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Article ; Online: Capital allocation in an asymmetric tax competition model with agglomeration economies

Susa, Taiki

Letters in spatial and resource sciences : LSRS Vol. 7, No. 3 , p. 185-193

2014 Volume 7, Issue 3, Page(s) 185–193

Author's details	Taiki Susa
Keywords	Tax competition ; Agglomeration ; Pecuniary externality
Language	English
Size	Online-Ressource
Publisher	Springer
Publishing place	Berlin ; Heidelberg
Document type	Article ; Online
ZDB-ID	2436019-3
ISSN	1864-404X
Database	ECONomics Information System

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Article ; Online: A novel LncRNA PTH-AS upregulates interferon-related DNA damage resistance signature genes and promotes metastasis in human breast cancer xenografts.

Akimoto, Miho / Susa, Takao / Okudaira, Noriyuki / Hisaki, Harumi / Iizuka, Masayoshi / Okinaga, Hiroko / Okazaki, Tomoki / Tamamori-Adachi, Mimi

The Journal of biological chemistry

2022 Volume 298, Issue 7, Page(s) 102065

Abstract: Long noncoding RNAs (lncRNAs) are important tissue-specific regulators of gene expression, and their dysregulation can induce aberrant gene expression leading to various pathological conditions, including cancer. Although many lncRNAs have been ... ...

Abstract	Long noncoding RNAs (lncRNAs) are important tissue-specific regulators of gene expression, and their dysregulation can induce aberrant gene expression leading to various pathological conditions, including cancer. Although many lncRNAs have been discovered by computational analysis, most of these are as yet unannotated. Herein, we describe the nature and function of a novel lncRNA detected downstream of the human parathyroid hormone (PTH) gene in both extremely rare ectopic PTH-producing retroperitoneal malignant fibrous histiocytoma and parathyroid tumors with PTH overproduction. This novel lncRNA, which we have named "PTH-AS," has never been registered in a public database, and here, we investigated for the first time its exact locus, length, transcription direction, polyadenylation, and nuclear localization. Microarray and Gene Ontology analyses demonstrated that forced expression of PTH-AS in PTH-nonexpressing human breast cancer T47D cells did not induce the ectopic expression of the nearby PTH gene but did significantly upregulate Janus kinase-signal transducer and activator of transcription pathway-related genes such as cancer-promoting interferon-related DNA damage resistance signature (IRDS) genes. Importantly, we show that PTH-AS expression not only enhanced T47D cell invasion and resistance to the DNA-damaging drug doxorubicin but also promoted lung metastasis rather than tumor growth in a mouse xenograft model. In addition, PTH-AS-expressing T47D tumors showed increased macrophage infiltration that promoted angiogenesis, similar to IRDS-associated cancer characteristics. Although the detailed molecular mechanism remains imperfectly understood, we conclude that PTH-AS may contribute to tumor development, possibly through IRDS gene upregulation.
MeSH term(s)	Animals ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Line, Tumor ; DNA Damage ; Female ; Gene Expression Regulation, Neoplastic ; Heterografts ; Humans ; Interferons/metabolism ; Mice ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
Chemical Substances	RNA, Long Noncoding ; Interferons (9008-11-1)
Language	English
Publishing date	2022-05-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2022.102065
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Article ; Online: Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF-nuclear IL-33-GATA3 pathway.

Akimoto, Miho / Susa, Takao / Okudaira, Noriyuki / Koshikawa, Nobuko / Hisaki, Harumi / Iizuka, Masayoshi / Okinaga, Hiroko / Takenaga, Keizo / Okazaki, Tomoki / Tamamori-Adachi, Mimi

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 18, Page(s) e2218033120

Abstract: As a decoy receptor, soluble ST2 (sST2) interferes with the function of the inflammatory cytokine interleukin (IL)-33. Decreased sST2 expression in colorectal cancer (CRC) cells promotes tumor growth via IL-33-mediated bioprocesses in the tumor ... ...

