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  1. Article: Crystal structures of (12

    Meenatchi, C Selva / Vishnupriya, R / Suresh, J / Rubina, S Raja / Selvanayagam, S / Bhandari, S R

    Acta crystallographica. Section E, Crystallographic communications

    2023  Volume 79, Issue Pt 4, Page(s) 392–396

    Abstract: The title compounds, ... ...

    Abstract The title compounds, C
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041947-8
    ISSN 2056-9890 ; 1600-5368
    ISSN 2056-9890 ; 1600-5368
    DOI 10.1107/S205698902300275X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical false positives resulting from recent intravenous immunoglobulin therapy: case report.

    Suresh, Janarthanee / Kyle, Barry D

    BMC infectious diseases

    2021  Volume 21, Issue 1, Page(s) 288

    Abstract: Background: Many clinicians are aware that certain therapies administered to their patients can have downstream consequences in the form of clinical laboratory test interferences. This is particularly true of laboratory tests that depend on, or directly ...

    Abstract Background: Many clinicians are aware that certain therapies administered to their patients can have downstream consequences in the form of clinical laboratory test interferences. This is particularly true of laboratory tests that depend on, or directly involve the use of, antibody-based methodology. Intravenously-administered immunoglobulin therapy is one such treatment that can in theory directly impact the results of particular tests in the area of viral serology. This study can help serve as a reference for clinicians researching the impact of intravenously-administered immunoglobulin therapy in the context of positive results that do not reflect the clinical background of the patient.
    Case presentation: We describe a case whereby an intravenously-administered immunoglobulin therapy led to a series of clinical false positives in viral serology, inconsistent with the known patient history as well as recent laboratory results. The patient presented to hospital with petechiae-type bleeding rashes and was investigated for thrombocytopenia after initial blood investigations indicated very low platelets. Subsequent testing of the potential causes for low-platelet involved several viral serology investigations, including hepatitis, cytomegalovirus and human immunodeficiency virus. Initial testing indicated patient exhibited negative status for all viral antibodies and antigens (except immunity for hepatitis B surface antigen antibody). As part of the thrombocytopenia treatment, intravenously-administered immunoglobulin therapy was administered, and subsequent viral serology was ordered. These investigations indicated a positive status for several hepatitis antibodies as well as cytomegalovirus.
    Conclusions: This case study illustrates the potential for improper diagnosis of previous or ongoing infection status in patients administered IVIg therapy. Caution should be exercised particularly when interpreting results involving cytomegalovirus and hepatitis.
    MeSH term(s) Adult ; Antibodies, Viral/blood ; Cytomegalovirus ; False Positive Reactions ; Female ; Hepatitis Antibodies/blood ; Hepatitis Viruses ; Humans ; Immunoglobulins, Intravenous/therapeutic use
    Chemical Substances Antibodies, Viral ; Hepatitis Antibodies ; Immunoglobulins, Intravenous
    Language English
    Publishing date 2021-03-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-021-05986-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: (

    Meenatchi, C Selva / Athimoolam, S / Suresh, J / Priya, R Vishnu / Rubina, S Raja / Bhandari, S R

    IUCrData

    2022  Volume 7, Issue Pt 3, Page(s) x220283

    Abstract: In the title compound, ... ...

    Abstract In the title compound, C
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Journal Article
    ISSN 2414-3146
    ISSN (online) 2414-3146
    DOI 10.1107/S2414314622002838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Network Formation, Properties, and Actuation Performance of Functionalized Liquid Isoprene Rubber.

    Nirmala Suresh, Jishnu / Liebscher, Hans / Komber, Hartmut / Tahir, Muhammad / Gerlach, Gerald / Wießner, Sven

    ACS omega

    2024  Volume 9, Issue 4, Page(s) 4754–4761

    Abstract: Due to some useful mechanical, dynamic, and dielectric properties along with the ease of processing and forming, liquid rubbers are ideal materials for fabricating dielectric elastomer actuators in various configurations and for many potential ... ...

