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  1. AU="Suo, Keke"
  2. AU=Tokonami Natsuko
  3. AU="Blevins, Hannah"
  4. AU="Sanders, Barton J."
  5. AU="Park, Hyun Ah"
  6. AU="Fields, Errol L"
  7. AU="Borisov, Alexander"
  8. AU="Ali, Ahmed E"
  9. AU="Carrasco Carrasco, E"
  10. AU="Massa, L"
  11. AU="Seki, Reiko"
  12. AU="Skowno, Justin"
  13. AU="Hikida, Hiroshi"
  14. AU="Wentzel, David C"
  15. AU="Priyadarshini, Subhadra"
  16. AU="Monemi, Sharareh"
  17. AU="Iannuzzi, Gregory"
  18. AU="Zhou, Ning"
  19. AU=Griffith A J
  20. AU="Schmidt-Pogoda, Antje"
  21. AU="A.Aich, "
  22. AU="Anding, Allyson L"

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  1. Artikel ; Online: Probiotic properties and proteomics analysis of ethanol-induced Lactococcus lactis subsp. lactis IL1403.

    Chen, Sisi / Yi, Juanjuan / Suo, Keke / Kang, Qiaozhen / Lu, Laizheng / Lu, Jike

    World journal of microbiology & biotechnology

    2023  Band 39, Heft 8, Seite(n) 197

    Abstract: Our previous study indicated that ethanol-induced intracellular extracts (E-IEs) of Lactococcus lactis subsp. Lactis IL1403 (L. lactis IL1403) alleviated hangovers more effectively in mice than untreated intracellular extracts (U-IEs), but the material ... ...

    Abstract Our previous study indicated that ethanol-induced intracellular extracts (E-IEs) of Lactococcus lactis subsp. Lactis IL1403 (L. lactis IL1403) alleviated hangovers more effectively in mice than untreated intracellular extracts (U-IEs), but the material basis was unclear. Considering that stress-related proteins might play a significant role, the effects of ethanol induction on probiotic properties of L. lactis IL1403 and the associated stress response mechanism were initially explored in this study. E-IEs of L. lactis IL1403 showed better biological activities, significantly increased bacteria survival rates in oxidative stress environments, increased ADH activity, and enhanced proliferation in RAW264.7 and AML-12 cells. Proteomic analyses revealed that 414 proteins were significantly changed in response to ethanol induction. The expression of proteins involved in the universal stress response, DNA repair, oxidative stress response, and ethanol metabolism was rapidly upregulated under ethanol stress, and quantitative real-time PCR (qRT-PCR) results were consistent with proteomic data. KEGG pathway analysis indicated that citrate metabolism, starch and sucrose metabolism, and pyruvate metabolism were significantly enriched during ethanol stress to increase energy requirements and survival rates of stressed cells. Based on this observation, the active induction is an effective strategy for increasing the biological activity of L. lactis IL1403. Exploring the molecular mechanism and material basis of their functions in vivo can help us understand the adaptive regulatory mechanism of microorganisms.
    Mesh-Begriff(e) Animals ; Mice ; Lactococcus lactis/genetics ; Lactococcus lactis/metabolism ; Ethanol/metabolism ; Proteomics
    Chemische Substanzen Ethanol (3K9958V90M)
    Sprache Englisch
    Erscheinungsdatum 2023-05-15
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1499109-3
    ISSN 1573-0972 ; 0959-3993
    ISSN (online) 1573-0972
    ISSN 0959-3993
    DOI 10.1007/s11274-023-03627-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Positive effect of ethanol-induced Lactococcus lactis on alcohol metabolism in mice

    Chen, Sisi / Jia, Shimin / Suo, Keke / Kang, Qiaozhen / Hao, Limin / Lu, Laizheng / Liu, Xin / Huang, Jinyong / Lu, Jike

    Food science and human wellness. 2022 Sept., v. 11, no. 5

    2022  

    Abstract: It is well known that exposure to environmental stresses could enhance the adaptability of bacteria and up-regulate the expression of a variety of oxidative stress-related genes and antioxidant enzymes. It is unclear whether the adaptability of ... ...

    Abstract It is well known that exposure to environmental stresses could enhance the adaptability of bacteria and up-regulate the expression of a variety of oxidative stress-related genes and antioxidant enzymes. It is unclear whether the adaptability of microorganisms formed naturally in special environments could transfer to other organisms. The study aimed to evaluate the effects of untreated and ethanol-induced Lactococcus lactis intracellular extracts (U-IE and E-IE) on alcohol metabolism in mice. The positive effects of E-IE on alcohol metabolism in mice were revealed by the enhanced latency of loss of righting reflex (LORR), the reduced duration of LORR, the decrease of blood alcohol concentration, as well as the elevation of alcohol dehydrogenase (ADH) activities in the stomach and liver tissues. Furthermore, the potential benefits of E-IE on the liver were evaluated by biochemical parameters including the activities of serum transaminase, the levels of antioxidant enzymes, and the pathological changes of liver tissue. The present work put forward a new point that appropriate ethanol stress could enhance the intracellular ADH activity of L. lactis, and its intracellular extracts could continue to enhance alcohol metabolism in mice.
    Schlagwörter Lactococcus lactis ; alcohol dehydrogenase ; blood serum ; ethanol ; food science ; humans ; liver ; metabolism ; stomach
    Sprache Englisch
    Erscheinungsverlauf 2022-09
    Umfang p. 1183-1190.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 2712869-6
    ISSN 2213-4530
    ISSN 2213-4530
    DOI 10.1016/j.fshw.2022.04.016
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel: Potential of natural products as radioprotectors and radiosensitizers: opportunities and challenges