Abstract	As a decoy receptor, soluble ST2 (sST2) interferes with the function of the inflammatory cytokine interleukin (IL)-33. Decreased sST2 expression in colorectal cancer (CRC) cells promotes tumor growth via IL-33-mediated bioprocesses in the tumor microenvironment. In this study, we discovered that hypoxia reduced sST2 expression in CRC cells and explored the associated molecular mechanisms, including the expression of key regulators of ST2 gene transcription in hypoxic CRC cells. In addition, the effect of the recovery of sST2 expression in hypoxic tumor regions on malignant progression was investigated using mouse CRC cells engineered to express sST2 in response to hypoxia. Our results indicated that hypoxia-dependent increases in nuclear IL-33 interfered with the transactivation activity of GATA3 for ST2 gene transcription. Most importantly, hypoxia-responsive sST2 restoration in hypoxic tumor regions corrected the inflammatory microenvironment and suppressed tumor growth and lung metastasis. These results indicate that strategies targeting sST2 in hypoxic tumor regions could be effective for treating malignant CRC.
MeSH term(s)	Animals ; Mice ; Interleukin-33/metabolism ; Down-Regulation ; Interleukin-1 Receptor-Like 1 Protein/metabolism ; Cell Nucleus/metabolism ; Colorectal Neoplasms/genetics ; Tumor Microenvironment ; GATA3 Transcription Factor/metabolism
Chemical Substances	Interleukin-33 ; Interleukin-1 Receptor-Like 1 Protein ; Gata3 protein, mouse ; GATA3 Transcription Factor
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2218033120
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Article: Long-term Pilocarpine Treatment Improves Salivary Flow in Irradiated Mice.

Taniguchi, Akie / Susa, Taketo / Kogo, Hiroshi / Iizuka-Kogo, Akiko / Yokoo, Satoshi / Matsuzaki, Toshiyuki

Acta histochemica et cytochemica

2019 Volume 52, Issue 3, Page(s) 45–58

Abstract: Radiation therapy for head and neck cancer frequently causes salivary gland dysfunction. Pilocarpine is a clinically approved and effective drug that induces saliva secretion, thereby keeping the oral mucosa moist and reducing discomfort in patients, but ...

Abstract	Radiation therapy for head and neck cancer frequently causes salivary gland dysfunction. Pilocarpine is a clinically approved and effective drug that induces saliva secretion, thereby keeping the oral mucosa moist and reducing discomfort in patients, but the effect is transient. We expected that this drug also has beneficial long-term effects that maintain the integrity of salivary glands by reducing, for instance, apoptosis. Here, we examined the effects of long-term pilocarpine administration in irradiated mice. The results indicated that long-term pilocarpine administration significantly improved salivary flow in irradiated mice, suggesting the potential beneficial effects of long-term administration. To elucidate the underlying mechanism, we analyzed the histology, apoptosis, and proliferation of acinar cells, and the expression of functional membrane proteins such as transmembrane member 16A, aquaporin-5, and Na-K-Cl cotransporter. Long-term pilocarpine treatment seemed to decrease irradiation-induced apoptosis, although the change was not statistically significant. The present results indicated that long-term administration of pilocarpine has beneficial effects on salivary flow in irradiated mice, and suggested that long-term administration possibly decreases apoptosis in irradiated salivary glands.
Language	English
Publishing date	2019-06-19
Publishing country	Japan
Document type	Journal Article
ZDB-ID	280005-6
ISSN	1347-5800 ; 0044-5991
ISSN (online)	1347-5800
ISSN	0044-5991
DOI	10.1267/ahc.19006
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Article ; Online: Without 1α-hydroxylation, the gene expression profile of 25(OH)D

Susa, Takao / Iizuka, Masayoshi / Okinaga, Hiroko / Tamamori-Adachi, Mimi / Okazaki, Tomoki

Scientific reports

2018 Volume 8, Issue 1, Page(s) 9024

Abstract: Recently, the antiproliferative action of 1,25(OH) ...

Abstract	Recently, the antiproliferative action of 1,25(OH)
MeSH term(s)	25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/metabolism ; Calcifediol/chemistry ; Calcifediol/pharmacology ; Calcitriol/chemistry ; Calcitriol/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Hydroxylation ; Male ; Metallothionein ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Transcriptome/drug effects ; Vitamins/pharmacology
Chemical Substances	MT2A protein, human ; Receptors, Calcitriol ; Vitamins ; Metallothionein (9038-94-2) ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.13.13) ; Calcitriol (FXC9231JVH) ; Calcifediol (P6YZ13C99Q)
Language	English
Publishing date	2018-06-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-27441-x
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Article ; Online: Intrinsic ubiquitin E3 ligase activity of histone acetyltransferase Hbo1 for estrogen receptor α.

