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  1. Article: Polyphenol compounds and PKC signaling.

    Das, Joydip / Ramani, Rashmi / Suraju, M Olufemi

    Biochimica et biophysica acta

    2016  Volume 1860, Issue 10, Page(s) 2107–2121

    Abstract: Background: Naturally occurring polyphenols found in food sources provide huge health benefits. Several polyphenolic compounds are implicated in the prevention of disease states, such as cancer. One of the mechanisms by which polyphenols exert their ... ...

    Abstract Background: Naturally occurring polyphenols found in food sources provide huge health benefits. Several polyphenolic compounds are implicated in the prevention of disease states, such as cancer. One of the mechanisms by which polyphenols exert their biological actions is by interfering in the protein kinase C (PKC) signaling pathways. PKC belongs to a superfamily of serine-threonine kinase and are primarily involved in phosphorylation of target proteins controlling activation and inhibition of many cellular processes directly or indirectly.
    Scope of review: Despite the availability of substantial literature data on polyphenols' regulation of PKC, no comprehensive review article is currently available on this subject. This article reviews PKC-polyphenol interactions and its relevance to various disease states. In particular, salient features of polyphenols, PKC, interactions of naturally occurring polyphenols with PKC, and future perspective of research on this subject are discussed.
    Major conclusions: Some polyphenols exert their antioxidant properties by regulating the transcription of the antioxidant enzyme genes through PKC signaling. Regulation of PKC by polyphenols is isoform dependent. The activation or inhibition of PKC by polyphenols has been found to be dependent on the presence of membrane, Ca(2+) ion, cofactors, cell and tissue types etc. Two polyphenols, curcumin and resveratrol are in clinical trials for the treatment of colon cancer.
    General significance: The fact that 74% of the cancer drugs are derived from natural sources, naturally occurring polyphenols or its simple analogs with improved bioavailability may have the potential to be cancer drugs in the future.
    MeSH term(s) Curcumin/therapeutic use ; Humans ; Neoplasms/drug therapy ; Neoplasms/enzymology ; Neoplasms/pathology ; Polyphenols/therapeutic use ; Protein Kinase C/antagonists & inhibitors ; Protein Kinase C/genetics ; Protein Kinase C/metabolism ; Signal Transduction/drug effects ; Stilbenes/therapeutic use
    Chemical Substances Polyphenols ; Stilbenes ; Protein Kinase C (EC 2.7.11.13) ; Curcumin (IT942ZTH98) ; resveratrol (Q369O8926L)
    Language English
    Publishing date 2016
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbagen.2016.06.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 2021 Canadian Surgery Forum: Virtual, online Sept. 21-24, 2021.

