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  1. Article: DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity.

    Ramesh, Rajendran / Sundaresh, Aparna / Rajkumar, Ravi Philip / Negi, Vir Singh / Vijayalakshmi, M A / Krishnamoorthy, Rajagopal / Tamouza, Ryad / Leboyer, Marion / Kamalanathan, A S

    NPJ schizophrenia

    2021  Volume 7, Issue 1, Page(s) 13

    Abstract: It is not uncommon to observe autoimmune comorbidities in a significant subset of patients with psychotic disorders, namely schizophrenia (SCZ) and bipolar disorder (BPD). To understand the autoimmune basis, the DNA abyzme activity mediated by serum ... ...

    Abstract It is not uncommon to observe autoimmune comorbidities in a significant subset of patients with psychotic disorders, namely schizophrenia (SCZ) and bipolar disorder (BPD). To understand the autoimmune basis, the DNA abyzme activity mediated by serum polyclonal IgG Abs were examined in psychoses patients, quantitatively, by an in-house optimized DNase assay. A similar activity exhibited by IgG Abs from neuropsychiatric-systemic lupus erythematosus (NP-SLE) patients was used as a comparator. Our data revealed that the IgG DNase activity of SCZ was close to that of NP-SLE and it was twofold higher than the healthy controls. Interestingly, the association between DNase activity with PANSS (positive, general and total scores) and MADRS were noted in a subgroup of SCZ and BPD patients, respectively. In our study group, the levels of IL-6 and total IgG in BPD patients were higher than SCZ and healthy controls, indicating a relatively inflammatory nature in BPD, while autoimmune comorbidity was mainly observed in SCZ patients.
    Language English
    Publishing date 2021-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2813844-2
    ISSN 2334-265X
    ISSN 2334-265X
    DOI 10.1038/s41537-021-00143-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Combined effects of nitric oxide synthase 3 genetic variant and childhood emotional abuse on earlier onset of suicidal behaviours.

    Lengvenyte, Aiste / Sundaresh, Aparna / Strumila, Robertas / Boukouaci, Wahid / Wu, Ching-Lien / Sugunasabesan, Sobika / Guillaume, Sebastien / Sénèque, Maude / Leboyer, Marion / Olié, Emilie / Tamouza, Ryad / Courtet, Philippe

    Progress in neuro-psychopharmacology & biological psychiatry

    2022  Volume 119, Page(s) 110617

    Abstract: Marked heterogeneity in suicide attempters has been observed, with earlier onset being linked to stronger heritability, more childhood maltreatment. Nitric oxide signalling system might be implicated in this relationship through its role in the stress ... ...

    Abstract Marked heterogeneity in suicide attempters has been observed, with earlier onset being linked to stronger heritability, more childhood maltreatment. Nitric oxide signalling system might be implicated in this relationship through its role in the stress response/adaptation. This study examined how NOS genetic variants and childhood maltreatment were associated with age at first suicide attempt (SA). Adult patients with SA history (N = 414) filled in the Childhood Trauma Questionnaire, and six functionally relevant NOS2 and NOS3 polymorphisms were genotyped. Analyses included χ
    MeSH term(s) Adult ; Child ; Child Abuse ; Emotional Abuse ; Genotype ; Humans ; Nitric Oxide ; Nitric Oxide Synthase Type III ; Suicidal Ideation ; Suicide, Attempted
    Chemical Substances Nitric Oxide (31C4KY9ESH) ; NOS3 protein, human (EC 1.14.13.39) ; Nitric Oxide Synthase Type III (EC 1.14.13.39)
    Language English
    Publishing date 2022-08-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 781181-0
    ISSN 1878-4216 ; 0278-5846
    ISSN (online) 1878-4216
    ISSN 0278-5846
    DOI 10.1016/j.pnpbp.2022.110617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1342: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: IL6/IL6R

    Sundaresh, Aparna / Oliveira, José / Chinnadurai, Raj Kumar / Rajkumar, Ravi Philip / Hani, Lylia / Krishnamoorthy, Rajagopal / Leboyer, Marion / Negi, Vir Singh / Tamouza, Ryad

    Heliyon

    2019  Volume 5, Issue 1, Page(s) e01124

    Abstract: Reports of association of genetic variants ... ...

    Abstract Reports of association of genetic variants of
    Language English
    Publishing date 2019-01-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2019.e01124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: IL6/IL6R genetic diversity and plasma IL6 levels in bipolar disorder: An Indo-French study

    Sundaresh, Aparna / Oliveira, José / Chinnadurai, Raj Kumar / Rajkumar, Ravi Philip / Hani, Lylia / Krishnamoorthy, Rajagopal / Leboyer, Marion / Negi, Vir Singh / Tamouza, Ryad

    Heliyon. 2019 Jan., v. 5, no. 1

    2019  

    Abstract: Reports of association of genetic variants of IL6 and its receptor (IL6R) with psychiatric disorders are inconsistent, and there are few population-based studies thus far in bipolar disorder (BD). We genotyped the IL6 rs1800795 and IL6R rs2228145 ... ...