    Yi, Juanjuan / Zhu, Jiaqing / Zhao, Changcheng / Kang, Qiaozhen / Zhang, Xiaomiao / Suo, Keke / Cao, Nana / Hao, Limin / Lu, Jike

    Food & function. 2021 June 21, v. 12, no. 12

    2021  

    Abstract: Natural products can be used as natural radiosensitizers and radioprotectors, showing promising effects in cancer treatments in combination with radiotherapy, while reducing ionizing radiation (IR) damage to normal cells/tissues. The different effects of ...

    Abstract Natural products can be used as natural radiosensitizers and radioprotectors, showing promising effects in cancer treatments in combination with radiotherapy, while reducing ionizing radiation (IR) damage to normal cells/tissues. The different effects of natural products on irradiated normal and tumor cells/tissues have attracted more and more researchers’ interest. Nonetheless, the clinical applications of natural products in radiotherapy are few, which may be related to their low bioavailability in the human body. Here, we displayed the radiation protection and radiation sensitization of major natural products, highlighted the related molecular mechanisms of these bioactive substances combined with radiotherapy to treat cancer, and critically reviewed their deficiency and improved measures. Lastly, several clinical trials were presented to verify the clinical application of natural products as radiosensitizers and radioprotectors. Further clinical evaluation is still needed. This review provides a reference for the utilization of natural products as radiosensitizers and radioprotectors.
    Schlagwörter bioavailability ; clinical examination ; humans ; irradiation ; neoplasms ; radioprotective agents ; radiotherapy
    Sprache Englisch
    Erscheinungsverlauf 2021-0621
    Umfang p. 5204-5218.
    Erscheinungsort The Royal Society of Chemistry
    Dokumenttyp Artikel
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d1fo00525a
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: Corrigendum to "Radioprotective effect of radiation-induced Lactococcus lactis cell-free extract against

    Suo, Keke / Chen, Sisi / Li, Xue / Liu, Xin / Yi, Juanjuan / Zhu, Jiaqing / Lu, Laizheng / Hao, Limin / Kang, Qiaozhen / Lu, Jike

    Journal of dairy science

    2022  Band 105, Heft 2, Seite(n) 1815

    Sprache Englisch
    Erscheinungsdatum 2022-01-20
    Erscheinungsland United States
    Dokumenttyp Published Erratum
    ZDB-ID 242499-x
    ISSN 1525-3198 ; 0022-0302
    ISSN (online) 1525-3198
    ISSN 0022-0302
    DOI 10.3168/jds.2022-105-2-1815
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Potential of natural products as radioprotectors and radiosensitizers: opportunities and challenges.

    Yi, Juanjuan / Zhu, Jiaqing / Zhao, Changcheng / Kang, Qiaozhen / Zhang, Xiaomiao / Suo, Keke / Cao, Nana / Hao, Limin / Lu, Jike

    Food & function

    2021  Band 12, Heft 12, Seite(n) 5204–5218

    Abstract: Natural products can be used as natural radiosensitizers and radioprotectors, showing promising effects in cancer treatments in combination with radiotherapy, while reducing ionizing radiation (IR) damage to normal cells/tissues. The different effects of ...

    Abstract Natural products can be used as natural radiosensitizers and radioprotectors, showing promising effects in cancer treatments in combination with radiotherapy, while reducing ionizing radiation (IR) damage to normal cells/tissues. The different effects of natural products on irradiated normal and tumor cells/tissues have attracted more and more researchers' interest. Nonetheless, the clinical applications of natural products in radiotherapy are few, which may be related to their low bioavailability in the human body. Here, we displayed the radiation protection and radiation sensitization of major natural products, highlighted the related molecular mechanisms of these bioactive substances combined with radiotherapy to treat cancer, and critically reviewed their deficiency and improved measures. Lastly, several clinical trials were presented to verify the clinical application of natural products as radiosensitizers and radioprotectors. Further clinical evaluation is still needed. This review provides a reference for the utilization of natural products as radiosensitizers and radioprotectors.
    Mesh-Begriff(e) Alkaloids/pharmacology ; Animals ; Biological Products/pharmacology ; Humans ; Neoplasms/drug therapy ; Polyphenols/pharmacology ; Polysaccharides/pharmacology ; Radiation Protection ; Radiation-Protective Agents/pharmacology ; Radiation-Sensitizing Agents ; Saponins/pharmacology
    Chemische Substanzen Alkaloids ; Biological Products ; Polyphenols ; Polysaccharides ; Radiation-Protective Agents ; Radiation-Sensitizing Agents ; Saponins
    Sprache Englisch
    Erscheinungsdatum 2021-05-21
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d1fo00525a
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Radioprotective effect of radiation-induced Lactococcus lactis cell-free extract against