Iizuka, Masayoshi / Susa, Takao / Tamamori-Adachi, Mimi / Okinaga, Hiroko / Okazaki, Tomoki

Proceedings of the Japan Academy. Series B, Physical and biological sciences

2017 Volume 93, Issue 7, Page(s) 498–510

Abstract: Estrogen receptors (ER) are important transcription factors to relay signals from estrogen and to regulate proliferation of some of breast cancers. The cycling of estrogen-induced DNA binding and ubiquitin-linked proteolysis of ER potentiates ER-mediated ...

Abstract	Estrogen receptors (ER) are important transcription factors to relay signals from estrogen and to regulate proliferation of some of breast cancers. The cycling of estrogen-induced DNA binding and ubiquitin-linked proteolysis of ER potentiates ER-mediated transcription. Indeed, several transcriptional coactivators for ER-dependent transcription ubiquitinate ER. Histone acetyltransferase (HAT) Hbo1/KAT7/MYST2, involved in global histone acetylation, DNA replication, transcription, and cellular proliferation, promotes proteasome-dependent degradation of ERα through ubiquitination. However, molecular mechanism for ubiquitination of ERα by Hbo1 is unknown. Here we report the intrinsic ubiquitin E3 ligase activity of Hbo1 toward the ERα. The ligand, estradiol-17β, inhibited E3 ligase activity of Hbo1 for ERα in vitro, whereas hyperactive ERα mutants from metastatic breast cancers resistant to hormonal therapy, were better substrates for ERα ubiquitination by Hbo1. Hbo1 knock-down caused increase in ERα expression. Hbo1 is another ERα coactivator that ubiquitinates ERα.
Language	English
Publishing date	2017
Publishing country	Japan
Document type	Journal Article
ZDB-ID	161781-3
ISSN	1349-2896 ; 0386-2208
ISSN (online)	1349-2896
ISSN	0386-2208
DOI	10.2183/pjab.93.030
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Article ; Online: Paired-related homeodomain proteins Prx1 and Prx2 are expressed in embryonic pituitary stem/progenitor cells and may be involved in the early stage of pituitary differentiation.

Susa, T / Kato, T / Yoshida, S / Yako, H / Higuchi, M / Kato, Y

Journal of neuroendocrinology

2012 Volume 24, Issue 9, Page(s) 1201–1212

Abstract: We recently cloned a paired-related homeodomain protein Prx2 as a novel factor in the pituitary. In the present study, we investigated the ontogenic profiles of Prx2 and another cognate Prx1 in the rat embryonic pituitary. Quantitative real-time ... ...

Abstract	We recently cloned a paired-related homeodomain protein Prx2 as a novel factor in the pituitary. In the present study, we investigated the ontogenic profiles of Prx2 and another cognate Prx1 in the rat embryonic pituitary. Quantitative real-time polymerase chain reaction showed low expression of Prx2 and a marked increase of Prx1 on rat embryonic day (E)20.5. Immunohistochemical analyses using an antibody that recognises both proteins, with the aim of investigating their roles in pituitary organogenesis, demonstrated that PRXs first appear in the Rathke's pouch on E13.5 in the pituitary stem/progenitor cells expressing Prop1 and Sox2. After E16.5, the number of Prx-expressing cells was increased in both anterior and intermediate lobes. SOX2(+) stem/progenitor cells in the intermediate lobe started to produce PRXs, and PRX(+) /SOX2(+) /PROP1(+) -cells were present on the anterior side of the marginal cell layer and were scattered in the parenchyma of the anterior lobe. On the other hand, PRX(+) -cells negative for PROP1 and SOX2 were located in the anterior lobe. Analysis of the relationship with pituitary endocrine cells revealed that a part of PRX(+) /PROP1(-) /SOX2(-) -cells in the anterior lobe co-expressed all types of hormones. The proportion of co-localisation of PRXs and hormones was highest on the day each hormone first appeared. These data indicate that PRXs are produced in the pituitary progenitor cells and may play roles in the process of terminal differentiation during early pituitary organogenesis. An in vitro small interfering RNA-knockdown experiment in the pituitary-derived cell line, TtT/GF, revealed that PRX1 and PRX2 play roles in proliferation by different mechanisms because knockdown of Prx2, but not Prx1, induced the p21 expression. Furthermore, immunohistochemical analysis demonstrated that 76% of PRXs(+) cells were positive for a cell proliferation marker Ki67 in the E18.5 pituitary. This is the first report of the involvement of PRX1 and PRX2 in organogenesis of tissue originating from the ectoderm other than the mesoderm.
MeSH term(s)	Animals ; Cell Differentiation/genetics ; Cell Line ; Cell Proliferation ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/physiology ; Gene Expression Regulation, Developmental/genetics ; Gene Expression Regulation, Developmental/physiology ; Gene Knockdown Techniques/methods ; Homeodomain Proteins/biosynthesis ; Homeodomain Proteins/physiology ; Male ; Molecular Imaging/methods ; Pituitary Gland/cytology ; Pituitary Gland/growth & development ; Pituitary Gland/physiology ; Rats ; Rats, Wistar
Chemical Substances	Homeodomain Proteins ; PRRX1 protein, rat
Language	English
Publishing date	2012-03-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1007517-3
ISSN	1365-2826 ; 0953-8194
ISSN (online)	1365-2826
ISSN	0953-8194
DOI	10.1111/j.1365-2826.2012.02336.x
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Article ; Online: 25(OH)D