    Abstract Reports of association of genetic variants of IL6 and its receptor (IL6R) with psychiatric disorders are inconsistent, and there are few population-based studies thus far in bipolar disorder (BD). We genotyped the IL6 rs1800795 and IL6R rs2228145 polymorphisms in two independent sets of patients exposed to different environmental stimuli such as climatic conditions or specific infectious burden – a French sample and a south Indian Tamil sample of BD with quantitation of circulating plasma IL-6 levels in the latter sub-sample.In both populations, allele and genotype frequencies did not differ significantly between cases and controls for either polymorphism. Upon stratifying based on age at onset, we found no associations with the IL6 rs1800795 variant. However, the IL6R rs2228145 C allele and CC genotype were associated with early onset of disease in the French sample when compared to late onset BD. A similar trend was observed in the Indian population where we also found that plasma IL-6 levels were significantly higher in BD and also in patients who were in residual phase or remission both as compared to controls.Our findings are in favour of a possible trans-ethnic implication of the IL6R genetic diversity in BD and reinforce the notion that IL-6 is an important marker of the operating inflammatory processes in the disease.
    Keywords alleles ; bipolar disorder ; genetic variation ; genotype ; interleukin-6 ; remission
    Language English
    Dates of publication 2019-01
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2019.e01124
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: An exploratory study of immune markers in acute and transient psychosis.

    Mahadevan, Jayant / Sundaresh, Aparna / Rajkumar, Ravi Philip / Muthuramalingam, A / Menon, Vikas / Negi, V S / Sridhar, M G

    Asian journal of psychiatry

    2017  Volume 25, Page(s) 219–223

    Abstract: The aim of this study was to look into the balance of pro-inflammatory (TNF-α, IL-6) and anti-inflammatory (TGF-β) cytokines and their association with stress, alterations in HPA axis activity and the disease severity in acute psychosis. Socio- ... ...

    Abstract The aim of this study was to look into the balance of pro-inflammatory (TNF-α, IL-6) and anti-inflammatory (TGF-β) cytokines and their association with stress, alterations in HPA axis activity and the disease severity in acute psychosis. Socio-demographic and clinical details were collected from 41 in-patients with a diagnosis of Acute and Transient Psychotic Disorder. Holmes and Rahe Stress Scale for stress in the preceding year, and Brief Psychiatric Rating Scale at baseline and follow up (4-12 weeks) for psychopathology were applied. IL-6, TNF-α (pro-inflammatory), TGF-β (anti-inflammatory) and Cortisol (morning and afternoon values) were measured at baseline and follow up. A total of 30 out of 41 cases recruited had follow up data available. The levels of IL-6 (p<0.001), TNF-α (p<0.001) and TGF-β (p<0.001) at baseline were all found to be significantly elevated compared to 42 age and gender matched healthy controls. There was a significant increase in the levels of TNF-α (p=0.020) and morning levels of cortisol (p=0.009) and a significant decrease in the levels of TGF-β (p=0.004) and afternoon levels of cortisol (p=0.043) from baseline to follow up. This study showed that there was an increased level of both pro and anti-inflammatory cytokines at baseline and a prolonged pro - inflammatory compared to anti - inflammatory response which warrants larger prospective studies and comparative studies to patients with schizophrenia and bipolar disorders.
    MeSH term(s) Acute Disease ; Adolescent ; Adult ; Female ; Follow-Up Studies ; Humans ; Hydrocortisone/blood ; Inpatients ; Interleukin-6/blood ; Male ; Middle Aged ; Pilot Projects ; Psychotic Disorders/blood ; Psychotic Disorders/physiopathology ; Transforming Growth Factor beta/blood ; Tumor Necrosis Factor-alpha/blood ; Young Adult
    Chemical Substances IL6 protein, human ; Interleukin-6 ; TNF protein, human ; Transforming Growth Factor beta ; Tumor Necrosis Factor-alpha ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2017-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2016.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The HLA-G Genetic Contribution to Bipolar Disorder: A Trans-Ethnic Replication.

    Sundaresh, Aparna / Wu, Ching-Lien / Chinnadurai, Raj Kumar / Rajkumar, Ravi Philip / Mariaselvam, Christina Mary / LeMaoult, Joël / Krishnamoorthy, Rajagopal / Leboyer, Marion / Negi, Vir Singh / Tamouza, Ryad

    Immunological investigations

    2018  Volume 47, Issue 6, Page(s) 593–604

    Abstract: Bipolar disorder (BD) is frequently associated with immune dysfunctions. Studying the genetic diversity of the immuno-modulatory human leukocyte antigen (HLA)-G locus in a French BD cohort, we previously reported an association between a functionally ... ...

