jonathan / Manchanda, Ranjit / Maxwell, Hilary / Michael, Agnieszka / Miles, Tracie / Nicum, Shibani / Nordin, Andrew / Ramsay, Bruce / Rundle, Stuart / Williams, Sarah / Wood, Nicholas J / Yiannakis, Dennis /
    Morrison, Jo

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2021  Volume 32, Issue 1, Page(s) 9–14

    Abstract: During the COVID-19 pandemic, pressures on clinical services required adaptation to how care was prioritised and delivered for women with gynecological cancer. This document discusses potential 'salvage' measures when treatment has deviated from the ... ...

    Abstract During the COVID-19 pandemic, pressures on clinical services required adaptation to how care was prioritised and delivered for women with gynecological cancer. This document discusses potential 'salvage' measures when treatment has deviated from the usual standard of care. The British Gynaecological Cancer Society convened a multidisciplinary working group to develop recommendations for the onward management and follow-up of women with gynecological cancer who have been impacted by a change in treatment during the pandemic. These recommendations are presented for each tumor type and for healthcare systems, and the impact on gynecological services are discussed. It will be important that patient concerns about the impact of COVID-19 on their cancer pathway are acknowledged and addressed for their ongoing care.
    MeSH term(s) COVID-19/epidemiology ; Female ; Genital Neoplasms, Female/epidemiology ; Genital Neoplasms, Female/therapy ; Gynecology ; Humans ; Pandemics ; SARS-CoV-2/isolation & purification ; United Kingdom/epidemiology
    Language English
    Publishing date 2021-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2021-002942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Advances in the management of cervical cancer.

    Sundar, Sudha S / Gornall, Robert J / Kehoe, Sean T

    The journal of the British Menopause Society

    2005  Volume 11, Issue 3, Page(s) 91–95

    Abstract: This review presents key advances in the management of cervical cancer. Traditionally, cervical cancer is staged clinically and has been treated either by radical hysterectomy or by radiotherapy. Improvements in imaging have led to more accurate ... ...

    Abstract This review presents key advances in the management of cervical cancer. Traditionally, cervical cancer is staged clinically and has been treated either by radical hysterectomy or by radiotherapy. Improvements in imaging have led to more accurate therapeutic decision making and treatment planning. The evidence on fertility-preserving surgery for cervical cancer and chemoradiotherapy for locally advanced cancer is summarized here. An improved understanding of the viral aetiology of cervical cancer has led to the development of therapeutic vaccination, with limited success. There is increasing recognition of the psychosexual needs of women who have survived cervical cancer.
    MeSH term(s) Combined Modality Therapy ; Female ; Humans ; Neoplasm Staging ; Papillomaviridae/immunology ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/therapy ; Uterine Cervical Neoplasms/virology ; Viral Vaccines
    Chemical Substances Viral Vaccines
    Language English
    Publishing date 2005-09-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2040397-5
    ISSN 1362-1807
    ISSN 1362-1807
    DOI 10.1258/136218005775544471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Analysis of outcome in women with borderline glandular change on cervical cytology.

    Jadoon, Bismeen A / Kehoe, Sean / Romain, Kathleen / Clelland, Colin / Sundar, Sudha S

    European journal of obstetrics, gynecology, and reproductive biology

    2009  Volume 147, Issue 1, Page(s) 83–85

    Abstract: Objective: To review the outcome of women presenting with borderline glandular smear on cervical cytology and to investigate correlation between cytology, colposcopy and histology and subsequent smear history.: Study design: A 5 year retrospective ... ...

    Abstract Objective: To review the outcome of women presenting with borderline glandular smear on cervical cytology and to investigate correlation between cytology, colposcopy and histology and subsequent smear history.
    Study design: A 5 year retrospective analysis of outcome in all women reported with borderline glandular changes on cytology between 2001 and 2005 at the John Radcliffe Hospital, Oxford, and Cheltenham General Hospital, Gloucestershire, was performed. Cytology, colposcopy, histology and follow-up cytology data at 6, 12 and 24 months after index smear were collated.
    Results: Of 92 women with borderline glandular smears, 56 were referred for colposcopy. This accounts for 0.9% of the total referral (6293) to the colposcopy units. A significant rate of abnormal histology was noted, with CIN 1, 2, 3, CGIN or worse in 20 women (36%) and benign pathology in 18 women (32%). Colposcopy had a sensitivity of 82%, specificity of 39%, negative predictive value of 80% and positive predictive value of 49% in predicting abnormal (premalignant/malignant) histology. Only one woman with normal histology at presentation had subsequent abnormal cytology (1/31), whereas abnormal histology at presentation was strongly associated with subsequent abnormality on follow-up cytology over 24 months (8/21) with a p value=0.0058.
    Conclusion: Colposcopic examination and biopsy of colposcopically identified abnormalities is reliable, with negative colposcopy having a high negative predictive value. We also recommend thorough colposcopic examination before any invasive investigation as over treatment may impact on the future reproductive outcome [1].
    MeSH term(s) Adult ; Cervix Uteri/pathology ; Colposcopy ; Cytological Techniques ; Female ; Follow-Up Studies ; Histological Techniques ; Humans ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Sensitivity and Specificity ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/pathology ; Vaginal Smears
    Language English
    Publishing date 2009-11
    Publishing country Ireland
    Document type Comparative Study ; Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2009.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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