    Suo, Keke / Chen, Sisi / Li, Xue / Liu, Xin / Yi, Juanjuan / Zhu, Jiaqing / Lu, Laizheng / Hao, Limin / Kang, Qiaozhen / Lu, Jike

    Journal of dairy science

    2021  Band 104, Heft 9, Seite(n) 9532–9542

    Abstract: Ionizing radiation (IR) is widely used in the diagnosis and treatment of various cancers. However, IR can cause damage to human health by producing reactive oxygen species. Lactococcus lactis is a type of microorganism that is beneficial to human health ... ...

    Abstract Ionizing radiation (IR) is widely used in the diagnosis and treatment of various cancers. However, IR can cause damage to human health by producing reactive oxygen species. Lactococcus lactis is a type of microorganism that is beneficial to human health and has a strong antioxidant capacity. In this study, the protective effect of normal and IR-induced L. lactis IL1403 cell-free extracts (CFE and IR-CFE, respectively) against oxidative damage in vitro and the radioprotective effect of IR-CFE in vivo was evaluated using
    Mesh-Begriff(e) Animals ; Antioxidants/metabolism ; Cell Extracts ; Hydrogen Peroxide/metabolism ; Lactococcus lactis ; Liver/metabolism ; Mice ; Oxidative Stress ; Radiation-Protective Agents
    Chemische Substanzen Antioxidants ; Cell Extracts ; Radiation-Protective Agents ; Hydrogen Peroxide (BBX060AN9V)
    Sprache Englisch
    Erscheinungsdatum 2021-07-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 242499-x
    ISSN 1525-3198 ; 0022-0302
    ISSN (online) 1525-3198
    ISSN 0022-0302
    DOI 10.3168/jds.2021-20291
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Radioprotective effect of radiation-induced Lactococcus lactis cell-free extract against 60Coγ injury in mice

    Suo, Keke / Chen, Sisi / Li, Xue / Liu, Xin / Yi, Juanjuan / Zhu, Jiaqing / Lu, Laizheng / Hao, Limin / Kang, Qiaozhen / Lu, Jike

    American Dairy Science Association Journal of dairy science. 2021 Sept., v. 104, no. 9

    2021  

    Abstract: Ionizing radiation (IR) is widely used in the diagnosis and treatment of various cancers. However, IR can cause damage to human health by producing reactive oxygen species. Lactococcus lactis is a type of microorganism that is beneficial to human health ... ...

    Abstract Ionizing radiation (IR) is widely used in the diagnosis and treatment of various cancers. However, IR can cause damage to human health by producing reactive oxygen species. Lactococcus lactis is a type of microorganism that is beneficial to human health and has a strong antioxidant capacity. In this study, the protective effect of normal and IR-induced L. lactis IL1403 cell-free extracts (CFE and IR-CFE, respectively) against oxidative damage in vitro and the radioprotective effect of IR-CFE in vivo was evaluated using ⁶⁰Coγ-induced oxidative damage model in mice. Results showed that IR-CFE exhibited a stronger oxidative damage–protective effect than CFE for L. lactis IL1403 under H₂O₂ in vitro. Moreover, IR-CFE also showed strong radioprotective effect on hepatocyte cells (AML-12) under radiation condition, and the effect was better than that of CFE. Animal experiment indicated that IR-CFE could reduce the IR-induced damage to the hematopoietic system by increasing the number of white blood cells and red blood cells in peripheral blood of irradiated mice. It was also observed that IR-CFE could markedly alleviate the ⁶⁰Coγ-induced oxidative stress via increasing the activities of superoxide dismutase and glutathione peroxidase, enhancing the levels of glutathione, and decreasing the contents of malondialdehyde in serum, liver, and spleen. In addition, IR-CFE also could reduce the activities of alanine transaminase and aspartate aminotransferase in serum, thereby reducing radiation damage to the liver. These results suggested that IR-CFE could be considered as potential candidates for natural radioprotective agents. This study provides a theoretical basis for improving the application of lactic acid bacteria.
    Schlagwörter Lactococcus lactis ; alanine transaminase ; animal experimentation ; antioxidant activity ; aspartate transaminase ; blood serum ; dairy science ; glutathione ; glutathione peroxidase ; human health ; irradiation ; lactic acid ; liver ; malondialdehyde ; models ; oxidative stress ; radioprotective effect ; spleen ; superoxide dismutase
    Sprache Englisch
    Erscheinungsverlauf 2021-09
    Umfang p. 9532-9542.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 242499-x
    ISSN 1525-3198 ; 0022-0302
    ISSN (online) 1525-3198
    ISSN 0022-0302
    DOI 10.3168/jds.2021-20291
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    Einzelsign.: Hefte anzeigen

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