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  1. AU="Suresh, Vinod"
  2. AU="Monferrer, Dominique"
  3. AU="John Tam"
  4. AU="Yi, Rong"
  5. AU="Bhandary, R P"
  6. AU="Merkebu, Jerusalem"
  7. AU="Han, Junhyek"
  8. AU="Muneoka, Yusuke"
  9. AU="Griggs, Lisa"
  10. AU="Klauck, Sabine M"
  11. AU="Turton, James A"
  12. AU="Patel, Abhijit A"
  13. AU="Shankowsky, Heather A"
  14. AU="Płóciennik, Przemysław"
  15. AU="Marchesi, Pietro"
  16. AU="Kim Je Hyoung"
  17. AU="Huber, Ingrid"
  18. AU="Hasuko, K."
  19. AU="Yao, Weigen"
  20. AU="Huang, Xiao-Fan"
  21. AU=Zuo Chuantian
  22. AU="Varchetta, Veronica"
  23. AU="Zhang, Lingye"
  24. AU="Venko, Katja"
  25. AU="Kasthuri, Thirupathi"
  26. AU="Pirtskhalava, Tamar"
  27. AU="Saridakis, E N"
  28. AU="Vithana, Eranga N"
  29. AU="Suárez-Lledó, M"
  30. AU="Olivo-Marston, Susan"
  31. AU="Denise P Momesso"
  32. AU="Obrecht-Sturm, Denise"

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Treffer 1 - 10 von insgesamt 36

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  1. Artikel: Permeability Properties of an

    Suresh, Vinod

    Cellular and molecular bioengineering

    2021  Band 14, Heft 6, Seite(n) 653–659

    Abstract: Cell culture models of epithelial barriers in the body are widely used to study the permeation of nutrients, drugs, infectious agents and pollutants into the body tissues and circulation. The NCI-H441 cell line cultured at the air-liquid interface mimics ...

    Abstract Cell culture models of epithelial barriers in the body are widely used to study the permeation of nutrients, drugs, infectious agents and pollutants into the body tissues and circulation. The NCI-H441 cell line cultured at the air-liquid interface mimics certain phenotypic and functional characteristics of the human alveolar epithelium. Here the permeability properties of the NCI-H441 model were characterised and compared against published data using experimental measurements and mathematical modelling. Cells were cultured under air-liquid interface conditions and trans-epithelial electrical resistance (TEER) and apparent permeability (
    Sprache Englisch
    Erscheinungsdatum 2021-07-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2416037-4
    ISSN 1865-5033 ; 1865-5025
    ISSN (online) 1865-5033
    ISSN 1865-5025
    DOI 10.1007/s12195-021-00690-z
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  2. Artikel ; Online: A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts.

    Su, Shan / Wahl, Amanda / Rugis, John / Suresh, Vinod / Yule, David I / Sneyd, James

    American journal of physiology. Gastrointestinal and liver physiology

    2024  Band 326, Heft 5, Seite(n) G555–G566

    Abstract: Cystic fibrosis (CF) is a genetic disease caused by the mutations of cystic fibrosis transmembrane conductance regulator ( ...

    Abstract Cystic fibrosis (CF) is a genetic disease caused by the mutations of cystic fibrosis transmembrane conductance regulator (
    Mesh-Begriff(e) Mice ; Animals ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Cystic Fibrosis/genetics ; Cystic Fibrosis/metabolism ; Cell Membrane/metabolism ; Epithelial Sodium Channels/genetics ; Epithelial Sodium Channels/metabolism ; Sodium/metabolism ; Models, Theoretical ; Sulfate Transporters/genetics ; Sulfate Transporters/metabolism ; Antiporters/genetics ; Antiporters/metabolism
    Chemische Substanzen Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Epithelial Sodium Channels ; Sodium (9NEZ333N27) ; Slc26a6 protein, mouse ; Sulfate Transporters ; Antiporters
    Sprache Englisch
    Erscheinungsdatum 2024-02-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00168.2023
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  3. Artikel ; Online: Landmark-free Shape Analysis of the Human Duodenum

    Palmada, Nadun / Cater, John E / Cheng, Leo K / Suresh, Vinod

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2023  Band 2023, Seite(n) 1–4

    Abstract: The primary function of the duodenum is to undertake chemical digestion by ensuring that the partially digested food received from the stomach is well-mixed with the enzymes and chemicals secreted into it. However, little is known about the anatomical ... ...