Kikuyama, Takahiro / Susa, Takao / Tamamori-Adachi, Mimi / Iizuka, Masayoshi / Akimoto, Miho / Okinaga, Hiroko / Fujigaki, Yoshihide / Uchida, Shunya / Shibata, Shigeru / Okazaki, Tomoki

The Journal of steroid biochemistry and molecular biology

2020 Volume 199, Page(s) 105593

Abstract: Recently, it was reported that 25(OH) ... ...

Abstract	Recently, it was reported that 25(OH)D
MeSH term(s)	25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics ; Animals ; Calcium/metabolism ; Gene Expression Regulation/drug effects ; Humans ; Kidney Tubules/drug effects ; Kidney Tubules/metabolism ; Mice ; Mice, Knockout ; Receptors, Calcitriol/genetics ; S100 Calcium Binding Protein G/genetics ; S100 Calcium Binding Protein G/metabolism ; Vitamin D/analogs & derivatives ; Vitamin D/genetics ; Vitamin D/metabolism ; Vitamin D/pharmacology ; Vitamin D3 24-Hydroxylase/genetics
Chemical Substances	Receptors, Calcitriol ; S100 Calcium Binding Protein G ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H) ; Cyp24a1 protein, mouse (EC 1.14.15.16) ; Vitamin D3 24-Hydroxylase (EC 1.14.15.16) ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.15.18) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-01-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1049188-0
ISSN	1879-1220 ; 0960-0760
ISSN (online)	1879-1220
ISSN	0960-0760
DOI	10.1016/j.jsbmb.2020.105593
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Article ; Online: Gene expression, function, and diversity of Nkx2-4 in the rainbow trout, Oncorhynchus mykiss.

Uemae, Youji / Sakamoto, Joe / Hidaka, Yoshie / Hiratsuka, Ai / Susa, Takao / Kato, Yukio / Suzuki, Masakazu

General and comparative endocrinology

2014 Volume 206, Page(s) 193–202

Abstract: Nkx2 homeodomain transcription factors are involved in various developmental processes and cell specification: e.g. in mammals, NKX2-1 is essential for thyroid-specific gene expression and thyroid morphogenesis. Among Nkx2 proteins, information is still ... ...