    Abstract Bipolar disorder (BD) is frequently associated with immune dysfunctions. Studying the genetic diversity of the immuno-modulatory human leukocyte antigen (HLA)-G locus in a French BD cohort, we previously reported an association between a functionally relevant 14 bp Ins/Del polymorphism and BD risk. The present study investigated the genetic and expression diversities of HLA-G in a geographically distinct South Indian population-group BD patients, as well as the influence of exposure to the neurotropic Toxoplasma gondii pathogen. Three functionally relevant HLA-G polymorphisms, i.e. HLA-G 14 bp Ins/Del (rs66554220), +3142G>C (rs1063320) and +3187A>G (rs9380142) were genotyped by polymerase chain reaction (PCR) and real-time PCR. Sub-samples of BD patients and healthy controls (HC) were investigated for plasma levels of soluble HLA-G (sHLA-G) isoforms, as well as circulating stigma of T. gondii infection. Findings indicate: (i) the frequency of the HLA-G 14 bp Del/Del genotype was higher in BD cases, as compared to HC; (ii) the HLA-G + 3142 C allele and CC genotype were more prevalent in BD patients than in HC; (iii) sHLA-G levels were significantly higher in BD cases, especially in females and in the early onset sub-group; and (iv) the InsGA haplotype was more prevalent in HC. Our findings further support the genetic contribution of HLA-G to BD risk, as well as indicate relevant expression profiles. Such data may also indicate a potential developmental role in BD etiology, given that HLA-G is an important immune regulator from the intrauterine period and across development.
    MeSH term(s) Adolescent ; Adult ; Bipolar Disorder/complications ; Bipolar Disorder/genetics ; Bipolar Disorder/immunology ; Case-Control Studies ; Ethnic Groups/genetics ; Female ; France ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; HLA-G Antigens/genetics ; HLA-G Antigens/immunology ; Humans ; INDEL Mutation/genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Toxoplasma ; Toxoplasmosis/complications ; Young Adult
    Chemical Substances HLA-G Antigens
    Language English
    Publishing date 2018-05-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 632565-8
    ISSN 1532-4311 ; 0882-0139
    ISSN (online) 1532-4311
    ISSN 0882-0139
    DOI 10.1080/08820139.2018.1469649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 988: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Combined effect of TLR2 gene polymorphism and early life stress on the age at onset of bipolar disorders.

    Oliveira, José / Etain, Bruno / Lajnef, Mohamed / Hamdani, Nora / Bennabi, Meriem / Bengoufa, Djaouida / Sundaresh, Aparna / Chaabane, Arij Ben / Bellivier, Frank / Henry, Chantal / Kahn, Jean-Pierre / Charron, Dominique / Krishnamoorthy, Rajagopal / Leboyer, Marion / Tamouza, Ryad

    PloS one

    2015  Volume 10, Issue 3, Page(s) e0119702

    Abstract: Gene-environment interactions may play an important role in modulating the impact of early-life stressful events on the clinical course of bipolar disorder (BD), particularly associated to early age at onset. Immune dysfunction is thought to be an ... ...

    Abstract Gene-environment interactions may play an important role in modulating the impact of early-life stressful events on the clinical course of bipolar disorder (BD), particularly associated to early age at onset. Immune dysfunction is thought to be an important mechanism linking childhood trauma with early-onset BD, thus the genetic diversity of immune-related loci may account for an important part of the interindividual susceptibility to this severe subform. Here we investigated the potential interaction between genetic variants of Toll-like receptors 2 (TLR2) and 4 (TLR4), major innate immune response molecules to pathogens, and the childhood trauma questionnaire (CTQ) in age at onset of BD. We recruited 531 BD patients (type I and II or not otherwise specified), genotyped for the TLR2 rs4696480 and rs3804099 and TLR4 rs1927914 and rs11536891 single-nucleotide polymorphisms and recorded for history of childhood trauma using the CTQ. TLR2 and TLR4 risk genotype carrier state and history of childhood emotional, physical and sexual abuses were evaluated in relation to age at onset as defined by the age at first manic or depressive episode. We observed a combined effect of TLR2 rs3804099 TT genotype and reported sexual abuse on determining an earlier age at onset of BD by means of a Kaplan-Meier survival curve (p = 0.002; corrected p = 0.02). Regression analysis, however, was non-significant for the TLR2-CTQ sexual abuse interaction term. The negative effects of childhood sexual abuse on age at onset of BD may be amplified in TLR2 rs3804099 risk genotype carriers through immune-mediated pathways. Clinical characteristics of illness severity, immune phenotypes and history of early life infectious insults should be included in future studies involving large patient cohorts.
    MeSH term(s) Adolescent ; Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Bipolar Disorder/genetics ; Bipolar Disorder/physiopathology ; Bipolar Disorder/psychology ; Child ; Child Abuse, Sexual ; Female ; Gene-Environment Interaction ; Genetic Predisposition to Disease ; Genotype ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Stress, Psychological ; Surveys and Questionnaires ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 4/genetics
    Chemical Substances TLR2 protein, human ; TLR4 protein, human ; Toll-Like Receptor 2 ; Toll-Like Receptor 4
    Language English
    Publishing date 2015-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0119702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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