    Abstract The primary function of the duodenum is to undertake chemical digestion by ensuring that the partially digested food received from the stomach is well-mixed with the enzymes and chemicals secreted into it. However, little is known about the anatomical variations in the shape of the duodenum within humans, and thus the effect of duodenum shape on the flow and mixing occurring within the lumen has not been studied. In this work, a methodology for analyzing shape variations in the normal duodenal anatomy has been developed and applied to a publicly available dataset of abdominal CT images. This method does not require the placement of landmarks as it is based on the underlying tubular 'C' shape of the duodenum. The average duodenal length and radius of this dataset (consisting of 34 subjects) were 212.8 ± 38 mm and 10.8 ± 2.5 mm respectively. A Principal Component Analysis (PCA) was conducted on a sample of 34 duodenums after normalizing their lengths and the first five principal components were found to contribute to 82 % of the total variation. The first shape component (accounting for 42 % of overall variation) consisted of variations in the radius along the duodenum with no deformations normal to the central plane, and the subsequent shape modes consisted of twists in the centerline either in and out of the central plane, and radial variations at either the inlet or outlet. This is the first study to analyze shape variations in the human duodenum and the results can be combined with flow modeling to analyze the effect of shape on the flow and mixing occurring within the duodenum.Clinical relevance- The methods developed in this study can be used by clinicians to diagnose abnormalities in an individual's duodenum shape.
    Mesh-Begriff(e) Humans ; Duodenum/diagnostic imaging ; Stomach
    Sprache Englisch
    Erscheinungsdatum 2023-12-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC40787.2023.10340464
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  4. Artikel ; Online: Development of closed-loop modelling framework for adaptive respiratory pacemakers.

    Ai, Weiwei / Suresh, Vinod / Roop, Partha S

    Computers in biology and medicine

    2021  Band 141, Seite(n) 105136

    Abstract: Objective: Ventilatory pacing by electrical stimulation of the phrenic nerve has many advantages compared to mechanical ventilation. However, commercially available respiratory pacing devices operate in an open-loop fashion, which require manual ... ...

    Abstract Objective: Ventilatory pacing by electrical stimulation of the phrenic nerve has many advantages compared to mechanical ventilation. However, commercially available respiratory pacing devices operate in an open-loop fashion, which require manual adjustment of stimulation parameters for a given patient. Here, we report the model development of a closed-loop respiratory pacemaker, which can automatically adapt to various pathological ventilation conditions and metabolic demands.
    Methods: To assist the model design, we have personalized a computational lung model, which incorporates the mechanics of ventilation and gas exchange. The model can respond to the device stimulation where the gas exchange model provides biofeedback signals to the device. We use a pacing device model with a proportional integral (PI) controller to illustrate our approach.
    Results: The closed-loop adaptive pacing model can provide superior treatment compared to open-loop operation. The adaptive pacing stimuli can maintain physiological oxygen levels in the blood under various simulated breathing disorders and metabolic demands.
    Conclusion: We demonstrate that the respiratory pacing devices with the biofeedback can adapt to individual needs, while the lung model can be used to validate and parametrize the device.
    Significance: The closed-loop model-based framework paves the way towards an individualized and autonomous respiratory pacing device development.
    Mesh-Begriff(e) Humans ; Lung ; Oxygen ; Respiration ; Respiration, Artificial ; Respiratory Rate
    Chemische Substanzen Oxygen (S88TT14065)
    Sprache Englisch
    Erscheinungsdatum 2021-12-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2021.105136
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    Zs.A 653: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Artikel ; Online: Quantification of the Regional Properties of Gastric Motility Using Dynamic Magnetic Resonance Images.

    Hosseini, Saeed / Avci, Recep / Paskaranandavadivel, Niranchan / Suresh, Vinod / Cheng, Leo K

    IEEE open journal of engineering in medicine and biology

    2023  Band 4, Seite(n) 38–44

    Abstract: ... ...

    Abstract Goal
    Sprache Englisch
    Erscheinungsdatum 2023-03-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2644-1276
    ISSN (online) 2644-1276
    DOI 10.1109/OJEMB.2023.3261224
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  6. Artikel ; Online: Likelihood-based estimation and prediction for a measles outbreak in Samoa.

    Wu, David / Petousis-Harris, Helen / Paynter, Janine / Suresh, Vinod / Maclaren, Oliver J

    Infectious Disease Modelling

    2023  Band 8, Heft 1, Seite(n) 212–227

    Abstract: Prediction of the progression of an infectious disease outbreak is important for planning and coordinating a response. Differential equations are often used to model an epidemic outbreak's behaviour but are challenging to parameterise. Furthermore, these ...