    Abstract Due to some useful mechanical, dynamic, and dielectric properties along with the ease of processing and forming, liquid rubbers are ideal materials for fabricating dielectric elastomer actuators in various configurations and for many potential applications ranging from automation to automobile and medical industry. In this study, we present a cross-linkable liquid rubber composition where amine-catalyzed esterification reactions lead to the formation of a network structure based on anhydride functional isoprene rubber, carboxyl-terminated nitrile-butadiene rubber, and epoxy end-capped prepolymers. The success of this intricate network formation procedure was verified by HR-MAS NMR spectroscopy. The new isoprene-based elastomeric material exhibits actuation-relevant attributes including a low elastic modulus of 0.45 MPa, soft response to an applied load up to a large deformation of 300%, and a dielectric constant value (2.6) higher than the conventional Elastosil silicone (2.2). A dot actuator comprising of an isoprene dielectric elastomer film in unstretched state and carbon paste electrodes was fabricated that demonstrated an electrode deformation of 0.63%, which is nearly twice as high as for the commercial Elastosil 2030 film (∼0.30%) at 5 kV. Compared to the Elastosil silicone film, the enhanced performance is attributed to the low modulus and high dielectric constant value of the new isoprene elastomer.
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c08022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Genetic Polymorphisms of XPC, XPD, XPG Genes and their Association with Radiotherapy Induced Toxicity among Head and Neck Cancer Patients: A Hospital Based Study from Maharashtra.

    Gudur, Anand K / Kale, Shivani R / Gudur, Rashmi A / Bhosale, Suresh J / Datkhile, Kailas D

    Asian Pacific journal of cancer prevention : APJCP

    2024  Volume 25, Issue 1, Page(s) 191–199

    Abstract: Background: The present study was planned to investigate possible association of single nucleotide polymorphisms (SNPs) of nucleotide excision repair (NER) genes such as XPC, XPD, XPG with acute radiation induced toxicities such as skin reactions and ... ...

    Abstract Background: The present study was planned to investigate possible association of single nucleotide polymorphisms (SNPs) of nucleotide excision repair (NER) genes such as XPC, XPD, XPG with acute radiation induced toxicities such as skin reactions and oral mucositis in normal tissue from head and neck cancer (HNC) patients receiving radiotherapy.  Methods: Two hundred and fifty HNC patients receiving radiotherapy were enrolled in this study and the acute toxicity reactions and radiation response were recorded. Association of SNPs rs2228001 of XPC, rs238406, rs13181 of XPD and rs17655 of XPG gene with normal tissue reactions in the form of dermatitis and mucositis were studied by PCR-RFLP and direct DNA sequencing.
    Results: The results of univariate analysis of SNPs of XPC, XPD and XPG showed that XPC polymorphism at codon 939 of exon 15 (A>C) was not associated with dermatitis (OR=0.30, 95% CI: 0.06-1.39; p=0.125), or oral mucositis (OR=1.14, 95% CI: 0.41-3.20; p=0.793). The XPD codon 156 of exon 6 (C>A) and codon 751 of exon-23 A>C) polymorphism showed no association with radiosensitivity in HNC patients (OR=1.50, 95% CI: 0.60-3.71; p=0.080) for dermatitis, (OR=1.54, 95% CI: 0.66-3.61; p=0.312) for oral mucositis. The 1104 Asp variant genotype or allele of XPG (OR=1.35 95% CI: 0.50-3.64; p=0.541) showed no association with degree of radiotherapy associated dermatitis or mucositis (OR=0.80, 95% CI: 0.32-2.03; p=0.648) in HNC patients. The variant C allele of 2920 A/C genotype of XPC gene at codon 939 of exon 15, found protective with developing skin reactions with grade >1 (OR=0.60, 95% CI: 0.36-0.97; p=0.039) in HNC patients treated with radiotherapy.
    Conclusion: The results obtained in this study concluded that the SNPs rs2228001of XPC, rs238406, rs13181 SNPs of XPD and rs17655 SNP of XPG are not associated with normal tissue toxicity in HNC patients treated with radiotherapy. Radiotherapy with high radiation dose was significantly associated with oral mucositis in response to radiotherapy.
    MeSH term(s) Humans ; Codon ; Dermatitis/genetics ; DNA Repair/genetics ; DNA-Binding Proteins/genetics ; Genetic Predisposition to Disease ; Genotype ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/radiotherapy ; India ; Mucositis/genetics ; Polymorphism, Single Nucleotide/genetics ; Stomatitis/genetics ; Xeroderma Pigmentosum Group D Protein/genetics
    Chemical Substances Codon ; DNA-Binding Proteins ; Xeroderma Pigmentosum Group D Protein (EC 3.6.4.12) ; XPC protein, human (156533-34-5) ; DNA excision repair protein ERCC-5
    Language English
    Publishing date 2024-01-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2024.25.1.191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cell- and Serum-Derived Proteins Act as DAMPs to Activate RAW 264.7 Macrophage-like Cells on Silicone Implants.