    Johnson, G / Vergis, A / Unger, B / Park, J / Gillman, L / Hickey, K / Pace, D / Azin, A / Guidolin, K / Lam-Tin-Cheung, K / Chadi, S / Quereshy, F / Catton, J / Rubin, B / Bell, J / Marangos, J / Heesters, A / Stuart-McEwan, T / Shariff, F /
    Wright, F / Ahmed, N / Nadler, A / Hallet, J / Gentles, J / Chen, L / Hwang, H / Parapini, M / Hirpara, D / Sidhu, R / Scott, T / Karimuddin, A / Guo, R / Nguyen, A / Osborn, J / Wiseman, S / Nabata, K / Ertel, E / Lenet, T / Baker, L / Park, L / Vered, M / Zahrai, A / Shorr, R / Davis, A / McIsaac, D / Tinmouth, A / Fergusson, D / Martel, G / Rummel, S / Stefic-Cubic, M / Stewart, M / Melck, A / McKechnie, T / Anpalagan, T / Ichhpuniani, S / Lee, Y / Ramji, K / Eskicioglu, C / Zhu, A / Deng, S / Greene, B / Tsang, M / Palter, V / Jayaraman, S / Mann, A / Tittley, J / Cadeddu, M / Nguyen, M / Madani, A / Pasternak, J / Hong, D / Qu, L / Istl, A / Tang, E / Gray, D / Zuckerman, J / Coburn, N / Callum, J / McLeod, R / Pearsall, E / Lin, Y / Turgeon, A / Mahar, A / Kammili, A / Kriviraltcheva-Kaneva, P / Lee, L / Cools-Lartigue, J / Ferri, L / Mueller, C / Haas, B / Tillman, B / Guttman, M / Chesney, T / Zuk, V / Hsu, A / Chan, W / Vasdev, R / D'Souza, K / Huynh, C / Ling, L Cadili J / Warburton, R / Hameed, M / Glass, L / Williamson, H / Murphy, P / Leslie, K / Hawel, J / Kerr, L / Zablotny, S / Roldan, H / He, W / Jiang, X / Zheng, B / Fiore, J / Feldman, L / Fried, G / Valanci, S / Balvardi, S / Cipolla, J / Kaneva, P / Demyttenaere, S / Boutros, M / Alhashemi, M / Miles, A / Purich, K / Verhoeff, K / Shapiro, J / Bigam, D / Kung, J / Fecso, A / Mosko, J / Skubleny, D / Hamilton, P / Ghosh, S / Widder, S / Schiller, D / Do, U / El Kefraoui, C / Pook, M / Barone, N / Montgomery, H / Nguyen-Powanda, P / Rajabiyazdi, F / Elhaj, H / Lapointe-Gagner, M / Olleik, G / Antoun, A / Safa, N / Di Lena, E / Meterissian, S / Meguerditchian, A / Lee, F / Baldini, G / Serrano Aybar, P E / Parpia, S / Ruo, L / Tywonek, K / Lee, S / O'Neill, C / Faisal, N / Alfayyadh, A / Gundayao, M / Meyers, B M / Habashi, R / Kruse, C / Levin, M / Aldrich, K / Grantcharov, T / Langerman, A / Forbes, H / Anantha, R / Fawcett, V / Hetherington, A / Pravong, V / Gervais, M / Rakovich, G / Selvam, R / Hu, R / Musselman, R / Raiche, I / Moloo, H / Liu, R / Elnahas, A / Alkhamesi, N / Alnumay, A / Schlachta, C / Walser, E / Zhang, C / Cristancho, S / Ott, M / Lee, A / Niu, B / Balaa, F / Gawad, N / Ren, K / Qiu, Y / Hamann, K / How, N / Leveille, C / Davidson, A / Eqbal, A / Sardiwalla, Y / Korostensky, M / Lee, E / Yang, I / Muaddi, H / Stukel, T / de Mestral, C / Nathens, A / Karanicolas, P / Frigault, J / Lemieux, S / Breton, D / Bouchard, P / Bouchard, A / Grégoire, R / Letarte, F / Bouchard, G / Drolet, S / Avoine, S / Gagné, J / Thibault, C / Jutras Bouthillette, N / Gosselin, M / Rosenzveig, A / Stuleanu, T / Jarrar, A / Kolozsvari, N / Skelhorne-Gross, G / Nenshi, R / Jerath, A / Gomez, D / Singh, K / Amir, T / Liu, E / Farquharson, S / Mao, R / Lan, L / Yan, J / Allard-Coutu, A / Mierzwa, A / Tin, R / Brisebois, R / Bradley, N / Wigen, R / Hartford, L / Van Koughnett, J / Vogt, K / Hilsden, R / Parry, N / Allen, L / Raskin, R / Jones, J / Neumann, K / Dwyer, C / Strickland, M / O'Dochartaigh, D / Lobay, K / Kabaroff, A / Chang, E / Sun, W / Beck, J / Davidson, J / Jones, S / Van Hooren, T / Schmitz, E / El Hafid, M / Dang, J / Mocanu, V / Lutzak, G / Sultanian, R / Wong, C / Karmali, S / Petrera, M / Pickell, M / Auer, R / Patro, N / Li, B / Wilson, H / Jogiat, U / Switzer, N / Li, C / Al Hinai, A / Cieply, A / Hawes, H / Joos, E / Saleh, A / Engels, P / Drung, J / Pang, G / Kwong, M / Ellsmere, J / Chang, D / Hutter, M / Spence, R / Abou Khalil, M / Vasilevsky, C / Morin, N / Longtin, Y / Liberman, S / Montpetit, P / Poirier, M / Mukherjee, K / Sebajang, H / Younan, R / Schwenter, F / De Broux, E / Larsen, K / Beckett, A / Nantais, J / Kay, J / Lohre, R / Ayeni, O / Goel, D / de Sa, D / He, R / Hylton, D / Bedard, E / Johnson, S / Laing, B / Valji, A / Hanna, W / Turner, S / Akhtar-Danesh, G / Akhtar-Danesh, N / Shargall, Y / Gupta, V / Kidane, B / Limbachia, J / Sullivan, K / Farrokhyar, F / Leontiadis, G / Patel, Y / Churchill, I / Xie, F / Seely, A / Spicer, J / Yasufuku, K / Beauchamp, M / Wald, J / Mbuagbaw, L / Agzarian, J / Finley, C / Fahim, C / Abbas, M / Olaiya, O / Begum, H / Ednie, A / Palma, D / Warner, A / Malthaner, R / Fortin, D / Qiabi, M / Nayak, R / Nguyen, T / Louie, A / Rodrigues, G / Yaremko, B / Laba, J / Inculet, R / Alaichi, J / Mador, B / Lai, H / White, J / Kim, M / Darling, G / Rousseau, M / Samarasinghe, Y / Lee, M / Thiru, L / Levine, O / Juergens, R / Brogly, S / Li, W / Lougheed, D / Petsikas, D / Mistry, N / Gatti, A / Abdul, S / Anestee, C / Gilbert, S / Sundaresan, S / Villeneuve, P / Maziak, D / Razzak, R / Ashrafi, A / Tregobov, N / Hassanzadeh, N / Stone, S / Panjwani, A / Bong, T / Bond, R / Hafizi, A / De Meo, M / Rayes, R / Milette, S / Vagai, M / Usatii, M / Chandrasekaran, A / Giannias, B / Bourdeau, F / Sangwan, V / Bertos, N / Moraes, C / Huang, S / Quail, D / Walsh, L / Camilleri-Broet, S / Fiset, P / Bilgic, E / Quaiattini, A / Maurice-Ventouris, M / Najmeh, S / Esther, L / Lu, J / Malhan, R / Brophy, S / Brennan, K / French, D / Resende, V / Momtazi, M / Solaja, O / Sisson, D / Donahoe, L / Bedard, P / Hansen, A / De Perrot, M / Alghamedi, A / Simone, A / Huang, J / Murthy, S / Lin, J / Li, H / Crowther, M / Linkins, L / Lau, E / Schneider, L / Douketis, J / Greenberg, B / Allen-Avodabo, C / Davis, L / Zhao, H / Sirois, C / Mulder, D / Al Rawahi, A / Aftab Abdul, S / Nguyen, D / Anstee, C / Delic, E / Sasewich, H / Islam, T / Low, D / Humer, M / Le Nguyen, D / Kay, M / Shayegan, B / Adili, A / Kaafarani, M / Chouiali, F / Muthukrishnan, N / Maleki, F / Ovens, K / Gold, M / Sorin, M / Falutz, R / Forghani, R / Hunka, N / Kennedy, R / Bigsby, R / Bharadwaj, S / Gowing, S / Pearce, K / Jones, D / Kumar, S / Gingrich, M / Ahmadzai, Z / Thavorn, K / Namavarian, A / Mohammed, A / Uddin, S / Behzadi, A / Brar, A / Peters, E / Buduhan, G / Tan, L / Srinathan, S / Levy, J / Ringash, J / Sutradhar, R / Robinson, M / Bednarek, L / Wang, H / MacDonald, D / Graham, K / Enns, S / Tan, A / Bruinooge, A / Poole, E / Pascoe, C / Karakach, T / Halayko, A / Fang, B / Birch, D / Singh, H / Hershorn, O / Hochman, D / Helewa, R / Robertson, R / Cahill, C / Lipson, M / Afzal, A / Maclean, A / Roen, S / Buie, W / Chu, M / Amin, N / Jaffer, H / Rebello, R / Doumouras, A / Hajjar, R / Oliero, M / Cuisiniere, T / Fragoso, G / Calvé, A / Djediai, S / Annabi, B / Richard, C / Santos, M / Zhou, Y / Dodd, S / Ring, B / Yuan, Y / Garfinkle, R / Dell'Aniello, S / Bhatnagar, S / Ghitulescu, G / Faria, J / Brassard, P / Salama, E / Amar-Zifkin, A / Talwar, G / Daniel, R / AlSulaim, H / Alqahtani, M / Al-Masrouri, S / Chen, A / Patel, A / Brissette, V / Al Busaidi, N / Moon, J / Demian, M / MacRae, H / Alam, F / Holland, J / Cwintal, M / Rigas, G / Pang, A / Marinescu, D / Brown, C / Raval, M / Phang, P / Ghuman, A / Li, M / Muncner, S / Mihajlovic, I / Dykstra, M / Snelgrove, R / Monton, O / Smith, A / AlAamer, O / AlSelaim, N / AlMalki, M / Al-Osail, A / Ruxton, R / Manuel, P / Mohamed, F / Motamedi, M K / Serahati, S / Rajendran, L / Phang, T / Caminsky, N / Alavi, K / Paquette, I / MacLean, T / Wexner, S / Steele, S / Patel, S / Bordeianou, L / Sylla, P / Bayat, Z / Kennedy, E / Victor, C / Govindarajan, A / Liang, J / Roy, H / Baig, Z / Karimmudin, A / Gill, D / Ginther, N / Alrashid, F / Wiseman, V / Zhang, L / MacDonald, P / Merchant, S M / Wattie Barnett, K / Caycedo-Marulanda, A / Patel, S V / Harra, Z / Hegagi, M / Alghaithi, N / Papillon, E / Kasteel, N / Kaur, G / Bindra, S / Malhotra, A / Graham, C / MacLean, A / Beck, P / Jijon, H / Ferraz, J / Szwimer, R / Merchant, S / Kong, W / Gyawali, B / Hanna, T / Chung, W / Nanji, S / Booth, C / Li, V / Awan, A / Serrano, P / Jacobson, M / Chanco, M / Wen, V / Singh, N / Peiris, L / Pasieka, J / Ghatage, P / Buie, D / Bouchard-Fortier, A / Mack, L / Marini, W / Zheng, W / Swallow, C / Reedijk, M / DiPasquale, A / Prus-Czrnecka, Z / Delmar, L / Gagnon, N / Villiard, R / Martel, É / Cadrin-Chênevert, A / Ledoux, É / Racicot, C / Mysuria, S / Bazzarelli, A / Pao, J / Zhang, M / McKevitt, E / Kuusk, U / Van Laeken, N / Bovill, E / Isaac, K / Dingee, C / Hunter-Smith, A / Cuthbert, C / Fergus, K / Barbera, L / Efegoma, Y / Howell, D / Isherwood, S / Levasseur, N / Scheer, A / Simmons, C / Srikantham, A / Temple-Orberle, C / Xu, Y / Metcalfe, K / Quan, M / Alqaydi, A / la, J / Digby, G / Brind'Amour, A / Sidéris, L / Dubé, P / De Guerke, L / Fortin, S / Auclair, M / Trilling, B / Tremblay, J / Di Lena, É / Hopkins, B / Wong, S / Dumitra, S / Kapur, H / Bazarelli, A / Cadili, L / DeGirolamo, K / Ng, D / Ali, A / Eymae, D / Lee, K / Brar, S / Conner, J / Magalhaes, M / Allen, K / Baliski, C / Cyr, D / Sari, A / Messenger, D / Driman, D / Assarzadegan, N / Juda, A / Brar, M / Kirsch, R / Lamontagne, A / Gamache, Y / Mardinger, C / Lee, C / Duckworth, R / Brindle, M / Fraulin, F / Austen, L / Kortbeek, J / Hyndman, M / Jamjoum, G / Langer, S / Yuan Xu, Y / Kong, S / Lim, D / Retrouvey, H / Kerrebijn, I / Butler, K / O'Neill, A / Cil, T / Zhong, T / Hofer, S / McCready, D / Look Hong, N / Skipworth, J / Mah, A / Desai, S / Chung, S / Scudamore, C / Segedi, M / Vasilyeva, E / Li, J / Kim, P / Deprato, A / Dajani, K / Gilbert, R / Smoot, R / Tzeng, C / Rocha, F / Yohanathan, L / Cleary, S / Bertens, K / Reyna-Sepulveda, F / Badrudin, D / Gala-Lopez, B / Hanna, N / Wei, X / Kaliwal, Y / Wei, A / Henault, D / Barrette, B / Pelletier, S / Thebault, P / Beaudry-Simoneau, E / Rong, Z / Plasse, M / Dagenais, A Roy M / Létourneau, R / Lapointe, R / Vandenbroucke-Menu, F / Nguyen, B / Soucy, G / Turcotte, S / Lemke, M / Waugh, E / Quan, D / Skaro, A / Lund, M / Glinka, J / Jada, G / Daza, J / Msallak, H / Zhang, B / Workneh, A / Faisal, S / Faisal, R / Fabbro, M / Gu, C / Claassen, M / Sapisochin, G / Breadner, D / Welch, S / Webb, A / Lester, E / Shapiro, A / Eurich, D / Essaji, Y / Shrader, H / Nayyar, A / Suraju, M / Williams-Perez, S / Ear, P / Chan, C / 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    Canadian journal of surgery. Journal canadien de chirurgie

    2021  Volume 64, Issue 6 Suppl 2, Page(s) S80–S159

    MeSH term(s) Canada ; Humans
    Language English
    Publishing date 2021-12-15
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 410651-9
    ISSN 1488-2310 ; 0008-428X
    ISSN (online) 1488-2310
    ISSN 0008-428X
    DOI 10.1503/cjs.021321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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