    Abstract Prediction of the progression of an infectious disease outbreak is important for planning and coordinating a response. Differential equations are often used to model an epidemic outbreak's behaviour but are challenging to parameterise. Furthermore, these models can suffer from misspecification, which biases predictions and parameter estimates. Stochastic models can help with misspecification but are even more expensive to simulate and perform inference with. Here, we develop an explicitly likelihood-based variation of the generalised profiling method as a tool for prediction and inference under model misspecification. Our approach allows us to carry out identifiability analysis and uncertainty quantification using profile likelihood-based methods without the need for marginalisation. We provide justification for this approach by introducing a new interpretation of the model approximation component as a stochastic constraint. This preserves the rationale for using profiling rather than integration to remove nuisance parameters while also providing a link back to stochastic models. We applied an initial version of this method during an outbreak of measles in Samoa in 2019-2020 and found that it achieved relatively fast, accurate predictions. Here we present the most recent version of our method and its application to this measles outbreak, along with additional validation.
    Sprache Englisch
    Erscheinungsdatum 2023-02-03
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 3015225-2
    ISSN 2468-0427 ; 2468-2152
    ISSN (online) 2468-0427
    ISSN 2468-2152
    DOI 10.1016/j.idm.2023.01.007
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  7. Artikel ; Online: In silico prediction of e-cigarette aerosol particle transport and deposition within the airways.

    Aghababaie, Marzieh / Suresh, Vinod / McGlashan, Sue / Tawhai, Merryn / Burrowes, Kelly

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2023  Band 2023, Seite(n) 1–4

    Abstract: Electronic cigarettes (ECs) generate aerosols by heating up a liquid ('e-liquid') that typically consists of propylene glycol (PG), vegetable glycerol (VG), nicotine and flavouring agents. These aerosols transport through the airway tree, and lung and ... ...

    Abstract Electronic cigarettes (ECs) generate aerosols by heating up a liquid ('e-liquid') that typically consists of propylene glycol (PG), vegetable glycerol (VG), nicotine and flavouring agents. These aerosols transport through the airway tree, and lung and deposit non-uniformly in the bronchi and alveoli. Studying the transport of aerosols through lung airways is necessary because it provides information about the concentration and deposition of particles in the upper and lower airways. Here, particle transport and deposition were simulated within an anatomically-realistic airway model, which was constructed from computed tomography imaging. Particle transport was simulated using the advection-diffusion equations. Particle deposition was estimated using three different mechanisms; including sedimentation, impaction and Brownian diffusion. Results show that by increasing the particle size (PS) from 50 nm to 500 nm, the total deposition efficiency decreased from 50% to 10%, and then by increasing the PS to 3 μm, it increased to 60%. In addition, Brownian deposition was the dominant mechanism for nanoparticles (PS≪0.5μm), while the sedimentation deposition mechanism was the dominant one for microparticles (PS≫0.5μm).Clinical relevance-There is an urgent need to understand the risk that ECs pose to human health and to determine the safest methods for using these devices to support smoking cessation whilst also minimising harm. The results of this study will be used to simulate the conditions such as aerosol concentration and flow rate in airways and alveoli to use in in vitro studies.
    Mesh-Begriff(e) Humans ; Electronic Nicotine Delivery Systems ; Aerosols ; Nicotine ; Lung ; Bronchi
    Chemische Substanzen Aerosols ; Nicotine (6M3C89ZY6R)
    Sprache Englisch
    Erscheinungsdatum 2023-12-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC40787.2023.10340944
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  8. Artikel ; Online: MRI Derived Simulations of Flow Patterns in the Stomach.

    Hosseini, Saeed / Palmada, Nadun / Avci, Recep / Suresh, Vinod / Cheng, Leo K

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2023  Band 2023, Seite(n) 1–4

    Abstract: A framework to simulate the flow in the stomach using subject-specific motility patterns and geometries was developed. Dynamic 2D magnetic resonance images (MRIs) were obtained. Motility parameters such as contraction speed and occlusion were quantified, ...

    Abstract A framework to simulate the flow in the stomach using subject-specific motility patterns and geometries was developed. Dynamic 2D magnetic resonance images (MRIs) were obtained. Motility parameters such as contraction speed and occlusion were quantified, and 3D stomach geometries were reconstructed using a semi-automated approach. Computational fluid dynamics (CFD) simulations were performed, and flow patterns were investigated. The stomach of both subjects had distinct anatomical features with computed volumes of 789 mL and 619 mL. For the one subject, the occlusion (i.e., normalized contraction size) was 12% while it was around 25% for the other subject. Contraction speeds were also different (1.9-2.8 mm/s vs 3.0-5.1 mm/s) for each subject. CFD simulations resulted in unsteady laminar flow for both subjects with average velocities of 2.1 and 3.2 mm/s. While antegrade flow was mainly observed in the simulations, a retropulsive jet was also present in both stomachs. The versatile framework developed within this study would allow the generation of CFD models of gastric motility from dynamic MRIs.Clinical Relevance- Subject-specific models of flow patterns informed by gastric motility features can elucidate the impact of contractions and anatomical variations on digestion. Such models can inform therapies to treat gastric dysfunctions and improve their efficacy.
    Mesh-Begriff(e) Humans ; Computer Simulation ; Magnetic Resonance Imaging/methods ; Stomach/diagnostic imaging ; Hydrodynamics ; Vascular Diseases
    Sprache Englisch
    Erscheinungsdatum 2023-12-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC40787.2023.10340717
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  9. Artikel ; Online: Simulation of Calcium Dynamics in Realistic Three-Dimensional Domains.