    Blackman, Samuel A / Miles, Dalton / Suresh, Joshita / Calve, Sarah / Bryant, Stephanie J

    ACS biomaterials science & engineering

    2024  Volume 10, Issue 3, Page(s) 1418–1434

    Abstract: Protein adsorption after biomaterial implantation is the first stage of the foreign body response (FBR). However, the source(s) of the adsorbed proteins that lead to damaged associated molecular patterns (DAMPs) and induce inflammation have not been ... ...

    Abstract Protein adsorption after biomaterial implantation is the first stage of the foreign body response (FBR). However, the source(s) of the adsorbed proteins that lead to damaged associated molecular patterns (DAMPs) and induce inflammation have not been fully elucidated. This study examined the effects of different protein sources, cell-derived (from a NIH/3T3 fibroblast cell lysate) and serum-derived (from fetal bovine serum), which were compared to implant-derived proteins (after a 30 min subcutaneous implantation in mice) on activation of RAW 264.7 cells cultured in minimal (serum-free) medium. Both cell-derived and serum-derived protein sources when preadsorbed to either tissue culture polystyrene or medical-grade silicone induced RAW 264.7 cell activation. The combination led to an even higher expression of pro-inflammatory cytokine genes and proteins. Implant-derived proteins on silicone explants induced a rapid inflammatory response that then subsided more quickly and to a greater extent than the studies with
    MeSH term(s) Mice ; Animals ; RAW 264.7 Cells ; Foreign-Body Reaction ; Proteomics ; Macrophages ; Inflammation ; Proteins ; Silicones
    Chemical Substances Proteins ; Silicones
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.3c01393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ptosis and dacryoadenitis following COVID.

    Rodrigues, Gladys / Hiran, Harshita / Suprasanna, K / Mendonca, Teena / Suresh, Jithin

    Clinical & experimental optometry

    2023  , Page(s) 1–3

    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639275-1
    ISSN 1444-0938 ; 0816-4622
    ISSN (online) 1444-0938
    ISSN 0816-4622
    DOI 10.1080/08164622.2023.2197580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Changes in work patterns during COVID-19 lockdown and its impact on the eyes and body.

    Regmi, Alisha / Suresh, Janani / Asokan, Rashima

    Clinical & experimental optometry

    2022  Volume 106, Issue 3, Page(s) 331–337

    Abstract: Clinical relevance: Greater usage of digital devices and change of work pattern as working from home have created an impact on both visual and musculoskeletal systems. Developing an understanding of these changes could assist in providing appropriate ... ...

    Abstract Clinical relevance: Greater usage of digital devices and change of work pattern as working from home have created an impact on both visual and musculoskeletal systems. Developing an understanding of these changes could assist in providing appropriate care.
    Background: The current study aims to elicit the changes in work patterns due to COVID-19 lockdown and understand the impact of the usage of digital devices on the visual system and musculoskeletal system.
    Methods: A survey was designed using Delphi technique and circulated through electronic communication sources using Google form to the working population and students across India, who consented to participate. The survey had components designed to develop an understanding of work patterns, digital device usage, associated visual/ocular symptoms, work-related musculoskeletal disorder (WRMSD) symptoms, and relevant information on psychological factors, and practice of yoga/exercises.
    Results: There were 1302 valid responses. Mean age of respondents was 24 (IQR 11) years and 548 (42.1%) were male. A total of 1231 (94.5%) reported having one or many visual and ocular symptoms associated with the use of digital devices and 1140 (87.6%) responses indicated WRMSD symptoms. Of the symptomatic respondents, 561 (43.1%) had reported visual/ocular symptoms and 586 (45%) WRMSD symptoms during lockdown, which they did not experience during regular work. Risk factors for visual/ocular symptoms and WRMSD were females, spending more than 6 h on digital devices, taking breaks from digital devices after 2 h, inability to maintain a fair sleep schedule, and inability to make ergonomic modifications at home.
    Conclusions: A high prevalence of both visual/ocular symptoms (43.1%) and WRMSD symptoms (45%) was encountered during COVID-19 lockdown.
    MeSH term(s) Female ; Humans ; Male ; Child ; COVID-19/epidemiology ; Communicable Disease Control ; Surveys and Questionnaires ; Sleep/physiology ; Risk Factors ; Musculoskeletal Diseases/epidemiology
    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639275-1
    ISSN 1444-0938 ; 0816-4622
    ISSN (online) 1444-0938
    ISSN 0816-4622
    DOI 10.1080/08164622.2022.2029682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Review Paper on Thermal Performance of Pulsating Heat Pipe