Abstract	Nkx2 homeodomain transcription factors are involved in various developmental processes and cell specification: e.g. in mammals, NKX2-1 is essential for thyroid-specific gene expression and thyroid morphogenesis. Among Nkx2 proteins, information is still very limited for Nkx2-4. In the present study, we have identified three distinct cDNAs encoding Nkx2-4 isoforms (Nkx2-4a, -b, and -c) from the rainbow trout thyroid tissue, and characterized their transcriptional properties. The trout Nkx2-4 proteins were all predicted to conserve three characteristic domains: the tinman-like amino terminal decapeptide, the NK2 homeodomain, and the NK2-specific domain, and also share 75-89% amino acid similarity. It was shown by dual luciferase assay that Nkx2-4a and Nkx2-4b, but not Nkx2-4c, significantly activated transcription from a cotransfected rat thyroglobulin (TG) promoter. An electrophoretic mobility shift assay indicated that all the Nkx2-4 isoforms could bind to the TG promoter, implying that the faint transcriptional activity of Nkx2-4c might result from some critical amino acid substitution(s) outside the homeodomain. RT-PCR analysis revealed similar tissue distribution patterns for Nkx2-4a and Nkx2-4b mRNAs. Both mRNAs were expressed abundantly in the thyroid, and weakly in the testis. On the other hand, Nkx2-4c mRNA was detected in the ovary as well as in the thyroid. The expression sites of Nkx2-4c mRNA were localized, by in situ hybridization histochemistry, to the ovarian granulosa cells and to the thyroid follicular cells. The results suggest that in the rainbow trout, Nkx2-4a and Nkx2-4b might play a major role in TG gene transcription whereas Nkx2-4c might have some functions in the ovary as well as the thyroid.
MeSH term(s)	Amino Acid Sequence ; Animals ; Cloning, Molecular ; DNA, Complementary/genetics ; Electrophoretic Mobility Shift Assay ; Gene Expression Regulation ; In Situ Hybridization ; Molecular Sequence Data ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Oncorhynchus mykiss/metabolism ; Phylogeny ; Protein Isoforms/metabolism ; RNA, Messenger/metabolism ; Sequence Homology, Amino Acid ; Thyroglobulin/metabolism ; Thyroid Nuclear Factor 1 ; Tissue Distribution ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcriptional Activation
Chemical Substances	DNA, Complementary ; Nuclear Proteins ; Protein Isoforms ; RNA, Messenger ; Thyroid Nuclear Factor 1 ; Transcription Factors ; Thyroglobulin (9010-34-8)
Language	English
Publishing date	2014-09-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1851-x
ISSN	1095-6840 ; 0016-6480
ISSN (online)	1095-6840
ISSN	0016-6480
DOI	10.1016/j.ygcen.2014.07.007
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Article ; Online: Significant quantitative and qualitative transition in pituitary stem / progenitor cells occurs during the postnatal development of the rat anterior pituitary.

Yoshida, S / Kato, T / Yako, H / Susa, T / Cai, L-Y / Osuna, M / Inoue, K / Kato, Y

Journal of neuroendocrinology

2011 Volume 23, Issue 10, Page(s) 933–943

Abstract: We reported recently that a pituitary-specific transcription factor PROP1 is present in SOX2-positive cells and disappears at the early stage of the transition from progenitor cell to committed cell during the embryonic development of the rat pituitary. ... ...

Abstract	We reported recently that a pituitary-specific transcription factor PROP1 is present in SOX2-positive cells and disappears at the early stage of the transition from progenitor cell to committed cell during the embryonic development of the rat pituitary. In the present study, we examined the localisation and identification of SOX2-positive and PROP1/SOX2-positive cells in the neonatal and postnatal rat pituitaries by immunohistochemistry. Quantitative analysis of immunoreactive cells demonstrated that SOX2-positive pituitary stem/progenitor cells are not only predominantly localised in the marginal cell layer, but also are scattered in the parenchyma of the adult anterior lobe. In the marginal cell layer, the number of PROP1/SOX2-positive cells significantly decreased after postnatal day 15, indicating that a significant quantitative transition is triggered in the marginal cell layer during the first postnatal growth wave of the anterior pituitary. By contrast, other phenotypes of SOX2-positive stem/progenitor cells that express S100β appeared in the postnatal anterior pituitary. These data suggested that quantitative and qualitative transition occurs by acquisition of a novel mechanism in terminal differentiation in the postnatal development of the anterior pituitary.
MeSH term(s)	Animals ; Base Sequence ; DNA Primers ; Gene Expression Profiling ; Immunohistochemistry ; Male ; Pituitary Gland, Anterior/cytology ; Rats ; Rats, Wistar ; Real-Time Polymerase Chain Reaction ; SOXB1 Transcription Factors/metabolism ; Stem Cells/cytology
Chemical Substances	DNA Primers ; SOXB1 Transcription Factors ; Sox2 protein, rat
Language	English
Publishing date	2011-08-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1007517-3
ISSN	1365-2826 ; 0953-8194
ISSN (online)	1365-2826
ISSN	0953-8194
DOI	10.1111/j.1365-2826.2011.02198.x
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