    Sneyd, James / Rugis, John / Su, Shan / Suresh, Vinod / Wahl, Amanda M / Yule, David I

    Biomolecules

    2022  Band 12, Heft 10

    Abstract: The cytosolic concentration of free calcium ions ([Ca2+]) is an important intracellular messenger in most cell types, and the spatial distribution of [Ca2+] is often critical. In a salivary gland acinar cell, a polarised epithelial cell, whose principal ... ...

    Abstract The cytosolic concentration of free calcium ions ([Ca2+]) is an important intracellular messenger in most cell types, and the spatial distribution of [Ca2+] is often critical. In a salivary gland acinar cell, a polarised epithelial cell, whose principal function is to transport water and thus secrete saliva, [Ca2+] controls the secretion of primary saliva, but increases in [Ca2+] are localised to the apical regions of the cell. Hence, any quantitative explanation of how [Ca2+] controls saliva secretion must take into careful account the spatial distribution of the various Ca2+ sources, Ca2+ sinks, and Ca2+-sensitive ion channels. Based on optical slices, we have previously constructed anatomically accurate three-dimensional models of seven salivary gland acinar cells, and thus shown that a model in which Ca2+ responses are confined to the apical regions of the cell is sufficient to provide a quantitative and predictive explanation of primary saliva secretion. However, reconstruction of such anatomically accurate cells is extremely time consuming and inefficient. Here, we present an alternative, mostly automated method of constructing three-dimensional cells that are approximately anatomically accurate and show that the new construction preserves the quantitative accuracy of the model.
    Mesh-Begriff(e) Calcium/metabolism ; Acinar Cells/metabolism ; Ion Channels/metabolism ; Ions/metabolism ; Water/metabolism
    Chemische Substanzen Calcium (SY7Q814VUP) ; Ion Channels ; Ions ; Water (059QF0KO0R)
    Sprache Englisch
    Erscheinungsdatum 2022-10-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12101455
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Effect of sedatives on rumen motility in sheep

    Waite, Stephen J / Cater, John E / Waghorn, Garry C / Suresh, Vinod

    Small ruminant research. 2021 Mar., v. 196

    2021  

    Abstract: Rumen motility is depressed by a number of anesthetic agents, making them unsuitable for the reduction of animal anxiety and distress during experimental investigations of rumen motility. Little is known about the influence on rumen motility of chemical ... ...

    Abstract Rumen motility is depressed by a number of anesthetic agents, making them unsuitable for the reduction of animal anxiety and distress during experimental investigations of rumen motility. Little is known about the influence on rumen motility of chemical agents that induce sedation without unconsciousness. A pilot trial was performed to assess the effect of three commonly used ruminant sedatives on rumen motility. Xylazine, acetylpromazine and diazepam were individually administered by intravenous injection to 3 adult sheep ewes. Animal behaviour was observed and ultrasound monitoring was used to assess rumen contractions in the animals over a range of sedative doses. At low dosages 0.05 mg/kg, xylazine reduced contraction frequency after 5 min, and at higher dosages 0.125 mg/kg full atony was observed. In contrast, neither acetylpromazine (0.02–0.1 mg/kg) and diazepam (0.2–0.5 mg/kg) depressed rumen motility. Diazepam was also observed to give greater sedative influence than acetylpromazine, both in terms of muscular and cognitive sedation. Sedative effects lasted approximately 20–30 min after administration, after which the effects diminished rapidly. We conclude that diazepam at dosages of 0.3–0.5 mg/kg is suitable for procedures requiring short term sedation of sheep while preserving rumen motility.
    Schlagwörter adults ; animal behavior ; anxiety ; cognition ; diazepam ; distress ; intravenous injection ; research ; rumen motility ; sedation ; ultrasonics ; unconsciousness ; xylazine
    Sprache Englisch
    Erscheinungsverlauf 2021-03
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 286928-7
    ISSN 0921-4488
    ISSN 0921-4488
    DOI 10.1016/j.smallrumres.2020.106284
    Datenquelle NAL Katalog (AGRICOLA)

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