    Suresh J. Venkata / Bhramara P. / Manisha B. / Ishitha K. / Nagalakshmi R. / subbiah Ram

    E3S Web of Conferences, Vol 391, p

    2023  Volume 01031

    Abstract: In past few years, as indirect convection cooling equipment, heat pipes have grown in favour for a variety of uses, including heat recovery and electronics. A sensible heat is categorized as not having a filter arrangement as a “pulsating heat pipe”. It ... ...

    Abstract In past few years, as indirect convection cooling equipment, heat pipes have grown in favour for a variety of uses, including heat recovery and electronics. A sensible heat is categorized as not having a filter arrangement as a “pulsating heat pipe”. It transfers heat from its evaporator to condenser portions by moving the circulating flow back and forth a reaction of its ongoing phase shift that occurs inside of it. It is difficult to truly understand how it operates since the two-phase flow is the result of combining physical and thermodynamic factors. Despite this, the PHPs have caught the interest of researchers all over the world because of its simple design and large several scenarios necessitating an elevated heat transfer rate. Presented here begins and a preface outlining several researchers’ trying to model experimental explain how PHPs work. A short tabular review of the most recent experimental investigations on PHPs is offered. Novel ideas have been explored, including the use of Nano-fluids to improve PHP performance.
    Keywords Environmental sciences ; GE1-350
    Subject code 621
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Azafluorene derivatives as inhibitors of SARS CoV-2 RdRp: Synthesis, physicochemical, quantum chemical, modeling and molecular docking analysis.

    Venkateshan, M / Muthu, M / Suresh, J / Ranjith Kumar, R

    Journal of molecular structure

    2020  Volume 1220, Page(s) 128741

    Abstract: The crystal structures of 2-(1H-indol-3-yl)-4-phenyl-5H-indeno [( Cheng et al., 2007; Lee et al., 2003) 1,21,2-b]pyridine-3-carbonitrile (Ia) and 2-(1H-indol-3-yl)-4-(4-methoxyphenyl)-5H-indeno [( Cheng et al., 2007; Lee et al., 2003) 1,21,2-b]pyridine-3- ...

    Abstract The crystal structures of 2-(1H-indol-3-yl)-4-phenyl-5H-indeno [( Cheng et al., 2007; Lee et al., 2003) 1,21,2-b]pyridine-3-carbonitrile (Ia) and 2-(1H-indol-3-yl)-4-(4-methoxyphenyl)-5H-indeno [( Cheng et al., 2007; Lee et al., 2003) 1,21,2-b]pyridine-3-carbonitrile (Ib) were determined using single crystal X-ray diffraction. Both the compounds belong to the triclinic system with the P-1 space group. The azafluorene ring system in both the compounds is effectively planar. The intermolecular interactions present in the compounds are discussed using Hirshfeld surface analysis, QTAIM and NCI. Compound Ib formed a strong interaction (-24.174 kJ/mol) with the solvent molecule. Both the compounds were geometry optimized using DFT/B3LYP level of theory. The compound's drug-like behaviors were studied using HOMO-LUMO analysis. The homology modeling of SARS CoV-2 RdRp was done utilizing the PDB 6NUR_A as a template. The model showed above 99% similarity with its preceder SARS CoV. The molecular docking analysis of the synthesized compounds was carried out along with some suggested drugs for COVID-19 and some phytochemicals. The docking results were then analyzed. The binding free energy of the complexes were calculated using MM-PB(GB)SA and ADMET properties of Ia and Ib were also predicted. Some suggestions are given from this analysis.
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 194476-9
    ISSN 0022-2860 ; 0377-046X
    ISSN 0022-2860 ; 0377-046X
    DOI 10.1016/j.molstruc.2020.128741
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